도심부 연속류 구간 무인단속카메라 설치 효과분석에 관한 연구 - 대구광역시를 중심으로 -

박신형,권오훈,박신형 한국ITS학회 2017 한국ITS학회 학술대회 Vol.2017 No.04

교통문화지수 실태조사 개선방안에 관한 연구

박신형,이주용,권오훈,박신형,김주영 한국ITS학회 2019 한국ITS학회 학술대회 Vol.2019 No.04

고속도로 리모델링 공사 차단 방식 검토

박신형,박용우 한국도로학회 2024 한국도로학회지 Vol.26 No.1

Virtual lymph node analysis to evaluate axillary lymph node coverage provided by tangential breast irradiation

박신형,김재철,이정은,박인규 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.1

Purpose: To investigate the coverage of axillary lymph node with tangential breast irradiation fields by using virtual lymph node (LN) analysis. Materials and Methods: Forty-eight women who were treated with whole breast irradiation after breast-conserving surgery were analyzed. The axillary and breast volumes were delineated according to the Radiation Therapy Oncology Group (RTOG) contouring atlas. To generate virtual LN contours, preoperative fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans with identifiable LN were fused with the CT scans, and the virtual LN contour were delineated on the CT. Results: The median level I and II axillary volume coverage percentages at the VD95% line were 33.5% (range, 5.3% to 90.4%) and 0.6% (range, 0.0% to 14.6%), respectively. Thirty-one LNs in 18 patients were delineated (26 in level I and 5 in level II). In the level I axilla, 84.6% of virtual LNs were encompassed by the 95% isodose line. In the level II axilla, by contrast, none of the virtual LNs were encompassed by the 95% isodose volumes. There was a substantial discrepancy between the RTOG contouring atlas-based axillary volume analysis and the virtual LN analysis, especially for the level I axillary coverage. The axillary volume coverage was associated with the body mass index (BMI) and breast volume. Conclusion: The tangential breast irradiation did not deliver adequate therapeutic doses to the axillary region, particularly those in the level II axilla. Patients with small breast volumes or lower BMI showed reduced axillary coverage from the tangential breast fields. For axillary LN irradiation, individualized anatomy-based radiation fields for patients would be necessary.

Incidences of Deep Vein Thrombosis and Pulmonary Embolism after Total Knee Arthroplasty Using a Mechanical Compression Device with and without Low-Molecular-Weight Heparin

박신형,안중현,박용복,이선근,임수재 대한슬관절학회 2016 대한슬관절학회지 Vol.28 No.3

purpose: To investigate the incidence of thromboembolic events and complications related to bleeding after total knee arthroplasty (TKA) with a mechanical compression device alone or in combination with low-molecular-weight heparin (LMWH).Materials and Methods: A total of 489 TKA patients (776 knees) were retrospectively reviewed for the incidence of thromboembolic events and complications related to bleeding. While 233 patients (354 knees) were treated with a mechanical compressive device without LMWH, 256 patients (422 knees) were treated with the mechanical compressive device along with LMWH. results: The incidences of deep vein thrombosis (DVT) and pulmonary embolism (PE) were 15 of 375 knees (4.0%) and 5 of 375 knees (1.3%), respectively, in the group that used only a mechanical compressive device, and 14 of 401 knees (3.4%) and 5 of 401 knees (1.2%), respectively, in the group that used the mechanical compressive device with LMWH. There was no significant difference between the two groups (p=0.125 and p=0.146, respectively). The postoperative hemovac drainage amount was 635±57 mL in the group with a mechanical compressive device only and 813±84 mL in the group with the device and LMWH; therefore, the amount of drainage was significantly greater in the latter group (p=0.013).conclusions: Mechanical compression alone for prophylaxis against DVT and PE after TKA can be an attractive option in Korean patients.

교통연계성을 고려한 지역낙후도 지표 산정방안 연구

박신형,김동선 대한토목학회 2015 대한토목학회논문집 Vol.35 No.3

When evaluating the feasibility of construction projects of large-scaled transportation facilities such as roads or railways based solely on the result of the economic analysis, less development indicators are politically reflected on the investment decision-making because regions whose socio-economic indicators are poor may be disadvantaged or underserved for the projects. Existing less development indicators, however, does not consider the transportation connectivity which indicates how effective the transportation networks are established for the transport of people and goods. In this study, travel time contour maps, travel distance and travel time between regions, and a route curvature were utilized to define new indices which reflect transportation connectivity on the less development indicators. When the new indices are applied, the existing rankings of under-developedness were changed, which means that transportation connectivity could effect on the political decision. In this study, we also suggested the necessity of considering the transportation connectivity when evaluating less development indicators, developed measures of inter-regional linkages, and performed the whole procedures of combining existing and new indices to evaluate the less development indicators. 도로, 철도 등 대규모 교통시설 투자사업의 예비타당성 조사에서 경제성 분석 결과만을 기준으로 사업의 타당성을 평가할 경우, 사회경제지표가 열악한 지역이 투자에서 소외될 수 있어 지역낙후도 지수를 정책적으로 반영하고 있다. 하지만 기존의 지역낙후도 산정 지표는 사람과 물자의 수송에 얼마나 유리한 교통 시설을 갖추고 있는가를 나타내는 교통연계성을 반영하지 못하고 있다. 따라서 본 연구에서는 지역낙후도 결정 시 교통연계성을 반영하기 위해 등시간선도, 지역 간 이동거리 및 소요시간, 우회도 등을 적용해 보았다. 새로운 지표 활용 시 기존의 낙후도 순위가 변경되는 결과를 확인할 수 있는데, 이는 현재의 낙후도 지수에 교통연계성을 반영하는 지표를 추가하는 것이 정책적 결정에 영향을 미칠 수 있음을 의미한다고 볼 수 있다. 본 연구에서는 지역낙후도 산정 시 교통연계성을 고려해야 할 당위성을 제시하였고, 기존의 연구들과는 달리 지역 간 교통연계성을 나타내는 지표를 개발하여 기존의 지역낙후도 지수에 반영하는 절차를 수행하였다는데 연구의 의의를 둘 수 있다.

Radiomics

박신형 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

청피 에탄올 추출물이 스트레스성 카테콜아민으로 유도한 간암세포의 전이를 억제하는 효과 및 기전 연구

박신형 한의병리학회 2024 동의생리병리학회지 Vol.38 No.1

Previous studies have highlighted the pivotal role of the β-adrenergic receptor (β-AR) signaling pathway in stimulating cancer metastasis induced by chronic stress. According to the theory of traditional Korean medicine, chronic stress can induce Qi stagnation. Based on the traditional role of premature citrus unshiu peel in moving Qi, we hypothesized that an ethanol extract of premature citrus unshiu peel (EPCU) can attenuate chronic stress-induced cancer progression. In this study, we investigated the potential role of EPCU on modulating the adrenergic agonists-induced metastatic properties of liver cancer cells. Our findings revealed that adrenergic agonists, including norepinephrine (NE), epinephrine (E), and isoproterenol (ISO), augmented the migratory capacity of Hep3B human hepatocellular carcinoma cells, which was completely abrogated by EPCU treatment in a concentration-dependent manner. Consistently, EPCU inhibited the E-induced invasive property of Hep3B cells in a dose-dependent manner. These results suggest that EPCU efficiently attenuates adrenergic agonists-induced metastatic abilities of liver cancer cells. As a molecular mechanism, EPF suppressed the phosphorylation of major components of β-AR signaling pathway, including Src, signal transducer and activator of transcription 3 (STAT3) and ERK, induced by E treatment. Taken together, our results demonstrate that EPCU impedes the adrenergic agonists-driven metastatic potential of cancer cells by inhibiting β-AR signaling pathway. This study provides basic evidence supporting the probable use of premature citrus unshiu peel to prevent metastasis in liver cancer patients under chronic stress.

Local and regional recurrence following mastectomy in breast cancer patients with 1–3 positive nodes: implications for postmastectomy radiotherapy volume

박신형,이지연,이정은,강민규,김미영,박호용,정진향,채의수,이수정,김재철 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.4

Purpose: To determine the necessity of postmastectomy radiotherapy (PMRT) and which regions would be at risk for recurrence, we evaluated local and regional recurrence in breast cancer patients with 1–3 positive nodes and a tumor size of <5 cm. Materials and Methods: We retrospectively analyzed data of 133 female breast cancer patients with 1–3 positive nodes, and a tumor size of <5 cm who were treated with mastectomy followed by adjuvant systemic therapy between 2007 and 2016. The median follow-up period was 57 months (range, 12 to 115 months). Most patients (82.7%) were treated with axillary lymph node dissection. Adjuvant chemotherapy, endocrine therapy, and trastuzumab therapy were administered to 124 patients (93.2%), 112 (84.2%), and 33 (24.8%), respectively. The most common chemotherapy regimen was anthracycline and cyclophosphamide followed by taxane (71.4%). Results: Three patients (2.3%), 8 (6.0%), and 12 (9.0%) experienced local, regional, and distant failures, respectively. The 5-year cumulative risk of local recurrence, regional recurrence, distant metastasis, and disease-free survival was 3.1%, 8.0%, 11.7%, and 83.4%, respectively. There were no statistically significant clinicopathologic factors associated with local recurrence. Lymphovascular invasion (univariate p = 0.015 and multivariate p = 0.054) was associated with an increased risk of regional recurrence. Conclusion: Our study showed a very low local recurrence in patients with 1–3 positive nodes and tumor size of <5 cm who were treated with mastectomy and modern adjuvant systemic treatment. The PMRT volume need to be tailored for each patient’s given risk for local and regional recurrence, and possible radiation-related toxicities.

소집단 독서교육 프로그램이 유아의 사회적 태도와 사회적 기술 증진에 미치는 효과

박신형 성균관대학교 生活科學硏究所 2003 生活科學 Vol.6 No.-