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고감도 H<sub>2</sub>S 감지를 위한 SnO<sub>2</sub> 장식된 Cr<sub>2</sub>O<sub>3</sub> nanorods 이종구조
정재한 ( Jae Han Chung ),조윤행 ( Yun-haeng Cho ),황준호 ( Junho Hwang ),이수형 ( Su Hyeong Lee ),이승기 ( Seunggi Lee ),박시형 ( See-hyung Park ),손성우 ( Sungwoo Sohn ),조동휘 ( Donghwi Cho ),이광재 ( Kwangjae Lee ),심영석 ( You 한국센서학회 2024 센서학회지 Vol.33 No.1
The creation of vertically aligned one-dimensional (1D) nanostructures through the decoration of n-type tin oxide (SnO<sub>2</sub>) on p-type chromium oxide (Cr<sub>2</sub>O<sub>3</sub>) constitutes an effective strategy for enhancing gas sensing performance. These heterostructures are deposited in multiple stages using a glancing angle deposition technique with an electron beam evaporator, resulting in a reduction in the surface porosity of the nanorods as SnO<sub>2</sub> is incorporated. In comparison to Cr<sub>2</sub>O<sub>3</sub> films, the bare Cr<sub>2</sub>O<sub>3</sub> nanorods exhibits a response 3.3 times greater to 50 ppm H<sub>2</sub>S at 300°C, while the SnO<sub>2</sub>-decorated Cr<sub>2</sub>O<sub>3</sub> nanorods demonstrate an eleven-fold increase in response. Furthermore, when subjected to various gases (CH<sub>4</sub>, H<sub>2</sub>S, CO<sub>2</sub>, H<sub>2</sub>), a notable selectivity toward H<sub>2</sub>S is observed. This study paves the way for the development of p-type semiconductor sensors with heightened selectivity and sensitivity towards H<sub>2</sub>S, thus advancing the prospects of gas sensor technology.
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박시형,이신원,정귀화,최창훈,이순희,한정훈,김정국,하승우,김보완 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4
Autoimmune insulin syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. This syndrome shows discordant levels between immunoreactive insulin and C-peptide. Negative results of an anatomic study of the pancreas and an inability to reproduce hypoglycemia during a prolonged fast may be helpful in excluding insulinoma. Symptomatic hypoglycemia usually develops during an oral glucose tolerance test. This syndrome is a self-limited disorder. Recently, we experienced one case that developed symptomatic hypoglycemia during both the fasting & oral glucose tolerance test, and another that developed symptomatic hypoglycemia during the oral glucose tolerance test but not the fasting test. Hereby, we present these cases with a review of the literature
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제2형 당뇨병 환자의 신체계측법을 이용한 비만도 측정의 임상적 의의
최영선,김보완,박시형 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.3
Background: It is well demonstrated that obesity is associated with many chronic disorders like type 2 diabetes, dyslipidemia, and hypertension. In Korea, there are numerous reports revealed the possible relationship between anthropometric indices of obesity and the aformentioned disorders in nondiabetic healthy population, but the reports in type 2 diabetics are limited. Therefore, in this study we evaluated the relationship among the anthropometric indices and fasting insulin, C-peptide, and serum lipid levels in recently diagnosed type 2 diabetics. Method: A total of 160 type 2 diabetics were recruited from the out-patient department of endocrinoloy of Kyungpook National University Hospital from March to June 1999. The following subjects were excluded from the study: duration of type 2 diabetes $gt; 5year, receiving of insulin or lipid lowering agents. For all participants, body mass index, percent of body fat, waist and hip circumference were measured. Fasting plasma insulin, C-peptide, blood glucose, HbA1c, total cholesterol, triglyceride and high-density lipoprotein cholesterol were also assayed. Partial correlation analysis was used to test the relationships between anthropometric indices and laboratory data. Results: 1) In male subjects, fasting plasma insulin level was not significantly correlated with any of the anthropometric variables. However, in female subjects, fasting plasma insulin level was significantly correlated with body mass index, percent of body fat, and waist circumference. 2) Fasting plasma C-peptide level significantly correlated to all of the anthropometric variables in female patients, but in males only significant association was seen between fasting plasma C-peptide level and waist circumference. 3) Total cholesterol level was significantly correlated with percent of body fat and waist/hip ratio in male and female subjects respectively. Conclusion: Anthropometric indices of abdominal obesity appear to be correlated with insulin production and lipid changes in recently diagnosed type 2 diabetics. Waist circumference is a more useful predictor of hyperinsulinemia than waist/hip ratio in both sexes.
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선천성 신성 요붕증 환자 가족의 항이뇨호르몬 V2 수용체 유전자 변이
최영선,김보완,이순희,최창훈,박시형,김정국,하승우 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.1
Background : Congenital nephrogenic diabetes insipidus(NDI) is a rare inherited disorder, in which two different hereditary forms, X-linked and autosomal recessive traits, have been identified. The X-linked recessive form, mostly($gt;90%) congenital NDI, has been known to be caused by mutation of the arginine-vasopressin receptor 2(AVPR2) gene. AVPR2 mutation sites are different in ethnic groups and recently 72 different mutation sites have been reported among AVPR2 gene. This study aimed to analyze AVPR2 gene in selected members in a Korean family with NDI and provided a report of the existence of a new mutation site in AVPR2 gene. Methods : Three-generation maternal pedigree of the index patient(21-year old male, patient I) and his younger brother(19-year old male, patient II) with NDI was collected. Genomic DNA was obtained from patient I, II, III(index patient's male maternal cousin with NDI), index patient's mother, three maternal aunts, one female maternal cousin and, for control, one healthy male voluntThree coding exons of AVPR2 gene were amplified by PCR using 4 pairs of oligonucleotide primers. After direct sequencing of amplified PCR products, the sequence was compared with whole squence of normal AVPR2 gene and identification of a new site of mutation in this gene was done. Results : 1) all three male patients had transversion of G to C at position 1033 of the AVPR2 gene, resulting in a subsequent change of amino acid from glycine to cysteine in codon 201. 2) Two small peaks of G and T, the result of direct sequencing in five female members in this family, would suggest that they are carriers of G to N transversion. Conclusion : These results can demonstrate the significant functional correlation of the mutation in AVPR2 gene sequence with clinical NDI, and suggest the clinical utility of direct mutation testing for congenital NDI in family(J Kor Soc Endocrinol 15:97-106, 2000).
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