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목향(木香)이 고지방 식이에 의한 비만으로 유발된 인슐린 저항성 mouse의 염증 및 인슐린 저항성에 미치는 영향
오재선,마영훈,최승범,김종호,김경국,전상윤,Oh, Jae-Seon,Ma, Young-Hun,Choi, Seung-Bum,Kim, Jong-Ho,Kim, Kyung-Kook,Jeon, Sang-Yun 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: Obesity is an important cause of insulin resistance that leads to obese type 2 diabetes. Recently it has been found that obesity is associated with adipose tissue accumulation which causes systemic inflammation. In this study, we investigated effects of Inula helenium on the inflammation in high fat diet-induced insulin resistance mouse. Methods: Insulin resistance was induced in C57BL/6 male mice (19~21 g) on a 60% fat diet. Mice were divided into 3 groups (n=6) of normal, control and Inula helenium. After 12 weeks, body weight, FBS, oral glucose tolerance test (OGTT), serum level of insulin, epididymal fat pad, liver weight and the gene expression of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6, interleukin (IL)-10 and cluster of differentiation (CD) 68 were measured. Also, adipose tissue macrophage was analyzed by fluorescence activated cell sorting. Results: Inula helenium significantly reduces oral glucose tolerance levels, insulin serum level and adipose tissue macrophage. Also Inula helenium increased IL-10 gene expression and decreased CD68 gene expression. Conclusions: These results show that Inula helenium has anti-insulin resistance and anti-inflammatory effects on a high fat diet-induced insulin resistance mouse model.
말초성 안면신경마비에 대한 황련해독탕약침과 자하거약침의 효능 후향적 비교 연구
이정훈 ( Jung Hun Lee ),양태준 ( Tae Jun Yang ),김선욱 ( Seon Wook Kim ),정주용 ( Joo Yong Jeong ),마영훈 ( Young Hun Ma ),오재선 ( Jae Seon Oh ),최정욱 ( Jeong Wook Choi ),이은지 ( Eun Ji Lee ),위통순 ( Tung Shuen Wei ) 경락경혈학회 2015 Korean Journal of Acupuncture Vol.32 No.4
Objectives: The purpose of this study is to compare the effects of Hwangryunhaedok-tang pharmacopuncture therapy with Hominis Placenta pharmacopncture therapy in hospitalized patients with peripheral facial paralysis. Methods : We investigated 34 cases of patients with peripheral facial paralysis who were admitted into the Dept. of Acupuncture & Moxibustion of Dongshin University Suncheon Oriental Hospital from February 1, 2014 to June 31, 2015. Subjects were divided into two groups, Hwangryunhaedok-tang pharmacopuncture group(HR group), and Hominis Placenta Pharmacopuncture group(JH group). HR group was treated by Hwangryunhaedok-tang pharmacopuncture five times a week and JH group was treated by Hominis Placenta Pharmacopuncture five times a week. And both groups were treated by acupuncture, electroacupuncture, herbal medicine therapy, western drug therapy equally. To investigate the effectiveness of treatment, we used House-Brackmann Grading System, Yanagihara’s unweighted grading system and Sunnybrook facial grading scale at before admission and after admission. Results : Each scores by 3 evaluation methods improved both in two groups. However, there were no significant differences in improvement between two groups. Conclusions : These results suggest that the Hwangryunhaedok-tang pharmacopuncture therapy is as effective as Hominis Placenta pharmacopuncture therapy to improve symptoms of peripheral facial paralysis.
한의학적 치료로 호전된 불면과 우울을 동반한 섬유근통 증후군 환자 치험 1례
김의수,신민구,김태련,오재선,마영훈,이영수,Kim, Eui-su,Shin, Min-koo,Kim, Tae-ryun,Oh, Jae-seon,Ma, Young-hun,Le, Young-su 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3
Objectives The study aimed to evaluate the therapeutic effect of Hyungtonghaeul-tang along with Korean medicine treatment for fibromyalgia syndrome. Methods A patient with fibromyalgia syndrome was treated with Hyungtonghaeul-tang as well as Korean medical treatment including acupuncture, electro-acupuncture, bee venom therapy, chuna, aromatherapy, and physical therapy. The counts of tenderness points, widespread pain index (WPI), symptom severity scale score (SS scale score), digital infrared thermal imaging (DITI), Ryodoraku diagnosis, visual analogue scale (VAS), fibromyalgia impact questionnaire (FIQ), and beck depression inventory (BDI) were measured. Results After treatment, the counts of tenderness point, WPI, SS scale score, VAS, FIQ, and BDI were decreased. The DITI and the Ryodoraku pattern recovered normally. Conclusions Hyungtonghaeul-tang along with Korean medicine treatment can be used in the treatment of fibromyalgia syndrome.
국내 한의학계의 항혈전 효과에 대한 실험 연구 고찰 -2001년 이후 한방부인과학회지에 발표된 논문을 중심으로-
정수정 ( Soo Jung Jung ),마영훈 ( Young Hun Ma ),최승범 ( Seung Bum Choi ),박경미 ( Kyung Mi Park ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.1
The purpose of this study is to compare with the result of experimentalstudy about antithrombotic effect by reviewing recent oriental medicine journalsthat have been published since 2001` in Korea. Methods: Articles on antithrombotic effect that have been published from2001` to 2013` in oriental medicine journals registered National Research Foundationof Korea were searched. After that, 12 articles using same ``thrombosis conditionmodel`` were selected and reviewed. Results: The results were as follows. 1. If there is no limit drug concentrations, platelet aggregation induced byadenosine diphosphate (ADP) in hyulbuchukeo-tanggamibang (HBCT) was the largestaggregation inhibitory effect and platelet aggregation induced by epinephrine inSaegeum-san (SGS), Jogan-tanggagambang (JGTG), hyulbuchukeo-tanggamibang (HBCT)had a large inhibitory effect on aggregation. 2. At the lowest concentration, Mokdan-san (MDS) of the inhibition of plateletaggregation induced by ADP and Hyunhosaik-san (HHS) of the inhibition of plateletaggregation induced by epinephrine were effective. 3. Pulmonary embolism induced by collagen and epinephrine in Neungasojeok-tang(NSJT) has the highest antithrombotic effect. 4. Pathological conditions of extravasated blood by dextran, Jogan-tanggagambang(JGTG) has the highest inhibitory effect on decrease in platelet numbers. Comparedto the rest of the experimental drug, Saegeum-san (SGS), Heanggyonghonghwa-tang(HGTHHT), Wusl-san (WSS), Mokdan-san (MDS) showed significant inhibitory effecton the prothrombin time (PT) increases. Honghwadanggui-san (HDS), Saegeum-san(SGS) showed significant inhibitory effect on increase in activated partial thromboplastintime (APTT) and Jogan-tanggagambang (JGTG), Heanggyonghonghwa-tang(HGTHHT) showed significant inhibitory effect on decrease in fibrinogen. Conclusions: This result will provide useful information for the prescriptionsof antithrombotic medicine in the field of Oriental medicine. We will have tocarry out further studies that will compare each herb used in the diseases causedby extravasated blood.
정수정 ( Soo Jung Jung ),박경미 ( Kyung Mi Park ),송유림 ( Yu Rim Song ),조성희 ( Seong Hee Cho ),양승정 ( Seung Jeong Yang ),마영훈 ( Young Hun Ma ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.2
Objectives: This study aims to report the effect of Korean medicine treatments on a sequela of operation of hallux valgus. Methods: The patient was treated with Dangkisoosan-gami, Acupuncture treatment including Herbal-Acupuncture and physical therapy. We evaluated treatment effects by circumference of foot and ankle, Edema index score by Body Composition Analyzer, Ankle-Brachial Index (ABI) and Visual Analogue Scale (VAS). Results: After 25 days of treatment, the symptoms such as lower extremity edema, foot pain and ankle pain were improved. Conclusions: In this case, Korean medicine treatments for a sequela of operation of hallux valgus was effective. But further studies are required to confirm the effect of these methods.