중증급성호흡기증후군(SARS) 및 중동호흡기증후군(MERS)의 중의 진료지침에 대한 고찰

류한성,오혜경,이지영,윤성우,Ryu, Han-sung,Oh, Hye-kyung,Lee, Jee-young,Yoon, Seong-woo 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.3

Objectives This study aims to overview traditional Chinese medicine (TCM) treatment guidelines for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) in order to facilitate the use of Korean medicine (KM) treatment in pandemic diseases. Methods We compared the characteristics between SARS and MERS, and overviewed the Traditional Chinese Medicine treatment guidelines for SARS and MERS. We assessed the efficacy of simultaneous administration of herbal medicine and Western medicine on SARS by studying Cochranes 2012's Systematic Review Studies. Results and Conclusions Based on wen bing (warm diseases) of KM as well as TCM, KM treatment can be an alternative for pandemic diseases such as SARS and MERS considering the Korean's characteristic environment.

한방병원 외래 환자의 한의사 복장에 따른 선호도에 관한 연구 - 한의사 복장에 따른 선호도에 관한 연구 -

류한성,이인,한창우,김소연,홍진우,박성하,권정남,최준용,Ryu, Han-Sung,Lee, In,Han, Chang Woo,Kim, So Yeon,Hong, Jin Woo,Park, Seong Ha,Kwon, Jung Nam,Choi, Jun-Yong 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.3

Purpose : This study was conducted to assess whether Korean medicine doctors' attire influences patients' preference (confidence, comfortability, neatness) in a university hospital. Materials and Methods : Employing a cross-sectional design, outpatients answered a questionnaire in a university hospital of Korean Medicine. Respondents were asked for completing the questionnaire to estimate their preference of doctor's attire for confidence, comfortability and neatness after watching 4 types of attire in both male and female Korean medicine doctors, including white coat, traditional attire, formal suit and casual clothes. Whether Korean medicine doctors' attire on a patients' preference is important was also asked for the respondents using a 5-point Likert scale. Results : All 175 patients were enrolled, of whom 38.9% were male respondents, 46.3% graduated from a university at least and mean age of responders was 47.1. Most had a tendency for preferring white coat followed by traditional attire and only a small portion of respondents preferred for formal suit and casual clothes. When comparing preferences in confidence between white coat and traditional attire only, male patients preferred white coat more than female patients did with statistical significance. In addition, 85.4% of respondents answered that Korean medicine doctors' attire is important to a clinical situation with higher ratio of female respondents (87.9%) than male respondents (80.9%). Conclusion : Patients preferred white coat and traditional attire mostly for the Korean Medicine doctor's attire with only small preference for formal suit and casual clothes. Also, Patients recognized that Korean medicine doctors' attire is important in the clinical situation.

항암 치료가 불가한 고령의 4기 담낭암 환자 한방치험 1례

류한성,오혜경,이지영,윤성우,Ryu, Han Sung,Oh, Hye Kyung,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2016 大韓癌韓醫學會誌 Vol.21 No.1

Background : This case is to report a gallbladder cancer patient treated with Korean Medicine who could not receive conventional cancer therapies such as operation and chemotherapy due to her underlying diseases, old age and poor performance. Method and Results : An eighty-year-old female patient was diagnosed with stage IV gallbladder cancer on Feb. 2014 and she already had hypertension, diabetes and Parkinsonism. Comprehensive Korean Medicine (KM) treatments instead of operation and chemotherapy were administrated due to her poor condition and old age. KM treatments were done focused on improving symptoms and quality of life combined with best supportive care. During KM treatments her abdominal pain was generally managed and she survived for 22 months. Conclusion : Further studies should be performed in the future to clarify the survival benefit and symptom management of comprehensive KM treatments.

한의 암 증상 완화에 대한 한의사 대상 설문 조사

류한성,이지영,오혜경,윤성우,Ryu, Han-Sung,Lee, Jee-Young,Oh, Hye-Kyung,Yoon, Seong-Woo 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.1

Backgrounds: The demand of complementary and alternative medicine (CAM) including Korean Medicine (KM) is increasing worldwide. But cancer patients (CP) still have a difficulty in gathering CAM information or communicating with their doctors, and clinical status in cancer care is unclear in the field of KM in Korea especially. The aim of this study is to examine clinical status of KM for cancer symptom care by KM doctors in medical service institutions. Methods: Total forty nine KM doctors completed the site survey questionnaire. The questionnaire items were to list chief symptom complaints of CP treated with KM and effective KM therapies. Results: The majority of the respondents were general physicians without KM specialist board (67.4%) who have 10-20 years clinical experience with CP (55.1%). Primary cancer lesion, diagnostic status, and treatment period were not different in KM clinical service institutions. In chief symptom complaints of CP treated with KM, gastrointestinal (32.9%), musculoskeletal (19.9%), circulatory & respiratory (16.2%), psychiatric (14.1%), urinary (5.8%) symptoms were in turn. In effective KM therapies assessed by KM doctors, xerostomia (45.7%) and cancer-related fatigue (44.8%) were more effective with herbal treatments. Peripheral neuropathy (43.4%), depression, insomnia (38.2%), and cancer pain (31.9%) were preferred to treat using acupuncture. Conclusion: The CP treated with KM used evenly KM medical service institutions regardless of hospital size, and there will be further survey for CP treated KM in the future.

한방 치료에 대한 암 환자의 인식 조사 : 단면조사연구

류한성,윤성수,이지영,윤성우,Ryu, Han-sung,Yoon, Sung-soo,Lee, Jee-young,Yoon, Seong-woo 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.3

Objective: The purpose of this study was to survey the general perspectives of cancer patients on Korean medicine (KM) treatments. Method: The after focus-group discussion consisted of six cancer patients. The questionnaire items were decided. Fifty randomized cancer patients completed the online survey questionnaire regarding the perspectives of KM in cancer treatment. Results: Cancer patients considered KM to be a treatment performed both by KM doctors (92%) and by others (46%), such as private practitioners. Cancer patients thought of KM treatment as effective (68%) and safe (64%), but not scientific (60%). The answers of the cancer patients regarded whether the KM treatment experiences were different in purpose, satisfaction, and types of KM treatment. The experienced KM cancer patients thought of the optimal purpose of KM as alleviating symptoms or side effects (73.7%). Experienced patients were more satisfied with KM and they preferred acupuncture and moxibustion to thermotherapy. Conclusion: Cancer patients consider KM treatment effective and safe, but not scientific. Cancer patients who are experienced with KM are favorable to KM treatment. The direction of future studies of KM in cancer care should be considered based on these findings.

가역 셀룰러 오토마타 기반 블록 암호에 대한 취약점 분석

류한성(Ryu Han-Seong),이제상(Lee Je-Sang),이창훈(Lee Chang-Hoon),성재철(Sung Jae-Chul),홍석희(Hong Seok-Hie) 한국방송·미디어공학회 2008 한국방송공학회 학술발표대회 논문집 Vol.2008 No.-

셀룰러 오토마타(CA:cellular automata)의 특징 중에서 확산(Diffusion)과 국소적인 상호 작용(Local Interaction)은 암호시스템을 설계하는데 적합하여 암호 알고리즘 의사난수 생성기를 비롯한 암호시스템의 설계 논리로 활용되고 있다. 본 논문에서는 2004년에 제안된 가역 셀룰러 오토마타 기반 블록 암호(BCRCA)에 대한 취약점 분석을 소개한다[1]. BCRCA는 224 비트의 안전성을 가져야 하지만, 균일한 키를 이용할 경우 통계적 취약점을 이용하여 191.8 비트의 안전성을 갖는다.

셀룰러 오토마타 기반 블록 암호에 대한 안전성 분석

류한성(Han Seong Ryu),이제상(Je Sang Lee),이창훈(Chang Hoon Lee),홍석희(Seok Hie Hong) 한국멀티미디어학회 2008 멀티미디어학회논문지 Vol.11 No.8

고형암 환자의 수술 후 통증에 대한 침 치료 효과 : 체계적 문헌고찰 및 메타분석

윤성수,류한성,오혜경,이지영,윤성우,Yoon, Sung Soo,Ryu, Han Sung,Oh, Hye Kyung,Lee, Jee Young,Yoon, Seong Woo 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.2

Objectives: Postoperative pain is one of postoperative complications in patients with solid tumor. This systematic review and meta-analysis were aimed to evaluate the efficacy of acupuncture for postoperative pain in solid tumor. Methods: We searched for randomized controlled trials (RCTs) using acupuncture for postoperative pain in adult patients with solid tumor up to September 2016. Acupuncture was defined as manual acupuncture, electroacupuncture and pharmacopuncture. The following databases were searched: PubMed, EMBASE, Cochrane Library, CNKI, CiNii, KoreaMed, Kmbase, KISS, NDSL, KISTI. The results of the studies were meta-analyzed and the risk of bias was assessed. Results: Five studies were included in this review. When acupuncture was compared with usual care, Prince-Henry pain scale score was significantly lower in acupuncture group (MD=-0.44, 95% CI: -0.62 to -0.26, P<0.001, $I^2=87%$) and 10 points pain score (including Numeric Rating Scale and Visual Analog Scale) was lower in acupuncture group but not significantly (MD=-1.00, 95% CI: -2.00 to -0.00, p=0.05). When acupuncture was compared with sham acupuncture, 10 points pain score was significantly lower in acupuncture group (MD=-0.39, 95% CI: -0.65 to -0.14, p=0.002, $I^2=0%$). Any serious adverse events were not reported. Conclusion: This review shows that acupuncture may be considered for postoperative pain in patients with solid tumor without serious adverse events. However, only a few studies were included in this study, further investigation is needed in this area.

한약 및 천연물의 항암 임상연구 방법론에 대한 고찰

오혜경,이지영,류한성,윤성우,Oh, Hye Kyung,Lee, Jee Young,Ryu, Han Sung,Yoon, Seong Woo 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.1

Objectives : The cancer incidence and cancer burden is increasing. In addition, the use of botanical agents in cancer care is increasing. This article aims to review a research strategy for botanical agents. Methods : The clinical studies of anticancer botanical agents and the papers about clinical research methodology of botanical agents were reviewed. Results : In phase I study, safety confirmation, optimal dose determination and drug interaction study are important. Most botanical agents have low toxicity and some have non-monotone dose response. Therefore, dose-response curve must be evaluated separately from the dose-toxicity curve to determine optimal dose. Although anticancer botanical agents can't shrink tumor size rapidly, they do extend survival. So, in phase II study, response should be evaluated by the survival. Conclusions : Clinical research of botanical agents in cancer is different from traditional methods and strategies. Considering the characteristics of botanical agents and experimental mechanism is necessary in conducting botanical based clinical trials.

진행성 대장직장암 환자군에 있어서 5-FU 혹은 capecitabine의 최적 시간 치료법에 대한 체계적 고찰 : 메타분석

이지영,오혜경,류한성,윤성우,Lee, Jee Young,Oh, Hye Kyung,Ryu, Han Sung,Yoon, Seong Woo 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.1

Background : The purpose of this study is to investigate the efficacy and safety of the circadian delivery schedule of fluorouracil or capecitabine based chemotherapy for advanced colorectal cancer. Patients and methods : A meta-analysis was performed using individual data from eight international randomized clinical trials, especially phase II or III trials, comparing 5-fluorouracil, or capeticabine in chronomodulated or conventional schedule. The data from 8 studies was composed of 692 patients receiving chronomodulated chemotheray and 684 patients receiving conventional chemotherapy. The main end point was response rate. Results : Response rate was insignificantly different from each group (RR 1.14, 95%CI 0.74-1.74, p=0.55). Overall survival and progresseion-free survival were not significant either. Chemotherapy induced anemia, diarrhea, and nausea/vomiting were worse in the chronotherapy group, with statistic significance respectively. On the other hand, chemotherapy induced thrombocytopenia, stomatitis, peripheral neuropathy, and dermatotoxicity were better but they were not statistically significant results. Conclusions : Patients lived longer but not significantly on chronomodulated chemotherapy rather than on conventional chemotherapy. Patients on chronomodulated chemotherapy experienced adverse events more. The chronomodulated chemotherapy schedule needs adjustment of its delivery schedule and further research is required.