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김형진,장선일,오기수,홍경환,김윤철,배현옥,윤용갑,정헌택,권태오,Kim Hyeong-Jin,Jang S.I.,Oh K,S.,Hong K.H.,Kim Y.C.,Pae H.O.,Yun Y.G.,Chung H.T.,Kwon T.O. 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
The fruiting bodies of Isaria japonica have been traditionally used in Korea to treat cancer. An apoptosis-inducing compound, 4-Acetyl-12, 13-epoxyl -9-trichothecene-3, I5-diol (AETD), was isolated from the methanol extract of fruiting bodies of Isaria japonica Yasuda by bioassay -guided fractionation. The apoptosis of murine bladder cancer cell line (NBT-Ⅱ) by the compound was accessed by propidium iodide staining flow cytometric analysis, and apoptosis-inducing activity at $IC_{50}$ concentration (5 nmol/L) was further confirmed by a nuclear morphological change, a ladder pattern of DNA fragmentation, and an activation of caspase-3. These results indicate that AETD induces apoptosis of NBT-Ⅱ cells via expression of caspase-3.
초임계유체 공정에 의한 유효 지방산이 풍부한 현미유의 추출
김형진,신명옥,이승범,홍인권 ( H . J . Kim,M . O . Shin,S . B . Lee,I . K . Hong ) 한국공업화학회 1997 응용화학 Vol.1 No.1
The oil including available fatty acids was extracted from the domestic brown rice using supercritical carbon dioxide(SCC), and analyzed with GC-MS. The extraction rate of brown rice oil depended upon the operating pressure and temperature, and the oil composition was varied with the reduced density (ρ_r) of the SCC. For constant temperature, it takes a short time to extract total amount of oil at high pressure. Extraction rate was increased linearly within the time, and decreased after the time with flow rate, temperaure and pressure. As reduced density was increased, partition coefficient was increased for large numbers of carbon atoms and double bonds, but it was in contrast with this for small numbers of carbon atoms and double bonds. So it was able to fractionate and concentrate available fatty acids from brown rice oil.
초임계유체 공정에 의한 유효지방산이 풍부한 현미유의 추출
김형진,신명옥,홍인권,박경애 ( H . J . Kim,M . O . Shin,I . K . Hong,K . A . Park ) 한국공업화학회 1997 공업화학 Vol.8 No.5
건강식품으로 각광받고 있는 현미유는 palmitic acid, linolenic acid, linoleic acid, oleic acid, stearic acid, tocopherol, squalene 등을 포함하고 있다. 본 연구에서는 국내산 현미겨로부터 초임계 이산화탄소를 이용하여 현미유를 추출하고, GC-MSD를 이용하여 조성을 분석 하였다. 현미유의 추출량은 추출공정의 조작온도와 압력에 의존하였으며, 초임계 이산화탄소의 환산밀도에 따라 추출된 기름내 지방산의 조성이 변화되었다. 또한 70∼80%의 기름이 4시간 정도의 조작시간내에 추출됨이 확인되었다. 특히 용매추출공정과 초임계유체 추출공정을 비교한 결과 초임계유체 추출공정에서 추출된 기름의 조성에서만 squalene이 포함되어 있음이 확인되었다. Brown rice oil contains palmitic acid, linolenic acid, linoleic acid, oleic acid, stearic acid, tocopherol, squalene, etc. The oil including essential fatty acids was extracted from the domestic brown rice bran using supercritical carbon dioxide(SCC) process, and the extracts were analyzed with GC-MSD. The extraction amount of brown rice oil was dependent upon the operating pressure and temperature, and the fatty acid composition of oil was varied with the reduced density(ργ) of the SCC. About 70-80% of brown rice oil was extracted in 4 hours. Especially, squalene which was not found in solvent extract phase was identified in supercritical fluid extraction phase only.