구기자 복합물 약침액이 간기능 개선에 미치는 영향

김용민,황동석,곽병문,김이화,Kim, Yong-Min,Hwang, Dong-Suk,Kwak, Byeong-Mun,Kim, Ee-Hwa 경락경혈학회 2019 대한침구의학회지 Vol.36 No.4

Objectives : This study investigated the hepatoprotective effect of herbal mixture including Lycii fructus (HML) in thioacetamide (TAA)-induced hepatotoxicity in mice. Methods : To confirm the liver protective effect, induced by TAA for 3 days injection at 100 mg/kg mice, HML were treated for 8 weeks at 300 mg/kg/day, 1000 mg/kg/day. Positive control was treated silymarin 50 mg/kg/day after TAA injection. The changes of mortality rate, clinical signs, organ weight, relative liver, blood chemistry and histopathological findings were analyzed after experiment. Results : Body weight gain was observed in all groups, but TAA treated group at 4th week and all treated groups decreased weight compared to the untreated group. As a result of organ weight measurement, organ weight gain due to hepatic injury was observed statistically significantly in TAA-treated group and TAA+Silymarin treated group, and the herbal mixture-treated group showed a tendency to decrease compared to the TAA treated group. Blood biochemistry showed that total cholesterol and very low density lipoprotein cholesterol decreased statistically in TAA+low-dose and high dose herbal mixture treated group compared to the TAA-treated group. Histopathological examination showed that liver abnormalities were not observed in untreated group, liver fibrosis was observed in liver injury with TAA treated and herbal mixture treated group. And, TAA+high dose herbal mixture group showed relaxation tendency on liver calcification compared to the TAA treated group. Conclusions : According to the above results, HML provided hepatoprotective effects on the hepatic injury by reduction of inflammatory responses.

항상외사시를 보이는 영아외사시의 임상양상

김용민,장지호,이종복,Yong Min Kim,M,D,Jee Ho Chang,M,D,Jong Bok Lee,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.8

Purpose: The purpose of this study is to evaluate the clinical course and surgical outcomes of constant infantile exotopia developed in the first year of life. Methods: Eighteen patients diagnosed with constant infantile exotropia who underwent surgery between June 1993 and July 2003 were reviewed retrospectively. Age at diagnosis and surgery, refractive error, and preoperative and postoperative prism diopters were evaluated for all patients. Results: The mean age at diagnosis was 7.3±2.2 months (2~11 months) and mean deviation was 47.2±16.6 prism diopters (PD) (25~90 PD). Inferior oblique muscle overaction was found in 3 (17%) patients. Bilateral lateral rectus muscle recession was performed in all patients and mean amount of recession was 8.0±0.9 mm (7.0~9.0 mm). The mean age at surgery was 16.7±4.1 months (7~24 months) and the mean postoperative follow-up period was 34.3±23.0 months (7~83 months). Thirteen patients (76%) showed stable alignments after the first operation and 3 patients (18%) required reoperation due to undercorrection and recurrence. Among them, one patient (6%) required a third operation. Conclusions: Early surgical intervention in constant infantile exotropia resulted in good postoperative outcome and stable alignments after the first operation.

학술발표회 초록 ( 분리기술 (Ⅴ) ) : 흡착탑내에서 coupled Langmuir isotherm 을 갖는 bulk gas 거동의 cell model 에의한 고찰

김용민,신흥수,서성섭 ( Yong Min Kim,Heung Soo Shin,Sung Sup Suh ) 한국화학공학회 1993 추계학술발표회 Vol.- No.-

당뇨황반부종의 치료에서 유리체 절제술의 효과와 유리체강 내 트리암시놀론 주입술과의 비교

김용민,김성수,이성철,권오웅,고형준,Yong Min Kim,Sung Soo Kim,Sung Chul Lee,Oh Woong Kwon,Hyung Jun Koh 대한안과학회 2006 대한안과학회지 Vol.47 No.7

Purpose: The purpose of this study is to evaluate the benefit of pars plana vitrectomy (PPV) and removal of the internal limiting membrane (ILM) in diabetic macular edema, and to compare the effects of PPV and removal of ILM with intravitreal triamcinolone acetonide injection. Methods: Fifteen eyes of 14 patients on whom PPV and removal of the ILM (group A) were performed and 14 eyes of 14 patients who received single intravitreal triamcinolone acetonide injection (group B) for diabetic macular edema over six months were included in this study. The main outcome measures were macular thickness, as measured by optical coherence tomography and visual acuity at 1, 3, and 6 months postoperatively. Results: The mean preoperative visual acuity was 0.06±0.05 and macular thickness 516.01±120.29 ?m in group A. At 1 month postoperatively, this group showed no significant improvement of visual acuity. However, there was significant improvement at 3 and 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 months postoperatively. In group B, the mean preoperative visual acuity was 0.10±0.08 and macular thickness was 548.82±116.44 ?m. At 1 and 3 months postoperatively, significant improvement of visual acuity was noted in this group. However, there was no significant difference at 6 months postoperatively. Macular thickness also decreased significantly at 1, 3, and 6 month postoperatively. Between two groups, visual acuity and macular thickness improved in Group B at 1 month postoperatively but at 6 months, visual acuity improved in Group A and there was no significant difference of macular thickness between the two groups. Conclusions: PPV and removal of the ILM are good therapeutic options for diabetic macular edema to improve visual acuity and macular thickness. These also offer more long term efficacy than intravitreal tiamcinolone acetonide injection.

커패시터 뱅크를 이용한 펄스고자기장 발생장치의 소개

김용민,Kim, Yong-Min 한국초전도저온공학회 2015 초전도와 저온공학 Vol.17 No.1

불포화 풍화토 사면의 모관흡수력 분포에 대한 지반조건과 강우강도의 영향

김용민,이광우,김정환,Kim, Yong Min,Lee, Kwang Woo,Kim, Jung Hwan 대한토목학회 2013 대한토목학회논문집 Vol.33 No.3

본 연구에서는 강우 침투에 의한 사면의 모관흡수력 분포특성을 분석하기 위하여 수리학적-역학적 특성을 고려한 동시연계해석을 수행하였다. 이를 위해, 국내 3가지 지역에서 채취한 풍화토를 대상으로 함수특성곡선(SWCC)을 산정하였으며, 이를 토대로 지반조건, 강우특성, 사면경사에 따른 모관흡수력의 변화를 관측하였다. 그 결과, 강우강도가 증가함에 따라 사면내의 모관흡수력은 급격히 감소하는 경향이 나타났으며, 사면 경사에는 큰 영향을 받지 않는 것으로 나타났다. 또한 강우강도보다 포화투수계수가 작은 지반은 표층에서 포화가 쉽게 일어나는 것을 확인하였으며, 다층으로 존재하는 경우에도 사면표층 지반의 수리학적 특성이 모관흡수력 분포에 큰 영향을 주는 것으로 나타났다. The monolithically coupled finite element analysis for a deformable unsaturated soil slope is performed to investigate matric suction distribution on a soil slope subjected to rainfall infiltration, which can consider the hydraulic-mechanical characteristics for the analysis. The soil-water characteristic curves (SWCC) are experimentally determined to estimate three types of hydraulic properties of domestic areas. Based on the physical properties, the distribution of matric suction is investigated by considering the major factors, such as soil conditions, rainfall intensities, and slope angles. It is found from the results of this study that the matric suction rapidly decreases with an increase in rainfall intensity, regardless a slope angle. The slope surface is more easily saturated when its saturated hydraulic conductivity is smaller than rainfall intensity, and for the case of multi-layered soil slope, hydraulic characteristics of slope surface has a significant influence on matric suction distribution.

전위성 관절내 종골 골절에서 최소 침습적 족근동 도달법 및 압박나사 내고정술을 이용한 수술적 치료

김용민,조병기,손현철,박지강,정호승,Kim, Yong-Min,Cho, Byung-Ki,Shon, Hyun-Chul,Park, Ji-Kang,Jeong, Ho-Seung 대한족부족관절학회 2012 대한족부족관절학회지 Vol.16 No.4

Purpose: This study was performed to evaluate the clinical outcomes of operative treatment using mini-open sinus tarsi approach for displaced intraarticular calcaneal fractures. Materials and Methods: We studied 18 cases (16 patients) of intraarticular calcaneal fractures who were treated with sinus tarsi approach by same surgeon. The mean age of patients was 44.8 years, and mean follow-up period was 17.2 months. The measurement of B$\ddot{o}$hler angle, Gissane angle, the degree of articular surface depression, and the period to union were performed through preoperative and postoperative radiographs. The clinical evaluation was performed according to hindfoot score of the American Orthopaedic Foot and Ankle Society (AOFAS) and scale of the Creighton-Nebraska health foundation (CNHF). Results: B$\ddot{o}$hler angle and Gissane angle had improved significantly from preoperative average $9.8^{\circ}$, $117.6^{\circ}$to average $22.4^{\circ}$, $113.4^{\circ}$ immediate postoperatively, and had maintained to average $21.8^{\circ}$and $114.2^{\circ}$ at the last follow-up. The degree of articular surface depression had improved significantly from preoperative average 5.2 mm to 1.2 mm at the last follow-up. All cases achieved bone union, and the period to union was average 10.5 weeks. AOFAS score was average 86.2 points at the last follow-up. There were 7 excellent, 9 good, and 2 fair results according to the CNHF scale. Therefore, 16 cases (88.8%) achieved satisfactory results. Conclusion: The minimally invasive sinus tarsi approach using headless compression screw seems to be an effective surgical method for displaced intraarticular calcaneal fractures, because of the possibility of accurate restoration of articular surface and the low risk of postoperative soft tissue complications.

습윤상태를 고려한 불포화 토사사면의 불안정성 해석

김용민,김재홍,Kim, Yong Min,Kim, Jaehong 대한토목학회 2013 대한토목학회논문집 Vol.33 No.4

본 연구에서는 불포화 사면에서 선행강우의 영향을 고려하고자 지반의 초기 포화도를 3가지(36, 51, 77%)로 설정하여 수리학적-역학적 동시 유한요소해석(monolithically coupled finite element analysis)을 수행하였다. 선행강우에 의한 불포화 사면의 불안정성은 사면 내 모관흡수력 분포와 사면표층의 변위를 통하여 확인할 수 있다. 또한 Drucker-Prager model의 항복경계기준(trial failure criterion)을 적용하여 강우 침투에 의한 불포화 사면의 탄성 및 소성거동을 파악하였다. 그 결과, 선행강우에 의한 지반의 초기 포화도가 클수록 강우에 의한 변위가 크게 발생하며 모관흡수력 또한 감소한다. 특히, 모관흡수력은 지반이 건조할수록 빠르게 감소하며, 초기에 동일한 모관흡수력을 갖는 사면표층에서 포화도가 작은 지반일수록 더 빠른 모관흡수력 감소를 보였다. 풍화토의 탄성과 소성거동을 구분하기 위해 사용된 Drucker-Prager model을 통해 사면 파괴가 시작되는 항복경계지점을 확인 할 수 있었다. The monolithically coupled finite element analysis for a deformable unsaturated soil slope is performed to investigate the effect of antecedent rainfall which is assumed by initial conditions varying degree of saturation (36, 51, 77%) in finite element analysis. The distributions of matric suction and deformation on slope surface obtained from numerical simulation show the instability of antecedent rainfall-induced unsaturated soil slope. Moreover, the numerical analysis using Drucker-Prager model can be checked if a soil slope has reached failure (trial failure criterion $f^{tr}$ >0, plastic behavior) or not (trial failure criterion $f^{tr}$ < 0, elastic behavior). It is found that displacement of slope surface layer increases and the matric suction on soil slope decreases with an increase of initial degree of saturation by antecedent rainfall. Especially, the matric suction of the soil slope in dry condition (S=36%) rapidly decreases rather than that in wet condition (S=51%) at the same rainfall duration. The results of the trial failure criterion ($f^{tr}$ > 0) show slope instability in the toe region and surface of the slopes.

Anti-Inflammatory Effects of Tongbi-san(通痺散) Extract on RAW264.7 Macrophages

김용민,김희택,김이화,Kim, Yong-Min,Kim, Hee-Taek,Kim, Ee-Hwa The Society of Korean Medicine Ophthalmology 2016 한방안이비인후피부과학회지 Vol.29 No.4

Objectives : This study is to investigate the anti-inflammatory and anti-oxidant effects of Tongbi-san extract (TS) on RAW264.7 macrophages using by cell cytotoxicity, Nitric Oxide (NO) and Prostaglandin $E_2$ ($PGE_2$) production and 1,1-diphenyl-2-picryl ghdrazyl (DPPH) free radical scavenging capability. Methods : Cell cytotoxicity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The production of NO was measured by Griess assay. The production of $PGE_2$ was measured by immunoassay. And the anti-oxidant activity was measured by the DPPH method. Results : TS did not increased significantly compared to the TS untreated group in the cell cytotoxicity. TS inhibited NO and $PGE_2$ production in lipopolysaccharide-stimulated RAW 264.7 cells. TS had the DPPH free radical scavenging capability. Conclusion : The anti-inflammtory and anti-oxidant effects of TS may be use for a treatment of anti-inflammatory diseases.

백내장 수술 후 각막 지각의 변화와 각막신경 회복의 비교

김용민,김선웅,김태임,김응권,서경률,Yong Min Kim,Sun Woong Kim,Tae Im Kim,Eung Kwon Kim,Kyung Ryul Seo 대한안과학회 2007 대한안과학회지 Vol.48 No.1

Purpose: To compare corneal sensitivity and recovery of corneal innervations after a temporal clear corneal incision in cataract surgery. Methods: We measured changes to corneal sensitivity using Cochet-Bonnet esthesiometer in 25 eyes of 20 patients and analyzed corneal nerve density with confocal microscopy in 20 eyes of 20 patients who had undergone cataract surgery. The parameters were measured before, and at 1 week, 1 month, and 3 months after cataract surgery. Results: The mean preoperative corneal sensitivity was 56.40±3.39 mm at the temporal corneal incision site, and there was a significantly decreased sensitivity of 29.80±2.69 mm and 42.40±4.36 mm postoperatively at 1 week and 1 month, respectively. Nonetheless, by three months, corneal sensitivity had returned to 56.00±2.89 mm and was not significantly different from measurements prior to the cataract surgery. The mean preoperative subbasal nerve density was 5296±1642 ?m/mm2. After cataract surgery, the subbasal nerve density was significantly reduced to 4113±1421, 3555±1448, 4198±1239 ?m/mm2 at 1 week, 1 month, and 3 months, respectively. Conclusions: Corneal sensitivity after cataract surgery returned to near preoperative levels within 3 months before complete restoration of normal corneal innervations. Therefore, regeneration of subbasal nerve fibers (, as determined by confocal microscopy,) requires more time than the return of corneal sensation after cataract surgery.