한국인의 Epstein-Barr Virus 항체 양성률 변화양상에 대한 분석: 단일기관 연구

김수경,최준식,김동섭,강철인,정두련,백경란,강은숙,김예진,Kim, Su Kyung,Choi, Joon-Sik,Kim, Dongsub,Kang, Cheol-In,Chung, Doo Ryeon,Peck, Kyong Ran,Kang, Eun-Suk,Kim, Yae-Jean 대한소아감염학회 2020 Pediatric Infection and Vaccine Vol.27 No.2

Purpose: Epstein-Barr virus (EBV) infection is related to infectious mononucleosis or nasopharyngeal cancer, and its epidemiology may change according to the socioeconomic development of communities. This study aimed to evaluate the recent epidemiology of EBV seropositive rate in Korea. Methods: We retrospectively reviewed EBV serology test results obtained from a part of clinical care at Samsung Medical Center, Seoul, South Korea, from January 2000 to December 2017. Results: The EBV seropositive rate in 26,527 subjects during the study period was 81.0% (21,485/26,527): 44.4% (2,716/6,122) in subjects aged 0-9 years, 75.8% (2,077/2,739) in those aged 10-19 years, and 94.5% (16,692/17,666) in those aged ≥20 years. The EBV seropositive rate decreased from 89.4% (8,592/9,616) in 2000-2008 to 76.2% (12,893/16,911) in 2009-2017 (P<0.001). Especially, the EBV seropositive rate in subjects aged 0-19 years significantly decreased from 2000-2008 to 2009-2017 (0-9 years, 62.8% [1,172/1,866] in 2000-2008 and 36.3% [1,544/4,256] in 2009-2017; 10-19 years, 83.8% [745/858] in 2000-2008 and 70.8% (1,332/1,881) in 2009-2017) (P<0.001). Conclusions: The EBV seropositive rate in children has decreased in the last 20 years. As the age of patients with primary EBV infection increased, there is a need for interest in clinical manifestation, such as infectious mononucleosis, in adolescents and young adults.

백서두개골 결손부에서 키토산/흡수성 콜라겐 전달체의 골재생

김수경,석헌주,김창성,조규성,채중규,김종관,최성호,Kim, Soo-Kyoung,Suk, Hun-Joo,Kim, Chang-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.3

The ultimate objective of periodontal treatment is to get rid of an on-going periodontal disease and further regenerate the supporting tissue, which is already destroyed, functionally. Currently, the bone grafting operation using various kinds of bone grafting materials and the operation for induced regeneration of periodontal tissue using the blocking membrane are performed for regeneration of the destroyed periodontal tissue. However, there are respective limitations Galenical preparations, which are used for regeneration of periodontal of tissue, has less risk of rejective reaction or toxicity that may be incidental to degradation and their effect is sustainable. Thus, in case they are applicable to a clinic, they can he used economically. Chitosan has such compatibility, biological actions including antibacterial activity, acceleration of wound treatment, etc., and excellent mechanical characteristics, which has recently aroused more interest in it. Also, it has been reported that it promotes osteogenesis directly or indirectly by functioning as a matrix to promote migration and differentiation of a specific precussor cell (for example, osteoblast) and further inhibiting the function of such a cell as fibroblast to prevent osteogenesis. In this study, the pure chitosan solution, which was obtained by purifying chitosan, was used. However, since this chitosan is of a liquiform, it is difficult to sustain it in a defective region. It is, therefore, essential to use a carrier for delivering chitosan to, and sustaining it gradually in the defective region. In the calvarial defect model of the Sprague-Dawley rat, it is relatively easy to maintain a space. Therefore, in this study, the chitosan solution with which ACS was wetted was grafted onto the defective region, For an experimental model, a calvarial defect of rat m s selected, and a critical size of the defective region was a circular defect with a diameter of 8 mm. A group in which no treatment was conducted for the calvarial defect was set as a negative control group. Another group in which treatment was conducted with ACS only was set as a positive control group (ACS group). And another group in which treatment was conducted was conducted with by grafting the pure chitosan solution onto the defective region through ACS which was wetted with the chitosan solution was set an experimental group (Chitosan/ACS group). Chitosan was applied to the Sprague-Dawley rat's calvarial bone by applying ACS which was wetted with the chitosan solution, and each Sprague-Dawley rat was sacrificed respectively 2 weeks and 8 weeks after the operation for such application. Then, the treatment results were compared and observed histologically and his tometrically. Thereby, the following conclusions were obtained. 1. In the experimental group, a pattern was shown that from 2 weeks after the operation, vascular proliferation proceeded and osteogenesis proceeded through osteoblast infiltration, and at 8 week after the operation, ACS was almost absorbed, the amount of osteogensis was increased and many osteoid tissue layers were observed. 2. At 2 weeks after the operation, each amount of osteogenesis appeared to be 8.70.8 %, 13.62.3 % and 4.80.7 % respectively in the experimental group, the positive control group and the negative control group. Accordingly, it appeared to be higher in the Experimental group and the positive control group than in the negative control group, but there was no significant difference statistically (p<0.01). 3. At 8 weeks after the operation, each amount of osteogenesis appeared to be 62.26.1%, 17.42.5 % and 8.21.4 % respectively in the experimental group, the positive control group and the negative control group. Accordingly, it appeared to be substantially higher in the experimental group than in the positive control group and the negative control group, and there was a significant difference statistically (p<0.01). As a result of conducting the experiment, when ACS

성인의 턱관절장애 자각증상에 영향을 미치는 요인

김수경,김소라,김현경,박지수,이유진,조민서,정은서,Kim, Soo-Kyung,Kim, So-Ra,Kim, Hyun-Kyung,Park, Ji-Su,Lee, Yu-Jin,Cho, Min-Seo,Jung, Eun-Seo 한국치위생학회 2017 한국치위생학회지 Vol.17 No.4

Objectives: The purpose of this study is to identify the perceived symptoms of oral and temporomandibular joint disorders in adults and to analyze the factors affecting subjective symptoms of temporomandibular joint disorders. Methods: 249 adults over 20 years old who had subjective symptoms of temporomandibular joint disorders were surveyed and analyzed. Independent t-test and ANOVA test were used to examine the relationship between oral habits and temporomandibular joint disorder according to general characteristics. $Scheff{\acute{e}}$ test was used for post-hoc analysis. Multiple regression analysis was conducted to examine the factors affecting oral habits and temporomandibular joint disorder. Results: First, the factors affecting oral and habitual behaviors were married (p<0.05) and monthly income between 1 million~1.9 million won (p<0.001), higher temporomandibular joint disorder (p<0.01) And the degree of habit was increased. Second, the factors affecting temporomandibular joint disorder were increased in occupation (p<0.05) and the degree of oral habit (p<0.01). Conclusions: In conclusion, it was confirmed that oral habit influences temporomandibular joint disorder. Especially, it is suggested that prevention and promotion of temporomandibular joint disorder are needed to recognize the removal of oral habits.

소수 곱셈 단원의 교과서 개선 방향 탐색

김수경,김진숙,권성룡,Kim, Sukyoung,Kim, Jinsook,Kwon, Sungyong 한국초등수학교육학회 2018 한국초등수학교육학회지 Vol.22 No.4

Although the multiplication of decimal fractions is expected to be easy for students to understand because of the similarity to natural numbers multiplication in computing methods, students show many errors in the multiplication of decimal fractions. This is a result of the instruction focused more on skill mastery than conceptual understanding. This study is a basic study for effectively developing a unit of multiplication of decimal fractions. For this purpose, we analyzed the curriculums' performance standards, significance in teaching-learning and evaluation, contents and methods for teaching multiplication of decimal fractions from the 7th curriculum to the revised curriculum of 2015 and the textbooks' activities and lessons. Further, we analyzed preceding studies and introductory books to suggest effective directions for developing teaching unit. As a result of the analysis, three implications were obtained: First, a meaningful instruction for estimation is needed. Second, it is necessary to present a visual model suitable for understanding the meaning of decimal multiplication. Third, the process of formalizing an algorithms for multiplying decimal fractions needs to be diversified. 소수의 곱셈은 계산방법에 있어 자연수 곱셈과의 유사성 때문에 학생들이 쉽게 이해할 것이라고 기대하지만 학생들은 소수의 곱셈에서 많은 오류를 보인다. 이는 개념적인 이해보다 기능적인 숙달에 치중한 결과라고 할 수 있다. 본 연구는 소수의 곱셈 단원을 효과적으로 구성하기 위한 기초연구로서 제7차 교육과정부터 2015 개정 교육과정까지 소수의 곱셈 단원의 성취기준, 교수학습 및 평가 상의 유의점, 지도내용 및 방법을 분석하였고, 2009 개정 교육과정까지 교육과정별 해당 교과서의 차시 구성 및 교과서별 활동을 분석하였다. 또한 소수의 곱셈과 관련된 개론서 및 논문을 분석하여 소수의 곱셈에 대한 학생들의 이해 실태 및 소수의 곱셈을 지도하기 위한 지도 방안을 살펴보고 공통적으로 제시된 방안을 요목화하였다. 분석 결과, 다음의 세 가지 시사점을 얻을 수 있었다. 첫째, 의미 있는 어림 지도가 필요하다. 둘째, 소수 곱셈의 의미에 적합한 시각적 모델을 제시해 줄 필요가 있다. 셋째, 소수의 곱셈 알고리즘을 형식화하는 과정을 다양화할 필요가 있다.

가수량을 달리한 쌀밥의 저장에 따흔 특성변화

김수경,신말식,Kim, Su-Gyeong,Sin, Mal-Sik 한국식품조리과학회 1992 한국식품조리과학회지 Vol.8 No.2

메탈핼라이드램프용 순시점등/재점등 전자식안정기 개발

김수경,장우진,Kim, Su-Kyoung,Jang, Woo-Jin 한국조명전기설비학회 2004 조명·전기설비학회논문지 Vol.18 No.5

메탈핼라이드 램프의 가장 큰 단점중 하나는 아크튜브가 뜨거운 상태에서는 순시 재점등이 불가능하다는 것이다. 메탈핼라이드 램프의 점등중 고온의 아크튜브는 초기 램프가 차가운 상태에서의 방전 전압보다 재점등 방전전압이 높아 재점등 시키는데 압력과 온도가 감소되어지는 약5분정도의 시간이 소요 된다. 만약 램프가 뜨거운 상태에서 재점등시키려면 램프전극 양단에 약20[kV] 이상의 높은 전압펄스를 공급해야한다. 따라서 이러한 목적의 전자식 안정기는 EMII필터, PFC회로, 플라이백 컨버터, 하프브리지 인버터, 고전압 이그나이터 회로로 구성되는데 이것은 순시점등은 물론 램프가 뜨거운 상태에서도 20[kV]의 전압으로 램프를 점등/재점등 할 수 있다. The most shortcoming of metalhalide lamps is what the instant restarting cannot be realized when the arc tube is in the hot condition. The discharge starting voltage of arc tube in the hot condition is much higher than in the cold condition. Therefore it takes about five minutes to restart the metalhalide lamps, that is to say, it is possible to start when the pressure and the temperature are decreased. But, if the lamp is restarted in the hot condition, we must supply the high voltage pulse with 20[kV] at the both electrode of lamp. The proposed electronic ballast is consist of a electromagnetic interference(EMI) filter, a power factor correction(PFC) circuit, a flyback converter, a half-bridge inverter, and a high voltage igniter circuit. By this composition we can start/restart the lamp with the voltage 20[kV], even if the lamp is in the hot condition.

Effects of Neuroleptics on the Opioid Receptor Binding in the Mouse Striatum

김수경,이성룡,박창교,Kim, Soo-Kyung,Lee, Seong-Ryong,Park, Chang-Gyo The Korean Society of Pharmacology 1994 대한약리학잡지 Vol.30 No.3

Our purpose was to gain insight into a possible modulatory role for ${\mu},\;{\delta},\;and\;{\kappa}$ opioid receptors by neuroleptics (chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide) in chronic morphine 5 mg/kg and 20 mg/kg treated mouse striatum. We attempted quantitative receptor assays using highly specific radioligands, $[^3H]\;DAGO\;([D-Ala^2,\;N-Mephe^4,\;Glycol^5]\;enkephalin)$, $[^3H]DPDPE\;([D-Pen^2,\;D-Pen^5]\;enkephalin)$ and $[^3H]\;DPN(diprenorphine)$ to measure the binding affinity in the experimental groups. The decrease of $[^3H]DAGO$ binding was potentiated by sulpiride and pimozide in the chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of $[^3H]DPDPE$ binding was inhibited by chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide in chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of $[^3H]\;DPN$ binding was significantly inhibited by chlorpromazine, thioridazine, sulpiride, and pimozide in chronic morphine 20 mg/kg treatment. $[^3H]\;DPN$ binding on the neuroleptics was antagonized by naloxone pretreatment in chronic morphine 20 mg/kg treatment. These findings suggest that neuroleptics influence opposing tonically active on the ${\delta},\;and\;{\kappa}$ opioid receptor compared with ${\mu}$ opioid receptor in the chronic morphine treated mouse striatum. 이 연구에서는 선조체에서 opioid 신경계와 dopamine 신경계의 상호 관계를 알아보기 위해서 morphine을 5m/kg, 20 mg/kg로 10일간 복강내 투여한 후 chlorpromazine, thioridazine, haloperidol, sulpiride, pimozide를 투여하였다. Opioid ${\mu},\;{\delta},\;{\kappa}$ 수용체의 binding의 변화를 관찰하고자 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ binding assay를 하였으며, 그 결과 morphine (20 mg/kg) 장기 투여된 실험군에서 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합이 감소되었다. Morphine 20 mg/kg 장기 투여군에 chlorpromazine, thioridazine 주사시에는 morphine 5mg/kg 투여군에 비하여 $[^3H]\;DAGO$ 결합의 감소와, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합의 증가를 나타내었고, haloperidol 주사군은 $[^3H]\;DAGO$, $[^3H]\;DPN$ 결합의 감소, 및 $[^3H]\;DPDPE$ 결합의 증가를 나타내었다. Sulpiride, pimozide 주사군은 morphine 5 m/kg 투여군에 비하여 20m/kg 투여군에서 $[^3H]\;DAGO$, $[^3H]\;DPDPE$, 및 $[^3H]\;DPN$ 결합의 증가를 나타내었다. 이상의 결과로 보아 각 약물간의 opioid 결합에 대한 차이점은 있었으나, morphine 5mg/kg 투여군보다 20m/kg 투여군에서 $[^3H]\;DPDPE$ 및 $[^3H]\;DPN$의 결합이 증가의 경향을 보임으로써, 다량의 morphine을 투여했을 때 ${\mu}\;opioid$ 수용체에 비하여 ${\delta}와 ${\kappa}\;opioid$ 수용체가 더 활성화되는 것을 알 수 있었다.

이슈 토론 - 국가장학금 정책에서의 쟁점

김수경,Kim, Su-Gyeong 한국대학교육협의회 2012 大學敎育 Vol.175 No.-

사립대학 구조개혁의 경제적 접근 방안 연구

김수경,문보은,Kim. Soo-Kyung,Moon. Bo-Eun 한국교육재정경제학회 2015 敎育財政 經濟硏究 Vol.24 No.1

이 연구의 목표는 인구학적, 경제적 접근을 통한 대학 구조개편 모형을 제 시하는데 있다. 이 연구의 방법은 크게 세 가지로 첫째, 인구학적 통계를 활용 한 대학입학자 추정, 둘째, 일반초월대수 비용함수모형을 이용한 대학특성별 규모의 경제성 분석, 셋째, 자료포락분석 CCR 모형을 통한 대학 전공계열의 효율성 분석이다. 이 연구의 결과는 크게 세 가지다. 첫째, 우리나라 대학입학 예정자 수는 평 균 대학진학률 70.9%가 유지된다고 가정할 때, 2016년 16,915명 감소 경향성을 시작으로, 2017년 23,789명, 2018년 14,575명, 2020년 56,441명이 각각 감소하여 2015~2020년까지 총 97,147명이 감축되는 것으로 추정되었다. 둘째, 대학 특성 별 규모의 경제성 분석 결과, 대학이 현재 교육의 질을 유지한다는 가정 하에, 수도권 소재 대규모 대학, 중규모 대학, 소규모 대학과 비수도권 소재 대규모 대학, 소규모 대학은 과대 규모를 보유하고 있으며, 규모의 경제성을 제고하기 위해서는 현재 대학 규모에서 7.9%~21.7%의 감축을 해야 하는 것으로 나타났 다. 다만, 비수도권 중규모 대학은 오히려 과소한 규모로 현재 규모 보다 10.9% 규모를 증대할 때 규모의 경제성을 갖는 것으로 분석되었다. 이러한 경 제성 규모는 앞에서 추정된 2015년~2020년의 대학입학 예정자 수 감소 규모와 유사한 수준이다. 셋째, 규모의 비경제성을 갖는 대학 유형 중 수도권 대규모, 비수도권 대규모 대학의 전공계열별 효율성을 분석한 결과, 규모의 경제성을 갖추기 위해서는 수도권 대규모 대학의 자연과학･예체능･공학계열에서 총 31,912명 감축이 필요하며, 비수도권 대규모 대학에서는 인문사회･자연과학･ 예체능･공학계열에서 총 38,775명 감축이 필요한 것으로 분석되었다. 사립대학의 구조조정을 경제적으로 접근하는 이 연구는 학령인구를 감안하 여 대학운영의 효율성을 가장 높일 수 있는 경제적 규모를 도출함과 동시에 사립대학 간 특성화를 실현할 수 있는 전공계열 효율성 분석 접근을 시도함으 로써 정부와 사립대학의 당면과제인 사립대학 구조개혁을 실현하는데 경제적 이고 전략적인 가이드라인을 제공한다는데 연구의 의의를 두고 있다. The purpose of this study is to provide a structural reform model for universities through economic and demographic approaches. For the study, the size of university application is estimated with demographic variation reflected; the economic scale of universities by their specialization is analysed; and the efficiency of college majors is compared and analyzed. Based on the finding, the strategic economic scale for universities by specialization is presented as a systematic restructuring model for universities to enhance their competitiveness. The results of the study are as follow. Firstly, it is estimated that if the average admission rate is maintained at 70.9%, the number of students admitted to college is going to start to decrease by 16,915 in 2016, 23,789 in 2017, 14,575 in 2018, and 56,441 in 2020, and the number will be added up to 97,147 in total between 2015 and 2020. Secondly, the result of the economic analysis of universities by specialization shows that if universities keeps the quality of the current education, it will be more economical for universities, except medium-sized ones located in non-capital regions, to reduce the size. The finding indicates that the size of university should be reduced by 7.9% ~ 21.7% to improve its competitiveness. Lastly, in order to obtain economies of scale, it is necessary to cut down total 31,912 of students in natural science, art, physical education and engineering in large-scale universities in metropolitan areas and to reduce total 38,775 of students in humanities, natural science, art, physical education and engineering in non-metropolitan areas.

제29회 대학교육 정책포럼

김수경,Kim, Su-Gyeong 한국대학교육협의회 2010 大學敎育 Vol.168 No.-