유방암의 Imprint 표본에서 p53 단백 발현

김동석,이은희,김기권,김미진,이수정,Kim, Dong-Sug,Lee, Eun-Hi,Kim, Ki-Kwon,Kim, Mi-Jin,Lee, Soo-Jung 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1

This study was carried out to determine the usefulness of imprint cytology for detecting p53 protein in breast carcinoma. NCL-DO7 (Novocastra, U.K.) was used to detect p53 protein immunocytochemically. A total of 33 cases was studied, Immunostaining of imprint cytology with NCL-DO7 was positive in 64% (21/33) and showed relatively high coincident rate (80%) with immunostaining of formalin-fixed, paraffin-embedded specimen p53 protein was related to negative estrogen receptor status, but not to the nuclear grade, lymph node metastasis, or tumor size. The fact that p53 protein expression was not related to nuclear grade might be due to predominance of nuclear grade 3. It was easier to determine the nuclear grade is one of the most important prognostic factors, in imprint cytology than in tissue specimen. p53 protein tended to be stained more strongly in imprint cytology than in tissue. It is concluded that the application of imprint cytology in p53 protein detection can be performed easily, and that it may contribute to the evaluation of prognostic factors in breast carcinoma.

모야모야병에서 염기성 섬모 세포 성장 인자의 역할

김동석,최중언,김세혁,양국희,김현숙,Kim, Dong-Seok,Choi, Joong-Uhn,Kim, Se-Hyuk,Yang, Kook-Hee,Kim, Hyeun-Sook 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1

Objectives and Importance : The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. Methods : The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation. Results : The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted. Conclusions : The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.

임펄스 UWB 네트워크에서의 일정진폭 다중접속 채널코딩

김동석(Tongsok Kim),김용철(Yong Cheol Kim) 대한전자공학회 2008 電子工學會論文誌-SC (System and control) Vol.45 No.6

이 논문은 임펄스 UWB 시스템을 위한 새로운 일정진폭 프리코딩을 제안한다. IEEE 802.15.4a 표준에 따르면 임펄스 UWB는 실내측위와 센서 데이터 전달에 사용될 수 있다. 대부분의 USN(ubiquitous sensor network)은 다중접속을 필요로 한다. 그러나 UWB 시스템은 다중접속으로 야기되는 중첩신호를 검출하는데 있어 제약성이 있다. 이를 극복하기 위하여 Wada 및 Kim의 CAMC(constant amplitude multi-code) 개념을 응용하였다. 제안하는 시스템은 체계적 일정진폭 프리코딩과 LDPC 디코딩으로 구성된다. 또한 컴퓨터 시뮬레이션을 통하여 BER 성능이 우수함을 확인하였다. In this article a novel constant amplitude precoding for impulse UWB system is proposed. According to IEEE 802.15.4a, impulse UWB can be used in indoor localization and sensor data transmission. Most USN(ubiquitous sensor networks) needs multiple access. However impulse UWB system has a limited capability to detect superpositioned signal induced by multiple access. To overcome this problem we have adopted the concept of CAMC(Constant Amplitude Multi-Code) deviced by Wada and Kim. The proposed system consists of systematic constant amplitude precoding and LDPC decoding. And this system shows a good BER performance in computer simulation.

실내공기질관련 국제규격의 KS 규격도입 현황

김동석,Kim, Dong-Seok 기술표준원 2005 기술표준 Vol.44 No.-

주거용 스프링클러의 소화특성에 관한 연구

김동석,Kim, Dong-Seok 한국화재보험협회 1999 방재기술 Vol. No.

해외기술 정보-속동형 스프링클러를 중심으로한 NFPA 설치기준 변화

김동석,Kim, Dong-Seok 한국화재보험협회 1997 방재기술 Vol.22 No.-

서로 다른 산포를 허용하는 이변량 영과잉 음이항 회귀모형

김동석,정슬기,이동희,Kim, Dong-Seok,Jeong, Seul-Gi,Lee, Dong-Hee 한국통계학회 2011 Communications for statistical applications and me Vol.18 No.5

본 연구에서는 두 반응 변수에 서로 다른 산포를 허용하는 새로운 이변량 영과잉 음이항 회귀모형을 제안하고, Deb과 Trivedi (1997)에 나타난 헬스케어 자료를 이용하여 두 반응변수가 갖는 서로 다른 산포도를 무시한 Wang (2003)이 제안한 이변량 영과잉 음이항 회귀모형과의 효율성을 로그우도와 AIC의 관점에서 비교 하였다. 모형적합결과, 본 연구에서 제안한 모형이 모형선택기준 관점에서 기존모형에 비하여 월등히 우수한 결과를 보여주었다. We propose a new bivariate zero-inflated negative binomial regression model to allow heterogeneous dispersions. To show the performance of our proposed model, Health Care data in Deb and Trivedi (1997) are used to compare it with the other bivariate zero-inflated negative binomial model proposed by Wang (2003) that has a common dispersion between the two response variables. This empirical study shows better results from the views of log-likelihood and AIC.

응집과 균질화가 팽화슬러지의 용존공기부상과 침전에 미치는 영향

김동석,박영식,Kim, Dong-Seog,Park, Young-Seek 한국환경보건학회 2007 한국환경보건학회지 Vol.33 No.1

The objective of this study is to examine the effect of the coagulation and homogenization in bulking sludge thickening of paper manufacturing plant using DAF(Dissolved Air Flotation) and gravitational sedimentation. The effects of parameters such as dosage of coagulant and homogenization time were examined. The results showed that DAF and sedimentation was affected aluminum sulfate and anion polymer coagulant differently. At the optimum dosage of aluminum sulfate, thickening efficiency of DAF and sedimentation process were increase 1.25 time and 2.02 time, respectively. At the optimum dosage of anion polymer coagulant, thickening efficiency of DAF process was increase 1.35 time, but thickening efficiency at sedimentation was 1.06 time. When anion polymer coagulant of 0.5 mg/l was added in DAF process, water content of sludge was decreased from 96.6% to 90.7% in dewatering process using Buchner funnel test device. After homogenization(20500 rpm, 10 min), Sauter mean diameter of sludge floc was decreased from 631 ${\mu}m$ to 427 ${\mu}m$, however increase of flotation efficiency by DAF was only 1.09 time.

스프링클러헤드의 열응답 특성해석

김동석,Kim, Dong-Seok 한국화재보험협회 1990 방재기술 Vol.7 No.-

전신 뼈 스캔의 오류 감소를 위한 프로세스 구축과 적용 효과

김동석,박장원,최재민,심동오,김호성,이영희,Kim, Dong Seok,Park, Jang Won,Choi, Jae Min,Shim, Dong Oh,Kim, Ho Seong,Lee, Yeong Hee 대한핵의학기술학회 2017 핵의학 기술 Vol.21 No.1

전신 뼈 스캔은 핵의학에서 가장 많은 비중을 차지하는 검사 중 하나이다. 기본적으로 전면상과 후면상을 동시에 획득하는데, 때때로 전면상과 후면상만으로는 병소를 분간하기 어려울 때가 있다. 이러한 경우 SPECT/CT나 추가 정적 영상을 통한 병소의 정확한 위치 확인이 중요하며, 추가 촬영 여부에 대한 최초 판단은 주로 방사선사에 의해 이루어진다. 이에 본원에서는 방사선사의 업무 능력 함양을 위한 다양한 개선활동이 이루어져 왔고, 본 연구에서는 방사선사의 교육 및 표준화된 업무 프로세스 적용이 전신 뼈 스캔 오류 감소에 어떠한 영향을 미치는지 확인하고자 한다. 새로운 프로세스 적용을 위해 몇 가지 시스템이 순차적으로 도입되었다. 첫 번째는 의국 교육 및 테스트의 시행, 두 번째는 추가 촬영이 예상되는 환자를 분류하여 촬영 전에 방사선사가 미리 확인할 수 있는 사전 여과 시스템 도입, 마지막으로 판독의가 방사선사에게 직접 촬영 영상에 대해 피드백 할 수 있는 NMQA라는 커뮤니케이션 시스템을 적용하였다. 결과 확인을 위해 2014년 1월부터 2016년 12월까지 서울아산병원 핵의학과를 내원한 전신 뼈 스캔 환자를 대상으로 조사하였다. 조사 기간 동안 전체 전신 뼈 스캔 대비 NMQA가 전송된 검사 건수를 백분율로 산출하였다. 연간 발생량은 2014년 141건, 2015년 88건, 2016년 86건으로 집계되었고 NMQA 발생률은 2014년 0.88%, 2015년 0.53%, 2016년 0.45%로 감소하였다. 새로운 프로세스가 적용된 2014년 이후 NMQA 발생률이 감소하는 경향을 보였다. 다만 통계적으로 유용성을 확인하기까지는 데이터가 부족하여 향후에도 지속적인 데이터 축적이 필요할 것으로 생각한다. 본 연구를 통해 전신 뼈 스캔 영상 질 향상을 위해 표준화된 업무와 교육의 필요성을 확인하였고 향후에도 지속적인 연구와 관심으로 업데이트가 필요하다고 사료된다. Purpose Whole body bone scan is one of the most frequently performed in nuclear medicine. Basically, both the anterior and posterior views are acquired simultaneously. Occasionally, it is difficult to distinguish the lesion by only the anterior view and the posterior view. In this case, accurate location of the lesion through SPECT / CT or additional static scan images are important. Therefore, in this study, various improvement activities have been carried out in order to enhance the work capacity of technologists. In this study, we investigate the effect of technologist training and standardized work process processes on bone scan error reduction. Materials and Methods Several systems have been introduced in sequence for the application of new processes. The first is the implementation of education and testing with physicians, the second is the classification of patients who are expected to undergo further scanning, introducing a pre-filtration system that allows technologists to check in advance, and finally, The communication system called NMQA is applied. From January, 2014 to December, 2016, we examined the whole body bone scan patients who visited the Department of Nuclear Medicine, Asan Medical Center, Seoul, Korea Results We investigated errors based on the Bone Scan NMQA sent from January 2014 to December 2016. The number of tests in which NMQA was transmitted over the entire bone scan during the survey period was calculated as a percentage. The annual output is 141 cases in 2014, 88 cases in 2015, and 86 cases in 2016. The rate of NMQA has decreased to 0.88% in 2014, 0.53% in 2015 and 0.45% in 2016. Conclusion The incidence of NMQA has decreased since 2014 when the new process was applied. However, we believe that it will be necessary to accumulate data continuously in the future because of insufficient data until statistically confirming its usefulness. This study confirmed the necessity of standardized work and education to improve the quality of Bone Scan image, and it is thought that update is needed for continuous research and interest in the future.