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김다혜,김윤명,서고훈,김구환,유한욱,염미선,고태성,이범희 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.2
Duchenne and Becker muscular dystrophies (DMD and BMD, respectively) are X-linked neuromuscular disorders characterized by progressive muscle weakness and severe skeletal muscle degeneration. BMD is a milder form with a later onset. Patients with BMD tend to survive much longer than those with DMD. The differentiation between DMD and BMD is important in the genetic counseling of affected patients and their families. Since muscle biopsies are invasive procedures, the differential diagnosis of BMD and DMD is often dependent on the mutation identified in the DMD gene in affected patients. However, when a novel DMD mutation is identified, the differential diagnosis should be based on muscle biopsy findings with other clinical findings. Here we describe two Korean patients with BMD confirmed by muscle biopsy and genetic testing. Two novel exonic deletions in the DMD gene were identified.
Impact of road embankment construction on groundwater system in alluvial aquifers
김다혜,차범근,여인욱 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.1
This study aims to evaluate the impact of road embankment construction on the groundwater system in alluvial aquifers that have excessively used groundwater. A road embankment was constructed across extensive flat alluvial deposits. Laboratory permeability tests demonstrated that the loading by road embankment significantly reduced the permeability of alluvial sediments, creating an impermeable boundary in the groundwater system. The numerical modeling results showed that road embankment acting as an impermeable boundary caused groundwater levels to rise in the upstream area but decline in the downstream area. However, unlike in other upstream areas, there was no noticeable rise in the groundwater level after the embankment construction in the area where the groundwater was in extensive use. The long-term water level monitoring also confirmed no meaningful change in water level during the road embankment construction. This is because the additional decline of the water level due to the decrease in the influence radius of groundwater pumping by the impermeable boundary offsets the increase in the upstream water level. The flow modeling and the water level monitoring showed that the overall impact of the road embankment construction on the groundwater supplies could be insignificant. However, the numerical modeling indicates that the degree of impact varies with the distance from the road embankment. This study implies that the impact of the road embankment construction on the groundwater supplies in the upstream area will depend on the geological and hydraulic settings, which determine the radius of influence, such as the hydraulic property of the alluvial aquifer, pumping rate, the number and location of pumps, etc.
Efficacy of various cleaning solutions on saliva-contaminated zirconia for improved resin bonding
김다혜,손준식,정성화,김영경,김교한,권태엽 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.2
PURPOSE. This study aimed to investigate the efficacy of cleaning solutions on saliva-contaminated zirconia in comparison to air-abrasion in terms of resin bonding. MATERIALS AND METHODS. For saliva-contaminated airabraded zirconia, seven cleaning methods)–no contamination (NC), water-spray rinsing (WS), additional airabrasion (AA), and cleaning with four solutions (Ivoclean [IC]; 1.0 wt% sodium dodecyl sulfate [SDS], 1.0 wt% hydrogen peroxide [HP], and 1.0 wt% sodium hypochlorite [SHC])–were tested. The zirconia surfaces for each group were characterized using various analytical techniques. Three bonded resin (Panavia F 2.0) cylinders (bonding area: 4.5 mm2) were made on one zirconia disk specimen using the Ultradent jig method [four disks (12 cylinders)/group; a total of 28 disks]. After 5,000 thermocycling, all specimens were subjected to a shear bond strength test with a crosshead speed of 1.0 mm/minute. The fractured surfaces were observed using an optical and scanning electron microscope (SEM). ESULTS. Contact angle measurements showed that groups NC, AA, IC, and SHC had hydrophilic surfaces. The X-ray photoelectron spectroscopy (XPS) analysis showed similar elemental distributions between group AA and groups IC and SHC. Groups IC and SHC showed statistically similar bond strengths to groups NC and AA (P>.05), but not groups SDS and HP (P<.05). For groups WS, SDS, and HP, blister-like bubble formations were observed on the surfaces under SEM. CONCLUSION. Within the limitations of this in vitro study, some of the cleaning solutions (IC or SHC) were effective in removing saliva contamination and enhancing the resin bond strength.
3D Inverse-Opal Structured Li4Ti5O12 Anode for Fast Li-Ion Storage Capabilities
김다혜,Nguyen Duc Quang,Truong Thi Hien,Nguyen Duc Chinh,김천중,김도진 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.6
Since the demand for high power Li-ion batteries (LIBs) is increasing,spinel-structured lithium titanate, Li4Ti5O12 (LTO), as the anodematerial has attracted great attention because of its excellent cycleretention, good thermal stability, high rate capability, and so on. However, LTO shows relatively low conductivity due to empty 3dorbital of Ti4+ state. Nanoscale architectures can shorten electronconduction path, thus such low electronic conductivity can beovercome while Li+ can be easily accessed due to large surface area. Herein, three dimensional bicontinuous LTO electrodes were preparedvia close-packed self-assembly with polystyrene (PS) spheresfollowed by removal of them, which leads to no blockage of Li+ iontransportation pathways as well as fast electron conduction. 3Dbicontinuous LTO electrodes showed high-rate lithium storagecapability (103 mAh/g at 20 C), which is promising as the powersources that require rapid electrochemical response.