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장원단이 CT105와 ${\beta}A$로 유도(誘導)된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향(影響)
김건진,정대규,Kim, Geon-Jin,Chung, Dae-Kyoo 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.2
Objective : This research investigates the effect of the Jangwon-Dan,(JWD) on Alzheimer's disease. Method : The effects of the JWN extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA, (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Result : 1. The JWN extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-1 cells treated with LPS. 2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and CD68/GFAP, in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the JWN extract for Alzheimer's disease is suggested for future research.
인진호탕가웅담(茵蔯蒿湯加熊膽)의 경구투여(經口投與)가 $CCl_4$ 투여(投與)로 유발(誘發)된 간경변(肝硬變)에 미치는 영향(影響)
김건진,이형식,서부일,변성희,변준석,김상찬,Kim, Geon-Jin,Lee, Hyung-Sik,Seo, Bu-Il,Byun, Sung-Hui,Byun, Joon-Seok,Kim, Sang-Chan 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1
In order to determine the effects of annexing bile extracts of bears on the anti-fibrotic effect of Injinhotang. Mix compound of Injinhotang and bile extracts of bears were administered to the carbon tetrachloride ($CCl_4$)-induced cirrhotic rats during 20 days and the changes of serum levels of GOT (glutamic-oxalacetic transaminase), GPT (glutamic pyruvic transaminase), LDH (lactate dehydrogenase), ALP (alanine phosphatase), GGT (gamma glutamyl transpeptidase) and T-BIL (total bilirubin) were monitored with comparison to the results of Injinhotang administered group. The results were summarized as follows. 1. A significant (p<0.01) increase of serum GOT levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. In addition, a significant (p<0.05) increase were also detected In Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 2. A significant (p<0.01) increase of serum GPT levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum GPT levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 3. A significant (p<0.01) increase of serum LDH levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum LDH levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 4. A significant (p<0.01 or p<0.05) increase of serum ALP levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. In addition, a significant (p<0.05) increase were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. 5. A significant (p<0.01) increase of serum GGT levels were observed in control and Injinhotang-administered group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang with Fel Ursi-administered group. 6. A significant (p<0.01) increase of serum T-BIL levels were observed in control group compared to those of normal group but these increased levels were dramatically decreased in Injinhotang and Injinhotang with Fel Ursi-administered group. Although significances were not recorded, increase of serum T-BIL levels were also detected in Injinhotang with Fel Ursi-administered group compared to that of Injinhotang-administered group. In conclusion, it is considered that bile extract of bears has some additional effect to the anti-fibrotic effect of Injinhotang but to know the exact mechanism of suitable dose and duration of administration, further studies such as pharmacokinetics and dose-dependent pharmacological studies were needed
장원단이 CT105와 βA로 유도(誘導)된 Alzheimer`s Disease 병태(病態) 모델에 미치는 영향(影響)
김건진 ( Geon Jin Kim ),정대규 ( Dae Kyoon Chung ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.2
Objective :This research investigates the effect of the JangWon-Dan,(JWD) on Alzheimer`s disease. Method :The effects of the JWN extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, IL-1β mRNA, and TNF-α mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer`s diseased mice induced with βA were investigated. Result :1. The JWN extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in THP-1 cells treated with LPS.2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105.3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105.4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, IL-1β mRNA, TNF-α mRNA, and CD68/GFAP, in the mice with Alzheimer`s disease induced by βA. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer`s disease induced by βA. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the JWN extract for Alzheimer`s disease is suggested for future research.
Glucose oxidase/Cellulose 나노멤브레인을 이용한 Glucose 응답형 Patch 센서의 전기화학적 특성
김규오,김건진,Kim, Kyu Oh,Kim, Geon Jin 한국섬유공학회 2018 한국섬유공학회지 Vol.55 No.1
Highly selective and efficient electrochemical non-invasive epidermal glucose sensors were fabricated using electrospun cellulose-immobilized glucose oxidase (cellulose/GOx) nanofiber membranes. CA nanofiber membranes displayed homogeneous, smooth, and strongly interconnected nanofibers with fiber diameter of $0.21{\pm}0.1{\mu}m$ after treatment with 0.05 NaOH aqueous solution. The electrochemical oxidation of glucose was chosen for the detection of glucose and was achieved through the fabricated nanofiber membranes. Furthermore, the fabricated nanofiber membrane exhibited good selectivity, high stability, and high reproducibility, and hence, it can be used in wearable noninvasive epidermal glucose sensors.