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- 저자 : 정대규 ( Dae Kyoon Chung ) (검색결과 1 건)
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장원단이 CT105와 βA로 유도(誘導)된 Alzheimer`s Disease 병태(病態) 모델에 미치는 영향(影響)
김건진 ( Geon Jin Kim ),정대규 ( Dae Kyoon Chung ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.2
Objective :This research investigates the effect of the JangWon-Dan,(JWD) on Alzheimer`s disease. Method :The effects of the JWN extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, IL-1β mRNA, and TNF-α mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer`s diseased mice induced with βA were investigated. Result :1. The JWN extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in THP-1 cells treated with LPS.2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105.3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105.4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, IL-1β mRNA, TNF-α mRNA, and CD68/GFAP, in the mice with Alzheimer`s disease induced by βA. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer`s disease induced by βA. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the JWN extract for Alzheimer`s disease is suggested for future research.
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