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고현선,신종철,이승옥,채효진,최새경,김명신,박인양,서병규 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.6
Congenital lipoid adrenal hyperplasia (CLAH) is caused by mutations to the steroidogenic acute regulatory protein (StAR) gene associated with the inability to synthesize all adrenal and gonadal steroids. Inadequate treatment in an infant with this condition may result in sudden death from an adrenal crisis. We report a case in which CLAH developed in Korean siblings; the second child was prenatally diagnosed because the first child was affected and low maternal serum estriol was detected in a prenatal screening test. To our knowledge, this is the first prenatal diagnosis of the Q258X StAR mutation, which is the only consistent genetic cluster identified to date in Japanese and Korean populations.
education, MSC, and engineering design at Chosun University
고현선,박길문 한국공학교육학회 2011 공학교육연구 Vol.14 No.6
The curriculum system and documentation for advanced general education, MSC (Mathematics, Basic Science, Computer Science), and engineering-design courses have been developed to improve the education of advanced undergraduate students in engineering and technology at Chosun University. In this paper, to obtain improved quality of engineering courses, we systemized the education of engineering and technology, which could be designed as the education satisfying students and provide awards for high-quality performance, through efficient management of education courses and establishment of basic and professional courses. In addition, by applying evaluation to the engineering courses and using the model of continuous quality improvement, we could achieve a high-quality education system for the engineering and technology courses.
고현선,곽동욱,오수영,최세경,홍준석,황한성,박현수,설현주,김문영,김사진,박중신 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.2
ObjectiveTo evaluate the clinical significance of soft markers for aneuploidy screening in Korean women. MethodsWe retrospectively reviewed the medical records of 5,428 singleton pregnant women who underwent sonographyduring the second trimester at seven institutions in South Korea. We evaluated the prevalence of the following softmarkers: intracardiac echogenic focus, choroid plexus cysts, pyelectasis, echogenic bowel, and mild ventriculomegaly. We developed best-fitted regression equations for the fetal femur and humerus length using our data and defineda short femur and humerus as both long bones below the fifth centile. The results of genetic testing and postnataloutcomes were investigated in patients who had been diagnosed with aforementioned soft markers. ResultsThe median maternal age of our study population was 33 years, and the median gestational age at the time ofultrasonographic examination was 21 weeks. We detected soft markers in 10.0% (n=540) of fetuses: 9.3% (n=504)were isolated cases and 0.7% (n=36) of cases had two or more markers. We identified only two aneuploides (trisomy18, 46,XX,t[8;10][q22.1;p13]), of which one was clinically significant. We presented the neonatal outcomes of thefetuses with the respective soft markers. Preterm delivery, low birth weight, and small-for-gestational-age (SGA)were significantly more common in women with a shortened fetal femur (P<0.001, all). However, the presence of ashortened fetal humerus was not associated with those outcomes excluding SGA. ConclusionSoft markers in second-trimester ultrasonography have limited use in screening for fetal aneuploidy in Korean women. However, these markers can be used as a screening tool for adverse outcomes other than chromosomal abnormality.
고현선,Hamisi Tindwa,Rong De Jin,이용성,홍성현,현해남,남이,김길용 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.4
Lysobacter antibioticus HS124 isolated from pepper rhizosphere soil produced catechol type siderophore. Purified siderophore by Diaion HP-20 and silica gel column chromatography showed several hydroxyl functional groups adjacent to benzene rings by analysis of 1H NMR spectroscopy. The strain HS124 showed different activities to suppress Phytophthora capsici with different concentrations of exogenous Fe (III) in minimal medium where antifungal activity with 100 μM Fe (III) was approximately 1.5 times higher than in absence of Fe (III). Bacterial population in this Fe (III)-amended medium was also highest with 8.9×10^8CFU ml^-1 which also corresponded to the strongest siderophore activity. When grown in rich medium (minimal medium with N, P_2O_5, K_2O and glucose), HS124 exhibited approximately 2 times stronger antifungal activity compared to minimal medium. In pot trials, treatments of bacterial culture grown in rich medium with (C1) or without (C2) 100 μM Fe (III) exhibited a high protection of pepper plants from disease, compared to medium only with (M1) or without (M2) 100 μM Fe (III). Especially, treatment C1 showed the best disease control effect of about 70 %. Thus, the strain HS124 should be recommended as a potential biocontrol agent against P. capsici in pepper.
고현선,최세경,위정하,박인양,박용규,신종철 대한의학회 2018 Journal of Korean medical science Vol.33 No.10
Background: The purpose of this study was to compare the fetal/infant mortality risk associated with each additional week of expectant management to that associated with immediate delivery in women with multiple gestations. Methods: This was a retrospective national cohort study of 94,170 multiple deliveries, 92,619 (98.4%) twin and 1,352 (1.44%) triplet pregnancies, between 32 0/7 and 42 6/7 weeks of gestation recorded in the Korean vital statistics database. We investigated the risks of stillbirth and infant death after birth in Korea according to the week of gestation in twin and triplet pregnancies. Results: The risk of stillbirth significantly increased between 34 and 35 weeks of gestation and between 37 and 38 weeks of gestation in twin pregnancies and between 34 and 37 weeks of gestation in triplet pregnancies. The risk of infant death following delivery gradually decreased as pregnancies approached full term. Week-by-week differences were statistically significant between 33 and 34 weeks, with decreasing risks of infant death at advancing gestational ages in twin pregnancies. At 37 weeks of gestation, the relative risk of mortality was significantly higher with expectant management compared with immediate delivery (relative risk, 3.00; 95% confidence interval, 1.41–6.38). Conclusion: In twin pregnancies, delivery at 37 weeks of gestation can minimize the risks of stillbirth and infant death in uncomplicated cases, although individual maternal and fetal characteristics must be considered when determining the optimal timing of delivery. In multiple pregnancies, close fetal surveillance is needed after 34 weeks of gestation.
고현선 한국공학교육학회 2016 공학교육연구 Vol.19 No.2
Today, the world economy is changing rapidly thanks to the rapid progress of glottalization and the development of technology. It is important to analyze and offer specialized start-ups effect factors for collegians in order to systematically and successfully support technology-centered start-ups of collegians. Through which Entrepreneurship and job creation in developed countries. This study explores the current status and characteristics of Entrepreneurship education in Korea and suggests some directions for effective management of Entrepreneurship education.