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The Change of Gastric Antral Mucin Expression after Helicobacter pylori Irradication
마명신 ( Myung Sin Ma ),이길홍 ( Kil Hong Lee ),최정기 ( Jeong Ki Choi ),이승옥 ( Seung Ok Lee ),이수택 ( Soo Teik Lee ),강명재 ( Myoung Jae Kang ),김대곤 ( Dae Ghon Kim ),안득수 ( Deuk Soo Ahn ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<Background and Aims> Helicobacter pylori colonizes the gastric surface epithelium, mucus glands and the mucus gel layer, It has been known that H. pylori infection causes aberrant gastric mucin expression. The aim of this study was to determine the effec
증예(症例) : Mesangial proliferative golmerulonephritis와 동반된 신정맥 혈전등 1례
고은영 ( En Young Koh ),나방주 ( Bang Joo La ),이식 ( Sik Lee ),김원호 ( Won Ho Kim ),채재건 ( Hae Kun Chae ),강명재 ( Myung Jae Kang ),김원 ( Won Kim ),박성광 ( Sung Kwang Park ),강성귀 ( Sung Kyew Kang ) 전북대학교 의과학연구소 2002 全北醫大論文集 Vol.26 No.1
심부정맥 혈전증(deep thrombosis)는 외과적은 수술, 급성심근경색, 뇌졸중, 하지마비, 암, 그리고 외상 시에 발생할 수 있다. 신증후군도 심부정맥 혈전증 특히, 신정맥 혈전증을 발생시킬 수 있는데 가장 흔하게 동반되는 신증후군으로는 막성사구체병증이 있다. 그러나 mesangial proliferative glomerulonephritis와 병발된 신정맥혈전증은 흔하지 않아 증례보고를 하고자 한다. 본 환자는 신생검에서 mesangial pro-liferative glomerulonephritis로 진단되면서 좌측 대퇴부와 하지의 부종과 통증을 호소하였다. 사지와 신장의 도플러 초음파상 신정맥을 포함하는 하대정맥 내에서 고음영을 보이는 혈전이 관찰되었고, 양측 총장골 정맥(common iliac vein), 외장골 정맥(external iliac vein), 대퇴정맥(femoral vein)등 하지 정맥 혈전으로 막혀있는 소견이 있었다. 항응고제와 스테로이드 요법 후에 정맥내 혈전과 단백뇨가 호전되어 3년째 외래에서 추적관찰중이다. Thrombosis of one or both renal veins occurs in a variety of settings such as trauma, dehydration, extrinsic compression, nephritic syndrome, pregnancy, oral contraceptives or invasion by tumor. Nephrotic syndrome and certain carcinomas seem to predispose to the development of renal vein thrombosis. The most common nephritic syndrome which is associated with renal vein thrombosis is the membranous nephropathy. But, renal thrombosis associated with glomerulonephritis other than membranous is extremely rare. Our patient was diagnosed as mesangial proliferative glomerulonephritis by histologic examination. The patient complained of left flank pain. Doppler ultrasonography revealed contrast-filling defect in the left renal vein. So we have presented a rare case of a renal vein thrombosis in a patient with mesangial proliferative glomerulonephritis.
췌장질환에서 점액단백 항원 발현에 대한 면역 조직학적 연구
김용성 ( Yong Song Kim ),이승옥 ( Seung Ok Lee ),이수택 ( Soo Teik Lee ),김대곤 ( Dae Ghon Kim ),안득수 ( Deuk Soo Ahn ),강명재 ( Myung Jae Kang ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 점액 단백질(이하, Mucin)은 고분자량의 당단백질로서 소화기관 점막, 호흡기 점막 등에서 분비되어 점막선관을 윤활하고 보호하는 작용을 할 뿐아니라 세포증식 및 면역반응을 조절하는 기능을 가진다고 알려져 왔다. 지금까지 밝혀진 연구에 따르면 모두 8종류의 Mucin이 존재한다고 알려져 있는데 이들 기관이 병적인 상태로 변화하면 점액의 생성과 분비에 변화가 나타날 뿐 아니라 점액 유전자의 발현에도 변화가 나타난다고 알려져 있다. 본 연구에서는
脾摘出白鼠에 있어서 肝臟의 組織學的 및 酵素組織化學的變化에 關한 硏究
尹在勝,姜明材,李惠洙,崔三任,崔湖烈 의과학연구소 1987 全北醫大論文集 Vol.11 No.4
To investigate the effect of splenectomy on the morphological changes of the rat liver, histological (H & E, PAS, and reticulin stains) and enzyme histochemical(alkaline phosphatase, nonspecific esterase, and succinic dehydrogenase strains) studies were performed at 3 days, 1, 2, 3, and 4 weeks after splenectomy. The results were as follows. 1. The most remarkable finding of the liver after spienectomy was increased hematooietic cells in the hepatic tissue. Initially, the hematopoietic cells appeared in blood vessels, sinusoid and portal area, but it becomes localized to portal area after 3 weeks. 2. Kupffer cells were proliferated from the beginning to 3 weeks after splenectomy, and then return to control level at 4th week. 3. Cells with PAS- positive granles were marked decreased in numbers at 2nd and 3rd week groups, but it returned to normal at 4th week. 4. Activities of nonspecific esterase and succinic dehydrogenase were increased in all experimental groups, but normalized at 4th week, but the activity of alkaline phosphatase was not altered throughout the experimental period. According to these results, in the splenectomized rat, the liver gradually compensates the splenic function, especially the hematopoietic function and reticuloendothelial function, which stabilize at 4th week. (Key words: histochemical, splenectomy, liver)
단백뇨 없는 Mesangial IgM Nephropathy 1예
이강휴,강경표,김원,강명재,박성광,강성귀 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2
An 51-year-old woman presented with microscopic hematuria without protenuria for long time. Laboratory studies demonstrated the presence of red blood cells in urine, a normal serum IgM level, the absence of antinuclear antibodies, and a normal complement level. Renal biopsy revealed that some glomeruli are enlarged with endocapillary cell proliferation and a few glomeruli exhibit prominent vascular pole of the tufts and segmental increase in mesangial cell and matrix. Immunofluorescence studies demonstrated segmental granular deposits for IgM. Electron microscopy showed well-preserved foot process associated with focal effacement. Biopsy findings were consistent with IgM nephropathy. We present this case to promote understanding of the pathogenesis of IgM nephropathy. (Korean J Nephrol 2002;21(2):317-321)