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토끼 赤血球 및 血漿 Cholinesterase 活性에 미치는 影響
金漢燮,金相仁 中央醫學社 1967 中央醫學 Vol.12 No.1
The in vivo effects of anticholinesterases in general vary not only on species, sex, means of administration, vehicle with which an anticholinesterase is administered, etc., but among others on the quality e. g. stability and purity of the preparations. There has been no report, experimental or clinical, concerning the influence of those anticholinesterase pesticides, sold and used in Korea, on the blood cholinesterase in mammals. The erythrocyte and plasma cholinesterase activities were traced in 20 grouped rabbits 6,24 and 72 hours after a single oral administration of 3 organophosphate anticholinesterases-Parathion, EPN and Malathion, and one carbamate anticholinesteraseDithane, -all korean products-in doses of one-third of estimated LD50's for rabbits. 1) Following doses of these compounds an inhibition of cholinesterase was noted in both erythrocyte and plasma, especially at 6 hours. 2) Plasma cholinesterase could be more depressed than erythrocyte enzyme (in cases of Parathion and Dithane groups) when the enzyme depression was marked, i.e. at 6 hours post-administration. 3) At 24 hours there was a tendency that the cholinesterase activities in erythrocyte and plasma dissociate from each other with the plasma enzyme mostly recovered, which the erythrocyte enzyme did not. 4) By 72 hours the erythrocyte cholinesterase was belatedly but mostly recovered. 5) Marked individual variation in cholinesterase activity was noted in each expert mental group. 6) Measurements of cholinesterase activities in 12 normal adult Korean males and 12 females were tried using Michel’s method, with the results (expressed as ?pH/hr): males: erythrocyte, 0.765± 0.121 (S. D. =Standard Deviation), plasma, 0.685 ±0.142 (S.D.); females: erythrocyte, 0.732 ±0.059 (S.D.), plasma, 0.639±0.257 (S.D.).
가상현실 기반 범죄 프로파일링 시뮬레이션 교육 및 평가 시스템
김한섭,김해지,이윤식,이지은 (사)한국컴퓨터그래픽스학회 2018 컴퓨터그래픽스학회논문지 Vol.24 No.3
In this paper, we propose a system to a criminal profiling simulation training and assessment with virtual reality technology. Profiling has emerged as the incidence of violent crime has increased by 45.2 % in the country over the past decade. However, the number of profilers in Korea is 36, due to the problem of existing courses. “Criminal Reproduction Learning” is the common way to profiling training, but there are numerous constraints that prevent practical training. Thus, the system used virtual reality technology to overcome existing constraints. Users can receive simulation training and assessment of profiling at crime scene that have been implemented as virtual reality, with an immersive experience through interaction. We expect this system to contribute to the activation of profiling education in many institutions and to the development of good profilers with diverse training. 본 논문에서는 가상현실 기술을 이용한 범죄 프로파일링 시뮬레이션 교육 및 평가 시스템을 제안한다. 국내에서는 지난 10년 동안 강력범죄의 발생비가 45.2% 증가함에 따라 프로파일링의 중요성이 대두되었다. 하지만 기존 교육과정 문제로 인해, 국내 프로파일러의 수는 서른여섯 명으로 매우 적은 수준이다. ‘범죄 재현 학습’은 프로파일링을 교육하는 대표적인 방법이지만, 여러 제약사항이 존재해 실질적인 교육이 이루어지지 못하는 실정이다. 따라서 본 시스템은 기존의 제약사항을 해결하고자 가상현실 기술을 활용하였으며, 사용자는 가상현실로 구현된 범죄 현장에서 상호작용을 통한 몰입형 체험으로 프로파일링에 대한 시뮬레이션 교육과 평가를 받을 수 있도록 하였다. 본 시스템의 활용으로 많은 기관에서 프로파일링 교육이 활성화될 수 있을 것이며, 다양한 프로파일링 기법을 교육받은 우수한 프로파일러를 양성하는 데 크게 기여할 것으로 기대된다.