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신건권,조철연 경주대학교 2002 論文集 Vol.15 No.-
As we move further into the Knowledge economy, the value of business will depend more and more on intangible rather than tangible assets. But the traditional accounting systems have been interested in measuring the value of tangible assets only, and have given up on the issue of valuing intellectual assets(or intangible assets, intellectual capital). The accounting systems have not been able to explain the difference between the market value and the book values of firms. The major purpose of this study was to review and evaluate some performance measurement models(Balanced Scorecard, Economic Value- Added, Skandia Navigator, Intangible Assets Monitor, KM's Balance Sheet) in the era of knowledge management. Without an appropriate system for evaluation of intellectual assets, firms could not efficiently manage intellectual assets and strategically utilize them. Because intellectual assets(or intangible assets) are critical resources to management, this study would provide theoretical bases to the systematic evaluation and utilization of them and help firms overcome the limitations of traditional accounting system in handling intangible assets.
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제 2형 당뇨병 환자에서 대사증후군의 유병률 및 관련요인의 특징
박철진,박거운,박일구,신지혜,김진화,배학연,김상용 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3
Background: People with insulin resistance has a higher risk of developing cardiovascular disease. This leads to the importance in diagnosing metabolic syndrome. The incidence of metabolic syndrome has increased significantly in korea because of an increased population of obese people and also the incidence of DM. There have been many studies done on the incidence of metabolic syndrome in the general population. Therefore, the authors have designed this study to identify the incidence of metabolic syndrome in patients with type 2 DM and also the associated characteristics in that population. Methods: The study included 169 adults over the age of 20 (84 males and 85 females) admitted to the endocrinology department of Chosun University between Jan, 1st 2005 and May, 31st 2006. Out of the people diagnosed with type 2 DM people were excluded when any of the physical measurements (height, weight, blood pressure, abdominal circumference) and blood measurements (TG, HDL-cholesterol, fasting blood sugar) were insufficient and when the patient was taking any drugs other than anti-hy-pertensive agents and oral anti-diabetic agents. Obesity and the other risk factors were defined by the Asian-Pacific guideline and 2001 ATP III of NCEP, respectively. Result: The each prevalence according to the metabolic syndrome criteria of the type 2 DM patients showed low HDL cholesterolemia with the highest incidence of 57.4% followed by hypertng1yceridemia(52.0%), obesity(40.9%) and hypertension(33.0%). The each incidence of diagnostic criteria in metabolic syndrome according to sex was different, In males, hypertriglyceridemia was the highest with the incidence of 57.7% followed by low HDL-cho1estero1emia(49.5%), obesity(40.9%) and hypertension (30.0%). In women, the incidence were low HDL-cho1estero1emia(64.8%), hyperthg1yceridemia(47.6%), obesity(45.0%) and hypertension(36.0%), in a descending order. The analysis between the diagnosis of metabolic syndrome in type 2 DM patients and the criteria showed that hyperthglyceridemia (correlative value 0.575) had the highest correlation followed by low HDL-cholesterolemia (correlative value 0.446), obesity (correlative value 0.350) and hypertension (correlative value 0.410). All the correlations were statistically significant with a p-value less than 0.01. Conclusions: Type 2 DM is a important factor of metabolic syndrome based on insulin resistance. The control of blood glucose with prevention and early diagnosis of the other factors related to metabolic syndrome in type 2 DM is important for preventing cardiovascular complications.
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宋坰松,申喆均,朱榮丞 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1
Objectives : This study was designed to establish a characteristic discrimination of internal and external morphological standard of original plants and herbal states in Polygoni Multiflori and Cynanchi Wilfordii Radix. Methods : In this studies, the external-internal morphological standards were determined by using stereoscope and butanol series. Results : 1. The external characteristics of original plants: Polygonum multiflorum has alternate leaves, and its flower with white color blooms at the shoot apex or leaf axil. In the other hand, Cymchum wilfor&i has opposite leaves, and its flower with yellowish green color blooms at the leaf axil. 2. The physical characteristics of herbal states: Polygoni Multiflori Radix is red-brown in outer surface, pink-brown in section. In the other hand, Cynanchi Wilfordii Radix is earthly-brown in outer surface, greyish white in section. 3. The physical characteristics according to the place of production: Demonstrable difference according to the place of production is not seen. Polygoni Multiflori Radix is brown or dark brown in outer surface, soft yellow-dark brown in section. In the other hand, Cynanchi Wilfordii Radix is white in outer surface, white-weak red in section, and has power type. 4. The internal characteristics: Pofygonum mulQt7orum has hetero-vascular bundle and lignification of cork layer is progressive. In the other hand, cynanchum wilfordii has not hetero-vascular bundle, and lignification of cork layer is weak. Conclusion : In the future, many fundamental study such as how to discriminate between Polygoni Multiflori Radix and Cynanchi Wilfordii Radix in origin and efficacy will be necessary. Also the standard of discrimination must be specific and distinct in that several kinds of fo-ti has been traded.
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박일구,박철진,신지혜,김진화,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.1
인슐린 자가면역 증후군은 항체에 결합되어 있던 인슐린이 혈당정도와 관계없이 유리됨으로써 저혈당이 야기되는 질환으로, 인슐린종 등과 감별을 필요로 하는 질환이다. 저자들은 고인슐린혈증과 인슐린 자가항체가 양성이면서 공복검사상에서 저혈당이 유발되며 경구 포도당 부하 검사에서 저혈당이 유발된 자가면역성 저혈당증을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hypoglycemia is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemia. Insulin autoimmune syndrome is characterized by insulin autoantibody, hyperinsulinemia, and fasting hypoglycemia without previous insulin immunization. Insulin autoimmune syndrome is usually related to autoimmune disease such as Graves' disease and to previous exposure to drugs. This syndrome is a self-limited disorder. The hypoglycemia was treated with prednisolone and the patient recovered from this. Recently we experinenced two cases of insulin autoimmune syndrome that developed symptomatic hypoglycemia during both the fasting and oral glucose tolerance test. Here in, We present those cases with a review of the literature.
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Increased cell-free DNA concentrations in patients with obstructive sleep apnea
Shin, Chol,Kim, Jin K.,Kim, Je H.,Jung, Ki H.,Cho, Kyung J.,Lee, Chang K.,Lee, Seung G. Blackwell Publishing Asia 2008 PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol.62 No.6
<P>Aim: </P><P>Blood concentrations of cell-free DNA, which is considered to be released during apoptosis, are elevated under some pathological conditions such as cardiovascular disease and cancer. The association between obstructive sleep apnea (OSA) and cell-free DNA concentrations has not been reported so far. The purpose of the present study was to examine the association between OSA and plasma DNA concentrations.</P><P>Methods: </P><P>A case–control study was conducted using a total of 164 men aged 39–67 years, who were free of coronary heart disease and cancer. Laboratory-based overnight polysomnography was performed for all participants.</P><P>Results: </P><P>On the basis of polysomnography, patients with an apnea–hypopnea index (AHI) = 5–30 events/h were defined as having mild–moderate OSA (<I>n</I> = 33) and those with >30 events/h were defined as having severe OSA (<I>n</I> = 49). All 82 controls had AHI < 5 events/h. Plasma DNA concentrations from all participants were analyzed for the &bgr;-globin gene using fluorescence-based real-time polymerase chain reaction. Patients with severe OSA had significantly higher plasma DNA concentrations than persons with mild–moderate OSA and those without OSA (<I>P</I> < 0.05). AHI was significantly associated with body mass index (<I>P</I> < 0.001), hypertension (<I>P</I> < 0.001), and plasma DNA concentration (<I>P</I> < 0.05).</P><P>Conclusion: </P><P>After taking into account hypertension and other potential risk factors, persons with high plasma DNA concentrations (>8 µg/L) had approximately fourfold higher odds of OSA than those with low DNA levels. Further data are warranted to confirm the association for men and to evaluate the association for women.</P>
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Chol Shin,KyuBum Kwack,Nam H Cho,Seong Hwan Kim,Inkyung Baik 대한지역사회영양학회 2015 Nutrition Research and Practice Vol.9 No.1
BACKGROUND/OBJECTIVES: It is well-known that alcohol consumption is associated with stroke risk as well as with aldehyde dehydrogenase 2 gene (ALDH2) polymorphisms. However, it is unclear whether ALDH2 polymorphisms are associated with stroke risk independent of alcohol consumption and whether such association is modified by sex. We evaluated sex-specific associations of a common ALDH2 polymorphism and alcohol consumption with stroke risk in a Korean population. SUBJECTS/METHODS: We conducted a prospective cohort study involving 8,465 men and women, aged 40-69 years and free of stroke between June, 2001 and January, 2003, and followed for the development of stroke. We identified new cases of stroke, which were self-reported or ascertained from vital registration data. Based on genome-wide association data, we selected a single-nucleotide polymorphism (rs2074356), which shows high linkage disequilibrium with the functional polymorphism of ALDH2. We conducted Cox proportional hazards regression analysis considering potential risk factors collected from a baseline questionnaire. RESULTS: Over the median follow-up of 8 years, 121 cases of stroke were identified. Carrying the wild-type allele of the ALDH2 polymorphism increased stroke risk among men. The multivariate hazard ratio [95% confidence interval] of stroke was 2.02 [1.03-3.99] for the wild-type allele compared with the mutant alleles, but the association was attenuated after controlling for alcohol consumption. Combinations of the wild-type allele and other risk factors of stroke, such as old age, diabetes mellitus, and habitual snoring, synergistically increased the risk among men. Among women, however, the ALDH2 polymorphism was not associated with stroke risk. CONCLUSIONS: The prospective cohort study showed a significant association between a common ALDH2 polymorphism and stroke risk in Korean men, but not in Korean women, and also demonstrated that men with genetic disadvantages gain more risk when having risk factors of stroke. Thus, these men may need to make more concerted efforts to control modifiable risk factors of stroke.
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Transferrin saturation concentrations associated with telomeric ageing: a population-based study
Shin, Chol,Baik, Inkyung Cambridge University Press 2017 The British journal of nutrition Vol.117 No.12
<B>Abstract</B><P>There are limited data on the association between Fe overload and leucocyte telomere length (LTL), known as a useful biomarker of the replicative ageing of cells. The aim of the study was to evaluate associations between Fe-status biomarkers and LTL. A cross-sectional study included 1174 men and women aged 50-79 years who provided blood samples for assays of Fe-status biomarkers including ferritin, transferrin saturation (TSAT), total Fe-binding capacity (TIBC) and relative LTL. They were free of hepatitis, potential infection or Fe deficiency. In multiple linear regression analysis adjusted for potential confounding variables, log-transformed LTL was positively associated with TIBC (adjusted coefficient estimate for its highest quartile: 0·17 (se 0·03), <I>P</I><0·001) and inversely associated with TSAT (adjusted coefficient estimate for its third and fourth quartiles: −0·09 (se 0·03), <I>P</I><0·01). These associations were consistent after additional adjustment for serum concentrations of high-sensitivity C-reactive protein, alanine transaminase and aspartate transaminase. In particular, participants with not only abnormally high concentrations (>45 %) but also with high-normal concentrations (35-45 %) of TSAT had shorter LTL compared with those with low-normal concentrations (<30 %) (<I>P</I><0·05). We also observed that less-active or obese persons with high TSAT concentrations had shorter LTL than others. Our findings that cellular ageing is influenced not only by Fe overload but also by high-normal concentrations of TSAT support the hypothesis regarding the detrimental effects of labile Fe, which has a potent pro-oxidant activity in the body.</P>
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