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So Kamada,Toshiro Itoga,Yasuhiro Unno,Wataru Takahashi,Takuji Oishi,MAMORU BABA 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We have measured energy angular distribution of secondary neutrons for 1) ^7Li(p,xn) and ^9Be(p,xn) reactions with thin targets at 70 MeV, 2)^9Be(p,xn) reactions with a thick target at 11 MeV, using the time-of-flight technique at Tohoku University Cyclotron facility. Data were obtained at several laboratory angles from 0° to 110° using a beam swinger system and an NE213 scintillation detector placed at a well collimated neutron flight path. The energy range was from maximum to ~4 MeV (at 70 MeV). The spectrum results at 70 MeV showed very strong angular dependence which should be considered in detail in the applied purposes, while the data at 11 MeV showed much milder dependence and in fair agreement with the prediction of MCNPX.
( Yosuke Shimodaira ),( Kengo Onochi ),( Kenta Watanabe ),( So Takahashi ),( Sho Fukuda ),( Noboru Watanabe ),( Shigeto Koizumi ),( Tamotsu Matsuhashi ),( Katsunori Iijima ) 대한장연구학회 2021 Intestinal Research Vol.19 No.2
Background/Aims: 5-Aminosalicylic acid (5-ASA) is a basic drug for inducing and maintaining remission for ulcerative colitis. One of its formulations has a coating with a pH-dependent degradation that ensures the release 5-ASA at the terminal ileum. No evidence has been shown concerning the effects of proton pump inhibitors (PPIs) or H<sub>2</sub> receptor antagonists (H<sub>2</sub>RAs) on the clinical course of ulcerative colitis patients in remission. The present study assessed the effect of PPIs or H2RAs on the relapse of ulcerative colitis patients in clinical remission maintained by pH-dependent released 5-ASA. Methods: Ulcerative colitis patients who had been prescribed time- or pH-dependent-released 5-ASA between January 2015 and December 2018 were enrolled in this multicenter retrospective study. The period of remission until relapse occurred was analyzed among the patients taking time-dependent-released 5-ASA or pH-dependent-released 5-ASA with/without PPIs or H2RAs. Results: One hundred and nineteen patients were analyzed in this study. In the primary endpoint, the relapse rate was higher in patients taking pH-dependent-released 5-ASA and PPIs or H2RAs than in those taking the pH-dependent-released 5-ASA without PPIs or H2RAs, while the relapse rate was similar in patients taking the time-dependent-released 5-ASA with or without PPIs or H2RAs concomitantly. Patients with a short duration of disease and middle-aged patients more frequently showed relapse with PPIs or H2RAs than the other patients. Conclusions: The coadministration of PPIs or H2RAs affects the clinical course of ulcerative colitis in remission maintained by pH-dependent-released 5-ASA. (Intest Res 2021;19:225-231)
Ken Hoshikawa,Ikuo Nakamura,Satoshi Endo,Shingo Mizuniwa,So Makabe,Hiroko Takahashi 한국식물생명공학회 2012 Plant biotechnology reports Vol.6 No.3
Genes encoding pathogenesis-related proteins,such as degrading enzymes of fungal cell wall polysaccharides,have been used to confer enhanced resistance to fungal pathogens of various plants. A new type of endo-bmannanase gene, amn5A, was isolated from alkaliphilic Bacillus strain (JAMB-602) found in deep-sea sediment. The AMN5A mannanase is active over a wide pH range (pH 7–10) and stable at high temperature. In this study,transgenic tobacco plants expressing the amn5A gene were generated using Agrobacterium-mediated transformation. Polymerase chain reaction (PCR) analysis revealed that the amn5A gene was integrated into the genome of transgenic tobacco plants. Southern blot analysis showed that transgenic plants contained 1–6 copies of amn5A transgenes in their genome. Expression of the amn5A transgene was confirmed by reverse transcription-PCR analysis. Leaf extracts from the transgenic plants showed degradation activity of Konjak mannan. Antifungal assay of detached leaves and in vitro whole plantlets indicated that transgenic plants expressing amn5A gene acquired enhanced resistance to the soil-borne pathogenic fungus, Fusarium oxysporum,compared to untransformed control plants.