http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Yozo Sato,Shigeru Matsushima,Yoshitaka Inaba,Tsuyoshi Sano,Hidekazu Yamaura,Mina Kato,Yasuhiro Shimizu,Yoshiki Senda,Tsuneo Ishiguchi 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3
To retrospectively evaluate relative enhancement (RE) in the hepatobiliary phase of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging as a preoperative estimation of future remnant liver (FRL) function in a patients who underwent portal vein embolization (PVE). In 53 patients, the correlation between the indocyanine green clearance (ICG-K) and RE imaging was analyzed before hepatectomy (first analysis). Twenty-three of the 53 patients underwent PVE followed by a repeat RE imaging and ICG test before an extended hepatectomy and their results were further analyzed (second analysis). Whole liver function and FRL function were calculated on the MR imaging as follows: RE x total liver volume (RE Index) and FRL-RE x FRL volume (Rem RE Index), respectively. Regarding clinical outcome, posthepatectomy liver failure (PHLF) was evaluated in patients undergoing PVE. Indocyanine green clearance correlated with the RE Index (r = 0.365, p = 0.007), and ICG-K of FRL (ICG-Krem) strongly correlated with the Rem RE Index (r = 0.738, p < 0.001) in the first analysis. Both the ICG-Krem and the Rem RE Index were significantly correlated after PVE (r = 0.508, p = 0.013) at the second analysis. The rate of improvement of the Rem RE Index from before PVE to after PVE was significantly higher than that of ICG-Krem (p = 0.014). Patients with PHLF had a significantly lower Rem RE Index than patients without PHLF (p = 0.023). Relative enhancement imaging can be used to estimate FRL function after PVE.
Hideyuki Nishiofuku,Shigeru Matsushima,Yoshitaka Inaba,Hidekazu Yamaura,Yozo Sato,Yasuo Morishima,Kimihiko Kichikawa 대한영상의학회 2010 Korean Journal of Radiology Vol.11 No.3
Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). Materials and Methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm. Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 0.17 × 106 / mm2 in FL and 1.0 ± 0.70 × 106 / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%. Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL. Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). Materials and Methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm. Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 0.17 × 106 / mm2 in FL and 1.0 ± 0.70 × 106 / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%. Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.
Chieko Taguchi,Fuyuki Sato,Chen Wang,Shigeru Nakamura,Kosuke Oikawa,Ujjal Kumar Bhawal,Hiroyuki Okada,Kazumune Arikawa 조선대학교 치의학연구원 2022 Oral Biology Research (Oral Biol Res) Vol.46 No.4
Aberrant wound closure occurs in a broad range of wounds and scars, and the altered regulation of transcription factors in wound areas can account for both of those conditions. This study aimed to explore the function of the transcription factor Smad3 in wound healing using a tongue wound model in Smad3 knockout (Smad3–/–) mice and with Smad3 small interfering RNA (siRNA) transfected human gingival fibroblasts (HGFs). Smad3 –/–mice were used to examine the extent of repair in tongue wounds. Cell migration was evaluated in HGFs using wound healing assays. The mRNA expression levels of Sox2, E-cadherin, fibronectin, and vimentin were examined in HGFs using reverse transcription-quantitative polymerase chain reaction. Histopathological analysis of wound closure in Smad3–/– mice showed rapid re-epithelialization and remodeling in tongue wound repair compared with Smad3+/+ mice. Increased numbers of neutrophils were identified in the wounds of Smad3 –/– mice. Sox2 and phospho-E-cadherin expression levels were increased in Smad3–/– mice. Smad3 knockdown by siRNA increased cell migration of HGFs. In addition, Sox2, E-cadherin, fibronectin, and vimentin mRNA levels were significantly increased in Smad3 siRNA-transfected HGFs compared with controls. Collectively, these findings demonstrate that a Smad3 deficiency can expedite wound healing and increase immune reactions and extracellular matrix formation after tongue injuries, boosting recovery through Sox2 and E-cadherin. Consequently, Smad3 inhibition would help stimulate tongue wound healing.
Kamiya,Seigo,Kito,Makoto,Kim,Chan-Shick,Utsumi,Shigeru,Sato,Toshiro 濟州大學校 放射能利用硏究所 1991 연구보고 Vol.6 No.-
글리시닌은 大豆의 주요 貯藏 단백질중의 하나이다. 글리시닌의 機能特性(겔화성과 乳化性)과 營養價를 改善하기 위하여 A1aB1b proglycinin subunit를 여러 종류의 콩과식물 혹은 비콩과식물의 단백질 그리고 글리시닌의 構造와 機能特性과의 상관관계로부터 글리시닌 형태의 글로블린의 아미노산 배열의 비교로부터 제안된 유전적으로 可變領域의 domain을 기초로 하여 改變하였다. 그러므로 각 可變領域에 상당하는 핵산 염기배열을 A1aB1b proglycinin을 code하고 있는 cDNA로부터 削除하거나, 4개의 연속된 methionine을 code하고 있는 合成 DNA를 각각의 可變領域의 domain에 상당하는 cDNA 領域에 揷入하였다. 改變된 cDNA의 발현 plasmid를 調製하고 대장균 JM 105에서 發現하였다. 改變된 단백질의 몇종류는 대장균체내에서 溶解性 단백질로 축적되었으며 self-assemble하였다. 改變된 단백질들은 자연에 있는 대두 글리시닌보다도 우수한 機能特性을 나타내었으며 이론적으로 高品質인 글리시닌을 創製하는 可能性을 확립하였다. Glycinin is one of the predominant storage proteins of soybean. To improve its functional properties (heat-induced gelation and emulsification) and/or nutritional value, the A??B?? proglycinin subunit was modified on the basis of genetically variable domains suggested from the comparison of amino acid sequences of glycinin-type globulins from ???? legumes and nonlegumes and the relationships between the structure and the functional properties of glycinin. Thus, nucleotide sequences corresponding to each of the variable domains were deleted from the cDNA encoding the A??B?? proglycinin, and a synthetic DNA encoding four continuous methionines was inserted into the cDNA region corresponding to each of the variable domains. Expression plasmids carrying the modified cDNAs were constructed and expressed in Escherichia coli strain JM105. Some of the modified proteins were accumulated as soluble proteins in the cells at a high level and self-assembled. They exhibited functional properties superior to those of the native glycinin from soybean, which establishes the possibility of creating theoretically designed novel glycinins with high food qualities.