Free Paper Presentation : OS-54 ; Hazards of Smoking in Korean Population

( Keu Sung Lee ),( Seung Soo Sheen ),( Ji Ye Jung ),( Sang Haak Lee ),( Yu Il Kim ),( Jae Yeol Kim ),( Eun Mi Chun ),( Kwang Ha Yoo ),( Chul Min Ahn ),( Tae Hoon Jung ),( Joo Hun Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Smoking is a major cause of many noncommunicable diseases and leads to the reduction of life span. However, there are few population based studies on how smoking is associated with our general health in Korea. Therefore, we performed this study to investigate hazards of smoking on our health and major diseases associated with smoking in Korean population. Methods: Data of 12,762 subjects aged 40 years or older were obtained from Korea National Health and Nutrition Survey (KNHANES) V from 2010 to 2012. Demographic data, laboratory findings, and major diseases were analyzed based on smoking status. Results: Blood pressure, leukocyte count, and serum glucose level were higher in smokers, however, serum cholesterol level and body mass index were higher in non-smokers (p<0.05). Smoking was associated with higher prevalence of COPD (23.6% vs 7.0%), diabetes mellitus (14.3% vs 10.5%), cerebral stroke (3.3% vs 2.2%), and coronary artery disease (4.7% vs. 3.5%), whereas depression (2.9% vs 6.1%) was more prevalent in non-smokers (p<0.05). Multivariate analysis after adjustment for age and sex showed that smoking was independently associated with COPD (OR = 2.37, 95% CI = 1.93 -2.92) and diabetes mellitus (OR = 1.32, 95% CI = 1.11 - 1.58), and no smoking (OR = 1.52, 95% CI = 1.16 - 1.99) was with depression (p<0.05). Conclusions: Our analyses suggest smoking has harmful effects on health in various aspects. Especially, smoking was an independent risk factor for COPD and diabetes mellitus.

The Korean Academy of Tuberculosis and Respiratory Diseases : Slide Session ; OS-056 : COPD ; Gender and the Prevalence of COPD in Korean Adult Smokers: A Population-Based Study

( Keu Sung Lee ),( Seung Soo Sheen ),( Ji Ye Jung ),( Sang Haak Lee ),( Yu Il Kim ),( Jae Yeol Kim ),( Eun Mi Chun ),( Kwang Ha Yoo ),( Chul Min Ahn ),( Tae Hoon Jung ),( Joo Hun Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: The objective of this study was to investigate smoking effect on gender and the prevalence of chronic obstructive pulmonary disease (COPD). Method: Data for this study were obtained from Korean National Health and Nutrition Examination Survey (KNHANES) from 2007 to 2012 containing demographics, smoking histories and spirometry data. We recruited 6,159 ever-smokers (male 5,543 and female 616) aged over 40 who adequately performed spirometry according to American Thoracic Society (ATS) guidelines. Subjects with FEV1/FVC<0.7 were defi ned as COPD. To evaluate the loss of lung function per pack-year smoked, we used susceptibility index (SI), calculated using the formula: (% predicted FEV1 - 100)/pack-years. Results: Mean age was lower in male than female (56.7 vs. 58.0, p<0.001) and total amount of smoking expressed as a pack-year was greater in male than female (25.7 vs. 11.0, p<0.001). Total 1,453 (23.6%) subjects were diagnosed with COPD. Even though the prevalence of COPD was higher in male (24.5%) than female (5.4%)(p<0.001), female showed more loss of lung function per pack-year smoked than male (SI in female = -1.43% vs. SI in male= -0.79, p<0.001). To evaluate smoking effect precisely, 3,440 subjects (male 3,337 and female 103) who smoked more than 20 pack-years through life were selected. Mean age was also lower in male than women (57.7 vs. 63.7, p<0.001) and total amount of smoking (pack-year) was greater in male than female (36.3 vs. 31.8, p=0.0029). However the prevalence of COPD was not different between in male (29.0%) and in females (24.3%) (p=0.567). Female stillshowed more loss of lung function per pack-year smoked than male (SI in female = -0.56% vs. SI in male = -0.39, p=0.0003). Conclusion: Korean female ever-smokers have a susceptibility to smoking effect on lung function decline.

S-681 Adverse Events and Persistency of Biologics in RA Patients with Interstitial Lung Disease

( Dam Kim ),( Soo-kyung Cho ),( Soyoung Won ),( Hoon-suk Cha ),( Chan-bum Choi ),( Seung-jae Hong ),( Jisoo Lee ),( Dong Hyuk Sheen ),( Dae-hyun Yoo ),( Sang-cheol Bae ),( Yoon-kyoung Sung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Objectives: We aimed to compare the incidence of adverse events (AEs) and persistency of biologics in RA patients with or without ILD. Methods: A total of 981 RA patients with chest radiograph or chest computed tomography (CT) data at enrollment were extracted from BIOlogics Pharmacoepidemiologic StudY (BIOPSY) cohort, a nationwide multicenter prospective cohort for biologic users of RA patients in Korea. We classified them into two groups: 1) RA-ILD group as patients with ILD, and 2) RA-non ILD group as patients without ILD. We compared the incidence of AEs during use of biologics between two groups, and then tested the differences of drug discontinuation rates due to AEs, infection, and respiratory infection between RA-ILD and RA-non ILD groups using Kaplan-Meier survival analysis and log-rank test. In addition, Cox proportional hazard model were used to identify the impact of ILD on AEs in RA patients with biologics. Results: The 42 patients (4.3%) revealed to have RA-ILD by chest radiograph or chest CT. Patients in RA-ILD group were older (p<0.01), and male patients were more in RA-ILD group (p<0.01). During mean follow-up of 20 months with 1,611 person years (PY), the incidence of AEs was higher in RA-ILD group (IRR 1.55, CI 1.11-2.17). In addition, the incidence of infection and respiratory infection were higher in RA-ILD group (IRR 2.38, CI 1.32-4.30 for infection, IRR 3.00, CI 1.50-5.99 for respiratory infection, respectively). The biologics discontinuation rate due to AEs was comparable in two groups (p=0.13), whereas the biologics discontinuation rate due to infection (p=0.03) and respiratory infection (p<0.01) were significantly higher in RA-ILD group. After adjusting for variables, age (HR 1.27, CI 1.15-1.41) and having ILD (HR 10.77, CI 2.26-51.41) were risk factors for mortality in RA patients with biologics. Conclusions: The incidence of adverse events, especially respiratory infections were higher in RA-ILD patients with biologics compared with RA-non ILD patients. In addition, the biologics discontinuation rate due to infection, especially respiratory infection was significantly higher in RA-ILD patients. Concerning the mortality, ILD increased the mortality in RA patients with biologics.

Simple Decompression of the Ulnar Nerve for Cubital Tunnel Syndrome

Cho, Yong-Jun,Cho, Sung-Min,Sheen, Seung-Hoon,Choi, Jong-Hun,Huh, Dong-Hwa,Song, Joon-Ho The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.42 No.5

Objective : Cubital tunnel syndrome is the second most common entrapment neuropathy of the upper extremity. Although many different operative techniques have been introduced, none of them have been proven superior to others. Simple cubital tunnel decompression has numerous advantages, including simplicity and safety. We present our experience of treating cubital tunnel syndrome with simple decompression in 15 patients. Methods : According to Dellon's criteria, one patient was classified as grade 1, eight as grade 2, and six as grade 3. Preoperative electrodiagnostic studies were performed in all patients and 7 of them were rechecked postoperatively. Five patients of 15 underwent simple decompression using a small skin incision (2 cm or less). Results : Preoperative mean value of motor conduction velocity (MCV) within the segment (above the elbow-below the elbow) was $41.8{\pm}15.2\;m/s$ and this result showed a decrease compared to the result of MCV in the below the elbow-wrist segment ($57.8{\pm}6.9\;m/s$) with statistical significance (p<0.05). Postoperative mean values of MCV were improved in 6 of 7 patients from $39.8{\pm}12.1\;m/s$ to $47.8{\pm}12.1\;m/s$ (p<0.05). After an average follow-up of $4.8{\pm}5.3$ months, 14 patients of 15 (93%) reported good or excellent clinical outcomes according to a modified Bishop scoring system. Five patients who had been treated using a small skin incision achieved good or excellent outcomes. There were no complications, recurrences, or subluxation of the ulnar nerve. Conclusion : Simple decompression of the ulnar nerve is an effective and successful minimally invasive technique for patients with cubital tunnel syndrome.

The effects of electrical shock on the expressions of aquaporin subunits in the rat spinal cords

Seong-Il Yeo,Hea Jin Ryu,Ji-Eun Kim,Wook Chun,Cheong Hoon Seo,Boung Chul Lee,Ihn-Geun Choi,Seung Hun Sheen,Tae-Cheon Kang 대한해부학회 2011 Anatomy & Cell Biology Vol.44 No.1

We analyzed aquaporin (AQP) expression in the rat spinal cord following an electrical shock (ES) to elucidate the roles of AQP in spinal cord injury (SCI) induced by an electrical burn. In control animals, AQP1 immunoreactivity was observed in the small diameter dorsal horn fibers of laminae I and II and in astrocytes and neurons in the spinal cord. Both AQP4 and AQP9 immunoreactivity were detected in astrocytes. One week after the ES, AQP1 immunoreactivity in dorsal horn fibers was downregulated to 83, 61, and 33% of control levels following a 1-, 4-, or 6-second ES, respectively. However, AQP1 immunoreactivity in ventral horn neurons increased to 1.3-, 1.5-, and 2.4-fold of control levels following a 1-, 4-, or 6-second ES, respectively. AQP4 immunoreactivity was upregulated after an ES in laminae I and II astrocytes in a stimulus-intensity independent manner. Unlike AQP1 and AQP4, AQP9 immunoreactivity was unaffected by the ES. These findings indicate that altered AQP immunoreactivity may be involved in SCI following an ES.

PET/CT 영상에서의 표준섭취계수(SUV)의 신뢰성 확보를 위한 시스템별 차이에 관한 연구 : 초기 연구

박훈희,박민수,김정열,이승재,신희순,임한상,김세영,장혜원,오기백,김재삼,이창호,Park, Hoon-Hee,Park, Min-Soo,Kim, Jung-Yul,Lee, Seung-Jae,Sheen, Hee-Soon,Lim, Han-Sang,Kim, Sei-Young,Jang, Hye-Won,Oh, Ki-Back,Kim, Jae-Sam,Lee, Chang-Ho 대한디지털의료영상학회 2008 대한디지털의료영상학회논문지 Vol.10 No.1

In this study, using an experiment, in certified an error between each system of SUV (standardized uptake value) that is one of the main analyses to diagnose a tumor in PET/CT, so, it would assure reliability and help to diagnose any lesions accurately. That is, a detailed analysis progressed. as all images reconstructed every setting time, then, clinical reliability between each system was expressed numerically at MBq/mL and SUV. Therefore, this study is considered that flexibility of follow-up using diverse system was insured, and it helps to offer accurate and beneficial information for diagnosis of various fields.

측두골 골절후 발생한 안면마비 환자의 안면신경감압술: 25명 환자들의 증례분석

남한가위 ( Han Ga Wi Nam ),황형식 ( Hyung Sik Hwang ),문승명 ( Seung Myung Moon ),신일영 ( Il Young Shin ),신승훈 ( Seung Hun Sheen ),정제훈 ( Je Hoon Jeong ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.3

Purpose: The aim of this study is to present a retrospective review of patients who had a sudden onset of facial palsy after trauma and who underwent facial nerve decompression. Methods: The cases of 25 patients who had traumatic facial palsy were reviewed. Facial nerve function was graded according to the House-Brackmann grading scale. According to facial nerve decompression, patients were categorized into the surgical (decompression) group, with 7 patients in the early decompression subgroup and 2 patients in the late decompression subgroup, and the conservative group(16 patients). Results: The facial nerve decompression group included 8 males and 1 female, aged 2 to 86 years old, with a mean age of 40.8. In early facial nerve decompression subgroup, facial palsy was H-B grade I to III in 6 cases (66.7%); H-B grade IV was observed in 1 case(11.1%). In late facial nerve decompression subgroup, 1 patient (11.1%) had no improvement, and the other patient(11.1%) improved to H-B grade III from H-B grade V. A comparison of patients who underwent surgery within 2 weeks to those who underwent surgery 2 weeks later did not show any significant difference in improvement of H-B grades (p>0.05). The conservative management group included 15 males and 1 female, aged 6 to 66 years old, with a mean age of 36. At the last follow up, 15 patients showed H-B grades of I to III(93.7%), and only 1 patient had an H-B grade of IV(6.3%). Conclusion: Generally, we assume that early facial nerve decompression can lead to some recovery from traumatic facial palsy, but a prospective controlled study should and will be prepared to compare of conservative treatment to late decompression.

Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide

( Dae Won Kim ),( Hyun Sook Hwang ),( Duk Soo Kim ),( Seung Hoon Sheen ),( Dong Hwa Heo ),( Gyojun Hwang ),( Suk Hyung Kang ),( Haeyong Kweon ),( You Young Jo ),( Seok Woo Kang ),( Kwang Gill Lee ),( 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.4

Silk fibroin (SF) peptide has been traditionally used as a treatment for flatulence, spasms, and phlegm. In this study, we examined whether SF peptide enhanced the antiinflammatory effect of PEP-1-FK506 binding protein (PEP-1-FK506BP) through comparing the anti-inflammatory activities of SF peptide and/or PEP-1-FK506BP. In the presence or absence of SF peptide, transduction levels of PEP-1-FK506BP into HaCaT cells and mice skin and anti-inflammatory activities of PEP-1-FK506BP were identified by Western blot and histological analyses. SF peptide alone effectively reduced both mice ear edema and the elevated levels of cyclooxygenase-2, interleukin-6 and -1β, and tumor necrosis factor-α, showing similar anti-inflammatory effect to that of PEP-1-FK506BP. Furthermore, co-treatment with SF peptide and PEP-1- FK506BP exhibited more enhanced anti-inflammatory effects than the samples treated with SF peptides or PEP- 1-FK506BP alone, suggesting the possibility that SF peptide and PEP-1-FK506BP might interact with each other. Moreover, the transduction data demonstrated that SF peptide did not affect the transduction of PEP-1- FK506BP into HaCaT cells and mice skin, indicating that the improvement of anti-inflammatory effect of PEP-1- FK506BP was not caused by enhanced transduction of PEP-1-FK506BP. Thus, these results suggest the possibility that co-treatment with SF peptide and PEP-1-FK506BP may be exploited as a useful therapy for various inflammationrelated diseases.

Imaging follow-up strategy after endovascular treatment of Intracranial aneurysms: A literature review and guideline recommendations

Yong-Hwan Cho,Jaehyung Choi,Chae-Wook Huh,Chang Hyeun Kim,Chul Hoon Chang,Soon Chan KWON,Young Woo Kim,Seung Hun Sheen,Sukh Que Park,Jun Kyeung Ko,Sung-kon Ha,Hae Woong Jeong,Hyen Seung Kang 대한뇌혈관외과학회 2024 Journal of Cerebrovascular and Endovascular Neuros Vol.26 No.1

Objective: Endovascular coil embolization is the primary treatment modality for intracranial aneurysms. However, its long-term durability remains of concern, with a considerable proportion of cases requiring aneurysm reopening and retreatment. Therefore, establishing optimal follow-up imaging protocols is necessary to ensure a durable occlusion. This study aimed to develop guidelines for follow-up imaging strategies after endovascular treatment of intracranial aneurysms.Methods: A committee comprising members of the Korean Neuroendovascular Society and other relevant societies was formed. A literature review and analyses of the major published guidelines were conducted to gather evidence. A panel of 40 experts convened to achieve a consensus on the recommendations using the modified Delphi method.Results: The panel members reached the following consensus: 1. Schedule the initial follow-up imaging within 3-6 months of treatment. 2. Noninvasive imaging modalities, such as three-dimensional time-of-flight magnetic resonance angiography (MRA) or contrast-enhanced MRA, are alternatives to digital subtraction angiography (DSA) during the first follow-up. 3. Schedule mid-term follow-up imaging at 1, 2, 4, and 6 years after the initial treatment. 4. If noninvasive imaging reveals unstable changes in the treated aneurysms, DSA should be considered. 5. Consider late-term follow-up imaging every 3–5 years for lifelong monitoring of patients with unstable changes or at high risk of recurrence.Conclusions: The guidelines aim to provide physicians with the information to make informed decisions and provide patients with high-quality care. However, owing to a lack of specific recommendations and scientific data, these guidelines are based on expert consensus and should be considered in conjunction with individual patient characteristics and circumstances.

Thematic Poster : TP-4 ; Effectiveness of Bronchoscopic Lung Volume Reduction Using Unilateral Endobronchial Valve: A Systematic Review and Meta-Analysis

( Mi Young Choi ),( Worl Suk Lee ),( Min Lee ),( Kyeong Man Jeon ),( Seung Soo Sheen ),( Sang Hoon Jheon ),( Young Sam Kim ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Bronchoscopic lung volume reduction (BLVR) can be suggested as an alternative for surgical lung volume reduction surgery for severe emphysema patients. This article intends to evaluate the safety and effectiveness of BLVR using one-way endobronchial valve by systematic review. Methods: A systematic search of electronic databases including MEDLINE, EMBASE, and Cochrane Library, as well as eight domestic databases up to December 2013 was performed. Two reviewers independently screened all references according to selection criteria. The Scottish Intercollegiate Guidelines Network (SIGN) criterion was used to assess quality of literature. Data from randomized controlled trials (RCTs) were combined and meta-analysis was performed. Results: This review included 15 studies. The forced expiratory volume in one second (FEV1) improved in the intervention group compared to the control group (MD=6.71, 95% CI: 3.31 to 10.11). Six minute walking distance (MD=15.66, 95% CI : 1.69 to 29.64) and cycle workload (MD= 4.43, 95% CI: 1.80- to7.07) also improved. In addition, the St. George’s Respiratory Questionnaire (SGRQ) score decreased (MD -4.29, 95% CI: -6.87 to -1.71) in the intervention group. In a subgroup analysis of patients with complete fissure, the FEV1 change from baseline was higher in the BLVR group than the control group for both 6 month (MD=14.75, p <.001) and 12 months (MD=17.43, p <.001) whereas patients with incomplete fissure the FEV1 and 6MWD showed no change. One year follow-up randomized controlled trials reported deaths although the cause of death was not related to BLVR. Respiratory failure and pneumothorax incidence rate was relatively higher in the BLVR group but the difference was not significant. Conclusions: Bronchoscopic lung volume reduction may be an effective and safe procedure for the treatment of severe COPD patients with emphysema based on existing studies.