Low Noise Oscillators at Radio Frequency

K. F. Tsang,P. W. Fung,W. S. Chan,W. H. Chan 대한전자공학회 1993 JTC-CSCC : Joint Technical Conference on Circuits Vol.- No.-

Association among self-compassion, resilience and positive mental health and risk of gaming disorder in 18-30 years old Asian population

Tang, A.C.Y.,Lee, R.L.T.,Lee, P. H.,Cheng, W.L.S.,Chan, S.,Guo, Y.,Wang, Y.,Wang, Q.,Wongchaiya, P.,Suen, L.K.P. 한국간호과학회 2023 한국간호과학회 학술대회 Vol.2023 No.11

A Quantitative Analysis of Word텱efinition in a Machine-Readable Dictionary

( Robert W. P. Luk ),( Venus M. K. Chan ) 한국언어정보학회 1995 국제 워크샵 Vol.1995 No.-

This paper investigates some of the distributional properties of word definitions in a machine?readable dictionary which was obtained from the Oxford Text Archive. Three types of dis?tributions were examined: (1) frequency-ranked distribution of words in the definitions, (2) the length distribution of word definitions and (3) the frequency distribution of the number of unique tags of an entry. In addition, the coverage characteristics of headwords over word defi?nitions are also explored. A rough-and-ready comparison of distributional properties between tokens and their morphologically decomposed ones are made. Our result shows that morpho?logical dcomposition does not change the length distribution of the word definitions nor the ranked-frequency distribution of words, significantly. However, it increases the coverage of word definitions dramatically compared with no decompositions. Furthermore, the frequency distribution of the number of unique tags per entry is approximately linear when the data is suitablely scaled (i.e. linear or logarithmic).

Fam83h is Associated with Intracellular Vesicles and ADHCAI

Ding, Y.,Estrella, M.R.P.,Hu, Y.Y.,Chan, H.L.,Zhang, H.D.,Kim, J.-W.,Simmer, J.P.,Hu, J.C.-C. SAGE Publications 2009 Journal of dental research Vol.88 No.11

<P>Defects in <I>FAM83H</I> on human chromosome 8q24.3 cause autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI). <I>FAM83H</I> does not encode a recognizable signal peptide, so we predicted that the Fam83h protein functions within the cell. We tested this hypothesis by constitutively expressing mouse Fam83h with green fluorescent protein (GFP) fused to its C-terminus in HEK293 and HeLa cell lines. Green fluorescent signal from the Fam83h-GFP fusion protein was associated with perinuclear vesicles, usually in the vicinity of the Golgi apparatus. No signal was observed within the nucleus. In addition, we identified <I> FAM83H</I> nonsense mutations in Hispanic (C1330C>T; p.Q444X) and Caucasian (c.1192C>T; p.Q398X) families with ADHCAI. We conclude that Fam83h localizes in the intracellular environment, is associated with vesicles, and plays an important role in dental enamel formation. <I>FAM83H</I> is the first gene involved in the etiology of amelogenesis imperfecta (AI) that does not encode a secreted protein.</P>

Advances in the management of diabetic kidney disease: beyond sodium-glucose co-transporter 2 inhibitors

( Anthony T. P. Chan ),( Sydney C. W. Tang ) 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.6

Progress in the treatment of diabetic kidney disease (DKD) has been modest since the early trials on renin-angiotensin-aldosterone system inhibitors (RAASis). Although sodium-glucose co-transporter 2 inhibitors (SGLT2is) have revolutionized the management of DKD by lowering proteinuria and protecting organs, other novel treatment approaches with good evidence and efficacy that can be used in conjunction with a RAASi or SGLT2i in managing DKD have emerged in the past few years. This review discusses the evidence for glucagon-like peptide-1 receptor agonist, selective mineralocorticoid receptor antagonist, and selective endothelin A receptor antagonist, emerging treatment options for DKD beyond SGLT2 inhibition.

Visualization of Relative Flow Patterns in Centrifugal Blood Pump

Weng Kong Chan,S. C. M Yu,L. P. Chua,Y. W. Wong 대한기계학회 2001 KSME International Journal Vol.15 No.12

일본 정지궤도 기상위성 Himawari-8을 이용한 에어로졸 광학정보 산출 및 검증

임현광 ( Hyunkwang Lim ),최명제 ( Myungje Choi ),김미진 ( Mijin Kim ),김준 ( Jhoon Kim ),( P. W. Chan ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.6

자외선, 가시광, 적외선 파장대역의 채널을 갖는 위성 관측에 기반한 다양한 에어로졸 정보산출 알고리즘에 대해 많은 연구가 이루어져 왔다. 본 연구에서는 최근 발사된 일본 기상위성 히마와리 8의 가시광-적외선 채널정보를 이용하여, 어두운 지표 위에서 에어로졸 광학정보를 산출하였다. 가시영역을 이용한 에어로졸 광학정보 산출은 지표신호의 정확한 제거가 매우 중요한데, 이는 최소반사도법을 사용하여 산출하였다. 본 알고리즘은 어두운 지표에서 에어로졸 광학정보를 산출을 하기에 구름, 사막 등과 같은 밝은 지표 위에서는 산출하지 않는다. AHI는 가시광채널 외에도, 다양한 적외 채널을 갖고 있어 공간 비균질성, 밝기온도차이(Brightness Temperature Difference, BTD) 등을 이용하여 구름제거가 가능하다. 밝기온도(Brightness Temperature, BT)를 이용해 하층운, 상층운 제거에 유리한 채널을 사용하여 구름을 제거하게 된다. Aerosol Optical Depth (AOD) 산출 결과로는 상관계수가 0.7, 기대오차(Expected Error, EE) 안에 있는 비율이 49%를 나타내고 있으며, 낮은 AOD에서도 정확한 산출이 이뤄지고 있음을 보이고 있다. 다만 베이징 허베이 지역에서는 에어로졸 광학두께를 과소모의하는 경향이 있는데, 이는 최소반사도법을 이용한 지표정보 산출이 실제 지표반사도보다 높게 지표면 정보를 추정하게 되기 때문으로 추정된다. Using various satellite measurements in UV, visible and IR, diverse algorithms to retrieve aerosol information have been developed and operated to date. Advanced Himawari Imager (AHI) onboard the Himawari 8 weather satellite was launched in 2014 and has 16 channels from visible to Thermal InfRared (TIR) in high temporal and spatial resolution. Using AHI, it is very valuable to retrieve aerosol optical properties over dark surface to demonstrate its capability. To retrieve aerosol optical properties using visible and Near InfRared (NIR) region, surface signal is very important to be removed which can be estimated using minimum reflectivity method. The estimated surface reflectance is then used to retrieve the aerosol optical properties through the inversion process. In this study, we retrieve the aerosol optical properties over dark surface, but not over bright surface such as clouds, desert and so on. Therefore, the bright surface was detected and masked using various infrared channels of AHI and spatial heterogeneity, Brightness Temperature Difference (BTD), etc. The retrieval result shows the correlation coefficient of 0.7 against AERONET, and the within the Expected Error (EE) of 49%. It is accurately retrieved even for low Aerosol Optical Depth (AOD). However, AOD tends to be underestimated over the Beijing Hefei area, where the surface reflectance using the minimum reflectance method is overestimated than the actual surface reflectance.

Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma

Abou-Alfa, G.K.,Puig, O.,Daniele, B.,Kudo, M.,Merle, P.,Park, J.W.,Ross, P.,Peron, J.M.,Ebert, O.,Chan, S.,Poon, T.P.,Colombo, M.,Okusaka, T.,Ryoo, B.Y.,Minguez, B.,Tanaka, T.,Ohtomo, T.,Ukrainskyj, S Elsevier Science Publishers 2016 Journal of hepatology Vol.65 No.2

<P>Background & Aims: Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3) that is expressed in hepatocellular carcinoma (HCC), interacts with CD16/FccRIIIa and triggers antibody-dependent cytotoxicity. Codrituzumab was studied vs. placebo in a randomized phase II trial in advanced HCC patients who had failed prior systemic therapy. Methods: Patients with advanced HCC who had failed prior systemic therapy, >= 18 years, Eastern cooperative oncology group (ECOG) 0-1, Child-Pugh A were randomized 2: 1 to biweekly codrituzumab 1600 mg vs. placebo. Patients were stratified based on GPC3 immunohistochemical expression: 2+/3+, 1+, and 0. Primary endpoint was progression free survival. Secondary endpoints include overall survival (OS), tolerability, pharmacokinetics, and an exploratory endpoint in biomarkers analysis. Results: 185 patients were enrolled: 125 received codrituzumab and 60 placebo: Median age 64/63, 85/75% male, 46/42% Asian, ECOG 0 65/63%, 74/77% having vascular invasion and/or extrahepatic metastasis. 84%/70% had prior sorafenib. Drug exposure was 98.4% of planned dose, with an identical adverse events profile between the 2 groups. The median progression free survival and overall survival in the codrituzumab vs. placebo groups in months were: 2.6 vs. 1.5 (hazard ratios 0.97, p = 0.87), and 8.7 vs. 10 (hazard ratios 0.96, p = 0.82). Projected Ctrough at cycle 3 day 1 based exposure, high CD16/FccRIIIa on peripheral immune cells, and GPC3 expression in the tumor, were all associated with prolonged progression free survival and overall survival. Conclusions: Codrituzumab did not show clinical benefit in this previously treated HCC population. Whether higher codrituzumab drug exposure or the use of CD16 and GPC3 as potential biomarkers would improve outcome remain unanswered questions. Lay summary: Codrituzumab is a manufactured antibody against a liver cancer protein called glypican-3. In this clinical trial, codrituzumab was not found be effective against liver cancer. It was suggested though that a higher dose of codrituzumab or selecting patients with high level of glypican-3 or its mediator CD16 might improve outcome. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</P>

Cross-Layer Routing and Scheduling for Onboard Processing Satellites with Phased Array Antenna

Choi, Jihwan P.,Chang, Seok-Ho,Chan, Vincent W. S. IEEE 2017 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.16 No.1

<P>The advanced multibeam satellite equipped with phased array antenna and solid state power amplifiers can generate flexible beams, by managing interbeam interference to serve a very large number of users effectively over its coverage area. Onboard processing (OBP) functionality can enhance the flexibility of a large-scale antenna by speeding up computational processes and saving precious radio link spectrum. In this paper, we derive a cross-layer OBP design of switching/routing, beamforming, and user scheduling as taking advantage of fine spatial resolution capability of phased array antenna satellites. We evaluate tradeoff between OBP computational complexity and throughput performance, showing that the additional complexity of an increased number of switch ports and phased array antenna gain patterning is compensated by high throughput gain achieved by mitigating interference. Our analysis shows that throughput gain for the next generation satellite system can be as high as 40, compared with the conventional multiple beam antenna with travelling wave tube amplifiers, and that beamforming is critical for achieving high spectral efficiency in the crowded service area. We then investigate the impacts of onboard switching and phased array antenna beamforming to practical routing protocols, such as open short path first and routing information protocol.</P>

Surface-Effect-Induced Optical Bandgap Shrinkage in GaN Nanotubes

Park, Young S.,Lee, Geunsik,Holmes, Mark J.,Chan, Christopher C. S.,Reid, Benjamin P. L.,Alexander-Webber, Jack A.,Nicholas, Robin J.,Taylor, Robert A.,Kim, Kwang S.,Han, Sang W.,Yang, Woochul,Jo, Y. American Chemical Society 2015 NANO LETTERS Vol.15 No.7

<P>We investigate nontrivial surface effects on the optical properties of self-assembled crystalline GaN nanotubes grown on Si substrates. The excitonic emission is observed to redshift by ∼100 meV with respect to that of bulk GaN. We find that the conduction band edge is mainly dominated by surface atoms, and that a larger number of surface atoms for the tube is likely to increase the bandwidth, thus reducing the optical bandgap. The experimental findings can have important impacts in the understanding of the role of surfaces in nanostructured semiconductors with an enhanced surface/volume ratio.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-7/acs.nanolett.5b00924/production/images/medium/nl-2015-00924p_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl5b00924'>ACS Electronic Supporting Info</A></P>