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A sensitive fluorescent probe for the polar solvation dynamics at protein-surfactant interfaces
Singh, P.,Choudhury, S.,Singha, S.,Jun, Y.,Chakraborty, S.,Sengupta, J.,Das, R.,Ahn, K. H.,Pal, S. Royal Society of Chemistry 2017 Physical chemistry chemical physics Vol.19 No.19
<P>Relaxation dynamics at the surface of biologically important macromolecules is important taking into account their functionality in molecular recognition. Over the years it has been shown that the solvation dynamics of a fluorescent probe at biomolecular surfaces and interfaces account for the relaxation dynamics of polar residues and associated water molecules. However, the sensitivity of the dynamics depends largely on the localization and exposure of the probe. For noncovalent fluorescent probes, localization at the region of interest in addition to surface exposure is an added challenge compared to the covalently attached probes at the biological interfaces. Here we have used a synthesized donor-acceptor type dipolar fluorophore, 6-acetyl-(2-((4-hydroxycyclohexyl)(methyl) amino) naphthalene) (ACYMAN), for the investigation of the solvation dynamics of a model protein-surfactant interface. A significant structural rearrangement of a model histone protein (H1) upon interaction with anionic surfactant sodium dodecyl sulphate (SDS) as revealed from the circular dichroism (CD) studies is nicely corroborated in the solvation dynamics of the probe at the interface. The polarization gated fluorescence anisotropy of the probe compared to that at the SDS micellar surface clearly reveals the localization of the probe at the protein-surfactant interface. We have also compared the sensitivity of ACYMAN with other solvation probes including coumarin 500 (C500) and 4-(dicyanomethylene)-2-methyl-6-(p-dimethylamino-styryl)-4H-pyran (DCM). In comparison to ACYMAN, both C500 and DCM fail to probe the interfacial solvation dynamics of a model protein-surfactant interface. While C500 is found to be delocalized from the protein-surfactant interface, DCM becomes destabilized upon the formation of the interface (protein-surfactant complex). The timescales obtained from this novel probe have also been compared with other femtosecond resolved studies and molecular dynamics simulations.</P>
Arp 202: a TDG formed in a parent's extended dark matter halo?
Scott, T C,Lagos, P,Ramya, S,Sengupta, C,Paudel, S,Sahu, D K,Misra, K,Woo, J -H,Sohn, B W Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.475 No.1
<P>We report on H alpha+ [N II] imaging of the Arp 202 interacting pair and its tidal dwarf galaxy (TDG) candidate as well as a GMOS long slit spectrum from the TDG candidate, observed with the Gemini North telescope. Our H alpha + [N II] imaging reveals the TDG to have an elongated structure, similar to 1.9 kpc in length with the two principal star-forming knots at either end. Our observations also show the TDG candidate has a recessional V-H alpha similar to 3032km s(-1), within 100 km s(-1) of the parent pair's mean velocity and an oxygen abundance of 12+log(O/H) = 8.10 +/- 0.41. The TDG's oxygen abundance is in good agreement with that of a star-forming region in NGC 2719A, one of the parent galaxies, which has an estimated oxygen abundance of 12+log(O/H) = 8.05 +/- 0.41. The TDG's V-H alpha and oxygen abundance confirm previous results validating the candidate as a TDG. The absence of detectable emission from the TDG in Spitzer 3.6 and 4.5 vim images together with the lack of absorption lines and weak continuum in the spectrum is consistent with absence the of an old population (greater than or similar to 0.5 Gyr). The location of the TDG within the interaction debris and the absence of indicators of an old stellar population in the TDG is consistent with a scenario in which the TDG is formed from H I stripped from the parent galaxies and within the extended dark matter halo of one of the parents as proposed by Bournaud et al. and Duc et al.</P>
Patel, Snahel,Cohen, Frederick,Dean, Brian J,De La Torre, Kelly,Deshmukh, Gauri,Estrada, Anthony A,Ghosh, Arundhati Sengupta,Gibbons, Paul,Gustafson, Amy,Huestis, Malcolm P,Le Pichon, Claire E,Lin, Ha American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.1
<P>Dual leucine zipper kinase (DLK, MAP3K12) was recently identified as an essential regulator of neuronal degeneration in multiple contexts. Here we describe the generation of potent and selective DLK inhibitors starting from a high-throughput screening hit. Using proposed hinge-binding interactions to infer a binding mode and specific design parameters to optimize for CNS druglike molecules, we came to focus on the di(pyridin-2-yl)amines because of their combination of desirable potency and good brain penetration following oral dosing. Our lead inhibitor GNE-3511 (26) displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that specific pharmacological inhibition of DLK may have therapeutic potential in multiple indications.</P>
Fritsche, Lars G.,Igl, Wilmar,Cooke Bailey, Jessica N.,Grassmann, Felix,Sengupta, Sebanti,Bragg-Gresham, Jennifer L.,Burdon, Kathryn P.,Hebbring, Scott J.,Wen, Cindy,Gorski, Mathias,Kim, Ivana K.,Cho, Nature Pub. Co 2016 Nature genetics Vol.48 No.2
<P>Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly with limited therapeutic options. Here, we report on a study of >12 million variants including 163,714 directly genotyped, most rare, protein-altering variant. Analyzing 16,144 patients and 17,832 controls, we identify 52 independently associated common and rare variants (P < 5×10<SUP>–8</SUP>) distributed across 34 loci. While wet and dry AMD subtypes exhibit predominantly shared genetics, we identify the first signal specific to wet AMD, near <I>MMP9</I> (difference-P = 4.1×10<SUP>–10</SUP>). Very rare coding variants (frequency < 0.1%) in <I>CFH</I>, <I>CFI</I>, and <I>TIMP3</I> suggest causal roles for these genes, as does a splice variant in <I>SLC16A8</I>. Our results support the hypothesis that rare coding variants can pinpoint causal genes within known genetic loci and illustrate that applying the approach systematically to detect new loci requires extremely large sample sizes.</P>
( P. Sengupta ),( J. W. M. Noordermeer ),( W. G. F. Sengers ),( A. D. Gotsis ) 한국고무학회 2003 엘라스토머 및 콤포지트 Vol.38 No.1
N/A This work presents a comparative study of the morphology and structure related properties of thermoplastic elastomer blends based on SEBS/PP/Oil and dynamically vulcanized EPDM/PP/Oil. A combination of ruthenium oxide staining and low voltage scanning electron microscopy (LVSEM) was found to be suitable for the study of morphology of these highly oil extended blends. A close analogy was found in the mechanical, thermal and rheological properties of the two systems made in an internal Brabender mixer and co-rotating twin screw extruder. The morphology of the blends, as made by the two techniques, was found to be significantly different. In the case of TPVs, the blends made in the extruder had smaller EPDM domains and better tensile properties. In the case of SEBS, the blends made in the Brabender had more co-continuous phases and showed better tensile properties. Crystallization behavior of the isotactic polypropylene in the blends was found to be influenced by the type of rubber. Blends of SEBS/PP crystallized at a lower temperature than the TPVs. These differences were probably caused by differences in the nucleating ability of the two rubbers.
Singh, Pawan,Sengupta, B.P.,Tripathi, V.N. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.2
In a summer study during May to July, involving 12 young Murrah buffalo bulls at forty months of average age, the effects of multiple shower vs single shower body cooling and vitamin A, D and E supplementation on the sexual behaviour, semen quality and freezability were investigated. The animals were divided into two groups (6 animals in each group) and housed in a half-walled shed with proper spacing, the feeding management being identical. The bulls in the control group were given a single shower at 1000 h, whereas the experimental bulls were given four showers at 10,12,14 and 16 h. In addition, the experimental bulls were given vitamin A, D and E injections at fifteen day intervals. The sexual behaviour of bulls was observed in terms of reaction time, sexual aggressiveness and ejaculatory thrust. Semen quality of all the bulls was assessed in terms of volume, mass activity, live-dead sperm and sperm concentration, sperm motility and morphology, and acrosomal abnormality. The sexual behaviour did not vary significantly between the groups, whereas semen quality differed significantly for volume, per cent live sperms, total sperms per ejaculate and total live sperm per ejaculate between groups. It can be concluded that sexual behaviour was not influenced by the thermal comfort treatment coupled with periodic vitamin A, D and E injections. But the treatments improved most of the seminal traits in the experimental group of bulls. However, benefit of treatment was not reflected in the freezability traits of the semen.
PREPARATION AND MICROSTRUCTURAL CHARACTERIZATION OF NANOCRYSTALLINE Mn-DOPED ZnO
B. ROY,O. MONDAL,A. DEB,S. P. SENGUPTA,P. CHATERJEE,M. PAL 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.4
Mn-doped ZnO, a dilute magnetic semiconductor (DMS), has been prepared in nanocrystalline form by using a soft chemical route. The concurrent diffusional growth of both nanocrystalline Mn-doped ZnO and secondary spinel phase ZnMn_2O_4 in annealed samples have been studied by using a modified Rietveld method and transmission electron microscope (TEM). Rietveld analysis reveals that both the compounds start growing when Mn concentration is lower and the volume fraction of crystalline spinel phase ZnMn_2O_4 decreases sharply when Mn concentration increases. TEM study indicates that average particle sizes of both the phases are in nanometer dimensions and are highly crystalline in nature. Magnetization increases initially and then almost saturates with the increase of Mn concentration. The enhanced magnetization could be a combined effect of Mn ions and surface ferromagnetism of nanoparticles.