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RISS 인기검색어
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- 저자 : ( Mingzi Li ) (검색결과 4 건)
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( Xue Cai ),( Dan Luo ),( Shuling Liu ),( Ruxue Li ),( Yanhui Lu ),( Mingzi Li ),( Shanhu Qiu ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.1
Background/Aims: Older adults are vulnerable to central obesity, while the association of changes in central fatness with risk of diabetes and metabolic control has not been investigated among this particular population. This study was aimed to address these issues. Methods: A total of 1,815 adults aged ≥ 60 years without diabetes at baseline were followed for 4 years. Incident diabetes was ascertained based on plasma glucose, hemoglobin A1c, medical history, and/or the use of anti-diabetic drugs. Central fatness was assessed by waist circumference (WC), waist-height ratio (WHtR), and body roundness index (BRI). Logistic re gression analyses were used to assess the association of changes in central fatness with risk of diabetes, along with dose-re sponse and mediation analyses. Results: During the 4-year follow-up, 177 participants developed diabetes. The risk of diabetes was increased by 42%, 41%, and 40% per 1 standard deviation increases in WC, WHtR, and BRI, respectively, in multivariable-adjusted models (all p < 0.01). Moreover, these relationships were all linearly-shaped (all p<sub>nonlinearity</sub> ≥ 0.11). Increases in WC, WHtR, and BRI correlat ed with increases in hemoglobin A1c, triglycerides-and-glucose index, triglycerides, white blood cell, and C-reactive protein (all p ≤ 0.04). Yet only changes in hemoglobin A1c and triglycerides-and-glucose index were identified as the possible mediators for risk of diabetes, with their mediating effect being about 35% and 21%, respectively. Conclusions: Increases in central fatness were related to elevated risk of diabetes, and this association might be partly ex plained by the worsening of glycemic control and insulin resistance in older adults.
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Xinliang Zheng,Juan Feng,Jiarui Zhang,Hongna Xing,Jiming Zheng,Mingzi Wang,Yan Zong,Jintao Bai,Xinghua Li 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.3
High-quality neodymium oxychlorides nanocrystals with cubic shape were synthesized by a nonhydrolytic thermolysis route. The morphology and crystal structure of the neodymium oxychlorides nanocubes were characterized by transmission electron microscopy at the nanoscale. Transmission electron microscope (TEM) image shows that the neodymium oxychlorides nanocrystals are nearly monodispersed with cube-like shape. X-ray diffraction (XRD) and selected area electron diffraction (SAED) patterns of numerous neodymium oxychlorides nanocubes suggest a pure crystal phase with tetragonal PbFCl matlockite structure. HRTEM image of individual neodymium oxychlorides nanocubes indicate that each nanocubes have a singlecrystalline nature with high quality. Unlike the anti-ferromagnetism of the bulk, the neodymium oxychlorides nanocubes show clearly anomalous ferromagnetic characteristic at room temperature. This finding provides a new platform for the exploration of diluted magnetic semiconductors, rare earth-based nanomaterials and so on.
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Role of Estrogen Receptor-α in the Regulation of Claudin-6 Expression in Breast Cancer Cells
Liu Yafang,Wu Qiong,Ren Yue,Xu Xiaoming,Yu Lina,Zhang Mingzi,Zhang Ting,Li Yulin,Quan Chengshi 한국유방암학회 2011 Journal of breast cancer Vol.14 No.1
Purpose: In our previous studies we showed that upregulating claudin-6 (CLDN6) expression may contribute to preventing breast cancer, and that 17β-estradiol induces a concentration- and time-related effect on CLDN6 mRNA and protein expression in MCF-7 cells. However, the mechanisms of 17β-estradiol regulation of CLDN6 are still unclear. We determined the role of estrogen receptors in the regulation of CLDN6 expression in human breast cancer tissues and a cell line. Methods: CLDN6, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) expression in breast cancer tissues were examined using immunohistochemistry. The human breast cancer cell line, MCF-7, which expresses ERα but not ERβ was used. CLDN6 and ERα expression were measured by reverse transcriptase-PCR, Western blotting and immunofluorescent staining. Treatments with propyl pyrazole triol (PPT) and ICI 182, 780 (ICI) were performed. Results: The results revealed that CLDN6 expression was related to ERα in breast cancer tissues (p=0.033). PPT, an ERα-selective ligand, upregulated CLDN6 expression at 10^(-5) mol/L after 24 hours. The effect of PPT on regulating CLDN6 expression in MCF-7 cells was blocked by ICI. Conclusion: These findings suggest that Erα reulates CLDN6 expression in breast cancer tissues and that 17β- estradiol induces CLDN6 expression through an ERα pathway in MCF-7 cells.
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