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조건부가치측정법(CVM)을 활용한 개발사업지구 내 유휴부지 유료주차장 활용방안 연구
김태균,박지은,윤정란,Kim, Tae Gyun,Park, Ji Eun,Yun, Jeong Ran 한국토지주택공사 토지주택연구원 2019 LHI journal of land, housing, and urban affairs Vol.10 No.3
In this study, the author suggests utilizing unsold and unused land as temporary commercial parking lots as a way to raise funds for active public transport use. In addition, reasonable parking fee scheme is suggested by estimating marginal parking fee and marginal parking distance for the commercial parking lots based on the CVM. The author conducts a survey to investigate citizens' opinion on utilizing unsold and unused land in the urban development project area as temporary commercial transport facilities such as parking lots. Based on survey outcome, travel behavior and requirements are analyzed and marginal parking fee and marginal parking distance are estimated through the Contingent Valuation Method (CVM). The results are as follows: in the single-bounded dichotomous choice model, people are willing to pay 216 KRW for 165m in average for 10 minutes and their willingness to pay goes down against reaching distance to the parking lots from 365 KRW for 50m, 295 KRW for 100m, 173 KRW for 200m, and 51 KRW for 300m; in the double-bounded dichotomous choice model, people are willing to pay 285 KRW for 165m in average for 10 minutes and their willingness to pay goes down as well against reaching distance to the parking lots from 310 KRW for 50m, 297 KRW for 100m, 272 KRW for 200m and 248 KRW for 300m. It is clearly appeared that people's willingness to pay goes higher as distance to reach the parking lots goes shorter.
The Immunosuppressive Potential of Cholesterol Sulfate Through T Cell Microvilli Disruption
Park Jeong-Su,Chung Ik-Joo,Kim Hye-Ran,전창덕 대한면역학회 2023 Immune Network Vol.23 No.3
Cholesterol (CL) is required for various biomolecular production processes, including those of cell membrane components. Therefore, to meet these needs, CL is converted into various derivatives. Among these derivatives is cholesterol sulfate (CS), a naturally produced CL derivative by the sulfotransferase family 2B1 (SULT2B1), which is widely present in human plasma. CS is involved in cell membrane stabilization, blood clotting, keratinocyte differentiation, and TCR nanocluster deformation. This study shows that treatment of T cells with CS resulted in the decreased surface expression of some surface T-cell proteins and reduced IL-2 release. Furthermore, T cells treated with CS significantly reduced lipid raft contents and membrane CLs. Surprisingly, using the electron microscope, we also observed that CS led to the disruption of T-cell microvilli, releasing small microvilli particles containing TCRs and other microvillar proteins. However, in vivo, T cells with CS showed aberrant migration to high endothelial venules and limited infiltrating splenic T-cell zones compared with the untreated T cells. Additionally, we observed significant alleviation of atopic dermatitis in mice injected with CS in the animal model. Based on these results, we conclude that CS is an immunosuppressive natural lipid that impairs TCR signaling by disrupting microvillar function in T cells, suggesting its usefulness as a therapeutic agent for alleviating T-cell-mediated hypersensitivity and a potential target for treating autoimmune diseases.
Park, Ji-Min,Bong, Ha-Yoon,Jeong, Hye-In,Kim, Yeon-Kyoung,Kim, Ji-Yeon,Kwon, O-Ran The Korean Nutrition Society 2009 Nutrition Research and Practice Vol.2 No.3
Postprandial hypoglycemic effect of mulberry leaf (Morus alba L.) was compared in two animal models: Goto-Kakizaki (GK) rats, a spontaneous non-obese animal model for type II diabetes, and their counterpart control Wistar rats. First, the effect of a single oral administration of mulberry leaf aqueous extract (MLE) on postprandial glucose responses was determined using maltose or glucose as substrate. With maltose-loading, MLE reduced peak responses of blood glucose significantly in both GK and Wistar rats (P < 0.05), supporting the inhibition of $\alpha$-glucosidase by MLE in the small intestine. With glucose-loading, MLE also significantly reduced blood glucose concentrations, measured at 30 min, in both animal models (P < 0.01), proposing the inhibition of glucose transport by MLE. Next, dried mulberry leaf powder (MLP) was administered for 8 weeks by inclusion in the diet. By MLP administration, fasting blood glucose was significantly reduced at weeks 4 and 5 (P < 0.05), but then returned to values that were similar to those of the control at the end of experimental period in GK rats. Insulin, HOMA-IR, C-reactive protein, and triglycerides tended to be decreased by MLP treatment in GK rats. All other biochemical parameters were not changed by MLP administration in GK rats. Collectively, these findings support that MLE has significant postprandial hypoglycemic effect in both non-obese diabetic and healthy animals, which may be beneficial as food supplement to manage postprandial blood glucose. Inhibitions of glucose transport as well as $\alpha$-glucosidase in the small intestine were suggested as possible mechanisms related with the postprandial hypoglycemic effect of MLE.
Proteomic Analysis of Thiol-active Proteins of Helicobacter pylori 26695
Jeong-Won Park,Jae-Young Song,Hyang-Ran Hwang,Hee-Jin Park,Hee-Shang Youn,Ji-Hyun Seo,Hyung-Lyun Kang,Kon-Ho Lee,Seung-Chul Baik,Woo-Kon Lee,Myung-Je Cho,Kwang-Ho Rhee 대한미생물학회 2012 Journal of Bacteriology and Virology Vol.42 No.3
Park Hye Ran,Jeong Sang Soon,Kim Jung Hoon,Myeong Ho Sung,Park Hyun Joo,Park Kwang Hyon,Park Kawngwoo,Yoon Byung Woo,Park Suyeon,Kim Jin Wook,Chung Hyun-Tai,Kim Dong Gyu,Paek Sun Ha 대한의학회 2023 Journal of Korean medical science Vol.38 No.40
Background: Since the long-term outcomes of 162 patients who underwent gamma knife radiosurgery (GKS) as an initial or adjuvant treatment for acoustic neuromas (ANs) with unilateral hearing loss were first reported in 1998, there has been no report of a comprehensive analysis of what has changed in GKS practice. Methods: We performed a retrospective study of the long-term outcomes of 106 patients with unilateral sporadic ANs who underwent GKS as an initial treatment. The mean patient age was 50 years, and the mean initial tumor volume was 3.68 cm3 (range, 0.10–23.30 cm3 ). The median marginal tumor dose was 12.5 Gy (range, 8.0–15.0 Gy) and the median follow-up duration was 153 months (range, 120–216 months). Results: The tumor volume increased in 11 patients (10.4%), remained stationary in 27 (25.5%), and decreased in 68 patients (64.2%). The actuarial 3, 5, 10, and 15-year tumor control rates were 95.3 ± 2.1%, 94.3 ± 2.2%, 87.7 ± 3.2%, and 86.6 ± 3.3%, respectively. The 10-year actuarial tumor control rate was significantly lower in the patients with tumor volumes of ≥ 8 cm3 (P = 0.010). The rate of maintaining the same Gardner-Robertson scale grade was 28.6%, and that of serviceable hearing was 46.4%. The rates of newly developed facial and trigeminal neuropathy were 2.8% and 4.7%, respectively. The patients who received marginal doses of less than 12 Gy revealed higher tumor control failure rates (P = 0.129) and newly occurred facial or trigeminal neuropathy rates (P = 0.040 and 0.313, respectively). Conclusion: GKS as an initial treatment for ANs could be helpful in terms of tumor control, the preservation of serviceable hearing, and the prevention of cranial neuropathy. It is recommended to perform GKS as soon as possible not only for tumor control in unilateral ANs with hearing loss but also for hearing preservation in those without hearing loss.
Proteomic Analysis of Thiol-active Proteins of Helicobacter pylori 26695
Park, Jeong-Won,Song, Jae-Young,Hwang, Hyang-Ran,Park, Hee-Jin,Youn, Hee-Shang,Seo, Ji-Hyun,Kang, Hyung-Lyun,Lee, Kon-Ho,Baik, Seung-Chul,Lee, Woo-Kon,Cho, Myung-Je,Rhee, Kwang-Ho The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.3
Helicobacter pylori are a capnophilic bacterium, which colonize gastric mucosa and are resistant to acidic and oxidative damage. Thiol-active proteins subserve redox functions in tolerating oxidative stress and environmental toxicants, such as hydrogen peroxide and hypochlorous acid. We analyzed disulfide-containing proteins of H. pylori strain 26695. Active disulfide-containing proteins were separated by thiol-affinity chromatography, displayed with two-dimensional electrophoresis (2-DE), and identified by MALDI-TOF-MS. Thirty-five putative disulfide proteins, including AhpC (HP1563), GroEL (HP0011), and FrdB (HP0191), were identified in this study. In addition, 4 disulfide proteins of HypB, FusA, TufB, and AhpC showed enhanced intensities in the periplasmic space when compared with the pellet, suggesting that these proteins might play roles in the first redox system against environmental oxidative stresses. Disulfide-containing proteins identified in this study will provide the standard landscape for constructing the proteome components responsible for redox regulation of H. pylori.
Approximate Controllability for Semilinear Neutral Differential Systems in Hilbert Spaces
Jeong, Jin-Mun,Park, Ah-Ran,Son, Sang-Jin Department of Mathematics 2021 Kyungpook mathematical journal Vol.61 No.3
In this paper, we establish the existence of solutions and the approximate controllability for the semilinear neutral differential control system under natural assumptions such as the local Lipschitz continuity of nonlinear term. First, we deal with the regularity of solutions of the neutral control system using fractional powers of operators. We also consider the approximate controllability for the semilinear neutral control equation, with a control part in place of a forcing term, using conditions for the range of the controller without the inequality condition as in previous results.