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- 저자 : ( Jae-gun Seo ) (검색결과 171 건)
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이제호,최병재,서원건,최형준 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4
점액종이란 소타액선 분비관의 폐쇄 또는 파열로 인한 타액의 저류로 나타나는 종창에 대한 임상적인 용어이다. 점액종은 조직학적으로 삼출형과 잔류낭종형으로 분류되어, 삼출형은 외상등으로 소타액선 분비관이 파열된 후 점액이 조직내로 유출되어 조직간격에 고여있는 상태이기 때문에 상피 피복을 볼 수 없고 낭종벽은 육아조직으로 둘러싸여있다. 그리고 잔류낭종형은 소타액선 분비관이 작은 타석에의해 폐쇄되거나 분비관 주위 반흔조직의 협착으로 발생하며 낭종강은 원주상피 또는 위중층 편평상피로 피개되어있다. 본 증례는 3년전 하순의 열창 치료를 위해 봉합된 후 발사되지 않은 silk 봉합사에 의해 발생한 점액종의 치험례로, 발사되지 않은 봉합사가 하순 소타액선의 분비관을 관통하여 파열시켜서 점액이 결체조직으로 유출되어 점액종이 발생하였다. Mucocele is clinical term used to describe swelling caused by the pooling of saliva at the site of a severed or obstructed minor salivary gland duct. Mucoceles are categorized into two subgroups, extravasation type and retention cyst type. The etiology of extravasation type mucocele is related to mechanical trauma to the minor salivary gland excretory duct, resulting in extravasation of mucus into the fibrous connective tissue so that a cystlike cavity is produced, but the epithelial lining is absent. Retention cyst type mucocele results from obstruction of minor salivary gland excretory duct, and cystic cavity is lined by epithelial cells. This case report presents a mucocele occurred on the lower lip, and caused by suture silk unremoved for 3 years. Suture silk penetrated and tore the minor salivary gland duct on the lower lip with subsequent extravasation of mucus into the fibrous connective tissue.
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충남 서북부지역 여성의 질세포진 검사에 대한 임상적 고찰
이석민,선우재근,장경택,서수형,김민관,배동한 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2
Pap smear were performed to 30,294 women living in the north-west of Chung-nam. The result are summarized below 1. Positive vaginal cytology was 1.09 percent. 2. 72 percents women in their 30's and 40's experienced vaginal cytology. 3. Vaginal cytology was performed at a decreasing rate as age increases. 4. Positive cytology rate is 2.42% higher than average for elderly women over the age of 65. The present date indicates that pap smear is being widely recognized to be important but they needs to be continued advocacy for pap smear.
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Seo, Jae-Keun,Ko, Ki-Han,Cho, Hyung-Jun,Choi, Won-Seok,Park, Mun-Gi,Seo, Kyung-Han,Park, Young,Lim, Dong-Gun The Korean Institute of Electrical and Electronic 2010 Transactions on Electrical and Electronic Material Vol.11 No.1
In this study, transparent and conductive Al-doped zinc oxide (AZO) films were prepared on a glass substrate by an radio frequency (RF) magnetron sputtering method using a 150-nm-thick AZO target (Al: 2 wt.%) at room temperature. We investigated the effects of RF power between 100-350 W (in steps of 50 W) on the structural, electrical, and optical properties of the AZO films. The thickness and cross-sectional images of the films were observed by field emission scanning electron microscopy. The thicknesses of all films were kept constant at 150 nm and grown on a glass substrate. The grain sizes of the AZO films were determined with the X-ray diffraction by using the Scherrer' equation, and their electrical properties were investigated using a Hall effect electronic transport measurement system. The transmittance of the AZO films was also measured by an ultraviolet-visible spectrometer.
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고콜레스테롤혈증 치료에서 심바스타틴 10mg 과 20mg 사용시의 효능 및 안전성 비교 연구
이재건(Jae Gun Lee),김화민(Hwa Min Kim),이현희(Hyun Hee Lee),최혜진(Hae Jin Choi),박창하(Chang Ha Park),서명덕(Myung Deok Seo),정재천(Jae Cheon Jeong),조한균(Han Kyun Cho),최성식(Sung Sik Choi),이지현(Ji Hyun Lee),김석연(Seok Yeon Ki 대한내과학회 2002 대한내과학회지 Vol.63 No.1
목적 : 지방공사 강남병원 순환기 내과에서 추적 검사 받는 고지혈증 환자 106명을 대상으로, 심바스타틴 상용량인 10 mg과 20 mg 사용시의 콜레스테롤 저하 효과, 부작용 등에 대해 조사하였다. 방법 : NCEP guideline에 따라 약물 치료가 필요한 환자 중 저비중 지단백 콜레스테롤 농도가 130 mg/dL 이상이면서 중성 지방 농도는 400 mg/dL 이하인 고콜레스테롤혈증 환자를 대상으로 심바스타틴 사용량을 10 mg 군과 20 mg 군으로 무작위적으로 나누어 처방한 후 6개월 후의 혈중 지질 농도를 분석하였다. 환자들은 매월 부작용 여부를 확인하기 위해 정기적 외래 검진을 받았으며 심각한 부작용이 나타나거나 합병증이 나타난 경우 치료 대상에서 제외하였다. 1997년 4월부터 2000년 11월까지의 115명 중 탈락되지 않은 106명의 결과를 분석하였다. 결과: 남녀비는 40:66이었고, 전체 대상군 중 55%에서 고혈압이 있었고, 9%에서 관상동맥 질환이 있었으며, 13%에서 당뇨병이 존재하였다. 심바스타틴 투여 전 평균 지질 농도는 258-201-50-167 (총 콜레스테롤-TG- HDL-LDL)이었다. 저비중 지단백 콜레스테롤 농도는 20 mg 군에서 34.9 mg/dL, 10 mg 군에서는 20.8 mg/dL 감소하였고, 20 mg 군이 10 mg 군에 비해 저비중 지단백 콜레스테롤 농도를 의미 있게 더 감소시켰다. 총 콜레스테롤 농도는 20 mg 군에서 22.7 mg/dL, 10 mg 군에서 21.7 mg/dL 감소하였고, 심바스타틴 복용 용량에 따른 감소 효과의 차이는 없었다. 심바스타틴 용량에 따른 NCEP guideline (ATP III)의 저비중 지단백 콜레스테롤 목표 농도 달성 정도를 조사한 결과 관상동맥 질환의 위험 인자가 0∼1개인 저위험군에서는 20 mg 군이 80%, 10 mg 군이 81%에서 목표 농도가 되었고, 고위험군에서는 20 mg 군 50%, 10 mg 군 35%가 목표 농도에 도달하여 저위험군에 비해 치료 성공률이 낮았다. 중성 지방 농도는 10 mg 군과 20 mg 군 모두에서 의미있게 감소하지 않았으나 200 mg/dL 이상의 고중성지방군에서는 심바스타틴 20 mg 사용 군에서 22.3 mg/dL, 10 mg 군에서 42.7 mg/dL 감소하여 10 mg 사용 군에서 20 mg 사용 군에 비해 의미 있게 중성 지방을 감소시켰다. 고비중 지단백 콜레스테롤은 심바스타틴 복용 전 농도가 40 mg/dL 미만인 경우에는 20 mg 복용 군에서 11.5 mg/dL, 10 mg 복용 군에서 8.3 mg/dL가 증가하였다. 6개월간의 심바스타틴 치료를 하는 동안에 부작용 때문에 약물 복용을 중단한 경우는 전신 근육통이 심해 중단한 것 외에는 없었고, 심각한 부작용을 가진 환자는 없었다. 연구 대상 환자들에 대한 약물 용량에 대한 선호도 조사 결과 10 mg에 대한 선호도가 높았다. 결론: 심바스타틴은 고콜레스테롤혈증 한국인에서 10 mg과 20 mg 사용시 모두 지질 농도를 개선하는데 효과적이었다. 그러나 관상동맥성 심질환을 가진 고위험군에서는 NCEP guideline을 만족시키는데 효과적이지 못했다. 환자들의 선호도를 고려할 때 고위험군외에는 초기 치료 용량을 10 mg으로 시작하는 것이 좋을 것으로 보인다. Background: Elevated serum cholesterol level is a major risk factor for cardiovascular morbidity and mortality. Simvastatin is effective for treating hypercholesterolemia. The aim of the study was to evaluate efficacy and safety of 6-month therapy with simvastatin with relatively low dose, 10 mg and 20 mg/day. Methods: One hundred six patients with hyperlipidemia (triglycerides<400 mg/dL and low- density lipoprotein (LDL) cholesterol>130 mg/dL) were randomized to receive either simvastatin 10 mg/day (n=43) or 20 mg/day (n=63). Efficacy was determined by measuring changes from baseline in lipid parameters including LDL cholesterol, total cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol. Results: Of the one hundred six patients randomized to treatment, forty patients were men and sixty-six patients were women. Fifty-five percent of patients had hypertension, nine percent coronary artery disease and thirteen percent type 2 diabetes mellitus. Mean baseline lipid concentrations were 258 (total cholesterol), 201 (triglycerides), 50 (HDL) and 167 mg/dL (LDL). Both 10 mg and 20 mg of simvastatin produced statistically significant improvements in all measured serum lipid parameters (p<0.001). Compared with 10 mg of simvastatin, 20 mg of simvastatin produced significantly greater (p<0.001) reductions from baseline LDL cholesterol (34.9 mg/dL vs 20.8 mg/dL). But 10 mg of simvastatin was more effective than 20 mg of simvastatin at reducing triglycerides level (42.7 mg/dL vs 22.3 mg/dL). There was no significant difference in both doses at improving total cholesterol and HDL cholesterol level. Percentage of patients at goal LDL as recommended by NCEP guideline (ATP III) were 81% and 80% for patients in low risk but 35% and 50% for patients in coronary heart disease and its risk equivalents, taking 10 mg and 20 mg/day respectively. Both doses were well tolerated. Only 3 patients (4.8%) in the 20 mg group and one patient (2.3%) in the 10 mg group experienced mild adverse events. Most patients contacted by telephone wanted to take 10 mg of simvastatin. Conclusion: In patients with hypercholesterolemia in Korea, both doses (10 mg, 20 mg) of simvastatin were effective in improving serum lipid parameters and well-tolerated. We recommend, considering patients' preference, that 10 mg of simvastatin be intial dosage and in patients with coronary heart disease, higher doses than 20 mg should be prescribed to allow most patients to reach their NCEP target levels.(Korean J Med 63:46-53, 2002)
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Seo, Dae-Gun,Kim, Sunggun,Lee, Da Kyung,Kim, Na Yeon,Lee, Jae-Sun,Hwang, Kwang Woo,Park, So-Young Elsevier 2019 Phytomedicine Vol.63 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>T helper 17 (Th17) cells, which are differentiated from CD4<SUP>+</SUP> T cells, drive inflammation, leading to autoimmune diseases such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Therefore, inhibiting Th17 polarization could be a therapeutic target for inflammatory diseases.</P> <P><B>Purpose</B></P> <P>We investigated the inhibitory effect of <I>Fraxinus rhynchophylla</I> (Oleaceae) on Th17 differentiation and found its active component.</P> <P><B>Study design</B></P> <P>The activity of <I>F. rhynchophylla</I> and its active constituent was verified using CD4<SUP>+</SUP> cells extracted from C57BL/6 mice.</P> <P><B>Methods</B></P> <P>Micro-environment for Th17 polarization was provided to CD4<SUP>+</SUP> cells and the effect of treatment with samples was measured by enzyme linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and Western blot.</P> <P><B>Results</B></P> <P>The extract of <I>F. rhynchophylla</I> Hance and its chemical constituent, α-amyrin acetate, which was isolated via bioassay-guided isolation, significantly inhibited Th17 polarization as revealed when interleukin (IL)-17, a characteristic cytokine produced by Th17 cells, was measured. Furthermore, the inhibitory effect of α-amyrin acetate was compared to the amyrin derivatives, α-amyrin and β-amyrin. All displayed a suppressive effect on Th17 polarization and all reduced the expression of single transducer and activator of transcription 3 (STAT3) and retinoic acid receptor-related orphan receptor γt (RORγt), which are crucial transcription factors regulating Th17 differentiation. α-Amyrin acetate, however, exhibited the most prominent effects, which indicates that the functional group, acetate, might strengthen the inhibitory effect on Th17 differentiation.</P> <P><B>Conclusion</B></P> <P>Taken together, these results suggest that the extract of <I>F. rhynchophylla</I> and its active constituent, α-amyrin acetate, could be applied as a potential therapeutic agent for autoimmune disorders such as rheumatoid arthritis.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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The Effect of the Foot Pressure between Skilled and Unskilled During Tee Ball Batting
( Gun Woo Kim ),( Eun Young Park ),( Mi Kyong Jeon ),( Bo Seob Heo ),( Jeung Hyung Cho ),( Jeung Il Seo ),( Sung Hui Jeung ),( Na Ri Bae ),( Yong Jae Kim ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-
This study is purposed to propose indices in order to achieve goals such as preventing one-sided movement of balance, preventing injuries to joints of legs, improving muscular strength of legs, and maximizing sporting achievement with the use of a bar pad for athletes as well as nonathletes. In terms of methodology, this study has compared foot pressure distribution and foot pressure ratio during full-squat and half-squat exercise. As a result of analysis on impact of full-squat and half-squat exercise on foot pressure distribution and foot pressure ratio with a bar pad and without a bar pad, conclusions have been obtained as shown below. Foot pressure distribution between left and right feet of subjects during full-squat exercise with and without a bar pad showing significant decline of the distintion of both feet pressure when using a bar pad. Foot pressure distribution between left and right feet of subjects during half-squat exercise with and without a bar pad showing significant drop of the distintion of both feet pressure when using a bar pad. Foot pressure ratio of front feet of subjects during full-squat exercise without and with a bar pad showing no significant difference. Foot pressure ratio of front feet of subjects during half-squat exercise without and with a bar pad showing no significant difference.
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