http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Nathanael, A. Joseph,Yuvakkumar, R.,Hong, Sun Ig,Oh, Tae Hwan American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.12
<P>A new type of high-quality zirconium nitride (ZrN) and hydroxyapatite (HA) bionanocomposite was prepared by radio-frequency (RF) magnetron sputtering for biomedical applications. Detailed analysis of this composite coating revealed that a higher substrate temperature (ST) (>300 °C) increased its crystallinity, uniformity, and functional properties. This nanocomposite showed some encouraging functional properties. Mechanical analyses of the nanocomposite showed improved hardness, modulus, and wear resistance, which were found to be due to the increasing volume fraction of ZrN at higher ST. Biomineralization and in vitro cell analysis revealed increased weight gain and enhanced cell activity with increased substrate temperature. Overall, the results of the present study indicate that this nanocomposite coating could become a promising alternative for biomedical applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-12/am5023557/production/images/medium/am-2014-023557_0014.gif'></P>
Metabolic syndrome as a risk factor for gestational diabebes mellitus
( Subeen Hong ),( Seung Mi Lee ),( So Yeon Kim ),( Ja Nam Koo ),( Ig Hwan Oh ),( Byoung Jae Kim ),( Sun Min Kim ),( Chan-wook Park ),( Jong Kwan Jun ),( Joong Shin Park ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Establishing the high risk group of DM in pregnancy is so important in terms of the early diagnosis and the intervention for the prevention of the complications of GDM. Metabolic syndrome is a cluster of metabolic abnormalities and GDM was regarded as a risk factor of metabolic syndrome for women and their offspring. However, there is not enough information about the influence of having metabolic syndrome at the early pregnancy period on GDM. In this study, we evaluated the effect of the metabolic syndrome on the risk of GDM. Methods: Metabolic syndrome was diagnosed by the National Cholesterol Education Program-Adult Treatment Panel III (NECP-ATP III) criteria. The maternal fasting blood sample was taken and measured for laboratory parameters at 10-14 weeks of gestation. GDM was diagnosed by the two step approaches, which are universal screening using 50g oral glucose tolerance test (OGTT) and then following 100g OGTT. The odds ratios of metabolic syndrome and the each component of metabolic syndrome were calculated by logistic regression analysis. Results: Among 913 pregnant women, 47 (5.1%) women was diagnosed for GDM and 12 (1.3%) women with GDM were managed on insulin. Women with metabolic syndrome had increased risk of GDM and insulin-treated GDM. [OR 11.09 (3.91-31.43) for GDM, OR 28.23 (7.77-102.53) for insulin-treated GDM]. Among the component of metabolic syndrome, impaired fasting glucose had the highest odds for GDM. [OR 24.51 (8.47-70.95)] The significance of metabolic syndrome as a risk factor for GDM remained after adjustment for age, body mass index, family history of diabetes and previous GDM (p<0.05). Conclusion: Metabolic syndrome is a significant risk factor for GDM. Evaluation for having metabolic syndrome at the first prenatal visit of pregnant women will be helpful for assessing the risk for development of GDM.
Seung Mi Lee,Suhyun Hwangbo,Errol R. Norwitz,Ja Nam Koo,Ig Hwan Oh,Eun Saem Choi,Young Mi Jung,Sun Min Kim,Byoung Jae Kim,Sang Youn Kim,Gyoung Min Kim,김원,Sae Kyung Joo,Sue Shin,Chan-Wook Park,Taesung 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.1
Background/Aims: To develop an early prediction model for gestational diabetes mellitus (GDM) using machine learning and to evaluate whether the inclusion of nonalcoholic fatty liver disease (NAFLD)-associated variables increases the performance of model. Methods: This prospective cohort study evaluated pregnant women for NAFLD using ultrasound at 10–14 weeks and screened them for GDM at 24–28 weeks of gestation. The clinical variables before 14 weeks were used to develop prediction models for GDM (setting 1, conventional risk factors; setting 2, addition of new risk factors in recent guidelines; setting 3, addition of routine clinical variables; setting 4, addition of NALFD-associated variables, including the presence of NAFLD and laboratory results; and setting 5, top 11 variables identified from a stepwise variable selection method). The predictive models were constructed using machine learning methods, including logistic regression, random forest, support vector machine, and deep neural networks. Results: Among 1,443 women, 86 (6.0%) were diagnosed with GDM. The highest performing prediction model among settings 1–4 was setting 4, which included both clinical and NAFLD-associated variables (area under the receiver operating characteristic curve [AUC] 0.563–0.697 in settings 1–3 vs. 0.740–0.781 in setting 4). Setting 5, with top 11 variables (which included NAFLD and hepatic steatosis index), showed similar predictive power to setting 4 (AUC 0.719– 0.819 in setting 5, P=not significant between settings 4 and 5). Conclusions: We developed an early prediction model for GDM using machine learning. The inclusion of NAFLDassociated variables significantly improved the performance of GDM prediction. (ClinicalTrials.gov Identifier: NCT02276144)
굽힘시험시의 Mg/Al/STS 3층 클래드재의 변형 및 파단특성 분석
김인규 ( In Kyu Kim ),송준영 ( Jun Young Song ),오기환 ( Oh Ki Hwan ),홍순익 ( Sun Ig Hong ) 대한금속재료학회 ( 구 대한금속학회 ) 2012 대한금속·재료학회지 Vol.50 No.5
A three-point bending test was performed on roll-bonded Mg/Al/STS clad-metal plates under two different testing conditions (Mg layer in tension, or STS in tension) and their mechanical response and fracture behavior were investigated. Bending strength was found to be greater under the condition of Mg layer in tension. Heat treatment at 200℃ increased the bending formability, suggesting the interfacial strength increased at 200℃. Under the condition of Mg in tension, the clad heat-treated at 300℃ and 400℃ fractured in two steps, with the first step associated with the interfacial fracture between Mg and Al, and the second the fracture of the Mg layer. STS/Al layers were found to be bent without complete fracture. Under the condition of STS in tension, the clad heat-treated at 300℃ and 400℃ exhibited a very small load drop at the displacement, which is similar to that of the first load drop associated with the interfacial fracture under the condition of Mg in tension. In this case, no interfacial cracks were found and the complete cut-through fracture of clad was observed at low temperature heat treatment conditions, suggesting excellent interfacial strength. When the heat treatment temperature was higher than 300℃, interfacial cracks were observed. The local stress condition and the position of the interface with respect to the surface were found to have a great influence on the fracture behaviors of clad metals.