RISS 검색 - 국내학술지논문 상세보기

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다국어 초록 (Multilingual Abstract)

Objective: Establishing the high risk group of DM in pregnancy is so important in terms of the early diagnosis and the intervention for the prevention of the complications of GDM. Metabolic syndrome is a cluster of metabolic abnormalities and GDM was regarded as a risk factor of metabolic syndrome for women and their offspring. However, there is not enough information about the influence of having metabolic syndrome at the early pregnancy period on GDM. In this study, we evaluated the effect of the metabolic syndrome on the risk of GDM.
Methods: Metabolic syndrome was diagnosed by the National Cholesterol Education Program-Adult Treatment Panel III (NECP-ATP III) criteria. The maternal fasting blood sample was taken and measured for laboratory parameters at 10-14 weeks of gestation. GDM was diagnosed by the two step approaches, which are universal screening using 50g oral glucose tolerance test (OGTT) and then following 100g OGTT. The odds ratios of metabolic syndrome and the each component of metabolic syndrome were calculated by logistic regression analysis.
Results: Among 913 pregnant women, 47 (5.1%) women was diagnosed for GDM and 12 (1.3%) women with GDM were managed on insulin. Women with metabolic syndrome had increased risk of GDM and insulin-treated GDM. [OR 11.09 (3.91-31.43) for GDM, OR 28.23 (7.77-102.53) for insulin-treated GDM]. Among the component of metabolic syndrome, impaired fasting glucose had the highest odds for GDM. [OR 24.51 (8.47-70.95)] The significance of metabolic syndrome as a risk factor for GDM remained after adjustment for age, body mass index, family history of diabetes and previous GDM (p<0.05).
Conclusion: Metabolic syndrome is a significant risk factor for GDM. Evaluation for having metabolic syndrome at the first prenatal visit of pregnant women will be helpful for assessing the risk for development of GDM.