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Cho, Hanna,Jeon, Seun,Kim, Changsoo,Ye, Byoung Seok,Kim, Geon Ha,Noh, Young,Kim, Hee Jin,Yoon, Cindy W,Kim, Yeo Jin,Kim, Jung-Hyun,Park, Sang Eon,Kim, Sung Tae,Lee, Jong-Min,Kang, Sue J.,Suh, Mee Kyun Cambridge University Press 2015 INTERNATIONAL PSYCHOGERIATRICS - Vol.27 No.1
<B>ABSTRACT</B><B>Background:</B><P>Epidemiological studies have reported that higher education (HE) is associated with a reduced risk of incident Alzheimer's disease (AD). However, after the clinical onset of AD, patients with HE levels show more rapid cognitive decline than patients with lower education (LE) levels. Although education level and cognition have been linked, there have been few longitudinal studies investigating the relationship between education level and cortical decline in patients with AD. The aim of this study was to compare the topography of cortical atrophy longitudinally between AD patients with HE (HE-AD) and AD patients with LE (LE-AD).</P><B>Methods:</B><P>We prospectively recruited 36 patients with early-stage AD and 14 normal controls. The patients were classified into two groups according to educational level, 23 HE-AD (>9 years) and 13 LE-AD (≤9 years).</P><B>Results:</B><P>As AD progressed over the 5-year longitudinal follow-ups, the HE-AD showed a significant group-by-time interaction in the right dorsolateral frontal and precuneus, and the left parahippocampal regions compared to the LE-AD.</P><B>Conclusion:</B><P>Our study reveals that the preliminary longitudinal effect of HE accelerates cortical atrophy in AD patients over time, which underlines the importance of education level for predicting prognosis.</P>
Clinical effect of white matter network disruption related to amyloid and small vessel disease
Kim, Hee Jin,Im, Kiho,Kwon, Hunki,Lee, Jong-Min,Kim, Changsoo,Kim, Yeo Jin,Jung, Na-Yeon,Cho, Hanna,Ye, Byoung Seok,Noh, Young,Kim, Geon Ha,Ko, En-Da,Kim, Jae Seung,Choe, Yearn Seong,Lee, Kyung Han,Ki Ovid Technologies (Wolters Kluwer) - American Acad 2015 Neurology Vol.85 No.1
<P>We tested our hypothesis that the white matter network might mediate the effect of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition.</P>
Kim, Hanna,Kang, Seunghyun,Kim, Hanul,Kim, Sanghee,Jung, Jongwoo The Korean Society of Systematic Zoology 2017 Animal Systematics, Evolution and Diversity Vol.33 No.2
A winged midge species, Parochlus steinenii is one of the most abundant species in Antarctica, which is distributed over a wide area from the South American continent to the South Shetland Islands in Antarctica. It was dispersed into islands in the South Shetland Islands from the South American continent, and it adapted to a variety of environments and settled. This species, therefore, is a good model organism to explain the evolutionary process of Antarctic terrestrial fauna. Nevertheless, there are few genetic studies on this species, which are necessary for understanding the genetic diversity, population structure, etc. Here, we developed and characterized 14 polymorphic microsatellite markers. The number of alleles per locus ranged from 2 to 5. The observed and expected heterozygosities were in the range of 0.024 to 0.561 and 0.024 to 0.535, respectively. Identifying genetic differences between populations, they are suitable markers for researches investigating genetic diversity and population structure of P. steinenii, which provide us with clues to dispersion, evolution and ecology of this species.
Gray and white matter changes linking cerebral small vessel disease to gait disturbances
Kim, Yeo Jin,Kwon, Hun Ki,Lee, Jong Min,Cho, Hanna,Kim, Hee Jin,Park, Hee Kyung,Jung, Na-Yeon,San Lee, Jin,Lee, Juyoun,Jang, Young Kyoung,Kim, Sung Tae,Lee, Kyung Han,Choe, Yearn Seong,Kim, Yun Joong Ovid Technologies (Wolters Kluwer) - American Acad 2016 Neurology Vol.86 No.13
<P>Objective: To investigate the topographic changes of white matter (WM) integrity and cortical thickness related to gait disturbances and determine whether these neural correlates mediate the association between cerebral small vessel disease (CSVD) and gait disturbances. Methods: A total of 129 patients with subcortical vascular cognitive impairment were included. CSVD severity was quantified as global and regional WM hyperintensities (WMH) volume and lacune and microbleed numbers. Amyloid burdens were assessed using Pittsburgh compound B (PiB)-PET scanning. Gait score was measured using a standardized scale. WM integrity was assessed by applying tract-based spatial statistics. Cortical thickness was measured using surface-based methods. Path analysis for gait score was performed using regional CSVD markers as predictors and fractional anisotropy (FA) and cortical thickness as mediators. Results: Periventricular WMH (PWMH) volume was associated with gait score, regardless of other CSVD. PiB retention ratio was not associated with gait score. Gait score was correlated with FA in the frontal and parietal WM and bilateral corpus callosum and with cortical thinning in the bilateral frontal and lateral temporo-parieto-occipital regions. Path analysis for gait score showed that PWMH contributed to gait disturbances with the mediation of mean FA or cortical thickness. Conclusions: Our findings suggest that WMH-related cortical thinning as well as disrupted integrity of periventricular WM is linked to gait disturbances.</P>
Kim, Hanna,Kim, Yerin,Kim, Sung-Gon American Chemical Society etc. 2017 Journal of organic chemistry Vol.82 No.15
<P>A catalytic highly enantioselective Mannich/aza-Michael cascade reaction of delta-formyl-alpha,beta-unsaturated ketones with cyclic N-sulfimines, promoted by diphenylprolinol TMS ether as an organocatalyst, has been developed for the synthesis of chiral benzosulfamidate-fused pyrrolidines, which generated in good yields and with high diastero- and enantioselectivities. Further chemical transformations have been performed with chiral benzosulfamidate-fused pyrrolidines</P>
Mechanisms for SU5416 as a radiosensitizer of endothelial cells
KIM, EUN HO,KIM, MI-SOOK,JEONG, YOUN KYOUNG,CHO, ILSUNG,YOU, SEUNG HOON,CHO, SUNG HO,LEE, HANNA,JUNG, WON-GYUN,KIM, HAG DONG,KIM, JOON Spandidos Publications 2015 International journal of oncology Vol.47 No.4
<P>Endothelial cells??(ECs), that comprise the tumor vasculature, are critical targets for anticancer radiotherapy. The aim of this work was to study the mechanism by which SU5416, a known anti-angiogenesis inhibitor, modifies the radiation responses of human vascular ECs. Two human endothelial cell lines (HUVEC and 2H11) were treated with SU5416 alone, radiation alone, or a combination of both. In??vitro tests were performed using colony forming assays, FACS analysis, western blotting, immunohistochemistry, migration assay, invasion assays and endothelial tube formation assays. The combination of radiation and SU5416 significantly inhibited cell survival, the repair of radiation-induced DNA damage, and induced apoptosis. It also caused cell cycle arrest, inhibited cell migration and invasion, and suppressed angiogenesis. In this study, our results first provide a scientific rationale to combine SU5416 with radiotherapy to target ECs and suggest its clinical application in combination cancer treatment with radiotherapy.</P>
Hanna Kim,Seunghyun Kang,Hanul Kim,Sanghee Kim,Jongwoo Jung 한국동물분류학회 2017 Animal Systematics, Evolution and Diversity Vol.33 No.2
A winged midge species, Parochlus steinenii is one of the most abundant species in Antarctica, which is distributed over a wide area from the South American continent to the South Shetland Islands in Antarctica. It was dispersed into islands in the South Shetland Islands from the South American continent, and it adapted to a variety of environments and settled. This species, therefore, is a good model organism to explain the evolutionary process of Antarctic terrestrial fauna. Nevertheless, there are few genetic studies on this species, which are necessary for understanding the genetic diversity, population structure, etc. Here, we developed and characterized 14 polymorphic microsatellite markers. The number of alleles per locus ranged from 2 to 5. The observed and expected heterozygosities were in the range of 0.024 to 0.561 and 0.024 to 0.535, respectively. Identifying genetic differences between populations, they are suitable markers for researches investigating genetic diversity and population structure of P. steinenii, which provide us with clues to dispersion, evolution and ecology of this species.