Adaptive particle filter based on the kurtosis of distribution

Piao, Songlin 한양대학교 대학원 2011 국내석사

Kurtosis based adaptive particle filter is presented in this paper. The concept of belief is proposed to each particle sampling and the distribution of particles can be adaptively changed according to the belief and motion information so that particles could track object in higher accuracy. The belief and motion information could be defined as a distance function of observation vector. In order to achieve this goal, we change the way of normal re-sampling technique. We introduce a framework that particles are re-sampled based on the distance function. We demonstrate the advantages of proposed method in two steps. First, we did strict simulation tests in 1D, 2D and 3D spaces to show that our method can give better result. Furthermore, we did the experiments in the real cases. One is real particle tracking in the hydraulic engineering area and the other is normal face tracking based on the color feature. We compared the result in each step to the result obtained from standard particle filter.

Controlled Release and Bioavailability of Poorly Water Soluble Drugs Using Nanoemulsifying Solid Dispersion

Piao, Zong Zhu 강원대학교 대학원 2009 국내박사

In the previous study, the solid self-nanoemulsifying solid dispersion system was prepared using the hot melting method. The optimal formulation was consisted of ITZ, poloxamer 407, oleic acid, glycerin, Brij 98, Primojel, adsorbent and butylated hydroxyl toluene (BHT). The objective of the present study was to prepare a solid dosage form containing solid dispersion system as well as to evaluate its in vitro dissolution and in vivo study. The core tablets consisting of the SD were formed by direct compression, and then coated with polymer. The in vitro release characteristics of tablet were evaluated in the enzyme-free simulated gastric fluid (SGF, 1.2) and simulated intestinal fluid (SIF, pH 6.8) and further investigated the stability at various storage conditions. In vivo study of tablets (containing 55 mg ITZ) was carried out in eight healthy male human, the eight volunteers were randomly divided into two groups for a balance 2×2 two-way crossover design. Concentration of ITZ in the plasma was determined using HPLC with UV detector. Although the test tablets were low dose, the pharmacokinetic parameters such as AUC_(0-72), C_(max) and T_(max) were almost similar to commercial Sporanox^(??) capsules (containing 100 mg ITZ) and insignificant sequence effect was found for all of the pharmacokinetic parameters. Hence, it was concluded that the solid self-nanoemulsifying SD system could be considered as a valuable alternative for oral dosage forms of ITZ. The primary objective of the present study was: (i) to improve the solubility and dissolution rate of a poorly water-soluble drug, valsartan (VAL) and (ii) to validate a sensitive method of determining VAL concentration in human plasma samples using high performance liquid chromatography (HPLC) combined with ultraviolet (UV) detection. The ternary solid dispersions (SDs) with poloxamer 407 as a carrier and Aeroperl^(??) 300 as an adsorbent were prepared using the hot melt method. The physicochemical properties of solid dispersed VAL were analyzed by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FT-IR). The particle size of VAL in dissolution medium was measured by dynamic light scattering (DLS). It was shown that VAL was an amorphous state in the system and the absence of any significant interaction with other additives. The dissolution rate of SDs was markedly enhanced compared to pure VAL in enzyme-free simulated gastric fluid (SGF), attaining drug releases of up to 80% after 2 hr. The SD loaded controlled release tablets were prepared by direct compression and further investigated the stability at various storage conditions and the pharmacokinetic parameters of VAL were compared to commercial Diovan^(??) tablets. After a plasma simple protein precipitation using methanol, the analytes were separated on a Phenomenex Luna C18 column using 42% acetonitrile with 15 mM potassium dihydrogenphosphate in water (pH 2.0; adjusted with phosphoric acid) as the mobile phase at a flow rate of 1.2 ml/min. The standard calibration curve constructed in the concentration range of 50-2000 ng/ml showed good linearity (r² >0.9997). Spironolactone was used as an internal standard (I.S). VAL and IS eluted at 10.25 and 12.17 min, respectively. The intra-day and inter-day precision and accuracy were satisfactory with relative standard deviations of less than 15%. No interference peaks or matrix effects were observed in human plasma. VAL concentration in human plasma was well established following a single 80 mg oral dose to eight healthy volunteers. The current determination of VAL concentration by protein precipitation using methanol followed by analysis using HPLC with UV detection was rapid and sensitive, and provide an alternative to the analysis of VAL by studying its clinical applications. The objective of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, itraconazole (ITZ), using a solid self-nanoemulsifying (SNE) solid dispersion system. The solid dispersion (SD) systems were prepared by the hot melt method. The physicochemical properties of solid dispersed ITZ were characterized by using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FT-IR). It was shown that ITZ was an amorphous state in the SD system and the absence of any significant interaction with other additives. The dissolution rate of ITZ from SD was evaluated using USP dissolution method II (paddle method) in the enzyme-free simulated intestinal fluid (SIF). The solid self-nanoemulsifying SD system was markedly enhanced dissolution rate of ITZ. The increased dissolution rate was attributed to increased solubility and improved wetting of ITZ crystals. The solid SNE solid dispersion system was also useful at improving the dissolution rate by forming a microemulsion droplets or dispersible particles within the gastrointestinal (GI) tract. Droplet size of ITZ emulsion measured by dynamic light scattering (DLS) and transmission electron microscope (TEM) was constant in the simulated intestinal fluid (SIF, pH 6.8) after 60 min of dissolution process. The release rate of solid SNE solid dispersion system was markedly enhanced compared to pure ITZ in the SIF. The method could simply and easily scaled up and have a general applicability to many poorly water-soluble drug entities in their oral routes. 본 논문의 목적은 난용성 약물인 Itraconazole (ITZ)과 Valsartan (VAL)를 함유한 새로운 self-emulsifying solid dispersion system을 구축하여 약물의 dissolution rate와 bioavailability를 제고하고 평가 하는 것이다. Chapter I 에서는 poorly water-soluble weakly basic ITZ를 모델약물로 선정하고 solid self-nanoemulsifying solid dispersion를 hot melt method으로 만든 후 평가하였다. ITZ를 함유한 Solid dispersion는 SIF (pH 6,8)에서 시판품 Sporanox^(??) 캡슐과 비하여 높은 용출율을 나타내었으며 DSC, PXRD and SEM 등 기계장비를 통하여 약물이 amorphous state로 존재하고 있음을 입증하었으며 또한 약물과 additives는 서로 interaction이 없이 안정함을 FT-IR로 증명하였다. Solid dispersion는 gastrointestinal (GI) tract에서 자율적으로 nanoemulsion droplet를 형성하었으며 DLS and TEM등 기계장비로 그 size를 측정한 결과 용출 1시간후 약 260 nm 었다. Chapter II 에서는 self-nanoemisifying solid dispersion을 로딩한 정제를 만들고 용출율과 생체이용율을 시판품과 비교평가 하였다. Solid dispersion를 loading 한 정제 (containing 55 mg ITZ)는 enzyme-free simulated gastric fluid (SGF) and simulated intestinal fluid (SIF)에서 높은 용출율을 나타내었으며 비록 낮은 dose이지만 AUC_(0-72), C_(max) and T_(max) 와 같은 pharmacokinetic parameters는 시판품 Sporanox^(??) capsules (containing 100 mg of ITZ)과 통계학적으로 유사하였다. Chapter III에서는 poorly water-soluble weakly acidic VAL를 모델약물로 선정하고 solid dispersion를 로딩한 controlled release (CR) matrix tablet를 만들고 용출율과 생체이용율을 평가하였다. VAL를 함유한 Solid dispersion는 SGF (pH 1.2)에서 시판품인 Diovan^(??) tablet과 비하여 높은 용출율을 나타내었으며 DSC, PXRD and SEM 등 기계장비를 통하여 약물이 amorphous state로 존재하고 있음을 역시 입증하었다. solid dispersion를 로당한 controlled release (CR) matrix tablet는 직타법으로 만들었으며 약물은 서방적인 방출 양상을 나타내었다. A rapid and reproducible HPLC-UV detection method was created using a one-step solvent extraction process for the determination of VAL concentration in human plasma for in vivo pharmacokinetic studies. 본 연구에서 개발한 새로운 silid nanoemlisifying solid dispersion system은 기타 난용성 약물의 생체이용율의 개선에도 이용될 수 있을 것으로 기대된다.

(The) effects of pre-task planning on low-level and advanced-level learners' oral performance

Piao, Meiying 한양대학교 대학원 2011 국내석사

Planning effects are generally believed to enhance oral performance among language learners, yet effects on accuracy have not been clear-cut. Despite the widespread adoption of planning in research studies, the literature has few attempts to combine the planning effects with mixed levels of proficiency. Based on experimental research involving two groups of advanced-level and low-level proficiency EFL learners, this thesis examined the effects of pre-task planning on narrative productions, and how differently these affect the two different levels. Two sets of picture series were provided in two tasks. Participants were to describe a complete story according to the picture series in three minutes. The first task was implemented directly, while the second task was conducted after a ten-minute pre-task planning opportunity. Students’ oral narratives were measured in two aspects: complexity and accuracy. Complexity was scored with four indices: the number of clauses per t-unit, the average length of t-unit, the amount of subordination per performance, and word types. On the other hand, to measure accuracy, five separate markers of past tense verb forms were examined, which were the past tense of verb forms of verb be, auxiliary verbs, regular verbs, irregular verbs, and general accuracy, that is, a sum of these four markers. The results support the trade-off effect in that there is competition between complexity and accuracy: the advanced-level learners benefited in one marker of accuracy (the irregular past verbs), but were not affected on complexity; on the other hand, learners with low proficiency gained the most in a marker of complexity (word types), but failed to significantly improve in accuracy. In the long run, EFL educators should consider proficiency gap, which is a factor that influences planning effects. In EFL classroom environments, teachers need to consider learners’ English levels in order to provide more valid and efficient planning conditions.

Site-specific Cleavage of Linear and Cyclic Peptoid Derivatives

Piao, Rui Qi 이화여자대학교 대학원 2015 국내석사

Peptoids are oligomeric synthetic peptidomimetics that are becoming a valuable molecular tool in bio-sciences. Of particular interest are their applications to the exploration of peptoid secondary structures and drug design. Major advantages of peptoid as research and pharmaceutical tools include the ease and economy of synthesis, high variation of side chain, resistance to proteolytic degradation and interesting biological activities. This dissertation consists of two kinds of studies towards the cleavage of linear and cyclic peptoid derivatives under acidic conditions. Recently, we reported the unusual truncation of N-acylated peptoids in acidic conditions. In chapter I, we throughly investigated the conformational and electronic effects for the TFA-mediated truncation of N-acetylated peptoids. In this study, it was revealed that the n→π* non covalent interaction plays an important role in the unusual truncation. It was also proved that electronic effects of both acylated groups and side chains at the terminal peptoid unit are crucial in the truncation reaction, supporting the proposed mechanism. In chapter II, we developed the strategy for ring-opening of cyclic peptoids. Cyclic peptoids wtih N-branched side chains were site-specifically opened to give the corresponding linear peptoids which could be sequenced by MALDI-TOF/TOF. This work provides a robust platform for sequencing of cyclic peptoids in on-based screening studies. 펩토이드는 펩타이드의 구조이성질체로서 최근 화학생물학, 신약개발 등에 유용한 화학도구로 각광을 받고 있다. 펩토이드는 매우 손쉽게 고체상에서 합성할 수 있고, 세포 투과성이 좋으며 단백질 가수분해에 대해서도 매우 안정하다고 알려져 있다. 또한 특이한 2차구조를 가지고 있고 재미난 생리활성도 보고 되고 있다. 이 논문은 N-아실화된 펩토이드와 고리형 펩토이드가 TFA 조건에서 특이적으로 절단되는 현상에 대한 체계적인 연구를 다루고 있다. 1장에서는 N-아실화된 펩토이드가 TFA 조건에서 특이적으로 말단 unit이 절단되는 현상에 대해 구조적, 전자적인 영향을 연구하였다. 이 연구로부터n→π* 비공유적 상호작용이 이런 특이적인 절단현상에 중요한 역할을 한다는것을 확인하였다. 또한 아실그룹이나 말단 곁가지의 전자적인 효과도 절단현상에 영향을 미치며, 이로부터 제안된 반응 메카니즘이 합리적임을 알수있다. 2장에서는 고리형 펩토이드의 아주 효율적이고 위치선택적인 고리열림 반응에 대해 연구하였다. 고리열림 반응을 위한 다른 작용기나 배열 확인 전략을 도입하지 않고도 말단에 가지가 있는 특정 펩토이드 unit을 도입하여 고리형 펩토이드의 고리를 열고 MS/MS로 배열을 확인할 수 있었다. 이러한 연구 결과는 고리형 펩토이드를 화학도구로 사용한 다양한 스크리닝 연구에서 hit 화합물을 확인하는 손쉽고도 확실한 방법이 된다.

A study on the effects of tie strength in the international technology alliance of Chinese companies on innovation performance

PIAO , YUCHEN 이화여자대학교 대학원 2018 국내석사

With the constant deepening of market economy structures, competition among enterprises in time and space is undergoing huge changes in the system. In the traditional sense of competition between individual enterprises,it has gradually evolved into league competition between groups, competition has become a new era of cooperation between the union competitive landscape. International technology alliance as a new approach to technical cooperation, not only improved the enterprise’s innovation development when needed, but also brought a higher level of knowledge exchange and technology transfer between enterprises. Through the development of technology alliances in recent years shows that individual enterprises are not beyond the advantage. The tie strength between partners can be an important factor of the international technology alliance. Since the international technology alliances between developed countries and developing countries most are asymmetric so that the tie strength will make the important influence on them. And tie strength can be defined into frequent, closeness and duration so that can also turn into repeated partner, technological distance, and relationship durability. Therefore,improving the international technology alliance between the relationship of partners can be an effective way to change the current situation. This article is stand on the developing countries’ point with this core problem and wants to expand the research to analysis the basic status of technology union and the tie strength of organization for innovation performance in effect and in-depth analysis between the relationship of partners’ effect factor. 시장 경제 구조가 끊임없이 심화되면서 기업들의 시간과 공간의 경쟁이 도 엄청난 변화를 일어나고 있다. 전통적인 기업 경쟁 의식에서 그룹 간 경쟁으로 점차 진화하고 있고 경쟁이 새로운 시대로 변하고 있다. 국제 기술 동맹은 기술 새로운 접근 방식으로서 기업의 혁신 개발을 필요할 때뿐만 아니라 지식 교환 및 기술 이전 수준을 높여줄 수 있습니다. 최근 몇 년 간에 기술연합의 발전을 통해 개인 기업의 장점은 결코 크지 않다. 협력 동반자 간의 연계 강도는 국제 기술 연맹의 중요 한 요소가 될 수 있다. 선진국과 개발도상국 사이의 국제 기술연합은 비대칭이기 때문에 이런 관계 연관성이 아주 중요 한 영향을 미칠 수 있다. 관계 강도는 잦고 친밀하고 지속적인 시간이 될 수 있으며, 이는 반복 되는 동반자, 기술적 거리와 관계의 지속 성이 될 수 있다. 이에 따라 협력 동반자 관계를 개선하는 것은 국제 기술 연맹은 현재의 형세를 바꾸는 효과적인 방법이다. 본문은 개발도상국에 입각에서 핵심 문제를 중심으로 연구 범위를 확대하고 기술연맹의 기본적 지위와 혁신적인 성과 그리고 조직의 연계 강도를 분석하고 협력 파트너의 효과를 분석하는 논문이다.

재한 중국인 유학생의 계획된 우연기술과 학교생활만족도가 진로태도성숙에 미치는 영향

PIAO YICHENG 경희대학교 대학원 2022 국내석사

21세기에 접어들어 급변하는 세계에서 많은 직업이 사라졌고 또 많은 직업이 새로 생겼다. 급변하고 있는 세계에서 직업세계로 진출하는 대학생들에게 더 많은 기능과 더 성숙한 진로태도를 요구한다. 재한 중국인 유학생의 진로발달을 돕기 위하여 본 연구에서 재한 중국인 유학생의 계획된 우연기술과 학교생활만족도가 진로태도성숙에 미치는 영향을 연구 및 검증하였다. 연구방법은 재한 중국인 유학생을 대상으로 온라인 설문을 실시, 260명에 대한 설문 결과를 바탕으로 중다회귀분석을 실시하였다. 연구도구는 65문항으로 계획된 우연기술 척도, 학교생활만족도 척도, 진로태도성숙 척도를 사용하였다. 본 연구의 결과에 대한 요약은 다음과 같다. 첫째, 재한 중국인 유학생의 계획된 우연기술은 그들의 진로태도성숙에 유의한 정적 영향을 미치는 것으로 나타났고 학교생활만족도는 진로태도성숙에 유의한 영향을 미치지 않다는 결과로 계획된 우연기술은 학교생활만족도보다 진로태도성숙을 설명하는데 있어서 더 의미 있는 예측변인으로 나타났다. 계획된 우연기술과 학교생활만족도가 진로태도성숙의 각 하위요인에 미치는 영향을 살펴보면, 계획된 우연기술은 진로태도성숙의 하위요인인 결정성, 목적성, 확신성에 유의한 영향을 미치지 않았으나, 준비성과 독립성에 유의한 정적 영향을 미치는 것으로 나타났다. 학교생활만족도는 준비성에 유의한 정적 영향을 미쳤으나, 다른 진로태도성숙의 하위요인에게 유의미한 예측변인으로 나타났지 않았다. 둘째, 계획된 우연기술의 하위요인별로 살펴보는 결과, 호기심은 진로태도성숙의 하위요인 중 확신성, 준비성, 독립성에 유의한 영향을 미치는 것으로 나타났다. 유연성은 결정성, 확신성, 진로태도성숙 전체, 목적성 순으로 유의한 부적 영향을 미치는 것으로 나타났다. 인내심은 진로태도성숙 전체와 모든 하위요인에 대해 유의한 영향을 미치지 않았다. 낙관성은 결정성, 진로태도성숙 전체, 확신성, 목적성 순으로 유의한 정적 영향을 미치는 것으로 나타났다. 위험감수성은 독립성에 유의한 부적 영향을 미치는 것으로 나타났다. 셋째, 학교생활만족도의 하위요인별로 살펴본 결과, 교우관계는 결정성, 준비성, 독립성에 유의한 영향을 미치는 것으로 나타났다. 교사관계는 확신성, 결정성, 진로태도성숙 전체 순으로 유의한 정적 영향을 미치는 결과가 나타났다. 학교학습은 진로태도성숙 전체나 하위요인의 예측변인으로 확인되지 않았다. 학교환경은 확신성, 결정성 순으로 유의한 부적 영향을 미치는 것으로 확인되었다. 학교생활만족도의 모든 하위요인이 목적성에 유의한 영향을 미치지 않은 것으로 나타났다. 결과를 통해 추측하면, 어느 정도로 개인이 현 상태에 대해 만족할수록, 진로선택에 있어 추구함이 없어 방향과 확신이 없을 수 있다. 교우관계와 교사관계에 대한 만족도는 학생들이 자신의 관계능력과 교사에 대한 인정, 그리고 친구에 대한 인정을 통해 자기자신에 대한 인정을 반영할 수 있으므로, 역시 진로태도성숙에 유의한 영향을 미치는 결과로 나타났다. 교우관계는 결정성에 부적 영향을 미치는 것을 보면, 역시 친구들과의 관계에 대한 만족도가 높을수록 그들의 선택과 의견은 자신의 진로선택의 방향에 영향을 미치는 것으로 추측할 수가 있다. 재한 중국인 유학생들에게 보다 더 적합한 진로선택과 진로발달을 돕기 위해, 계획된 우연기술의 높이기를 통해 진로태도성숙을 향상시키는 것이 필요가 있다, 그러나 진로태도성숙의 수준만 향상시키기 위한 진로상담 및 진로교육보다는 이러한 작업에서 계획된 우연기술도 중점에 둘 필요가 있어 보인다. 또한, 학교생활만족도를 증진시키기 위한 진학 전후의 상담과 교육도 중요할 것으로 대학교로 진학하기 전, 개인에게 더 적합한 대학교와 전공선택을 할 수 있게 돕기 위한 진학상담 및 교육, 또는 대학교에 입학한 후, 학생에게 교우관계 및 교사관계를 좋은 방향으로 증진하는 방법과 태도와 스스로의 학습에 대한 관심도와 성취욕구, 또한, 학교환경을 효과적으로 활용하는 방법과 태도 등을 지도해주는 학교상담을 필요할 것 같다. 따라서 본연구를 통해 도출된 결과가 재한 중국인 유학생의 계획된 우연기술과 진로태도성숙에 대한 추후 연구방향 및 실용성의 확보를 위한 개선점의 기초를 마련하는 데 도움이 될 것을 기대한다. Here we are in the 21st century, as many jobs disappearing, so many new ones are being crated in this rapidly changing world, in such a changing era, college students who are entering the world of work must acquire more skills and have a more mature career attitude. To help the career development of Chinese students in South Korea, this study was conducted to verify the effect of planned happenstance skills and students' life satisfaction on career attitude maturity of Chinese students in South Korea with an online approach. Subject to the study were 260 Chinese students in South Korea. Based on the results of an online survey of 260 people, multiple regression analysises were conducted. The questionnaire consisted of 65questions, including Planned Happenstance Career Inventory (PHCI) scale, students' life satisfaction scale and career attitude maturity scale. The results of this study are summarized as follows. First, is has been shown that the planned happenstance skills of Chinese students of South Korea have significantly positive influence on the career maturity inventory attitude, and the students' life satisfaction of Chinese students of South Korea has no significant impact on the career maturity inventory attitude, planned happenstance skills as the predictor variable of career maturity inventory attitude is more meaningful than students' life satisfaction. Looking through the planned happenstance skills and students' life satisfaction’s influences on the career maturity inventory attitude’s sub-factors, planned happenstance skills was found to have no significant impact on career decisiveness, goal orientation and confidence, but have significantly positive influences on preparation and independence. students' life satisfaction has been shown to have a significantly positive influence on preparation, but no significant impact on the others. Second, looking through the sub-factor of planned happenstance skills, curiosity has been shown to have a significant influence on confidence, preparation, and independence. Flexibility has shown to have significantly negative influences on career decisiveness, confidence, the whole of career maturity inventory attitude and goal orientation. Persistence was found to have no significant influences on the whole of career maturity inventory attitude and its sub-factors. Optimism has been shown to have a significantly positive influence on career decisiveness, the whole of career maturity inventory attitude, confidence, and goal orientation. Risk-taking has been shown to have a significantly negative influence on independence. Third, looking through the sub-factor of students' life satisfaction, satisfaction of relationship with classmates was found to have significant influences on the career decisiveness, preparation, and independence. satisfaction of relationship with teachers has been shown to have a significantly positive influence on confidence, career decisiveness and the whole of career maturity inventory attitude. And then, satisfaction of school learning activities does not have any significant impact on career maturity inventory attitude at all. Satisfaction of school environment has been shown to have significantly negative influences on confidence and career decisiveness. For helping Chinese students in South Korea to choose more suitable career path and development, it is necessary to improve career maturity inventory attitude through the enhancement of planned happenstance skills, rather than career counseling and career education to only improve the career maturity inventory attitude, it also seems necessary to focus on the planned happenstance skills in these works. Also, counseling and education before and after entering school to improve students' life satisfaction are important. Such as admission counseling and education to help individuals choose a more suitable university and major before entering the university, and, after entering the university, it seems that school counseling is necessary to guide students on how to improve their relationship with classmates and teachers in a good way and attitude, and then guides students improving interest in their own learning, their desire for achievement, and how to effectively use the school environment and correct attitudes. Therefore, it is expected that the results derived from this study will help lay the foundation for improvement to secure practicality and future research directions on planned happenstance skills, students’ life satisfaction, and career maturity inventory attitude of Chinese students in South Korea.

산업용 아크릴 재료에 대한 마찰 특성

Piao, Shi Rong 부산대학교 2011 국내석사

Ontology-based Optimization Modelling Tool for distributed and ad-hoc business problems

Guangyuan, Piao Graduate School, Yonsei University 2012 국내석사

Semantic Web Constraint Language (SWCL) was proposed in 2006 with the vision of enhancing the quality of humans’ decision-making by machines in Semantic Web environments, complementing the missing but important part which acknowledges constraints on concepts represented by ontology. Even though, the XML syntax for SWCL itself is too verbose and has a downside that needs to be generated by hand with deep knowledge of OWL. In this respect, users have to be aware of the syntax and semantics of OWL in deep in order to generate a problem description in SWCL by hand without any error. Moreover, due to the complexity of SWCL, it would be tedious work to generate all constraints with SWCL in many cases. These reasons causes decrease of the efficiency and popularity for SWCL. In order to cope with these issues, we developed ontology-based optimization modelling tool using SWCL which can help users to manipulate the problem model in SWCL straightforward and make the optimization model intuitive as well. Through our research and development, we supplement the method to represent the class description for each variable in SWCL with Manchester syntax which is developed in response to a demand from a wide range of users, who do not have the background knowledge for Description Logic (DL). We developed and implemented the variable detection algorithm and the related constraints extraction algorithm to construct the optimization model selecting the constraints in SWCL that are distributed and shared in the Semantic Web environments. In addition, the translation algorithm and tool that could be able to convert the problem model in SWCL to problem description in OPL modelling language. The developed tool was applied to a production scheduling problem for virtual enterprise to validate the usability of our methodology. This research shows that various problems with different objective and constraints could be manipulated to construct the optimization model by the ontology-based optimization modelling tool.

(The) analysis of Chinese OFDI into the EU : based on the EU 20 panel data from 2010 to 2019

Piao, Zhenhui Graduate School of International Studies, Korea Un 2022 국내석사

The European Union and China are both active participants in global economic and political affairs. Strengthening their connections and collaboration will have long-term benefits in a multitude of settings and propel world economic development upward. By analyzing available panel data from 2010 to 2019, this paper aims to examine the current state of the EU and China economic relations from the perspective of investing scales, investing countries, and industry distribution and to identify the key determinants that may have a significant impact on Chinese OFDI motivations toward the EU. Combining qualitative with quantitative research methods, the findings demonstrate the EU's and China's strong collaboration potential, while also emphasizing the contributions and critical role of these two significant economic blocks in driving global economic recovery.

Measuring similarity of diabetic patients via CNN-based framework

Piao, Liying Graduate School, Yonsei University 2019 국내석사

질병 환자 코호트를 찾아내는 것은 헬스케어 영역 중 기본적인 주제로 개개인의 질병 예방과 치료에 있어 의료종사자들의 의사결정에 긍정적인 영향을 가져다줄 수 있다. 그러나 이것을 실현하는 기본적인 과제인 환자들간 유사성을 측정하는 일은 그닥 쉬운 일이 아니다. EHR 데이터는 계층적이어서 매 환자들의 상이한 시간적인 정보를 포함하고 있다. 이외에도 여러가지 의료적 컨섭이 담겨져 있다. 이러한 복잡하고 규칙성이 떨어진 데이터들은 유사성을 직접 측정하기에 어려워 보인다. 기존 연구에서 EHR 데이터를 통합하고 환자들간의 유사성을 평가하는 방법으로 환자들을 벡터화 하였으나 거의 EHR 데이터에 담긴 시간적인 요소를 무시하였다. 따라서 본 연구의 목적은 기존 역사적 기록을 통한 시간적 정보가 담긴 환자들의 벡터와 환자 유사성 매트릭스에 의한 방법으로 그 정확도를 제고하는 것이다. 본 연구는 주의 기제 모형을 Bi-CNN 프레임에 넣고 end-to-end 학습을 시행하였다. 이렇게 하므로 환자의 벡터와 종적인 역사적 기록이 담긴 유사성 매트릭스를 동시에 포함시켰다. 본 실험은 현존하는 데이터에 기반하였고 결과적으로 주의 모형은 유사성 측정 정확율 제고에 효과적이었다. 이외에도 본 연구의 유사성 매트릭스는 실제 상황에서도 타당하는 결과를 보였다. As a fundamental topic in the healthcare field, discovering patient cohort has relative positive effect on personalized healthcare scenarios such as prevention of diseases and supporting treatment making for physicians. However, measuring the similarities between patients as a basis for this topic often faces enormous challenges. The EHR data is hierarchical, which contains different visits for each patient. Furthermore, each visit includes a variety of medical concepts. This highly complex, irregular data is difficult for measuring similarity directly. Although some previous studies have obtained vector representations of patients by integrating EHR data and evaluated similarity between patients, most of them ignored the temporal information of EHR data. The purpose of this paper is to obtain a vector representation of patient historical records with consideration of temporal characteristics and to learn a method of patient similarity metrics. In this paper, we introduce an attention module into the framework of Bi-CNN to implement ‘end-to-end’ learning, which can simultaneously obtain vector representation and similarity metric for patient longitudinal historical records. The experiment is based on real world data and results show that introducing attention module can improve the effectiveness of similarity learning. In the end, we also verify the similarity metric learned by the proposed model is reasonable in the actual situations.