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Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function
Parsa, Afshin,Fuchsberger, Christian,Kö,ttgen, Anna,O’Seaghdha, Conall M.,Pattaro, Cristian,de Andrade, Mariza,Chasman, Daniel I.,Teumer, Alexander,Endlich, Karlhans,Olden, Matthias,Chen, Ming-Hue American Society of Nephrology 2013 Journal of the American Society of Nephrology Vol.24 No.12
Alexander Krüttgen 대한백신학회 2022 Clinical and Experimental Vaccine Research Vol.11 No.1
Purpose: Studies on the immune responses to severe acute respiratory syndrome coronavirus 2 vaccines are necessary to evaluate the ongoing vaccination programs by correlating serological response data and clinical effectiveness data. We performed a longitudinal immunological profiling of health care workers vaccinated with mRNA-1273 (Moderna, Cambridge, MA, USA). Half of these vaccinees had experienced a mild coronavirus disease 2019 (COVID-19) infection in the spring of 2020 (“COVID-recovered” cohort), whereas the other half of the vaccinees had no previous COVID-19 infection (“COVID-naive” cohort). Materials and Methods: Serum was drawn at multiple time points and subjected to assays measuring anti-Spike immunoglobulin G (IgG), avidity of anti-Spike IgG, avidity of anti-receptor binding domain (RBD) IgG, virus neutralizing activity, and interferon-ɣ release from stimulated lymphocytes. Results: Between both cohorts and within each cohort, we found remarkable inter-individual differences regarding cellular and humoral immune responses to the Moderna mRNA-1273 vaccine. Conclusion: First, our study indicates that the success of mRNA-1273 vaccinations should be verified by serological assays in order to identify “low-responders” to vaccination. Second, the kinetics of anti-S IgG and neutralizing activity correlate well with clinical effectiveness data, thus explaining incipient protection against infection 2 weeks after the first dose of mRNA-1273 in COVID-naive vaccinees. Third, our IgG-avidity data indicate that this incipient protection is mediated by low-avidity anti-RBD IgG and low-avidity anti-S IgG.
Hanna Klingel,Maike Lauen,Alexander Krüttgen,Matthias Imöhl,Michael Kleines 대한백신학회 2022 Clinical and Experimental Vaccine Research Vol.11 No.1
Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific Tcells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity
Alexander Strom,Kirti Kaul,Jutta Brüggemann,Iris Ziegler,Ilka Rokitta,Sonja Püttgen,Julia Szendroedi,Karsten Müssig,Michael Roden,Dan Ziegler,the GDS Group 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations of extracellular superoxide dismutase (SOD3), thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) in 107 type 1 and 215 type 2 diabetes patients from the German Diabetes Study baseline cohort and 37 glucose-tolerant individuals (controls). DSPN was defined by electrophysiological and clinical criteria (Toronto Consensus, 2011). SOD3 and GSH concentrations were lower in individuals with type 1 and type 2 diabetes compared with concentrations in controls (Po0.0001). In contrast, the TBARS concentration was higher in participants with type 1 diabetes and type 2 diabetes compared with levels in controls (Po0.0001). In addition, the SOD3 concentration was higher in participants with type 1 diabetes compared to concentrations in those with type 2 diabetes (Po0.0001). A low SOD3 concentration was associated with DSPN in individuals with type 1 diabetes (β=− 0.306, P=0.002), type 2 diabetes (β=− 0.164, P=0.017), and in both groups combined (β=− 0.206, P=0.0003). Lower SOD3 concentrations were associated with decreased motor nerve conduction velocity (NCV) in men and, to a lesser degree, with reduced sensory NCV in women with diabetes. In conclusion, several biomarkers of oxidative stress are altered in recent-onset diabetes, with only a lower SOD3 concentration being linked to the presence of DSPN, suggesting a role for reduced extracellular antioxidative defense against superoxide in the early development of DSPN