Geographic Distribution and Epidemiology of Lung Cancer During 2011 in Zhejiang Province of China

Lin, Xia-Lu,Chen, Yan,Gong, Wei-Wei,Wu, Zhao-Fan,Zou, Bao-Bo,Zhao, Jin-Shun,Gu, Hua,Jiang, Jian-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: To explore etiology for providing scientific clues for the prevention of lung cancer. Materials and Methods: Data for lung cancer incidence and meteorological geographic factors from 25 counties in Zhejiang province of China during 2011 were studied. Stepwise multiple regression and correlation analysis were performed to analyze the geographic distribution and epidemiology of lung cancer. Results: 8,291 new cases (5,998 in males and 2,293 females) of lung cancer during 2011 in Zhejiang province were reported in the 25 studied counties. Reported and standardized incidence rates for lung cancer were 58.0 and 47.0 per 100,000 population, respectively. The incidence of lung cancer increased with age. Geographic distribution analysis shows that the standardized incidence rates of lung cancer in northeastern Zhejiang province were higher than in the southwestern part, such as in Nanhu, Fuyang, Wuxing and Yuyao counties, where the rates were more than 50 per 100,000 population. In the southwestern Zhejiang province, for instance, in Yueqing, Xianju and Jiande counties, the standardized incidence rates of lung cancer were lower than 37 per 100,000 population. Spearman correlation tests showed that forest coverage rate, air quality index (AQI), and annual precipitation level are associated with the incidence of lung cancer. Conclusions: Lung cancer in Zhejiang province shows obvious regional differences. High incidence appears associated with low forest coverage rate, poor air quality and low annual precipitation. Therefore, increasing the forest coverage rate and controlling air pollution may play an important role in lung cancer prevention.

The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students

Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7

Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.

Current-induced Polarization in (Ga,Mn)As Dilute Magnetic Semiconductor

Xiaofang Gu,Xuan Qian,Yang Ji,Lin Chen,Weizhu Wang,Jianhua Zhao 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

Catalytic cracking of inedible camelina oils to hydrocarbon fuels over bifunctional Zn/ZSM-5 catalysts

Xianhui Zhao,Lin Wei,James Julson,Zhengrong Gu,Yuhe Cao 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.8

Catalytic cracking of camelina oils to hydrocarbon fuels over ZSM-5 and ZSM-5 impregnated with Zn2+ (named bifunctional catalyst) was individually carried out at 500 oC using a tubular fixed-bed reactor. Fresh and used catalysts were characterized by ammonia temperature-programmed desorption (NH3-TPD), X-ray diffractometer (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and nitrogen isothermal adsorption/desorption micropore analyzer. The effect of catalysts on the yield rate and qualities of products was discussed. The loading of Zn2+ to ZSM-5 provided additional acid sites and increased the ratio of Lewis acid site to Brønsted acid site. BET results revealed that the surface area and pore volume of the catalyst decreased after ZSM-5 was impregnated with zinc, while the pore size increased. When using the bifunctional catalyst, the pH value and heating value of upgraded camelina oils increased, while the oxygen content and moisture content decreased. Additionally, the yield rate of hydrocarbon fuels increased, while the density and oxygen content decreased. Because of a high content of fatty acids, the distillation residues of cracking oils might be recycled to the process to improve the hydrocarbon fuel yield rate.

Molecular and Cellular Microbiology / Biomedical Sciences : A Homogeneous Immunoassay Method for Detecting Interferon-Gamma in Patients with Latent Tuberculosis Infection

( Fei Wu ),( Lin Wang ),( Qiaomei Guo ),( Mingna Zhao ),( Hongchen Gu ),( Hong Xu ),( Jiatao Lou ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3

IFN-γ release assays (IGRAs) have been developed as viable alternative diagnostic tools for detecting latent tuberculosis infection (LTBI). A customized homogeneous sandwich luminescent oxygen channeling immunoassay (LOCI) was used to quantify IFN-γ levels in IGRAs. Samples were collected from healthy volunteers (n = 40) who were T-Spot-negative and T-Spot-positive patients (n = 32) at rest. Then the amount of IFN-γ in the supernatant of IGRAs was measured by LOCI. The results demonstrated a low background, and high sensitivity, specificity, accuracy, and reproducibility, and a short assay time (only 30 min) with LOCI for IFN-γ. The recovery range was 81.63-102.06%, the coefficients of variation were below 5%, and the limit of detection was 19.0 mIU/ml. Excellent agreement between LOCI IFN-γ and the T-SPOT.TB test was obtained (97.2% agreement, κ = 0.94). The LOCI IFN-γ concentrations were significantly higher in T-Spot-positive patients than in the healthy group (p < 0.001). Moreover, as observed for the comparative LOCI IFN-γ assay, IFN-γ concentrations were related to the numbers of T-SPOT.TB spots. We have established an in vitro blood test for LTBI diagnosis, defined as LOCI IFN-γ. A high level of agreement between the LOCI IFN-γ method and T-SPOT.TB assay was observed in clinical studies that showed the LOCI IFN-γ method could determine LTBI. This study shows acceptable performance characteristics of the LOCI IFN-γ assay to diagnose LTBI.

The Possible Mechanisms Involved in Citrinin Elimination by Cryptococcus podzolicus Y3 and the Effects of Extrinsic Factors on the Degradation of Citrinin

( Xiaoyun Zhang ),( Zhen Lin ),( Maurice Tibiru Apaliya ),( Xiangyu Gu ),( Xiangfeng Zheng ),( Lina Zhao ),( Mandour Haydar Abdelhai ),( Hongyin Zhang ),( Weicheng Hu ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 Journal of microbiology and biotechnology Vol.27 No.12

Citrinin (CIT) is a toxic secondary metabolite produced by fungi belonging to the Penicillium, Aspergillus, and Monascus spp. This toxin has been detected in many agricultural products. In this study, a strain Y3 with the ability to eliminate CIT was screened and identified as Cryptococcus podzolicus, based on the sequence analysis of the internal transcribed spacer region. Neither uptake of CIT by cells nor adsorption by cell wall was involved in CIT elimination by Cryptococcus podzolicus Y3. The extracellular metabolites of Cryptococcus podzolicus Y3 stimulated by CIT or not showed no degradation for CIT. It indicated that CIT elimination was attributed to the degradation of intracellular enzyme(s). The degradation of CIT by C. podzolicus Y3 was dependent on the type of media, yeast concentration, temperature, pH, and initial concentration of CIT. Most of the CIT was degraded by C. podzolicus Y3 in NYDB medium at 42 h but not in PDB medium. The degradation rate of CIT was the highest (94%) when the concentration of C. podzolicus Y3 was 1 × 10⁸ cells/ml. The quantity of CIT degradation was highest at 28°C, and there was no degradation observed at 35°C. The study also showed that acidic condition (pH 4.0) was the most favorable for CIT degradation by C. podzolicus Y3. The degradation rate of CIT increased to 98% as the concentration of CIT was increased to 20 μg/ml. The toxicity of CIT degradation product(s) toward HEK293 was much lower than that of CIT.

ANALYSIS ON MEMBRANE HEAT EXCHANGER APPLIED TO ABSORPTION CHILLER

ZAN-SHE WANG,ZHAO-LIN GU,GUO-ZHENG WANG,FENG CUI,SHI-YU FENG 대한설비공학회 2011 International Journal of Air-Conditioning and Refr Vol.19 No.3

A novel membrane heat exchanger was proposed and analyzed. It was expected that the novel heat exchanger could be applied to the lithium bromide absorption chiller. Polyvinylidene fluoride hollow fiber module was adopted as the solution heat exchanger. The hot feed solution from the generator flowed into the lumen side of the membranes while the cold feed solution from the absorber flowed away from the shell side. Heat transfer and mass transfer occurred simultaneously in the membrane module, and only water vapor could diffuse across the membrane pore due to the water vapor pressure difference between the inside and outside of the membrane. Mathematical equations of the heat and mass transfer processes in the membrane heat exchanger were built, and the parallel flow process and the counter flow process were compared by numerical simulation. The simulation results show that the counter flow process was the better flow mode because the mean temperature difference was larger and the mass transfer was more steadily from the lumen side to the shell side. The heat caused by water vapor mass transfer may account for one-third of the total heat transfer. As a result, the membrane heat exchanger not only reinforced the heat recovery but also enlarged the deflation range and reduced the circulation rate and the heat loads of the generator and absorber. Eventually, the coefficient of performance of the heat exchanger was increased.

Adaptive control for small-hole EDM process with wavelet transform detecting method

Yi Jiang,Wansheng Zhao,Xuecheng Xi,Lin Gu 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.6

To achieve an efficient small-hole EDM process, an accurate pulse monitoring strategy and a precise control are both required. In order to improve the efficiency and stability of the small-hole drilling process, an adaptive control system with a self-tuning regulator is developed. A high-speed EDM pulses monitoring system based on wavelet transform is implemented to measure the gap status, whose output is adopted as the feedback signals of the adaptive control system. The discharge waveforms are recorded and analyzed. The experimental results demonstrate that the arc pulse ratio during small-hole drilling process is reduced remarkably. The machining efficiency as well as the machining quality is improved significantly.

Precision machining of high aspect-ratio rotational part with wire electro discharge machining

Yingmou Zhu,Tongsheng Liang,Lin Gu,Wansheng Zhao 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.3

Precision and micro rotational parts are widely used in various industries, such as micro probes for medical instruments, contact pins for micro assembly applications, micro electrodes for micro Electrical discharge machining (μ-EDM) or micro Electro-chemical discharge machining (μ-ECDM). In this research, a uniform annular area layer by layer feeding strategy was proposed to fabricate high aspect ratio, small radii rotational components on a conventional Wire electrical discharge machining (WEDM) machine equipped with an auxiliary spindle. The uniform annular area layer by layer feeding strategy consisted of the roughing and finishing stages. First, the theoretical Material removal rate (MRR) and radial infeed rate for each layer were determined for the roughing stage, and the theoretical surface roughness, R z in the finishing stage was researched. Then, a series of optimization experiments were conducted to investigate the influence of the parameters on MRR and the machined surface roughness. A group of pin electrodes were machined by applying this feed strategy with the optimized parameters, and the minimum diameter of the pin electrodes was 40 μm with an aspect-ratio of 60. Finally, micro electrodes for an injection nozzle were achieved with this novel process and a qualified injection nozzle for powder metallurgy was fabricated with the machined micro electrodes.

Protein target identifi cation of ginsenosides in skeletal muscle tissues: discovery of natural smallmolecule activators of muscle-type creatine kinase

Feiyan Chen,Kexuan Zhu,Lin Chen,Liufeng Ouyang,Cuihua Chen,Ling Gu,Yucui Jiang,Zhongli Wang,Zixuan Lin,Qiang Zhang,Xiao Shao,Jianguo Dai,Yunan Zhao 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.3

Background: Ginseng effectively reduces fatigue in both animal models and clinical trials. However, themechanism of action is not completely understood, and its molecular targets remain largely unknown. Methods: By screening for proteins that interact with the primary components of ginseng (ginsenosides)in an affinity chromatography assay, we have identified muscle-type creatine kinase (CK-MM) as a potentialtarget in skeletal muscle tissues. Results: Biolayer interferometry analysis showed that ginsenoside metabolites, instead of parent ginsenosides,had direct interaction with recombinant human CK-MM. Subsequently, 20(S)-protopanaxadiol(PPD), which is a ginsenoside metabolite and displayed the strongest interaction with CK-MM in thestudy, was selected as a representative to confirm direct binding and its biological importance. Biolayerinterferometry kinetics analysis and isothermal titration calorimetry assay demonstrated that PPDspecifically bound to human CK-MM. Moreover, the mutation of key amino acids predicted by moleculardocking decreased the affinity between PPD and CK-MM. The direct binding activated CK-MM activityin vitro and in vivo, which increased the levels of tissue phosphocreatine and strengthened the functionof the creatine kinase/phosphocreatine system in skeletal muscle, thus buffering cellular ATP, delayingexercise-induced lactate accumulation, and improving exercise performance in mice. Conclusion: Our results suggest a cellular target and an initiating molecular event by which ginsengreduces fatigue. All these findings indicate PPD as a small molecular activator of CK-MM, which can helpin further developing better CK-MM activators based on the dammarane-type triterpenoid structure.