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Park, Yunji,Yoo, Ran,Park, Seung ryull,Lee, Jun Ho,Jung, Hwaebong,Lee, Hyun-Sook,Lee, Wooyoung Elsevier 2019 Sensors and actuators. B Chemical Vol.290 No.-
<P><B>Abstract</B></P> <P>We report the quantum-size effect on the sensing properties of ZnO nanoparticles for the detection of isoprene. For this purpose, two types of ZnO particles with different sizes, including nanoparticles (NPs, ˜25 nm) and quantum dots (QDs, ˜5 nm), were prepared by a wet chemical method. The ZnO QDs exhibited excellent sensing performance to 1 ppm isoprene compared to NPs. The maximum sensing response and response time were ˜42 and 8 s at 350 °C for the QDs, while ˜5.6 and 40 s at 500 °C for the NPs, respectively. The higher sensing response, rapid response, and lower optimal working temperature of the ZnO QDs can be attributed to an increase in oxygen vacancies, band gap, and specific surface area owing to the small size effect. Both ZnO NPs and QDs showed the lower limit of 0.01 ppm for detecting isoprene. It is noted that the sensing properties of ZnO QDs to 1 ppm isoprene are superior to previously reported isoprene sensors that are based on semiconducting metal oxides. Furthermore, we demonstrated that the low concentration (0.4–6.2 ppm) of isoprene can be selectively detected within ˜83 s using a recently developed miniaturized gas chromatography integrated with the ZnO QD sensor.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report the size effect on the sensing properties of ZnO for isoprene detection. </LI> <LI> The ZnO nanoparticles and quantum dots were prepared by a wet-chemical method. </LI> <LI> The ZnO quantum dots exhibited enhanced sensing performance to 1 ppm isoprene. </LI> <LI> The higher sensing performance was explained by the quantum size effect. </LI> <LI> Isoprene could be selectively detected using a miniaturized gas chromatography. </LI> </UL> </P>
Negative role of inducible PD-1 on survival of activated dendritic cells
Park, Seong Jeong,Namkoong, Hong,Doh, Junsang,Choi, Jong-Cheol,Yang, Bo-Gie,Park, Yunji,Chul Sung, Young Society for Leukocyte Biology 2014 Journal of Leukocyte Biology Vol.95 No.4
<P>PD-1 expressed on activated DCs suppresses T cell activation via decreasing DC survival.</P>
Yunji Park,Shintae Kim,Jeongjin Park,Kyungmi Kim,Woojin Jun 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was aimed to investigate the effects of Perilla frutescens var. acuta water extract (PFE) on hydrogen peroxide-induced skeletal muscle cells. As a preliminary study, we confirmed the potential compounds contents and activities of antioxidant. To confirm the impact of PFE on muscle cells, we next conducted the cytotoxicity and intracellular ROS measurement in C2C12 myoblast. Results showed that safety concentration of PFE was under 200 μg/mL. Additionally, PFE might protect muscle cells on oxidative stress through the decrease of intracellular ROS level increased by hydrogen peroxide. In order to further assess the effects of PFE on myotube atrophy induced by hydrogen peroxide, we measured mRNA expression level using RT-PCR. Muscle atrophy induced by hydrogen peroxide was associated with up-regulation of atrophic factor (myostatin) and down-regulation of protein synthesis factor (mTOR). Compared to H₂O₂ groups, PFE suppressed the expression of myostain, but increased the expression of mTOR. In conclusion, PFE might have the potential to protect against myotube atrophy by regulating proteostasis and cellular redox signaling.
Park, Boyoung,Choi, Ji-Yeob,Sung, Ho Kyung,Ahn, Choonghyun,Hwang, Yunji,Jang, Jieun,Lee, Juyeon,Kim, Heewon,Shin, Hai-Rim,Park, Sohee,Han, Wonshik,Noh, Dong-Young,Yoo, Keun-Young,Kang, Daehee,Park, Su Wolters Kluwer Health 2016 Medicine Vol.95 No.14
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>We conducted a heterogeneous risk assessment of breast cancer based on the hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) calculating the risks and population-based attributable fractions (PAFs) for modifiable and nonmodifiable factors.</P><P>Using matched case–control study design from the Seoul Breast Cancer Study and the national prevalence of exposure, the risks and PAFs for modifiable and nonmodifiable factors were estimated for total breast cancers and subtypes.</P><P>The attribution to modifiable factors was different for each subtype (luminal A, PAF = 61.4% [95% confidence interval, CI = 54.3%–69.8%]; luminal B, 21.4% [95% CI = 18.6–24.9%]; HER2-overexpression, 59.4% [95% CI = 47.8%–74.3%], and triple negative tumors [TNs], 27.1% [95% CI = 22.9%–32.4%)], and the attribution to the modifiable factors for the luminal A and HER2-overexpression subtypes was higher than that of the luminal B and TN subtypes (<I>P</I> heterogeneity ≤ 0.001). The contribution of modifiable reproductive factors to luminal A type in premenopausal women was higher than that of the other subtypes (18.2% for luminal A; 3.1%, 8.1%, and −3.1% for luminal B, HER2-overexpression, and TN subtypes, respectively; <I>P</I> heterogeneity ≤ 0.001). Physical activity had the highest impact preventing 32.6% of luminal A, 14.5% of luminal B, 38.0% of HER2-overexpression, and 26.9% of TN subtypes (<I>P</I> heterogeneity = 0.014). Total reproductive factors were also heterogeneously attributed to each breast cancer subtype (luminal A, 65.4%; luminal B, 24.1%; HER2-overexpression, 57.9%, and TN subtypes, −3.1%; <I>P</I> heterogeneity ≤ 0.001).</P><P>Each pathological subtype of breast cancer by HRs and HER2 status may be associated with heterogeneous risk factors and their attributable risk, suggesting a different etiology. The luminal B and TN subtypes seemed to be less preventable despite intervention for alleged risk factors, even though physical activity had a high preventable potential against breast cancer.</P></▼2>
Park, Min Sun,Lee, Jun Ho,Park, Yunji,Yoo, Ran,Park, Seungryol,Jung, Hwaebong,Kim, Wonkyung,Lee, Hyun-Sook,Lee, Wooyoung Elsevier 2019 Sensors and actuators. B, Chemical Vol.299 No.-
<P><B>Abstract</B></P> <P>We report on the doping effect on the sensing properties of ZnO quantum dots (QDs) for the detection of acetylene. We found that In-doped ZnO (IZO) QDs exhibited a better sensing performance to 10 ppm acetylene than undoped ZnO (ZO) QDs and Al-doped ZnO (AZO) QDs. The higher sensing response of IZO QDs can be attributed to a greater number of reactive sites for detecting acetylene, which is likely to originate from the increased number of oxygen vacancies, and the larger optical band gap and surface area of IZO. This is due to a higher valence dopant and a smaller particle size. The sensing properties of IZO QDs to 10 ppm acetylene was also found to be superior to previously reported acetylene sensors that are based on semiconducting metal oxides. Furthermore, we demonstrated that 10 ppm of acetylene can be selectively detected in air within ∼100 s using a recently developed miniaturized gas chromatography (GC) integrated with the IZO QDs sensor. In addition, we found that the device can detect the major fault gases of hydrogen and acetylene separately within ∼100 s. Our study demonstrates that the device can be utilized in the GC-based on-line dissolved gas analysis to detect small amounts of acetylene gas in transformer oil.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report the doping effect on the sensing properties of ZnO quantum dots for acetylene. </LI> <LI> Doping of ZnO quantum dots modified oxygen vacancies and optical band gaps. </LI> <LI> In-doped ZnO quantum dots exhibited a better sensing performance to 10 ppm acetylene. </LI> <LI> 10 ppm acetylene could be selectively detected using a miniaturized gas chromatography. </LI> <LI> The device can detect the major fault gases of hydrogen and acetylene separately within ∼100 s. </LI> </UL> </P>
Hwang, Yunji,Lee, Kyu Eun,Park, Young Joo,Kim, Su-Jin,Kwon, Hyungju,Park, Do Joon,Cho, Belong,Choi, Ho-Chun,Kang, Daehee,Park, Sue K. Wolters Kluwer Health 2016 Medicine Vol.95 No.9
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>We evaluated the association between weight change in middle-aged adults and papillary thyroid cancer (PTC) based on a large-scale case-control study.</P><P>Our study included data from 1551 PTC patients (19.3% men and 80.7% women) who underwent thyroidectomy at the 3 general hospitals in Korea and 15,510 individually matched control subjects. The subjects’ weight history, epidemiologic information, and tumor characteristics confirmed after thyroidectomy were analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were determined for the annual average changes in weight and obesity indicators (body mass index (BMI), body surface area, and body fat percentage (BF%) in subjects since the age of 35 years.</P><P>Subjects with a total weight gain ≥10 kg after age 35 years were more likely to have PTC (men, OR, 5.39, 95% CI, 3.88–7.49; women, OR, 3.36, 95% CI, 2.87–3.93) compared with subjects with a stable weight (loss or gain <5 kg). A marked increase in BMI since age 35 years (annual average change of BMI ≥0.3 kg/m<SUP>2</SUP>/yr) was related to an elevated PTC risk, and the association was more pronounced for large-sized PTC risks (<1 cm, OR, 2.34, 95% CI, 1.92–2.85; ≥1 cm, OR, 4.00, 95% CI, 2.91–5.49, <I>P</I> heterogeneity = 0.005) compared with low PTC risks.</P><P>Weight gain and annual increases in obesity indicators in middle-aged adults may increase the risk of developing PTC.</P></▼2>
전자선 검역처리선량이 파프리카의 품질 및 관능특성에 미치는 영향
박윤지(Yunji Park),조윤희(Yunhee Jo),권중호(Joong-Ho Kwon) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.2
신선 채소인 파프리카에 검역처리 선량의 전자선 처리(0, 0.4, 1, 2 kGy) 후 냉장저장 40일 동안 미생물학적, 이화학적 및 관능적 품질을 평가하였다. 파프리카의 미생물 농도는 총세균, 효모 및 곰팡이의 경우 104 CFU/g, 대장균군은 102 CFU/g 수준이었고, 1 kGy 선량은 미생물 농도를 1 log cycle 감소시킬 수 있었다. 중량감소율은 조사처리에 따른 차이를 보이지 않았고, 경도와 카로티노이드 함량은 조사 직후 1 kGy 이상의 선량에서 유의적으로 감소하였으며, 저장 중에도 선량에 관계없이 감소하였다. 비타민 C 함량은 선량에 따른 유의적인 차이를 보이지 않았고, 0, 0.4 및 1 kGy 처리 시료는 저장 40일째 저장 초기 함량의 87-90% 수준으로 감소하였다. 파프리카에 대한 관능평가 결과, 2 kGy 수준의 전자선 처리는 색과 조직감 저하에 영향을 미치는 것으로 확인되었다. 이상의 결과, 수출용 파프리카의 해충구제 및 검역처리를 위한 0.4-1 kGy 수준의 전자선 처리는 냉장저장 동안 미생물학적 안전성을 확보하면서 이화학적 품질을 유지시키는 것으로 확인되었다. The aim of this study was to evaluate the quality characteristics of fresh red paprika treated by electron-beam irradiation at quarantine doses. The initial microbial loads were low with 104 and 102 colony-forming units/g for total aerobic bacteria and coliform, respectively; however, a dose of 1 kGy resulted in load reduction of 1 log cycle. A dose level of more than 1 kGy caused significant decreases in the hardness and carotenoid content parameters. An applied dose level of less than 2 kGy did not affect vitamin C content; however, a decrease of 87-90% was observed after 40-day storage. Samples treated with 2 kGy showed significantly lower acceptance compared to the control, with lower sensory evaluation scores for color and texture. Therefore, e-beam irradiation at dose range of 0.4 and 1 kGy was found to be appropriate for quarantine applications for microbiological control and quality maintenance of paprika.