Serum Talin-1 is a Potential Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in Egyptian Patients

Youns, Mahmoud M.,Abdel Wahab, Abdel Hady A.,Hassan, Zeinab A.,Attia, Mohamed S. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Background: Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. The outcome of HCC depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory. Talins were firstly identified as cytoplasmic protein partners of integrins but Talin-1 appears to play a crucial role in cancer formation and progression. Our study was conducted to assess the diagnostic value of serum Talin-1 (TLN1) compared to the most feasible traditional biomarker alpha-fetoprotein (AFP) for the diagnosis of HCC. Methods: TLN1 was detected using enzyme linked immunosorbent assay (ELISA) in serum samples from 120 Egyptian subjects including 40 with HCC, 40 with liver cirrhosis (LC) and 40 healthy controls (HC). Results: ROC curve analysis was used to create a predictive model for TLN1 relative to AFP in HCC diagnosis. Serum levels of TLN1 in hepatocellular carcinoma patients were significantly higher compared to the other groups (p<0.0001). The diagnostic accuracy of TLN1 was higher than that of AFP regarding sensitivity, specificity, positive predictive value and negative predictive value in diagnosis of HCC. Conclusions: The present study showed for the first time that Talin-1 (TLN1) is a potential diagnostic marker for HCC, with a higher sensitivity and specificity compared to the traditional biomarker AFP.

디젤엔진개량에 의한 천연가스차량전환에 관한 연구

한영출(Youns-Chool Han),오용석(Yong-Suk Oh),나완용(Wan-Yong Rha) 한국공작기계학회 1999 한국공작기계학회지 Vol.8 No.2

TALENs Construction: Slowly but Surely

Hegazy, Wael Abdel Halim,Youns, Mahmoud Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Cancer is thought to be a direct result of transcriptional misregulation. Broad analysis of transcriptional regulatory elements in healthy and cancer cells is needed to understand cancer development. Nucleases regulatory domains are recruited to bind and manipulate a specific genomic locus with high efficacy and specificity. TALENs (transcription activator-like effector nuclease) fused to endonuclease FokI have been used widely to target specific sequences to edit several genes in healthy and cancer cells. This approach is promising to target specific cancer genes and for this purpose it is needed to pack such TALENs into viral vectors. There are some considerations which control the success of this approach, targeting appropriate sequences with efficient construction of TALENs being crucial factors. We face some obstacles in construction of TALENs; in this study we made a modification to the method of Cermk et al 2011 and added one step to make it easier and increase the availability of constructs.

사료(史料)로 살펴본 윤성덕(尹聖德)의 삶과 음악 활동

장정윤 ( Chang Jeong Youn ) 한국음악학학회 2021 음악학 Vol.29 No.1

본 논문은 근대 시기 음악유학을 경험한 여성 음악가 윤성덕(尹聖德, 1903~1968)에 대한 연구로서 지금껏 알려지지 않은 그녀의 삶을 당시의 신문기사, 잡지, 유학 기관에서의 기록, 미국 이민국 서류 등 새롭게 발굴한 1차 자료를 통해 구체화하고 음악 활동을 살펴보는 것에서 출발한다. 윤성덕의 삶과 음악 활동은 크게 세 시기로 나누어 살펴볼 수 있다. 첫 번째 시기는 평양의 기독교 가정에서 자라고 이화학당에서 교육을 받으며 음악에 대한 꿈을 키운 시기이며, 두 번째 시기는 선교사들의 전폭적인 지원을 받아 미국 유학을 경험하고 이후 이화여전의 교수로 부임하여 음악 교육시스템의 발전에 헌신한 시기이다. 그리고 세 번째 시기는 미국의 발전된 최신 음악 교육시스템을 경험하고 조선으로 도입하기 위해 이화여전 교수의 신분으로 다시 미국으로 건너간 이후이다. 윤성덕의 삶과 활동 전반에 나타난 음악에 대한 소명은 개인적인 성공과 명성을 위한 자아실현보다는 당시의 기독교와 여성 교육정책이라는 강력한 영향 아래에서 음악교육자의 모습으로 발현되었다. 또한 그녀는 김애식 이후 이화학당출신 미국음악유학생으로 김메리, 김영의같이 보다 많은 여성 음악가들이 선교사들의 네트워크와 지원을 통해 미국 유학을 경험하고 귀국하여 이화에 교육자로 투입되는 연장선의 시작점에 있다. 본 연구는 윤성덕이라는 인물의 삶과 음악 활동을 보다 구체화하고 관련 인물들을 밝힘으로써 한국 근대 초기에 활동한 여성 음악가의 갈등과 욕망을 심도 있게 살펴볼 수 있는 계기를 마련할 것이다. This paper is a fundamental study on Mary Sungduk Youn (尹聖德, 1903~1968), a female musician who studied abroad in early modern Korea, and starts to discover her life and her musical activities based on primary sources and historical records such as newspapers, magazines, copies of personal documents and the records from the universities and the archives in the U.S. Based on them, Youn’s life can be divided into 3 periods. The first period is the time when she was raised and educated under the Christian family and Ewha Haktang. And the second is the time when she went abroad to study music in the U.S., supported by several missionaries involved in Ewha College and the time she devoted herself as a professor to improve the music educational system of Ewha College after coming back from America. The last is the time after she revisited the U.S. for having experience on the latest music educational system and for introducing it to Ewha College. The vocation for music that appeared throughout Youn’s life and activities was manifest as a music educator under the strong influence of Christianity and women’s education policy rather than self-actualization for personal success and fame. And Youn was an important figure after Alice Kim (1890~1951) who was the first music educator going abroad to study in the U.S., and as a pioneer Youn was at the beginning of studying abroad of female musicians such as Mary Chesik Kim (1906~2005) and Youngyi Kim (1908~1986), supported by missionaries within their strong network. By discovering Youn’s life and musical activities with the people involved, this study will provide the opportunity to examine the conflicts and desires of female musicians who were active in the early modern Korea.

Effect of oxidation states of vanadium precursor solution in V₂O₅/TiO₂ catalysts for low temperature NH₃ selective catalytic reduction

Youn, S.,Jeong, S.,Kim, D.H. Elsevier Science Publishers 2014 CATALYSIS TODAY - Vol.232 No.-

In this study, we aimed at finding the optimum condition to prepare V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalyst for the selective catalytic reduction with NH<SUB>3</SUB> (NH<SUB>3</SUB>-SCR) by changing oxidation states in vanadium precursor solution. Using three precursor solutions with different oxidation states (V<SUP>3+</SUP>, V<SUP>4+</SUP> and V<SUP>5+</SUP>), TiO<SUB>2</SUB> supported V<SUB>2</SUB>O<SUB>5</SUB> catalysts (1, 3, 5 and 7wt%) were prepared by applying wet impregnation method. We utilized various analytical techniques, such as N<SUB>2</SUB> adsorption-desorption with BET method, inductively coupled plasma (ICP), X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), UV-visible diffuse reflectance spectroscopy (UV-Vis DRS) and temperature programmed reduction with hydrogen (H<SUB>2</SUB> TPR) to investigate the physicochemical properties of V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalysts. In addition, the SCR reactivity of these catalysts was evaluated to obtain a structure-activity relationship. It was found that V<SUB>2</SUB>O<SUB>5</SUB>/TiO<SUB>2</SUB> catalysts prepared from the precursor solution of V<SUP>3+</SUP> oxidation state (VT(3+)) has good activity over wide temperature range and selective to N<SUB>2</SUB> production, respectively. Also, they produced the least amount of N<SUB>2</SUB>O during SCR reaction, which is beneficial from the view point of greenhouse gas emission. The superiority of low temperature Such desirable reaction behavior of the VT(3+) catalyst is attributed to the formation of highly coordinated polymeric vanadyl species on the sample.

白耕 金茂圭의 風流 硏究

具潤國(Koo Youn-Kook) 한국전통음악학회 2005 한국전통음악학 Vol.- No.6

필자가 1962년부터 국립국악원에 부임 이후 오늘날까지 절실히 느낀 점은 명인들이 세상을 떠나면 그 유품은 물론 귀중한 자료들도 같이 사라진다는 사실이었다. 그래서 시작한 것이 거문고 명인들의 유음이나 악보 등을 찾아야 되겠다는 일념으로 오늘에 이르고 있다. 생존해 있는 분들은 직접 녹음이나 비디오로 촬영을 하였고, 작고한 분들은 유음이나 악보 등을 구하려고 노력하였으나 얻은 것은 별로 없다. 지난날들이 그렇고, 지금도 우리민족의 정신이요 우리의 귀중한 문화유산이 이 땅에서 영원히 사라져 가고 있음은 실로 안타까운 일이 아닐 수 없다. 백경 김무규 선생은 일찌기 추산 전용선 선생께 단소풍류를 배워 후계 양성과 개인 발표도 하였으나 얼마나 원형대로 전수되었고 전승되고 있는지 필자는 잘 알지 못하고 있다. 또한 조선 정악전습소에서 우당 김윤덕에게 배운 거문고 풍류는 전승자가 없는 것으로 알고 있다. 조선 정악 전습소가 설립된 지 100년이 다 되어 가고 있지만 당시의 거문고 교수인 김경남, 조이순, 고익상, 김윤덕 등등… 이들의 가락은 물론, 이력사항, 생몰연대까지 찾을 수 없는 것이 현실이다. 한편 국악기의 개량, 국악의개선 국악의 현대화 등등이 물결치고 있는 것이 지금 국악계의 현실임을 간과할 수 없다. 그러나 이러한 상황을 인정하지 않는 것은 아니다. 다만 우리의 전통음악이 변질 되고 원형을 잃어 가는 현싯점에서 원형을 잃은 개량과, 개선 그리고, 현대화는 개악과 변질에 이르러 결국 국적 없는 음악으로 전락할 가능성이 높다는 것이 필자의 생각이다. 그리하여 늦었지만 닞혀진 옛 금사들의 유음을 다시 보존 전수해야한다는 일념에서 拙稿(졸고) “백경 김무규의 풍류 연구”라는 글을 쓰게 된 것이다. 풍류는 크게 2가지로 나눌 수 있다. 하나는 국립국악원 계통의 음악이고 또 하나는 정악원 계통의 음악이다. 국립국악원 계통의 풍류와 정악원 계통의 풍류는 서로 같거나 비슷한 것 같으나 상당부분 다른 점을 발견할 수 있다. 몇 가지 차이점만을 골라 보면 다음과 같다. 1) 악곡명은 다른 점이 별로 없고 비슷한 이름을 쓰는데 이는 같다고 보아진다. 2) 연주 순서는 현행 가진 회상과 같다. 3) 각 악곡별 악장 구분 및 악장의 각 수가 서로 다르다 4) 각 가락에서 음을 한음씩 나누어 비교해 보면 음이 서로 다른 경우가 많다. 5) 뜰동이 서로 다르고 출현회수도 다르게 내는 경우가 많다. 6) 정악원계통은 음을 생략하는 경우가 많은데 주로 동음 생략, 장2도 하행 생략, 그리고 단3도와 완전 4도 하행음의 생략이 많다. 7) 정악원 계통은 첨가음(잔가락)이 많은데 1)동음의 첨가 2)완전 4도 상행음과, 하행음 첨가 단3도, 장2도의 첨가 등을 들 수 있다. 8) 박의 한배가 다르다 국악원 계통이 1박을 낼 때 1/3을 낸다던가 2/3를 내는 경우 등등이다. 9) 리듬이 세분화되어 있는 경우가 많다. 10) 리듬에 있어 같은 음으로 구성되어 있거나 전연 다른 음으로 구성 된 경우가 많다. 11) 영산회상을 연주 할 때는 현행 다스름과 다른 21박정도의 다스름을 반드시 연주한다. 이상 국립국악원 계통의 풍류와 정악원 계통 풍류를 비교하여 본 결과 차이점이 많음을 발견 할 수 있다. 또한 같은 정악원 계통의 풍류라고 해도 지방에 따라 그 곡태가 다른데 중부지방과 전라도 지방의 차이가 바로 그것이다. 전라도 지방의 풍류는 그 흐름과 떠는음(bivrato) 농현 등에서 거의가 산조풍의 음악이라는 점이다.(초숙자, 경주 이말량) Since I have been appointed to Kungrip Kugawon (The National Center for Korean Traditional Performing Arts) in 1962, it makes my heart hurt to see after a master died, all their articles and precious things are disappeared with their death. That's why I decided to find the musical notes of the masters of Korean harp. So I took a photograph of living experts with sound recording and videotapes, also tried to get musical notes of past masters. But it wasn't that easy and I couldn't get satisfactory results. It makes me feel sorry to see disappearing all our cultural heritages which also means spirits of Nations in this country. Baekyoung Mu-Kyu Kim learned a short bamboo flute from Choosan Yong-Sun, Cheon and trained students and presented. But I don't know if it is being inherited well or not. Also Poongliu of Korean harp from Woodang Youn-Duck Kim in Chosun Classical Music Institute hasn't been taught anyone. About 100 years have passed after Chosun Classical Music Institute had found, but nowadays it is very hard to find their melodies, career and period of master Kyung-Nam Kim, E-Soon Cho, Ik-Sang Go, Youn-Duck Kim and so on.. In Korean Classical Music society, Korean Classical Music and instruments are developing and Korean Classical Music is being modernized. But if we lost our original form, the more we change our music the more our music will be in the state of disorder and chaos and lose nationality. In this reason I begin to write this “A Study on Poongliu of Baekyoung Mu-Kyu Kim”. Poongliu can be divided into two kinds. One is the kind of Kungrip Kugawon and the other is Jeongakwon. Both seem the same but there are some differences as followings : 1) Both of them use same names as the titles of musical compositions. 2) Both of them have the same performing order of the current Kazunhoesang. 3) However, dividing section and the numbers in each movement are different. 4) If analysing one note in terms of one beat, a lot of different notes are noticed. 5) ‘Teuldong’ is different and doesn't appear the same. 6) In Jeongakwon, a note is usually left out when it is the same note, the major 2degree one, the minor 3 degree one, or the perfect 4 degree one, etc. 7) In Jeongakwon, adds a note when it is the same note, the perfect 4 degree one, the minor 3 degree one, the major 2 degree one. 8) The length of one beat is different, too. 9) Rhythms are subdivided frequently. 10) Rhythms are made of same notes or entirely different notes. 11) When play Youngsanhoesang, play 21 beats surely. There are lots of differences between Kungrip Kugawon Poongliu and Jeongakwon Poongliu. Besides same kind of Kungrip Kugawon Poongliu differs from place to place ; Central province and Ch?lla-do province. Poongliu of Ch lla-do is kind of Sanjo style in each current and vibrato Nonghyun.

계속기업의 존속능력에 대한 평가

윤윤석 광운대학교 디지털경영연구소 2002 디지털 경영연구 Vol.8 No.-

계속기업은 근대회계의 기본전제의 하나이지만 경영자, 재무제표이용자, 감사인에게는 때에 따라 입장을 달리한다. 경영자는 기업의 존속을 위해 끝까지 노력하고, 재무제표이용자는 기업의 존속에 대한 보증 또는 도산의 조기경고정보를 기대하며, 감사인은 재무제표의 적성성에 대한 의견을 표명하려는 입장이므로 감사인은 경영자와 재무제표이용자 사이에서 사회적 기대갭에 직면하며 이러한 기대갭의 해소를 위해 노력해야 한다. 국제적으로 볼 때 1965년 전에는 공인회계사에 대한 소송이 거의 제기된 바 없다. 그러나 1960년대 후반부터 소송제기가 시작되어 1970년대 후반부터 1980년대에 소송이 급증하여 많은 손해배상 또는 화해금을 공인회계사가 부담하게 되었으므로 AICPA는 이에 대처하여 소위 기대갭에 관련된 9개의 SAS를 1988년에 발표하였다. SAS No.59는 이러한 과정에서 발표되었는데 이에 따라 재무제표강사를 직접적이고 능동적으로 수행하게 됨으로써 감사인의 책임이 확장되었다. 우리나라 계속기업의 존속능력에 대한 감사는 자율적으로 제도화된 것이 아니고 감사업무의 국제화에 따라 타율적으로 도입된 제도이다. 우리나라 기업의 존속능력 평가에 대한 선행연구는 외국의 도산예측모델을 이용한 것들이므로 우리나라 감사환경에 적합한 제도로 정착되기 위해서는 우리나라 감사환경에 맞는 실증적인 연구가 많이 이루어져야 할 것으로 본다. The purposes of this thesis are the evolution process of auditing shown in the on Auditing Standards (SAS) No.34 and No.59 to broaden understanding of auditors and people who work in the field auditing. The American Instititute of CPA's SAS issued SAS No.59 to better serve financial statement users by requring additors to evaluate going concern. Increasing public's concern about external audit is because of auditor's failures to modify their opinions for companies. Cohen commission and Treadway Commission were established to reconsider independent auditor's role in society. Both Commission's view of the independent auditor's role is an evaluator of financial information to financial statements reliability, not a provider of financial information. Going concern assumption is a basic assumption of accounting. Going concern evaluation is management's responsibility. An entity's management has direct responsibility to evaluate entity's ability to continue as a going concern, and the auditor has second responsibility. Framework showing relationship between bankruptcy process and degree of doubt about an entity's ability to continue as a going concern was reviewed. Framework about auditor's going concern evaluation was driven in view of risk base audit. The necessary projects of auditing are the reviewing of auditor's going concern evaluation, the reviewing of analytical procedures, and the deploying of framework about auditor's going concern evaluation.

非營利會計에 관한 硏究 : 政府會計, 學校法人會計, 病院會計의 評價 및 改善方案을 中心으로 Emphasis on Evaluation and Improvement of Governmental Accounting, Private School Accounting, Hospital accounting

윤윤석 光云大學校 1988 論文集 Vol.17 No.-

The purpose of this study is to evaluate and improve of governmental accounting, private school accounting and hospital accounting in Korea. In recent years, governments and other nonbusiness organizations have experienced dramatic growth and have emerged as major economic, political and social forces in our society. Nonbusiness accounting provides a wide range of services to the public. It is different from business accounting in that it does not seek to earn a profit. The profit motive is absent in nonbusiness accounting and its major reason for existence is to provide services. Financial reporting by nonbusiness accounting should provide information that is useful to present and potential resource providers and other users. Hence, the main purpose of the governmental accounting is to hold the accountability to provide with the financial resources in the procedure of the fund and budget circulation which happens in accordance with the requirements. The notable distinction of the governmental accounting is having budgetary accounting and fund accounting. Budgetary accounting has the budget cycle which used to empasis the periodity of the budget. In order to report on the stewarship responsibility, nonbusiness organizations must use a fund accounting which permits the segregation of restricted and nonrestricted assets. For the improvement of governmental accounting in Korea, it is necessary to establish the permanent and efficient committee, efficiently for the appropriation budget and budget public hearing system, to accomplish the middle period operation policy, to introduce double entry method, and to simplify the funds and special accounting. The accounting standard for private schools should include the important aspects of reliability and public interest. The following suggestion is provided to develop accounting standard for private schools of Korea. Private schools must adopt double entry book-keeping systems and recognition of depreciation on the fixed assets. The private school accounting system can be devided profit-making accounting and nonprofit-making accounting. Hospital; accounting considered its own characters and circumstances must be established because the purpose of hospital is the improvement of the national health and the social welfare. Therefore the stabilization and soundness of hospital finance is essential. Finally, in order to settle the rational accounting, continuous study should be accomplished in future, and this study should contribute to establishment of the nonbusiness accounting system.

國際的 租稅回避와 規制에 관한 硏究

윤윤석 光云大學校 1990 論文集 Vol.19 No.-

International tax avoidance has been a pervading economic and political issue in recent years. Under the contemporary economic environment in Korea, various researches on international tax avoidance are to be implemented. Korea requires the oversea business activities in advanced forms by opening the liaison offices, branch offices, subsidiary companies in foreign countries. Objectives of this study is to detect a probable way of tax avoidances in oversea business activities and searches for the alternatives of regulations to prevent tax avoidance. The types of international tax avoidance are transfer pricing, treaty shopping, tax havens. International double taxation is caused by conflicts of taxation laws between countries. Tax convention means the treaty concluded between two nations or multi-nations. The purpose of such a tax convention lies in solving disputes arising in taxation by taking close connections between the parties of the convention and preventing tax avoidance. It is the intent- ion of tax convention to adjust the competing taxation rights of the parties by concluding the tax convention and setting up international taxation regulations.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

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