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A Compound Isolated from Rumex japonicus Induces Early Growth Response Gene-1 Expression
Geunhyeong Jo,신순영,Younggiu Lee,Jiye Hyun,Kwang Sik Dong,Jun Cheol Park,Hyun Su Kim,이영한,임융호 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
A Peptide Produced by Pseudomonas tolaasi, Tolaasin Binds to Metal Ions
Geunhyeong Jo,Doseok Hwang,Yoonkyung Woo,Younggiu Lee,Yeonjoong Yong,강경래,Jiye Hyun,Young-Kee Kim,Dong-Woon Kim,Yoongho Lim 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
Brown blotch disease in mushrooms is caused by Pseudomonas tolaasin, which produces a peptide toxin, tolaasin I, and zinc ion inhibits the channel formed by tolaasin I. NMR experiments revealed that zinc, sodium, and calcium ions can bind to tolaasin I and their binding position on tolaasin I is the lactone ring.