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Mohd Zaidi Abd Rozan,Yoshiki Mikami 세종대학교 언어연구소 2007 Journal of Universal Language Vol.8 No.1
The widespread use of communication tools on the Internet has provided greater possibilities as well as increased flexibility for orthographic reforms. As a result, spellings have been established that are closely matched to written speech, which emulate verbal expression plus the elegant addition of letters from foreign languages. This study will look in particular at Evolutionized Malay (EM), which is cultivated on the Internet. Our analysis of EM reveals two principal functions: 1) EM words performed better in 130 Orthographic Reforms of Standard Malay Online displaying pronunciation properties and 2) EM words are able to form an environment we termed as Cross Language Environment (CLE). It may be that these roles hold a greater degree of attraction and motivates toward higher interaction within a cyberspace community. Surveys on the frequency of the occurrence of EM in the cyberspace of Malaysia are shown based on web forums and blogs pages. It is fascinating to see that EM has quite a substantial number of users throughout Malaysian cyberspace.
Shiho Kuji,Akira Endo,Manabu Kubota,Atsushi Uekawa,Fumi Kawakami,Yoshiki Mikami,Junki Koike,Nao Suzuki 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1
Objective: Previously, we reported that insulinoma-associated protein 1 (INSM1) immunohistochemistry (IHC) showed high sensitivity for neuroendocrine carcinoma of the uterine cervix and was an effective method for histopathological diagnosis, but that its specificity remained to be verified. Therefore, the aim was to verify the specificity of INSM1 IHC for a large number of non-neuroendocrine neoplasia (NEN) of the cervix. Methods: RNA sequences were performed for cell lines of small cell carcinoma (TCYIK), squamous cell carcinoma (SiHa), and adenocarcinoma (HeLa). A total of 104 cases of formalin-fixed and paraffin-embedded specimens, 16 cases of cervical NEN and 88 cases of cervical non-NEN, were evaluated immunohistochemically for conventional neuroendocrine markers and INSM1. All processes without antigen retrieval were performed by an automated IHC system. Results: The transcripts per million levels of INSM1 in RNA sequences were 1505 in TCYIK, 0 in SiHa, and HeLa. INSM1 immunoreactivity was shown only in the TCYIK. Immunohistochemical results showed that 15 cases of cervical NEN showed positive for INSM1; the positivity score of the tumor cell population and the stain strength for INSM1 were high. Two of the 88 cases of cervical non-NENs were positive for INSM1 in one case each of typical adenocarcinoma and squamous cell carcinoma. The sensitivity of INSM1 for cervical NEN was 94%; specificity, 98%; the positive predictive value, 88%; and the negative predictive value, 99%. Conclusion: INSM1 is an adjunctive diagnostic method with excellent specificity and sensitivity for diagnosing cervical NEN. Higher specificity can be obtained if morphological evaluation is also performed.
Ji Yon Agnes Jang,Nozomu Yanaihara,Eric Pujade-Lauraine,Yoshiki Mikami,Katsutoshi Oda,Michael Bookman,Jonathan Ledermann,Muneaki Shimada,Takako Kiyokawa,김병기,Noriomi Matsumura,Tsunehisa Kaku,Takafumi K 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4
There has been significant progress in the understanding of the pathology and molecular biologyof rare ovarian cancers, which has helped both diagnosis and treatment. This paper provides anupdate on recent advances in the knowledge and treatment of rare ovarian cancers and identifiesgaps that need to be addressed by further clinical research. The topics covered include: low-gradeserous, mucinous, and clear cell carcinomas of the ovary. Given the molecular heterogeneity andthe histopathological rarity of these ovarian cancers, the importance of designing adequatelypowered trials or finding statistically innovative ways to approach the treatment of these raretumors has been emphasized. This paper is based on the Rare Ovarian Tumors Conferencefor Young Investigators which was presented in Tokyo 2015 prior to the 5th Ovarian CancerConsensus Conference of the Gynecologic Cancer InterGroup (GCIG).