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- 저자 : Yatsuhashi, Hiroshi (검색결과 4 건)
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Natural Course of Hepatitis C Infection in Japan
Yano, KoJi,Yatsuhashi, Hiroshi,Yano, Michitami 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
The natural course of chronic hepatitis C can be classified into several phases. These phases include persistent phase, asymptomatic phase, and active or aggressive phase. Chronic persistent hepatitis progresses very slowly, if any. On the other hand, chronic aggressive hepatitis frequently develops liver cirrhosis soon. The difference between these two probably depends on the host immune system that is related to age, rather than the duration of infection. Our longitudinal study revealed that chronic persistent hepatitis often transforms to active or aggressive hepatitis at around the age of 45. Chronic persistent hepatitis progresses very slowly, if any. On the other hand, chronic aggressive hepatitis frequently develops liver cirrhosis soon. The difference between these two probably depends on the host immune system that is related to age. The unknown factor(s) that are related to the host immune system changes around 45 years of age. Our longitudinal study revealed that chronic persistent hepatitis often transforms to aggressive hepatitis around the age of 45. Accordingly, aging is one of the most important factors that contribute to LC and HCC development.
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Shichijo, Chizuko,Yatsuhashi, Hiroko,Hashimoto, Tohru Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
In broom sorghum, Sorghum bicolor Moench, UV causes anthocyanin synthesis having action peaks in UVA and UVB regions. We previously reported that UV induces anthocyanin synthesis through UVB photoreceptor and phytochrome activated by UV. Furthermore, UVA and UVB amplify phytochrome-induced anthocyanin synthesis (PIAS). Our action- spectroscopic research indicated that a UV -receptor for amplification of PIAS is likely to be the same or same type of UVB photoreceptor for induction of anthocyanin synthesis. UVA-amplification of PIAS can be explained by the action of a cryptic red light signal (CRS), an amplification factor for PIAS produced by a distinct phytochrome-species activated by UVA. We suggest that UVA photoreceptors are not involved in anthocyanin synthesis in the broom sorghum.
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( Hiroshi Yotsuyanagi ),( Hiroshi Yatsuhashi ),( Masayuki Kurosaki ),( Richard Zur ),( Steve Sherman ),( Mindie H. Nguyen ),( Sooji Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: CHB affects approximately 1% of the general population in Japan with higher prevalence in older people. This study aims to characterize the evolving CHB patient demographics and co morbidity burden in Japan as well as their changes over 2011- 2016. Methods: We used the Medical Data Vision (MDV) claims da tabase to identify patients =18 years with =1 ICD-10 codes for CHB (B18.1), having =1 HBsAg test and =1 HBeAg test, viral load test, or HB core antibody test. Patients were required to have continuous enrollment for 6 months prior and post index date (first date of CHB diagnosis) during 1/1/2011-12/31/2016. Patient demographic and comorbidity data was reported from 2011 to 2016. Results: A total of 13,639 patients met inclusion and exclusion criteria. Males made up 58% of patients in 2011 and decreased to 54% in 2016 (P<0.0001). The average age of patients was 60.7±13.1 years in 2011 and increased to 63.9±13.2 years in 2016 (P<0.0001). The proportion of the population over 65 increased from 42% in 2011 to 57% in 2016 (P<0.0001). The Charlson comorbidity index, an overall measure of patient co morbidity (covering 17 conditions), increased from 2.7 to 3.7 (P<0.0001) from 2011 to 2016. In 2016, 14% of CHB patients in Japan had diabetes (DM), 16% with nonalcoholic fatty liver disease, 5% with chronic kidney disease (CKD), and 9% with fragility (non-traumatic) bone fractures; all of which have in creased significantly from 2011 (all P<0.05) [Figure 1]. Similarly there was a high prevalence of comorbidities in 2016 such as hypertension (38%), renal impairment (20%), hyperlipidemia (19%), liver impairment (15%), and osteoporosis (9%), al though these did not show a significant increase over time. Conclusions: Between 2011 and 2016, the Japanese CHB population has aged (~80% =55) and are having more comor bidities, which may affect CHB management and should be considered in their treatment and monitoring.
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