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RISS 인기검색어
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- 저자 : Machijima, Hiraku (검색결과 1 건)
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Effect of Several Adsorbents on The Gastrointestinal Absorption of Paraquat
Machijima, Hiraku,Nakamura, Hiroyuki,Hatanaka, Tomomi,Sugibayashi, Kenji,Morimoto, Yasunori The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The effect of several adsorbents on paraquat poisohing was investigated (1) by measuring the saturatd amount of the poison adhered on the adsorbents in vitro and (2) by assaying the blood level of paraquat in the rat in in situ intestinal absorption experiments. Activated charcoal powder, natural aluminum silifonate) were used as adorbents. The steady-state blood level of paraquat in its absorption experiment with the cationic exchange resins was markedly lower than those without the resins or with other adsorbents. A good relationship was achieved between the calculated AUC or adsorptioin rate (in situ) and the saturated adsorption amount (in vitro). The rank order of the effect was sodium polystyene sulfonate > calcium polystyene sulfonate>natural aluminum silicate>activated charcoal powder. The effect of sodium polystyrene sulfonate after intestinal washing with physiological saline ws also measured, and a synergistic effect (marked decrease in blood paraquat level0 was found as compared with the intestinal washing alone. The simultaneous use of G.I. weshing and powerful adsorbent was scientifically proven to be most benefical.
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