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- 저자 : Kazuhisa Yamada (검색결과 2 건)
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Oku, Yusuke,Kurokawa, Kenji,Matsuo, Miki,Yamada, Sakuo,Lee, Bok-Luel,Sekimizu, Kazuhisa American Society for Microbiology 2009 Journal of Bacteriology Vol.191 No.1
<B>ABSTRACT</B><P>Lipoteichoic acid (LTA) is one of two anionic polymers on the surface of the gram-positive bacterium <I>Staphylococcus aureus</I>. LTA is critical for the bacterium-host cell interaction and has recently been shown to be required for cell growth and division. To determine additional biological roles of LTA, we found it necessary to identify permissive conditions for the growth of an LTA-deficient mutant. We found that an LTA-deficient <I>S. aureus</I> Δ<I>ltaS</I> mutant could grow at 30°C but not at 37°C. Even at the permissive temperature, Δ<I>ltaS</I> mutant cells had aberrant cell division and separation, decreased autolysis, and reduced levels of peptidoglycan hydrolases. Upshift of Δ<I>ltaS</I> mutant cells to a nonpermissive temperature caused an inability to exclude Sytox green dye. A high-osmolarity growth medium remarkably rescued the colony-forming ability of the Δ<I>ltaS</I> mutant at 37°C, indicating that LTA synthesis is required for growth under low-osmolarity conditions. In addition, the Δ<I>ltaS</I> mutation was found to be synthetically lethal with the Δ<I>tagO</I> mutation, which disrupts the synthesis of the other anionic polymer, wall teichoic acid (WTA), at 30°C, suggesting that LTA and WTA compensate for one another in an essential function.</P>
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Effects of Val-Pro-Pro and Ile-Pro-Pro on Nondipper Patients: A Preliminary Study
Mari Takahashi Kurosawa,Yasunori Nakamura,Naoyuki Yamamoto,Kazuhisa Yamada,Toshiro Iketani 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5
Much clinical evidence on the antihypertensive effects of the milk-derived antihypertensive peptides Val-Pro-Pro and Ile-Pro-Pro (lactotripeptides) has been reported. However, circadian rhythm effects determined by ambulatory blood pressure monitoring (ABPM) to eliminate the confounding influence of the white-coat effect have not been fully studied. Twelve hypertensive patients not receiving antihypertensive medication (2 men, 10 women; mean age±standard deviation, 63.5±8.3 years) who had been visiting our clinic for more than 1 year participated in this study. Mean (±standard deviation) systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 142.4±2.6 and 83.5±6.4 mm Hg, respectively, at the first office visit. After patients ingested a fermented milk product containing antihypertensive peptides (2.53 mg Val-Pro-Pro; 1.52 mg Ile-Pro-Pro) for more than 4 weeks, both office SBP and DBP were significantly reduced to a mean (±standard deviation) of 133.3±7.0 mm Hg and 76.5±8.4 mm Hg (P<.001 and P<.005 by paired t-test), respectively. The 24-hour SBP and DBP determined by ABPM were reduced from 127.3±2.4 and 78.7±2.3 mm Hg to 120.2±2.4 and 75.0±2.2 mm Hg (P<.001 and P<.05), respectively. Awake-time SBP (08:00–21:00), night-time SBP (0:00–05:00), and early-morning SBP (06:00–07:00) were reduced from 130.9±2.4 to 123.3±2.3 mm Hg, 118.7±2.9 to 113.2±3.4 mm Hg, and 132.8±4.3 to 122.4±3.9 mm Hg (by paired t-test: P<.001, P<.05, and P<.05), respectively. As seen with DBP measured by ABPM, 24-hour DBP and awake-time DBP were significantly reduced from 78.7±2.3 to 75.0±2.2 mm Hg and 82.1±2.5 to 77.3±2.2 mm Hg (P<.05 and P<.01), respectively. Office BP and 24-hour blood pressure did not significantly differ between the dipper and nondipper groups at baseline. However, after treatment, night-time and early-morning blood pressure were significantly reduced from baseline in the nondipper group (−8.5±2.5 and −15.6±3.7 mm Hg; P<.05 and P<.01, respectively) but not in the dipper group (−2.5±3.6 and −1.2±4.7 mm Hg; P not significant), and the reduction in early-morning blood pressure significantly differed between the groups (P<.05). These results suggest that Val-Pro-Pro and Ile-Pro-Pro decrease blood pressure in patients with stage I hypertension and result not only in lower blood pressure at night-time but also in lower early-morning SBP in nondipper patients.
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