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채희주,Hee-Ju Chae,Yasuhiro Koike 대한화학회 1989 대한화학회지 Vol.33 No.4
완전히 불순물을 제거한 투명한 polymethylmethacrylate(PMMA)의 prerod를 제조하여 연속 열연신하여 얻은 플라스틱 섬유의 연신온도($T_d$)에 따른 굴절율, 굴절율분포, 복굴절율 및 전송손실율을 측정하였다. $T_d$가 높을수록 다소 낮은 굴절율을 보였으나, 섬유의 중심에서 주변으로 감에 따른 굴절율분포는 오히려 낮은 $T_d$에서가 현저했고, 높은 $T_d$에서는 주변에서만 급격한 굴절율의 강하를 보였다. 또한 $T_d$가 220$^{\circ}C$ 미만에서는 복굴절을 ${\Delta}$n = $5{sim}6{\times}10^{-4}$을 보이고 그 보다 높은 온도의 $T_d$에서는 이러한 현상이 나타나지 않았다. Attenuation은 높은 $T_d$일수록 낮은 값을 보였다. The refractive index, refractive-index distribution, birefringence, and the attenuation of the plastic fiber prepared from the transparent PMMA prerod were measured in accordance with continuous heat drawing temperature($T_d$). The refractive indices were decreased with $T_d$ elevation but the refractive-index distribution from the center of fiber to periphery was higher at lower $T_d$. The steep decrease of gradient index was only at the periphery of higher $T_d$. Birefringence was observed only below $220^{\circ}C$ and ranged $5{\times}10^{-4}$ to $6{\times}10^{-4}$. No birefringence was observed above $220^{\circ}C$. An elevation of $T_d$ brought about a monotonous decrease in the attenuation of the fiber.
Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy
Takashi Miwa,Mitsuro Kanda,Chie Tanaka,Daisuke Kobayashi,Masamichi Hayashi,Suguru Yamada,Goro Nakayama,Masahiko Koike,Yasuhiro Kodera 대한위암학회 2019 Journal of gastric cancer Vol.19 No.2
Purpose: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods: We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results: Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08–20.1; cutoff value, –2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69–7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33–45.8; P=0.002). Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.
Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy
Miwa, Takashi,Kanda, Mitsuro,Tanaka, Chie,Kobayashi, Daisuke,Hayashi, Masamichi,Yamada, Suguru,Nakayama, Goro,Koike, Masahiko,Kodera, Yasuhiro The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.2
Purpose: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods: We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results: Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08-20.1; cutoff value, -2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69-7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33-45.8; P=0.002). Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.