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      • Impedance Coordinative Control for Cascaded Converter in Bidirectional Application

        Yanjun Tian,Fujin Deng,Zhe Chen,Xiaofeng Sun,Yanting Hu 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

        Two stage cascaded converters are widely used in bidirectional applications, but the negative impedance may cause system instability. Actually the impedance interaction is much different between forward power flow and reversed power flow, which will introduce more uncertainty to the system stability. This paper proposes a control method for the constant power controlled converter in cascaded system, and consequently it can change the negative impedance of constant power converter into resistive impedance, which will improve the cascaded system stability, as well as merge the impedance difference between forward and reversed power flow. This paper addresses the analysis with the topology of cascaded dualactive - bridge converter (DAB) with inverter, and the proposed control method can also be implemented in unidirectional applications and other general cascaded converter system. The effectiveness has been validated by both simulation and experimental results.

      • Impedance Interaction Modeling and Analysis for Bidirectional Cascaded Converters

        Yanjun Tian,Fujin Deng,Zhe Chen,Xiaofeng Sun,Yanting Hu 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

        For the cascaded converter system, the output impedance of source converter interacts with the input impedance of load converter, and the interaction may cause the system instability. In bidirectional applications, when the power flow is reversed, the impedance interaction also varies, which brings more uncertainty to the system stability. An investigation is performed here for showing that the forward and reverse interactions are prominently different in terms of dynamics and stability even though the cascaded converter control remains unchanged. An important guideline has been drawn for the control of the cascaded converter. That is when voltage mode converter working as the load converter; the constant power mode converter as the source converter, the system is more stable. The concluded findings have been verified by simulation and experimental results.

      • KCI등재

        Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling

        Li, Aiguo,Yang, Libin,Geng, Xiaolin,Peng, Xingmei,Lu, Tan,Deng, Yanjun,Dong, Yuzheng Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.11

        Rheumatoid arthritis is a chronic inflammatory disease that leads to bone and cartilage erosion. The inhibition of osteoblast differentiation by the inflammatory factor TNF-${\alpha}$ is critical for the pathogenesis of rheumatoid arthritis. To modulate TNF-${\alpha}$ mediated inhibition of osteoblast differentiation is required to improve therapeutic efficacy of rheumatoid arthritis. Here, we explored the potential role of rocaglamide-A, a component of Aglaia plant, in osteoblast differentiation. Rocaglamide-A prevented TNF-${\alpha}$ mediated inhibition of osteoblast differentiation, and promoted osteoblast differentiation directly, in both C2C12 and primary mesenchymal stromal cells. Mechanistically, Rocaglamide-A inhibited the phosphorylation of NF-${\kappa}B$ component p65 protein and the accumulation of p65 in nucleus, which resulted in the diminished NF-${\kappa}B$ responsible transcriptional activity. Oppositely, overexpression of p65 reversed rocaglamide-A's protective effects on osteoblast differentiation. Collectively, rocaglamide-A protected and stimulated osteoblast differentiation via blocking NF-${\kappa}B$ pathway. It suggests that rocaglamide-A may be a good candidate to develop as therapeutic drug for rheumatoid arthritis associated bone loss diseases.

      • KCI등재

        Rocaglamide-A Potentiates Osteoblast Differentiation by Inhibiting NF-κB Signaling

        Aiguo Li,Libin Yang,Xiaolin Geng,Xingmei Peng,Tan Lu,Yanjun Deng,Yuzheng Dong 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.11

        Rheumatoid arthritis is a chronic inflammatory disease that leads to bone and cartilage erosion. The inhibition of osteoblast differentiation by the inflammatory factor TNF-α is critical for the pathogenesis of rheumatoid arthritis. To modulate TNF-α mediated inhibition of osteoblast differentiation is required to improve therapeutic efficacy of rheumatoid arthritis. Here, we explored the potential role of rocaglamide-A, a component of Aglaia plant, in osteoblast differentiation. Rocaglamide-A prevented TNF-α mediated inhibition of osteoblast differentiation,and promoted osteoblast differentiation directly,in both C2C12 and primary mesenchymal stromal cells. Mechanistically, Rocaglamide- A inhibited the phosphorylation of NF-κB component p65 protein and the accumulation of p65 in nucleus, which resulted in the diminished NF-κB responsible transcriptional activity. Oppositely, overexpression of p65 reversed rocaglamide-A’s protective effects on osteoblast differentiation. Collectively, rocaglamide-A protected and stimulated osteoblast differentiation via blocking NF-κB pathway. It suggests that rocaglamide-A may be a good candidate to develop as therapeutic drug for rheumatoid arthritis associated bone loss diseases.

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