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Yang Jingyu,Si Hailong,Dong Bo,Qin Qin 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
Purpose Endothelial progenitor cells (EPCs) have been revealed to interventions in atherosclerosis (AS) progressions. Traditional Chinese medicines (TCMs) have been discovered to modulate the functions of EPCs. Herein, effects of allicin on EPCs were explored in coronary atherosclerosis (CAS). Methods Allicin (5 or 10 mg/kg/d) was used to treat the ApoE−/− mice fed with high-fat diet (HFD. TC, TG, LDL-C, and HDL-C were examined. HE staining was applied for observation of CAS lesions. In vitro, EPCs were induced by ox-LDL and then treated with allicin and an eNOS inhibitor, L-NAME. Thereafter, the cell viability, apoptosis and migration were examined using CCK-8, flow cytometry and Transwell methods. Western blot was applied for evaluating eNOS, Nrf2 and HO-1 protein expression. NO production, MDA content, and SOD activity were also measured. Results Allicin inhibited CAS progression, decreased serum levels of TC, TG, and LDL-C but increased HDL-C. Moreover, counts of circulating EPCs, and the protein levels of eNOS, Nrf2 and HO-1 were increased by allicin treatment in mice fed with HFD. Allicin suppressed MDA contents but enhanced SOD activities. In vitro, allicin reversed the impacts of ox-LDL induction in EPCs, facilitating cell mobility and NO production, and decreasing apoptosis. L-NAME treatment reversed effects of allicin. Conclusion Allicin alleviated CAS progressions in mice, modulating the cell apoptosis and migration of EPCs via eNOS/ Nrf2/HO-1 pathway.
Research Progress of the Structure Vibration-Attitude Coordinated Control of Spacecraft
Yang, Jingyu,Qu, Shiying,Lin, Jiahui,Liu, Zhiqi,Cui, Xuanming,Wang, Chu,Zhang, Dujiang,gu, Mingcheng,Sun, Zhongrui,Yang, Kang,Zhou, Lanwei,Chen, Guoping The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
This paper gives an overview of research on the field of structure vibration-attitude coordinated control of spacecraft. First of all, the importance of the technology has been given an introduction, and then later the research progress of space structure dynamics modeling, research progress of structure vibration-attitude coordinated control of flexible spacecraft have been discussed respectively. Finally, future research on application of structure vibration-attitude coordinated control of spacecraft has been recommended.
Experimental Study of Adaptive Sliding Mode Control for Vibration of a Flexible Rectangular Plate
Yang, Jingyu,Liu, Zhiqi,Cui, Xuanming,Qu, Shiying,Wang, Chu,Lanwei, Zhou,Chen, Guoping The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.1
This paper aims to address the intelligent active vibration control problem of a flexible rectangular plate vibration involving parameter variation and external disturbance. An adaptive sliding mode (ASM) MIMO control strategy and smart piezoelectric materials are proposed as a solution, where the controller design can deal with problems of an external disturbance and parametric uncertainty in system. Compared with the current 'classical' control design, the proposed ASM MIMO control strategy design has two advantages. First, unlike existing classical control algorithms, where only low intelligence of the vibration control system is achieved, this paper shows that high intelligent of the vibration control system can be realized by the ASM MIMO control strategy and smart piezoelectric materials. Second, the system performance is improved due to two additional terms obtained in the active vibration control system. Detailed design principle and rigorous stability analysis are provided. Finally, experiments and simulations were used to verify the effectiveness of the proposed strategy using a hardware prototype based on NI instruments, a MATLAB/SIMULINK platform, and smart piezoelectric materials.
Yang Mi,Jingyu Wang,Jinfeng Wu,Xiaopeng Wang,Bin Yang,Ruimin Ren,Yangang Zhang,Xiaobin Yuan,Xuhui Zhang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1
Purpose: Bulbar injury is the most common type of urethral injury. This study investigated the efficacy and safety of a novel technique, local urethral flushing, in preventing stricture formation after blunt bulbar urethra injuries. Materials and Methods: This retrospective study included 205 males diagnosed with straddle injury-induced bulbar urethra injury at the Shanxi Bethune Hospital and First Hospital of Shanxi Medical University between January 2015 and January 2019. Patients were diagnosed by retrograde urethrography and classified as partial or complete urethral rupture according to the urethral integrity after injury. Complete urethral rupture patients received suprapubic cystostomy and received urethroplasty 3 months later. Patients with partial urethral rupture underwent endoscopic urethral realignment by cystoscopic guide-wire guided catheterization. Patients with both injury types were divided into 3 groups. The treatment groups received urethral flushing with 0.05% dexamethasone through a secondary ureteral catheter that locked at the urethral lesion. The blank control groups received normal saline. The negative control groups had only a single ureteral catheter placed. Patients were assessed for pain during catheterization, infection, and stenosis, and followed for at least 2 years. Results: Stenosis rates and length were significantly reduced in the normal saline groups, and even further reduced in the dexamethasone groups. The negative control groups had significantly higher infection rates than patients in the dexamethasone or saline groups. Conclusions: Local urethral flushing with dexamethasone could significantly decrease urethral stenosis rates and severity without increasing patients’ discomfort or infection risk.
Experimental Study of Adaptive Sliding Mode Control for Vibration of a Flexible Rectangular Plate
Jingyu Yang,Zhiqi Liu,Xuanming Cui,Shiying Qu,Chu Wang,Zhou Lanwei,Guoping Chen 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.1
This paper aims to address the intelligent active vibration control problem of a flexible rectangular plate vibration involving parameter variation and external disturbance. An adaptive sliding mode (ASM) MIMO control strategy and smart piezoelectric materials are proposed as a solution, where the controller design can deal with problems of an external disturbance and parametric uncertainty in system. Compared with the current ‘classical’ control design, the proposed ASM MIMO control strategy design has two advantages. First, unlike existing classical control algorithms, where only low intelligence of the vibration control system is achieved, this paper shows that high intelligent of the vibration control system can be realized by the ASM MIMO control strategy and smart piezoelectric materials. Second, the system performance is improved due to two additional terms obtained in the active vibration control system. Detailed design principle and rigorous stability analysis are provided. Finally, experiments and simulations were used to verify the effectiveness of the proposed strategy using a hardware prototype based on NI instruments, a MATLAB/SIMULINK platform, and smart piezoelectric materials.
Hybrid RCD-WTA Multiplexer for MR-compatible PET Detector
Jingyu Yang,Minho Lee,Jihoon Kang 한국자기학회 2020 Journal of Magnetics Vol.25 No.4
A hybrid multiplexer readout circuit one dimensional resistive charge division (1D-RCD) chain and winner takes all (WTA) circuit was proposed for MR-compatible PET detector modules. To prove the effectiveness of the circuit, three different readout circuits including WTA, 2D-RCD and proposed hybrid RCD-WTA multiplexer were evaluated for 4 × 4 LYSO-GAPD PET detector. Various parameters were precisely measured and quantitatively characterized. While there were considerable differences observed in rise time, fall time, pulse width and amplitude of analog output waveforms for each circuit, the detector performance was quite similar in crystal identification and energy resolution. However, pincushion distortion was observed in the flood histogram of 2D-RCD, and spatial linearity was relatively degraded. The coincidence time resolutions were 487 ps, 955 ps, and 676 ps for WTA, 2D-RCD, and hybrid RCD-WTA multiplexer, respectively. These results demonstrated that proposed hybrid multiplexer could effectively reduce the number of analog electronic channels from N² to only 2 for an N × N photosensor array, while maintaining intrinsic performance of multichannel PET detector requiring energy, position and time information for incidence photons.
Coupled Structure Vibration–Attitude Dynamics Evolution and Control of China’s Space Station
Jingyu Yang,Fei Liu 한국항공우주학회 2019 International Journal of Aeronautical and Space Sc Vol.20 No.1
In this paper, a dynamics equation for Spacecraft has first been created using vector mechanics. Second, several attitude dynamics equations of spacecraft have been deduced. Third, a simulation of the coupled structure vibration–attitude dynamics evolution of China Space Station has been researched. Simulation results reveal the generating mechanism and evolutive law of the coupled structure vibration–attitude dynamics of spacecraft. Finally, a simplified experimental platform has been set up, and the experimental results verify the structure vibration–attitude dynamics evolution of the spacecraft and proposed experimental setup.
Research Progress of the Structure Vibration-Attitude Coordinated Control of Spacecraft
Jingyu Yang,Shiying Qu,Jiahui Lin,Zhiqi Liu,Xuanming Cui,Chu Wang,Dujiang Zhang,Mingcheng gu,Zhongrui Sun,Kang Yang,Lanwei Zhou,Guoping Chen 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
This paper gives an overview of research on the field of structure vibration-attitude coordinated control of spacecraft. First of all, the importance of the technology has been given an introduction, and then later the research progress of space structure dynamics modeling, research progress of structure vibration-attitude coordinated control of flexible spacecraft have been discussed respectively. Finally, future research on application of structure vibration-attitude coordinated control of spacecraft has been recommended.