Solutions of a Generalized Anharmonic Oscillatory Noncentral Potential in Higher Spatial Dimensions

Ya Bai,Min-Cang ZHANG 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.71 No.5

A generalized anharmonic oscillatory noncentral potential is presented and the D-dimensional Schr¨odinger equation for this noncentral potential is examined in hyperspherical coordinates. The Nikiforov-Uvarov (N-U) method is applied to obtain the D-dimensional energy eigenvalues and the corresponding eigenfunctions. The angular/radial wavefunction is expressed in terms of Jacobi/ Laguerre polynomials. Some special cases of this potential model including the Quesne potential and the ring-shaped non-spherical harmonic oscillatory (RNHO) potential are discussed also.

유기용제용 시료채취기 개발을 위한 활성탄 성능검정에 관한 연구

배야성 ( Ya Soung Bai ),박두용 ( Doo Young Park ),임대성 ( Dai Soung Lim ),박병무 ( Byung Moo Park ) 한국산업위생학회 2005 한국산업보건학회지 Vol.15 No.1

Adsorption capacity for the charcoal were tasted in this study to verify the performance of them for the use of the sampling media in industrial hygiene field. Two set of experiments were conducted. The first experiment was to test performance of the tested charcoal tube that were assembled in the laboratory with the use of the GR grade charcoal. The other tests were investigate the adsorption capacity of the charcoal tested in this study and charcoals embedded in the commercial charcoal tubes. Known air concentration samples for benzene, toluene, and o-xylene were prepared by the dynamic chamber. 1. At low air concentration levels (0.1×TLV), there was no significant differences between the tested charcoal tubes and the SKC charcoal tubes. This implies that there is no defect with the adsorption capacity of the charcoal. 2. At high concentration with 60 minutes sampling, the breakthrough were found only in the tested charcoal while no breakthrough were shown in the SKC charcoal. 3. From the breakthrough tests for the charcoal, the micropore volume(Wo) were calculated by the curve fitting with the use of Dubinin/Radushkevich(D/R) adsorption isotherm equation. The calculated values were 0.687cc/g for SKC, 0.504cc/g for Sensidyne, and 0.419cc/g for the tested charcoal(Aldrich). 4. Adsorption capacities were obtained from the isotherm curves shown adsorption capacities at several levels of the challenge concentration. All range of the air concentration concerned in industrial hygiene, the SKC charcoal showed approximately two times of adsorption capacity compared to the tested charcoal.

Holographic charged fluid with anomalous current at finite cutoff surface in Einstein-Maxwell gravity

Bai, Xiaojian,Hu, Ya-Peng,Lee, Bum-Hoon,Zhang, Yun-Long Springer-Verlag 2012 Journal of high energy physics Vol.2012 No.11

Soluble Epoxide Hydrolase Inhibitory and Anti-inflammatory Components from the Leaves of <i>Eucommia ulmoides</i> Oliver (Duzhong)

Bai, Meng-Meng,Shi, Wei,Tian, Jun-Mian,Lei, Ming,Kim, Jang Hoon,Sun, Ya Nan,Kim, Young Ho,Gao, Jin-Ming American Chemical Society 2015 Journal of agricultural and food chemistry Vol.63 No.8

<P><I>Eucommia ulmoides</I> leaves have been used as a functional food and drink in China. The purpose of this study was to identify the bioactive constituents with soluble epoxide hydrolase (sEH) inhibitory activity and anti-inflammatory properties. Twenty-seven known compounds (<B>1</B>–<B>27</B>) were isolated from the leaves of <I>E. ulmoides</I> Oliver, and their structures were identified by NMR and ESIMS analysis; three of these, 2,5-dimethoxy-3-glucopyranosyl cinnamic alcohol (<B>11</B>), foliasalacioside E<SUB>2</SUB> (<B>26</B>), and icariside F<SUB>2</SUB> (<B>27</B>), were obtained from this plant for the first time. Compounds <B>1</B>–<B>7</B> exhibited soluble epoxide hydrolase (sEH) inhibitory activity at 100 μM; among them, quercetin (<B>1</B>) and kaempferol (<B>5</B>) displayed potential activities with IC<SUB>50</SUB> values of 22.5 ± 0.9 and 31.3 ± 2.6 μM, respectively, with noncompetitive inhibition mode. Nuclear factor kappa B (NF-κB) inhibitory activity of the isolated compounds was evaluated by the NF-κB liciferase assay in HepG2 cells. Compounds <B>1</B>, <B>9</B>, <B>20</B>, and <B>27</B> displayed potent NF-κB inhibitory effects, with IC<SUB>50</SUB> values of 15.14 ± 2.29, 15.23 ± 2.34, 16.88 ± 2.17, and 16.25 ± 2.19 μM, respectively, whereas other compounds showed weak inhibition of NF-κB transcriptional activity ranging from 17.54 to 92.6 μM. A structure–activity relationship of flavonoids <B>1</B>–<B>9</B> was also discussed. The results obtained in this work might contribute to the understanding of pharmacological activities of <I>E. ulmoides</I> leaves and further investigation on its potential application values for food and drug.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2015/jafcau.2015.63.issue-8/acs.jafc.5b00055/production/images/medium/jf-2015-00055j_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf5b00055'>ACS Electronic Supporting Info</A></P>

Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review

Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3

Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.

Verification of the Correlation between Progression-free Survival and Overall Survival Considering Magnitudes of Survival Post-progression in the Treatment of Four Types of Cancer

Liu, Li-Ya,Yu, Hao,Bai, Jian-Ling,Zeng, Ping,Miao, Dan-Dan,Chen, Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Background: With development and application of new and effective anti-cancer drugs, the median survival post-progression (SPP) is often prolonged, and the role of the median SPP on surrogacy performance should be considered. To evaluate the impact of the median SPP on the correlation between progression-free survival (PFS) and overall survival (OS), we performed simulations for treatment of four types of cancer, advanced gastric cancer (AGC), metastatic colorectal cancer (MCC), glioblastoma (GBM), and advanced non-small-cell lung cancer (ANSCLC). Materials and Methods: The effects of the median SPP on the statistical properties of OS and the correlation between PFS and OS were assessed. Further, comparisons were made between the surrogacy performance based on real data from meta-analyses and simulation results with similar scenarios. Results: The probability of a significant gain in OS and HR for OS was decreased by an increase of the SPP/OS ratio or by a decrease of observed treatment benefit for PFS. Similarly, for each of the four types of cancer, the correlation between PFS and OS was reduced as the median SPP increased from 2 to 12 months. Except for ANSCLC, for which the median SPP was equal to the true value, the simulated correlation between PFS and OS was consistent with the values derived from meta-analyses for the other three kinds of cancer. Further, for these three types of cancer, when the median SPP was controlled at a designated level (i.e., < 4 months for AGC, < 12 months for MCC, and <6 months for GBM), the correlation between PFS and OS was strong; and the power of OS reached 34.9% at the minimum. Conclusions: PFS is an acceptable surrogate endpoint for OS under the condition of controlling SPPs for AGC, MCC, and GBM at their limit levels; a similar conclusion cannot be made for ANSCLC.

Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

( Xiao Zhao ),( Ya-juan Cui ),( Sha-sha Bai ),( Zhi-jie Yang ),( Miao-cai ),( Sarah Megrous ),( Tariq Aziz ),( Abid Sarwar ),( Dong Li ),( Zhen-nai Yang ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.8

Casein-derived antioxidant peptides by using microbial proteases have gained increasing attention. Combination of two microbial proteases, Protin SD-NY10 and Protease A “Amano” 2SD, was employed to hydrolyze casein to obtain potential antioxidant peptides that were identified by LC-MS/MS, chemically synthesized and characterized in a oxidatively damaged HepG2 cell model. Four peptides, YQLD, FSDIPNPIGSEN, FSDIPNPIGSE, YFYP were found to possess high 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ability. Evaluation with HepG2 cells showed that the 4 peptides at low concentrations (< 1.0 mg/ml) protected the cells against oxidative damage. The 4 peptides exhibited different levels of antioxidant activity by stimulating mRNA and protein expression of the antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), as well as nuclear factor erythroid-2-related factor 2 (Nrf2), but decreasing the mRNA expression of Kelch-like ECH-associated protein 1 (Keap1). Furthermore, these peptides decreased production of reactive oxygen species (ROS) and malondialdehyde (MDA), but increased glutathione (GSH) production in HepG2 cells. Therefore, the 4 casein-derived peptides obtained by using microbial proteases exhibited different antioxidant activity by activating the Keap1-Nrf2 signaling pathway, and they could serve as potential antioxidant agents in functional foods or pharmaceutic preparation.

Bone Morphogenetic Protein 9 Overexpression Reduces Osteosarcoma Cell Migration and Invasion

Zilan Lv,Ya-guang Weng,Dandan Yang,Jie Li,Min Hu,Min Luo,Xiaoqin Zhan,Peipei Song,Chen Liu,Huili Bai,Baolin Li,Yang Yang,Yingying Chen,Qiong Shi 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2

Transforming growth factor- (TGF-) is known to pro-mote tumor migration and invasion. Bone morphogenetic proteins (BMPs) are members of the TGF- family expressed in a variety of human carcinoma cell lines. The role of bone morphogenetic protein 9 (BMP9), the most powerful osteogenic factor, in osteosarcoma (OS) progression has not been fully clarified. The expression of BMP9 and its receptors in OS cell lines was analyzed by RT-PCR. We found that BMP9 and its receptors were expressed in OS cell lines. We further investigated the influence of BMP9 on the biological behaviors of OS cells. BMP9 overexpression in the OS cell lines 143B and MG63 inhibited in vitro cell migration and invasion. We further investigated the ex-pression of a panel of cancer-related genes and found that BMP9 overexpression increased the phosphorylation of Smad1/5/8 proteins, increased the expression of ID1, and reduced the expression and activity of matrix metalloproteinase 9 (MMP9) in OS cells. BMP9 silencing induced the opposite effects. We also found that BMP9 may not affect the chemokine (C-X-C motif) ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) axis to regulate the invasiveness and metastatic capacity of OS cells. Interestingly, CXCR4 was expressed in both 143B and MG63 cells, while CXCL12 was only detected in MG63 cells. Taken together, we hypothesize that BMP9 inhibits the migration and invasiveness of OS cells through a Smad-dependent pathway by downregulating the expression and activity of MMP9.

Direct Determination of Uric Acid in Human Serum Samples Using Polypyrrole Nanoelectrode Ensembles

Guangming Yang,Lin Tan,Ya Shi,Suiping Wang,Xuxiao Lu,Huiping Bai,Yunhui Yang 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.2

Polypyrrole (PPy) nanotubes have been synthesized by chemical oxidative polymerization of pyrrole within the pores of polycarbonate membrane using the technology of diffusion of solutes. The nanotubes array prepared by the proposed method can be considered as nanoelectrode ensembles (NEEs). An amperometric uric acid sensor based on PPy NEEs has been developed and used for determination of uric acid in human serum samples. The electrode can direct response to uric acid at potential of 0.60V vs. SCE with wide linear range of 1.52×10-6 to 1.54×10-3 M. The detection limit is 3.02×10-7 M. This sensor has been used to determine uric acid in real serum samples. PPy NEEs is thought of as a good application in the foreground.

Recyclable Fe3O4/Au Nanocomopsites for Oxidation Degradation of Methylene Blue in Near Neutral Solution

Yan Xing,Xiao-Hui Bai,Ming-Li Peng,Xiang-Rong Ma,Norbert Buske,Ya-Li Cui 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.10

Fe3O4/Au nanocomopsites (Fe3O4/Au NPs) with much improved catalytic activity were successfully fabricated through a simple seed growth method in aqueous solution. The petal-like structure, high saturation magnetization, the negatively charged sodium citrate-stabilized Fe3O4/Au NPs was characterized by transmission electron microscopy (TEM), X-ray diffractometer (XRD), dynamic light scattering (DLS) and vibrating sample magnetometry (VSM). The activated-H2O2 ability of Fe3O4/Au NPs was evaluated by using methylene blue (MB) as a cationic phenothiazines dye to be degraded in near neutral solution. The results showed Fe3O4/Au NPs removed over 95% MB from an aqueous solution within 60 min under the optimum conditions. The apparent rate constant of Fe3O4/Au NPs was 10.8 x 10 -2 min -1 which was 43.2 and 8.3 times higher than pure Fe3O4 (2.5 x 10 -3 min -1) and Au (1.3 x 10 -2 min -1) NPs. The enhanced catalytic activity and increased oxidation rate constant probably owing to the synergistic effect between Fe3O4 and Au NPs to activate H2O2 generate a large amount of strong oxidizing species, such as ·OH. In addition, nanocrystalline structure of Fe3O4/Au NPs was also very important to the peroxidase-like effect, especially the interaction interface between Fe3O4 and Au NPs. Moreover, Fe3O4/Au NPs was stable and could be regenerated and reused for at least five cycles.