Controlled pH- and glucose-responsive drug release behavior of cationic chitosan based nano-composite hydrogels by using graphene oxide as drug nanocarrier

Xiaowen Zhao,Xue Zou,Lin Ye 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.49 No.-

To realize tight control of hyperglycemia for diabetic patients, cationic chitosan (HTCC) based nanocompositehydrogels were prepared by using graphene oxide (GO) as nano-carrier for the model drug(bovine serum albumin, BSA). BSA intercalated into the layers of GO and the intercalation process wasmainly driven by the mutual electrostatic interaction. By introducing GO-BSA, a more compact GOcenterednetwork structure formed for the hydrogel. Compared with HTCC/BSA, HTCC/2.0wt%GO-BSAhydrogels exhibited a more distinct pH-/glucose-sensitivity and a much lower initial burst release, whichwas attributed to the compact structure and strong interactions among HTCC, GO and BSA in the hydrogelsystem

Design of On-line Monitoring System for Intelligent Package Substation based on WSN and GPRS

Xiaowen Wang,Zhanguo Xia,Yan Zhao,Xuan Fu 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.8

An idea of applying wireless sensor network and GPRS to intelligent package substation on-line monitoring system is brought to light in this paper. Network schemes of intelligent package substation are given based on wireless sensor network and GPRS. The detailed analysis has also been made on some key technologies. At the same time, the combination of special CT and accumulators is adopted to solve the power supply shortage of sensor nodes effectively. To reduce the routing hops and improve the transmission efficiency, the two-layer and three-cluster of network structure is used. Finally, the on-line monitoring system of transformer room is taken as an example, it is discussed how to obtained optimal layout of sensor nodes. The paper also points out which can be taken as the research focus in the future such as intellectualized reconstruction of package substation, network security and clock synchronization.

Mass transfer and kinetics study on the sulfite forced oxidation with manganese ion catalyst

Zhao Bo,Li Yan,Zhuo Yuqun,Tong Huiling,Zhang Xiaowen,Chen Changhe 한국화학공학회 2007 Korean Journal of Chemical Engineering Vol.24 No.3

limestone scrubbing is the most common flue gas desulfurization process (FGD) for control of sulfurdioxide emissions from the combustion of fossil fuels. Forced oxidation, which controls the overall reaction of the sulfurdioxide absorption, is the key path of the process. Manganese which comes from the coal is one of the catalysts duringthe forced oxidation process. In the present work, the two-film theory was used to analyze the sulfite forced oxidationreaction with an image boundary recognition technique, and the oxidation rate was experimentally studied by contactingpure oxygen with a sodium sulfite solution. There was a critical sulfite concentration 0.328 mol/Lwithout catalyst ortion constant k; furthermore, we obtained the order with respect to the sulfite and Mn2+ concentrations. When the Mn2+catalyst concentration was kept unchanged, the sulfite oxidation reaction rate was controlled by dual film and the reac-tion kinetics was first order with respect to sulfite while concentration was below 0.328 mol/L; the sulfite oxidationreaction rate was controlled by gas film only and the reaction kinetics was zero order with respect to sulfite while concentration over 0.328 mol/L. When concentration was kept unchanged, the sulfite oxidation reaction rate de-pended on gas-liquid mass transfer and the reaction kinetics was diferent in various stages with respect to Mn2+ con-centrations.

A Time-Enhanced Topic Clustering Approach for News Web Search

Jie Zhao,Xiaowen Li,Peiquan Jin 보안공학연구지원센터 2012 International Journal of Database Theory and Appli Vol.5 No.4

Preparation and drug release behavior of pH-responsive bovine serum albumin-loaded chitosan microspheres

Xue Zou,Xiaowen Zhao,Lin Ye,Qi Wang,Hao Li 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1

A novel inverse emulsion-ionic crosslinking approach was adopted to prepare pH-responsive chitosanmicrospheres and effect of preparation technique, such as chitosan concentration, emulsifierconcentration, water/oil ratio and homogenization speed, on the morphology and property of themicrospheres were investigated. The chitosan microspheres with spherical in shape, smooth surface,high productivity and promising pH responsiveness were obtained. On this basis, bovine serum albumin(BSA)-loaded chitosan microspheres was prepared to test the drug release behavior in buffers withdifferent pH values. BSA-chitosan microspheres with particle sizes in range from 5 to 10mmreleased BSAslowly in neutral medium and released rapidly in acidic medium, and exhibited obviously pH-responsiverelease behavior. Korsmeyer–Peppas model can be used for describing BSA release kinetics from chitosanmicrospheres, which corresponded with a Fickian release behavior, and the diffusion through theswelling of chitosan microspheres was the main factor in controlling BSA release.

Super-strong and anti-tearing poly(vinyl alcohol)/graphene oxide nano-composite hydrogels fabricated by formation of multiple crosslinking bonding network structure

Jinlong Cao,Xiaowen Zhao,Lin Ye 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.112 No.-

As load-bearing material in biomedical-applications as cartilage replacement, artificial meniscus and tendons,etc., poly(vinyl alcohol) (PVA)/graphene oxide (GO)-tannic acid (TA) nano-composite hydrogelswith multiple-crosslinking network were fabricated by establishing freezing/thawing-annealing-swellingmethod. By TA anchoring, PVA molecules were grafted onto GO surface efficiently, and strong interfacialinteraction led to exfoliation and uniform distribution of GO in matrix. By introducing annealing process,the crystallinity and crystallite size of PVA increased and introducing GO-TA led to more perfect and densercrystalline structure, while physical crosslinking network centered on GO-TA and hydrogen bondabundantcrystalline phase formed, resulting in increasing crosslinking density of hydrogel. By furtherswelling in CaCl2 aqueous solution, hydroxyl-Ca2+ coordination formed, and multiple-crosslinking networkwas constructed with high crosslinking density. The tensile strength and fracture toughness of compositehydrogel were remarkably improved, reaching 14.38 MPa/27.93 MJ/m3, approximately 11-/26-foldhigher than those of neat PVA hydrogel, while tearing strength was significantly enhanced, attributed tohigh energy dissipation through unzipping multiple interactions.

Structure and biocompatibility of highly oriented poly(lactic acid) film produced by biaxial solid hot stretching

Zhengqiu Li,Lin Ye,Xiaowen Zhao,Phil Coates,Fin Caton-Rose,Michael Martyn 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.52 No.-

Highly oriented long-chain-branched poly(lactic acid) (LCB-PLA)film was fabricated through biaxial hotstretching in solid state. Compared with neat PLA, more homogeneousfilm with higher draw ratio can beobtained for LCB-PLA. With increasing draw ratio, the long period, lamellae thickness and grain size ofLCB-PLA decreased, while the crystallinity increased. For LCB-PLA with draw ratio of 6*6, the tensilestrength and elongation at break can reach up to 208 6 MPa and 85% respectively. After drawing, theincreasing content ofCH3 and C¼O group on the surface of LCB-PLAfilm was beneficial for celladhesion and growth on it.

Heat transfer characteristics in regenerator cell for gaseous organic compound treatment

Fulin Liu,Kaiming Ren,Junyan Pei,Xuze Zhao,Xiaowen Hao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.2

Regenerative combustion technology can efficiently decompose organic gases with high thermal efficiency. This capability is attributed to the regenerator and the periodic gas switching technology. However, published findings regarding the regenerator were inconsistent with some important parameters, and investigations into the regenerative chamber did not provide a comprehensive explanation of the heat transfer characteristics. Therefore, a regenerator cell was investigated in this study. The temperature distribution pattern inside the cell was simulated after model verification. The effects of the superficial velocity, switching time, side width, and wall thickness of the regenerator cell on the outlet temperature, energy recovery ratio, and heat-transfer coefficient were investigated. The outlet temperature, heat transfer, and energy recovery ratio of the regenerator cells varied monotonically during each period. The average energy recovery ratio and heat transfer coefficient indicated that the side width of the regenerator cell was the most significant factor. Meanwhile, the switching time and wall thickness did not significantly affect the energy recovery ratio. The superficial velocity and wall thickness did not significantly affect the heat transfer coefficient.