http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Xiaoli Ran (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Xiaoli Ran,Wenwen Zhao,Wenping Li,Jingshan Shi,Xiuping Chen 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha (TNF-α) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of TNF-α on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and Western blotting respectively. The formation of intracellular ROS was determined with fluorescence probe CM-DCFH2-DA. The endothelial ox-LDL uptake was evaluated with DiI-ox-LDL. The effect of CPT on LOX-1 expression was also evaluated with SD rats. TNF-α induced LOX-1 expression in a dose- and time- dependent manner in endothelial cells. TNF-α induced ROS formation, phosphorylation of NF-κB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT. NF-κB inhibitor BAY11-7082 and ERK inhibitor PD98059 inhibited TNF-α-induced LOX-1 expression. CPT and NAC suppressed TNF-α-induced LOX-1 expression and phosphorylation of NF-κB p65 and ERK in rat aorta. These data suggested that TNF-α induced LOX-1 expression via ROS activated NF-κB/ERK pathway, which could be inhibited by CPT. This study provides new insights for the anti-atherosclerotic effect of CPT.
-
Ran, Xiaoli,Zhao, Wenwen,Li, Wenping,Shi, Jingshan,Chen, Xiuping The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor alpha ($TNF-{\alpha}$) induced lectin-like receptor for oxidized low density lipoprotein (LOX-1) were investigated. Human umbilical vein endothelial cells (HUVECs) were cultured and the effect of $TNF-{\alpha}$ on LOX-1 expression at mRNA and protein levels was determined by Real-time PCR and Western blotting respectively. The formation of intracellular ROS was determined with fluorescence probe $CM-DCFH_2-DA$. The endothelial ox-LDL uptake was evaluated with DiI-ox-LDL. The effect of CPT on LOX-1 expression was also evaluated with SD rats. $TNF-{\alpha}$ induced LOX-1 expression in a dose- and time- dependent manner in endothelial cells. $TNF-{\alpha}$ induced ROS formation, phosphorylation of $NF-{\kappa}B$ p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT. $NF-{\kappa}B$ inhibitor BAY11-7082 and ERK inhibitor PD98059 inhibited $TNF-{\alpha}-induced$ LOX-1 expression. CPT and NAC suppressed $TNF-{\alpha}-induced$ LOX-1 expression and phosphorylation of $NF-{\kappa}B$ p65 and ERK in rat aorta. These data suggested that $TNF-{\alpha}$ induced LOX-1 expression via ROS activated $NF-{\kappa}B/ERK$ pathway, which could be inhibited by CPT. This study provides new insights for the anti-atherosclerotic effect of CPT.
-
Research on the Compression Behavior of Steel Reinforced Concrete Columns With Built-in Steel Tubes
Cun Hui,Fan Zhang,Zhizeng Zhang,Xiaoli Liu,Ran Hai,John J. Myers 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.4
In order to study the compression behavior of rectangular steel reinforced concrete columns with built-in steel tubes under diff erent eccentric loads, three 1/10 scale specimens were designed and monotonic loading tests were carried out on them. The dimensions, steel bars and steel tube of the three specimens were the same except for the location of the loading point. The eccentricity ratios of the three specimens were 0, 0.25 and 0.5, respectively. The failure modes, load-bearing capacity and displacement characteristics of the test specimens were analyzed. According to the Chinese code, the load-bearing capacity calculation principles and methods of steel reinforced concrete columns with built-in steel tube were investigated for the comparison. The study shows that the peak vertical loads of specimens decrease and the corresponding vertical and horizontal peak displacement increase as the eccentricity increases. The load-bearing capacity calculation results from Chinese code are slightly smaller than the test result because of the unconsidered sleeve eff ect of the internal steel tube. The errors between them are small, and the calculation methods are benefi cial to ensure the structural safety.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
