Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD

Zehong Yang,Yuanyuan Yu,Nannan Sun,Limian Zhou,Dong Zhang,HaiXin Chen,Wei Miao,Weihang Gao,Canyang Zhang,Changhui Liu,Xiaoying Yang,Xiaojie Wu,Yong Gao The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3

Background: Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, while its role in regulating lipid metabolism remain vacant. Thus, we investigated the function and mechanism of ginsenosides Rc in defending high fat diet (HFD)-induced NAFLD. Methods: Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects of ginsenosides Rc on intracellular lipid metabolism. RNAseq and molecular docking study were performed to explore potential targets of ginsenosides Rc in defending lipid deposition. Wild type and liver specific sirtuin 6 (SIRT6, 50721) deficient mice on HFD for 12 weeks were subjected to different dose of ginsenosides Rc to determine the function and detailed mechanism in vivo. Results: We identified ginsenosides Rc as a novel SIRT6 activator via increasing its expression and deacetylase activity. Ginsenosides Rc defends OA&PA-induced lipid deposition in MPHs and protects mice against HFD-induced metabolic disorder in dosage dependent manner. Ginsenosides Rc (20mg/kg) injection improved glucose intolerance, insulin resistance, oxidative stress and inflammation response in HFD mice. Ginsenosides Rc treatment accelerates peroxisome proliferator activated receptor alpha (PPAR-α, 19013)-mediated fatty acid oxidation in vivo and in vitro. Hepatic specific SIRT6 deletion abolished ginsenoside Rc-derived protective effects against HFD-induced NAFLD. Conclusion: Ginsenosides Rc protects mice against HFD-induced hepatosteatosis by improving PPAR-α-mediated fatty acid oxidation and antioxidant capacity in a SIRT6 dependent manner, and providing a promising strategy for NAFLD.

MEGH: A New Affine Invariant Descriptor

( Xiaojie Dong ),( Erqi Liu ),( Jie Yang ),( Qiang Wu ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.7

An affine invariant descriptor is proposed, which is able to well represent the affine covariant regions. Estimating main orientation is still problematic in many existing method, such as SIFT (scale invariant feature transform) and SURF (speeded up robust features). Instead of aligning the estimated main orientation, in this paper ellipse orientation is directly used. According to ellipse orientation, affine covariant regions are firstly divided into 4 sub-regions with equal angles. Since affine covariant regions are divided from the ellipse orientation, the divided sub-regions are rotation invariant regardless the rotation, if any, of ellipse. Meanwhile, the affine covariant regions are normalized into a circular region. In the end, the gradients of pixels in the circular region are calculated and the partition-based descriptor is created by using the gradients. Compared with the existing descriptors including MROGH, SIFT, GLOH, PCA-SIFT and spin images, the proposed descriptor demonstrates superior performance according to extensive experiments.

Numerical analysis of elastohydrodynamic lubrication characteristics of the spatial cam mechanism in the air splicer

Fuqin Yang,Dexing Hu,Xiaojie Han,Jingwei Jiang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7

An equivalent lubrication model of line contact was established for the cam mechanism in air splicer when its steel roller rolls over the cam transition curve. Complete numerical solutions of the lubrication film thickness, pressure, and temperature rise were obtained by solving the control equations of the lubrication model, and the lubrication performance under isothermal and thermal conditions was analyzed. Results show that under isothermal and thermal conditions, increasing the stroke s and transition angle θ is disadvantageous for improving lubrication conditions at the transition curve. On the contrary, increasing the cam base circle radius R 0 and roller radius R 1 is favorable for improving the lubrication conditions. However, attention should also be paid to avoid the root-cutting phenomenon caused by excessive steel roller use. The changes of the above four parameters affect the EHL characteristics of the cam mechanism more significantly under thermal conditions than they do under isothermal conditions.

Aerodynamic stabilization of central stabilizers for box girder suspension bridges

Yaojun Ge,Xiaojie Zou,Yongxin Yang 한국풍공학회 2009 Wind and Structures, An International Journal (WAS Vol.12 No.4

For long-span suspension bridges with their intrinsic limit in flutter, some counter measures, for example, central stabilizers, should be adopted to improve aerodynamic stability to meet with the appropriate wind resistance requirements. The present paper introduces aerodynamic stabilization for longspan suspension bridges with box girders by using central stabilizers based on Xihoumen Bridge with the main span of 1650 m. The aerodynamic stabilization study covers experimental investigation of sectional model testing, comprehensive evaluation of three central stabilizers and theoretical analysis of stabilizing mechanism related to flutter derivatives, aerodynamic damping and degree participation.

An Empirical Research on Influencing Factors of Microblogging Marketing Effectiveness

Yanhong Guo,Xiaojie Yang,Yaroslav Ryabov,Wei Liu 보안공학연구지원센터(IJUNESST) 2013 International Journal of u- and e- Service, Scienc Vol.6 No.4

Experimental Investigation of the Deformation and Failure Behavior of a Tunnel Excavated in Mixed Strata Using Transparent Soft Rock

Yuanhai Li,Shuo Yang,Xiaojie Tang,Yanfeng Ding,Qi Zhang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.3

To investigate the deformation and failure behavior of a tunnel excavated in mixed strata, transparent soft rock test and numerical simulations were performed. The distribution features of displacement and failure and the evolution laws were analyzed. In this study, a transparent material for simulating mixed strata was developed. The visualization of the spatial deformation inside rock masses will improve the understanding of this process. The tests suggest that the mechanical properties of transparent soft rock are similar to those of natural rock. Experiments on the isotropic and mixed strata conditions were carried out to study the deformation rules during tunnel boring machine (TBM) excavation. The test results show that the dominant deformation position and direction exist in isotropic and mixed strata. A shear slip band occurs in both mixed and isotropic strata but with different distributions. Finally, numerical simulations were conducted to study the failure process, and the damage pattern of the transparent soft rock experiment was similar to that of the numerical simulation. The interface of the softness and hardness layers controls the extension of rock damage.

Aerodynamic stabilization of central stabilizers for box girder suspension bridges

Ge, Yaojun,Zou, Xiaojie,Yang, Yongxin Techno-Press 2009 Wind and Structures, An International Journal (WAS Vol.12 No.4

For long-span suspension bridges with their intrinsic limit in flutter, some counter measures, for example, central stabilizers, should be adopted to improve aerodynamic stability to meet with the appropriate wind resistance requirements. The present paper introduces aerodynamic stabilization for long-span suspension bridges with box girders by using central stabilizers based on Xihoumen Bridge with the main span of 1650 m. The aerodynamic stabilization study covers experimental investigation of sectional model testing, comprehensive evaluation of three central stabilizers and theoretical analysis of stabilizing mechanism related to flutter derivatives, aerodynamic damping and degree participation.

The fabrication of aminoquinoline-functionalized polydiacetylene-based hybrid vesicles with partially reversible thermochromic property

Yue Gao,Zhiguo Zhao,Xiaojie Huang,Huan Xing,Guang Yang 한국고분자학회 2024 Macromolecular Research Vol.32 No.3

The development of smart materials with reversible thermochromic properties is of great importance in the fields of sensors, displays and anticounterfeitings. In this article, a diacetylene monomer (AQDA) containing aminoquinoline as a head group was synthesized. Together with fluorescein-substituted diacetylene (FDA) and 10,12-pentacosadiynoic acid (PCDA), hybrid PDA vesicles were obtained through self-assembly and topochemical polymerization process. The hybrid PDA vesicles (FDA, AQDA and PCDA with molar ratio of 7:2:1) display an partially reversible green-to-orange red colorimetric change in a wider temperature range from 20 to 100 °C focusing on the stronger hydrogen bonding and aromatic interactions. This work may provide fundamental understanding of the mechanism and strategies for the design of reversible thermochromic PDA materials.

Tidal Effect on Grouting in Karst Fracture with Flowing Water: Experimental Investigation and Its Application

Qing Jin,Zehua Bu,Dong-dong Pan,Xiaojie Gao,Pengshuai Yang,Haiyan Li,Zhaofeng Li,Zhenhao Xu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.2

To address the problem on grouting control of water inflow disaster in coastal area, a caisson-type grouting experimental system of a single fracture in flowing water under tidal action was developed independently. Through the tide simulation system, the tidal action of different intensity and frequency was effectively described. Tide simulation system, fracture system, grouting system, water supply system and information monitoring system were combined to realize the visualization of the whole grouting process under tidal action. Furthermore, the grouting experiments of a plate fracture under different tidal action were developed and the blocking mechanism under tidal action was revealed. The conclusions were as follow: 1) Under constant water head, the slurry had three typical diffusion patterns, which were circular distribution, double U-shaped distribution and elliptical distribution respectively. 2) Under tidal action, the pressure showed a periodic fluctuation growth, and the growth rate slowed down with the increase of fracture aperture. 3) Strong tidal action would promote the diffusion of and increased the outflow amount of slurry, which was not conducive to grouting. Based on the water inflow treatment project of limestone mine in Guangxi, Through the field grouting tests, the 2# water inflow point was blocked. The research results have a certain reference value for the technology optimization of grouting engineering in coastal areas.

Well-designed Te/SnS₂/Ag artificial nanoleaves for enabling and enhancing visible-light driven overall splitting of pure water

Yan, Changzeng,Xue, Xiaolan,Zhang, Wenjun,Li, Xiaojie,Liu, Juan,Yang, Songyuan,Hu, Yi,Chen, Renpeng,Yan, Yaping,Zhu, Guoyin,Kang, Zhenhui,Kang, Dae Joon,Liu, Jie,Jin, Zhong unknown 2017 Nano energy Vol.39 No.-

<P><B>Abstract</B></P> <P>To produce hydrogen and oxygen from photocatalytic overall splitting of pure water provides a promising green route to directly convert solar energy to clean fuel. However, the design and fabrication of high-efficiency photocatalyst is challenging. Here we present that by connecting different nanostructures together in a rational fashion, components that cannot individually split water into H<SUB>2</SUB> and O<SUB>2</SUB> can work together as efficient photocatalyst with high solar-to-hydrogen (STH) energy conversion efficiency and avoid the use of any sacrificial reagent. Specifically, Te/SnS<SUB>2</SUB>/Ag artificial nanoleaves (ANLs) consist of ultrathin SnS<SUB>2</SUB> nanoplates grown on Te nanowires and decorated with numerous Ag nanoparticles. The appropriate band structure of Te/SnS<SUB>2</SUB> p-n junctions and the surface plasmon resonance of Ag nanoparticles synergistically enhance the quantum yield and separation efficiency of electron-hole pairs. As a result, Te/SnS<SUB>2</SUB>/Ag ANLs enable visible-light driven overall water-splitting without any sacrificial reagent and exhibit high H<SUB>2</SUB> and O<SUB>2</SUB> production rates of 332.4 and 166.2μmolh<SUP>−1</SUP>, respectively. Well-preserved structure after long-term measurement indicates its high stability. It represents a feasible approach for direct H<SUB>2</SUB> production from only sunlight, pure water, and rationally-designed ANL photocatalysts.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Te/SnS<SUB>2</SUB>/Ag ANLs heterostructure is prepared to catalyze overall water splitting. </LI> <LI> The catalyst show impressive H<SUB>2</SUB> and O<SUB>2</SUB> production rate under visible light. </LI> <LI> The structure and efficiency of catalyst shows no degradation after 10 days. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>