High Temperature Deformation Behavior and Processing Map for a Nickel-Titanium Shape Memory Alloy

Xiang-Qian Yin,이상원,Yan-Feng Li,박찬희,Xu-Jun Mi,염종택 대한금속·재료학회 2017 METALS AND MATERIALS International Vol.23 No.5

The hot deformation behavior of 49.2Ti-50.8Ni shape memory alloy was studied using hot compressive deformationtesting in the temperature range of 1023-1323 K and at strain rates of 0.01-10 s-1. The work-hardening rate wasinduced to analyze the stress-strain curves, and the critical stress σc and the dynamic recovery saturation stress σsatwere measured which can be specified approximately by the expressions: σsat-1.12σp and σc-0.86σp. An Arrheniusmodel was calculated to describe the relationship between peak stress and the Z parameter. The relationshipbetween deformation activation energy, the deformation conditions and the effect of Ni component in a binaryTiNi alloy on the activation energy were discussed in this work. With the help of electron backscattering diffraction,a connected mode dynamic recrystallization microstructure was confirmed in peak efficiency regimes(850 °C & 0.01 s-1 and 1050 °C & 10 s-1) of the processing map.

The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation

Han Yin,Muzhe Li,Guangzhao Tian,Yang Ma,Chao Ning,Zineng Yan,Jiang Wu,Qian Ge,Xiang Sui,Shu-Yun Liu,Jinxuan Zheng,Weimin Guo,Quan-Yi Guo 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4

Osteoarthritis (OA) is a degenerative joint disease that is common among the middle-aged and older populations, causes patients to experience recurrent pain in their joints and negatively affects their quality of life. Currently, therapeutic options for patients with OA consist of medications to alleviate pain and treat the symptoms; however, due to typically poor outcomes, patients with advanced OA are unlikely to avoid joint replacement. In recent years, several studies have linked disrupted homeostasis of the joint cavity microenvironment to the development of OA. Recently, extracellular vesicles (EVs) have received increasing attention in the field of OA. EVs are natural nano-microcarrier materials with unique biological activity that are produced by cells through paracrine action. They are composed of lipid bilayers that contain physiologically active molecules, such as nucleic acids and proteins. Moreover, EVs may participate in local and distal intercellular and intracellular communication. EVs have also recently been shown to influence OA development by regulating biochemical factors in the OA microenvironmental. In this article, we first describe the microenvironment of OA. Then, we provide an overview of EVs, summarize the main types used for the treatment of OA, and describe their mechanisms. Next, we review clinical studies using EVs for OA treatment. Finally, the specific mechanism underlying the application of miRNA-enriched EVs in OA therapy is described.

Vibration Suppression Analysis of a Long-Span Bridge Subjected to Combined Service and Extreme Loads

Xinfeng Yin,Wanli Yan,Qian Liao,Xiang Chen,Yang Liu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.5

The long-span bridge structures are loaded by service loads including traffic and/or wind loads almost every day. The earthquake load may occur on the bridges simultaneously except for these two common service loads. The vibration response of long-span bridges under earthquake and service loads usually exceeds the expected values. Therefore, the suppressed system should be extensively studied to control the vibration of the bridges. In the work, a pounding tuned mass damper (PTMD) system was designed, which can be effectively used for the dissipation of impact energy. It is mainly made up of a tuned mass and an additional limit device. Based on the earthquake/wind/traffic/bridge coupled system, the numerical simulation of multiple PTMDs (MPTMDs) was carried out. Different parameters of MPTMDs were studied including different numbers, mass ratio, pounding stiffness, and the gap values. The simulations show that the MPTMDs are very effective in suppressing the displacements of the bridge caused by both the traffic flows/wind and traffic/earthquake, and the suppressing effectiveness for bridge vibration under traffic and earthquake is more than that under traffic and wind.

Familial aggregation and heritability of hypertension in Han population in Shanghai China: a case-control study

An-le Li,Xiang Fang,Yi-ying Zhang,Qian Peng,Xian-hong Yin 대한고혈압학회 2019 Clinical Hypertension Vol.25 No.4

Background: To explore the familial aggregation and heritability of hypertension in Han in Shanghai China. Methods: According to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension. Results: The prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%. Conclusion: The distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.

MLH1 Polymorphisms and Cancer risk: a Meta-analysis Based on 33 Case-control Studies

Xu, Jia-Li,Yin, Zhi-Qiang,Huang, Ming-De,Wang, Xie-Feng,Gao, Wen,Liu, Ling-Xiang,Wang, Rong-Sheng,Huang, Pu-Wen,Yin, Yong-Mei,Liu, Ping,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Objective: Cumulative evidence suggests that MLH1, the key component in the mismatch pathway, plays an important role in human cancers. Two potential functional polymorphisms (-93G>A and I219V) of MLH1 have been implicated in cancer risk. The aim of this meta-analysis was to summarize the evidence for associations. Methods: Eligible studies were identified by searching the electronic literature PubMed, ScienceDirect and Embase databases for relevant reports and bibliographies. Studies were included if of case-control design investigating MLH1 polymorphisms (-93G>A and I219V) and cancer risk with sufficient raw data for analysis. Odds ratios (OR) and 95% confidence intervals (95% CI) were used to evaluate the strength of associations. Results: Our meta-analysis from 33 published case-control studies showed the variant A allele of -93G>A polymorphism to be associated with increased risk in all genetic models (AA vs. GG: OR = 1.22, 95% CI: 1.03-1.44), especially among non-Asians (AA vs. GG: OR = 1.28, 95% CI: 1.04-1.58). For the I219V polymorphism, however, there was no main effect associated with overall cancer risk in any genetic model. Conclusions: The meta-analysis suggested that the MLH1 -93G>A polymorphism may be a biomarker of cancer susceptibility. Large sample association studies and assessment of gene-to-gene as well as gene-to-environment interactions are required to confirm these findings.

Therapeutic Effects and Adverse Drug Reactions are Affected by Icotinib Exposure and CYP2C19 and EGFR Genotypes in Chinese Non-Small Cell Lung Cancer Patients

Chen, Jia,Zheng, Xin,Liu, Dong-Yang,Zhao, Qian,Wu, Yi-Wen,Tan, Fen-Lai,Wang, Yin-Xiang,Jiang, Ji,Hu, Pei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: The aim of this study was to evaluate how CYP2C19 affects icotinib and metabolite' exposure, and to determine whether the exposure and EGFR genotype influences survival time, tumor metastasis and adverse drug reactions. Materials and Methods: 274 NSCLC patients who accepted 125mg icotinib/t.i.d. were chosen from a phase III study. Blood samples were obtained in $672^{nd}$ ($4^{th}$ week) and $1,680^{th}$ hours ($10^{th}$ week), and plasma was used to quantify the concentration of icotinib and blood cells were sampled to check the genotypes. Clinical data were also collected at the same time, including EGFR genotypes. Plasma concentrations were assessed by HPLC-MS/MS and genotype by sequencing. All data were analyzed through SPSS 17.0 and SAS 9.2. Results: CYP 2C19 genotypes affected bio-transformation from icotinib to M24 and M26, especially in poor-metabolisers. Higher icotinib concentrations (>1000 ng/mL) not only increased patient PFS and OS but also reduced tumor metastasis. Patients with mutant EGFR experienced a higher median PFS and OS (234 and 627 days), especially those with the 19del genotype demonstrating higher PR ratio. Patients who suffered grade II skin toxicity had a higher icotinib exposure than those with grade I skin toxicity or no adverse effects. Liver toxic reactions might occur in patients with greater M20 and M23 plasma concentrations. Conclusions: CYP2C19 polymorphisms significantly affect icotinib, M24 and M26 exposure. Patients with mutant EGFR genotype and higher icotinib concentration might have increased PFS and OS and lower tumor metastasis. Liver ADR events and serious skin effects might be respectively induced by greater M20, M23 and icotinib concentrations.