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Chen, P.,Tian, Q.,Baek, S.J.,Shang, X.L.,Park, A.,Liu, Z.C.,Yao, X.Q.,Wang, J.Z.,Wang, X.H.,Cheng, Y.,Peng, J.,Shen, A.G.,Hu, J.M. WILEY‐VCH Verlag 2011 Laser physics letters Vol.8 No.7
<P><B>Abstract</B></P><P>Early and differential diagnosis of Alzheimer's disease (AD) is a problem that puzzled many doctors. Reliable markers in easy‐assembling samples are of considerable clinical diagnostic value. In this work, laser Raman spectroscopy (LRS) was developed a new method that potentially allows early and differential diagnosis of AD from the platelet sample. Raman spectra of platelets isolated from different ages of AD transgenic mice and non‐transgenic controls were collected and analyzed. Multilayer perceptron networks (MLP) classification method was used to classify spectra and establish the diagnostic models. For differential diagnosis, spectra of platelets isolated from AD, Parkinson’s disease (PD) and vascular dementia (VD) mice were also discriminated. Two notable spectral differences at 740 and 1654 cm<SUP>–1</SUP> were revealed in the mean spectrum of platelets isolated from AD transgenic mice and the controls. MLP displayed a powerful ability in the classifying of early, advanced AD and the control group, and in differential diagnosis of PD and advanced AD, as well as VD and advanced AD. The results suggest that platelet detecting by LRS coupled with MLP analysis appears to be an easy and accurate method for early and differential diagnosis of AD. This technique could be rapidly promoted from laboratory to the hospital. (© 2011 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA) (© 2011 by Astro Ltd., Published exclusively by WILEY‐VCH Verlag GmbH & Co. KGaA)</P>
Measurement ofe+e−→π+π−ψ(2S)via initial state radiation at Belle
Wang, X. L.,Yuan, C. Z.,Shen, C. P.,Wang, P.,Abdesselam, A.,Adachi, I.,Aihara, H.,Al Said, S.,Arinstein, K.,Asner, D. M.,Ayad, R.,Bakich, A. M.,Bansal, V.,Bhuyan, B.,Bobrov, A.,Bonvicini, G.,Brax10d American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.11
Measurement ofe+e−→γχcJvia initial state radiation at Belle
Han, Y. L.,Wang, X. L.,Yuan, C. Z.,Shen, C. P.,Wang, P.,Abdesselam, A.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Aushev, T.,Babu, V.,Badhrees, I.,Bansal, V.,Bhardwaj, V.,Biswal, J.,Bozek, A.,Bra& American Physical Society 2015 PHYSICAL REVIEW D - Vol.92 No.1
Preparation and thermoelectric properties of AgPb18SbTe20−xSex (x = 1, 2, 4) materials
H. Li,K.F. Cai,Y. Du,H.F. Wang,S.Z. Shen,X.L. Li,C.W. Zhou,Y.Y. Wang 한국물리학회 2012 Current Applied Physics Vol.12 No.1
AgPb18SbTe20xSex (x ¼ 1, 2, 4) bulk materials were prepared by combining hydrothermal synthesis and melting. Thermoelectric properties were measured from room temperature up to 773K. The materials showed n-type conduction and exhibited degenerate semiconductor behavior. The power factors of the materials varied greatly with increase of Se content (x). Partial substitution of Se for Te in AgPb18SbTe20resulted in remarkable reduction of thermal conductivity in the whole temperature range and increase of power factor at lower temperatures; therefore, the dimensionless figure of merit, ZT, was enhanced below 600K. A maximum ZT value of w0.82 is obtained at 523K for the AgPb18SbTe18Se2 sample.
Zhang, X.,Shi, L.,Li, X.,Sheng, Q.,Yao, L.,Shen, D.,Lu, Z.R.,Zhou, H.M.,Park, Y.D.,Lee, J.,Zhang, Q. Society for Bioscience and Bioengineering, Japan ; 2014 Journal of bioscience and bioengineering Vol.117 No.6
Understanding the mechanism of inhibition of α-glucosidase (EC 3.2.1.20) is clinically important because of the involvement of this enzyme in type 2 diabetes mellitus. In this study, we conducted inhibition kinetics of α-glucosidase with Ca<SUP>2+</SUP> and 10-ns molecular dynamics simulations. We found that direct binding of Ca<SUP>2+</SUP> to the enzyme induced structural changes and inhibited enzyme activity. Ca<SUP>2+</SUP> inhibited α-glucosidase in a mixed-type reaction (K<SUB>i</SUB> = 27.0 +/- 2.0 mM) and directly induced the unfolding of α-glucosidase, which resulted in the exposure of hydrophobic residues. The simulations suggest that thirteen Ca<SUP>2+</SUP> ions may interact with α-glucosidase residues and that the Ca<SUP>2+</SUP> binding sites are associated with the structural changes in α-glucosidase. Our study provides insight into the mechanism of the Ca<SUP>2+</SUP>-induced structural changes in α-glucosidase and the inhibition of ligand binding. These results suggest that Ca<SUP>2+</SUP> could act as a potent inhibitor of α-glucosidase for the treatment of type 2 diabetes mellitus.