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- 저자 : Woo-Dae Park(박우대) (검색결과 3 건)
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The Influence of Cranial Cervical Ganglion Block in Beagle Dogs with Normal Intraocular Pressure
Woo-Dae Park(박우대),Chun-Sik Bae(배춘식),Hwi-Yool Kim(김휘율) 한국생명과학회 2007 생명과학회지 Vol.17 No.11
본 연구는 정상적인 안압을 가진 비글견에서 4 가지의 다른 농도를 가진 lidocaine을 사용하여 앞쪽목신경절 차단 후 안압의 변화를 관찰하기 위하여 시행하였다. 실험군은 전향적 교차시험으로 10두의 비글견을 2%, 1%, 0.5% 및 0.25% lidocaine group으로 4군으로 나뉘었다. 모든 실험견들은 4 가지의 다른 농도를 가진 2 ml의 lidocaine을 사용하여 각 4번의 앞쪽목신경절 차단을 받았으며 신경 차단은 무작위로 1주일 간격으로 각각 시행되었다. 실험결과 호르너 증후군은 모든 실험군에서 관찰되었다. 1% lidocaine group에서는 대조군과 비교하여 차단 후 5분에서 안압의 유의한 상승이 있었으며(p<0.05), 2%와 1% lidocaine group의 안압은 앞쪽목신경절 차단 후 25분과 45분 사이 감소하였으나, 0.5%와 0.25% lidocaine group은 변화가 없었다. 이상의 결과를 종합하면, 앞쪽 목신경절 차단술은 정상 안압의 변화에 영향을 미치며 0.5%와 0.25% lidocaine은 안압을 변화시키기에는 부적당한 농도로 사료된다. This study was performed to observe changes of the intraocular pressure following cranial cervical ganglion block with the four different concentrations of lidocaine in beagle dogs with the normal intraocular pressure. We performed by the crossover test in ten beagle dogs divided into four groups, which were 2%, 1%, 0.5% and 0.25% lidocaine group. All experimental dogs received each four times cranial cervical ganglion block using 2 ml of lidocaine with the four different concentrations. The blocks were separately done at a week intervals in random order. Horner’s syndrome was observed in all groups. The intraocular pressure in the blocked side was significantly increased to 5 min in the 1% lidocaine group compared to the baseline (p<0.05). The intraocular pressure of 2% and 1% lidocaine groups were decreased between 25 and 45 min following cranial cervical ganglion block, while those of 0.5% and 0.25% lidocaine groups were unchanged. In conclusion, these results suggest that cranial cervical ganglion block affect on the change of intraocular pressure and 0.5% and 0.25% lidocaine are inadequate concentrations for the change of intraocular pressure in the dog with normal intraocular pressure.
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박우대(Woo-Dae Park) 한국생명과학회 2008 생명과학회지 Vol.18 No.1
In human, sympathetic nerve blocks with local anesthetics are widely used to treat a variety of diseases in the innervating regions. However, its procedure in dogs is difficult to approach and process repeatedly because of anatomically location. Therefore, this study was designed to develop a new technique of sympathetic nerve block in beagle dogs. Fifteen healthy beagle dogs, which did not show any neurologic abnormalities and disease, were used for the study. Radiograghs were taken after injected radiopaque mate-rial mixed with 2% lidocaine at the cranial cervical ganglion and injected methylene blue using the same percutaneous technique to verify the reliability of this newly developed technique. The successful block rate of the cranial cervical ganglion block was present in 80% of all dogs and the stained cranial cervical ganglions were shown in all dogs. The results show that this new technique of the cranial cervical ganglion block is a reliable and simple method that can be used for clinical studies in dogs.
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장화석,양희택,김상영,우동철,박우대,용준환,최보영,김휘율,최치봉,Chang, Hwa-Seok,Yang, Hee-Taek,Kim, Sang-Youn,Woo, Dong-Cheol,Park, Woo-Dae,Yong, Joon-Hwan,Choe, Bo-Young,Kim, Hwi-Yool,Choi, Chi-Bong 한국의학물리학회 2008 의학물리 Vol.19 No.2
수의 임상에서 캡슐 내시경(capsule endoscopy, CE)의 사용에 기본적인 기준과 유용성을 정립하기 위하여 정상 중형견($7{\sim}13\;kg$)에서 캡슐의 위 통과시간(gastric transit time, GTT), 작은창자 통과시간(small intestinal transit time, SITT), 완전통과율(complete transit time, CTT)을 측정하고 통과율을 분석하였다. 1군(capsule 투여), 2군(capsule+water 투여), 3군(metoclopramide+capsule 투여) 그리고 (metoclopramide+capsule+water 투여)의 총 4군으로 나누어 방사선 촬영을 통하여 평가를 실시했다. GTT는 평균 $45{\sim}20\;min$ (group 1), $117{\pm}35\;min$ (group 2), $150{\pm}40\;min$ (group 3), $154{\pm}65\;min$ (group 4)였으며 SITT는 평균 $75{\pm}20\;min$ (group 1), $195{\pm}55\;min$ (group 2), $75{\pm}15\;min$(group 3), $76{\pm}15\;min$ (group 4)로 나타났다. 완전통과율(complete passage rate)은 각각 20% (group 1), 40%, (group 2), 20% (group 3), 50% (group 4)로 나타났다. 실험결과 캡슐이 유문부를 통과하기만 하면 내시경 캡슐 배터리 수명인 8시간 이내로 위장관을 모두 통과하였으며 물을 위내로 투여한 후 volume의 증가에 의한 위 운동성의 증가는 캡슐의 유문부 통과에 도움이 되었다. 그러나 metoclopramide의 투여는 유문부의 통과와 SITT의 시간에 대한 유의적인 효과가 나타나지 않았다. The object of this study is to measure the transit time and passage rate of capsule endoscopy (CE) in the gastrointestinal tract in medium sized beagle dogs ($7{\sim}13\;kg$). Animals were divided into four groups: only capsule (group 1, n=10), capsule+water (group 2, n=10), mettoclopramide+capsule (group 3, n=10), metoclopramide +capsule+water (group 4, n=10). The capsule transit times through the stomach and small bowel were evaluated by radiography findings. Gastric transit time (GTT), small intestinal transit time (SITT) and complete passage rate were measured in four groups. GTT's for each group were as follows; $45{\pm}20\;min$ (group 1), $117{\pm}35\;min$ (group 2), $150{\pm}40\;min$ (group 3), and $154{\pm}65\;min$ (group 4), while SITT's were $75{\pm}20\;min$ (group 1), $195{\pm}55\;min$ (group 2), $70{\pm}15\;min$ (group 3), and $76{\pm}15\;min$ (group 4). The complete passage rates were 20% (group 1), 40% (group 2), 20% (group 3), 50% (group 4). In all groups, if CE could pass through the pylorus, it passed all small intestinal tracts within 8 hours (battery life). Administration of water helped CE to pass pylori, except in case of metoclopramide administration. These results indicate that CE could be an useful tool for examining gastrointestinal diseases in the veterinary medicine.
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