Concurrent Weekly Docetaxel Chemotherapy in Combination with Radiotherapy for Stage III and IVA-B Nasopharyngeal Carcinoma

Wei, Wei-Hong,Cai, Xiu-Yu,Xu, Tao,Zhang, Guo-Yi,Wu, Yong-Feng,Feng, Wei-Neng,Lin, Li,Deng, Yan-Ming,Lu, Qiu-Xia,Huang, Zhe-Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Background and Purpose: Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. Methods and Materials: Eighty-four patients with Stage III and IVA-B NPCs, treated between 2007 and 2008, were retrospectively analyzed. Thirty received weekly docetaxel-based concurrent chemotherapy, and 43 were given weekly cisplatin-based concurrent chemotherapy. Radiotherapy was administered using a conventional technique (seven weeks, 2.0 Gy per fraction, total dose 70-74 Gy) with 6-8 Gy boosts for some patients with locally advanced disease. Results: Median follow-up time was 42.3 months (range, 8.6-50.8 months). There were no significant differences in the 3-year loco-regional failure-free survival (85.6% vs. 92.3%; p=0.264), distant failure-free survival (87.0% vs. 92.5%; p=0.171), progression-free survival (85.7% vs. 88.4%; p=0.411) or overall survival (86.5% vs. 92.5%, p=0.298) of patients treated concurrently with docetaxel or cisplatin. Severe toxicity was not common in either group. Conclusions: Weekly docetaxel-based concurrent chemoradiotherapy is potentially effective and has a tolerable toxicity; however, further investigations are required to determine if docetaxel is superior to cisplatin for advanced stage NPC.

B3GNT2, a Polylactosamine Synthase, Regulates Glycosylation of EGFR in H7721 Human Hepatocellular Carcinoma Cells

Qiu, Hao,Duan, Wei-Ming,Shu, Jie,Cheng, Hong-Xia,Wang, Wei-Ping,Huang, Xin-En,Chen, Hui-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

The epidermal growth factor receptor (EGFR) is an important surface receptor with N-glycans in its extracellular domain, whose glycosylation is essential for its function, especially in tumor cells. Here, we demonstrated that polylactosamine is markedly increased in H7721 hepatocellular carcinoma cells after treatment with EGF, while it apparently declined after exposure to all-trans retinoic acid (ATRA). In the study of the enzymatic mechanism of this phenomenon, we explored changes in the expression of poly-N-acetyllactosamine (PLN) branching glycosyltransferases using RT-PCR. Among the four glycosyltransferases with altered expression, GnT-V was most elevated by EGF, while GnT-V and B3GNT2 were most declined by ATRA. Next, we conducted co-immunoprecipitation experiments to test whether B3GNT2 and EGFR associate with each other. We observed that EGFR is a B3GNT2-targeting protein in H7721 cells. Taken together, these findings indicated that the altered expression of B3GNT2 will remodel the PLN stucture of EGFR in H7721 cells, which may modify downstream signal transduction.

Experimental study on timing and pattern of gas injection in low permeability reservoir

Wei Huang,Shenglai Yang,Meng Chen,Zhipeng Qiu,Can Chen,Hao Chen 한국자원공학회 2014 Geosystem engineering Vol.17 No.3

Experiments were conducted to study the selection of development methods for low permeability reservoir exploitation after water drive, including the effects of different gas injection cycle times and different injection modes on oil displacement efficiency. Results showed that both gas injection cycle time and injection mode have significant effects on oil displacement efficiency. Based on the results of gas injection cycle time of the displacement with mode shifting to gas drive when water cut reaches 50% and 100%, it can be concluded that in the low permeability reservoir, which is exploited by water drive in the early time, the sooner the gas injection, the higher the oil displacement efficiency is. Because high water saturation can cause serious water-blocking effect, leading to a large amount of trapped oil and low displacement efficiency. Further, in view of the results of water drive, gas injection, and water alternating gas (WAG) flooding, it is obvious that WAG flooding is one of the best methods in enhanced oil recovery. Under the effect of gravity differentiation, WAG flooding can spread to the upper reservoir, which cannot be swept by water drive. Thus, the oil recovery factor can be improved effectively. However, it should be noted that gas injectivity should be considered in the field test.

Improved Centripetal Force Type-Magnetic Bearing with Superior Stiff ness and Anti-interference Characteristics for Flywheel Battery System

Wei-Yu Zhang,Pengfei Zhu,Ling Cheng,Huang-Qiu Zhu 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.3

In this study, an improved centripetal force type-magnetic bearing (CFT-MB) for a fl ywheel battery system is proposed, which is easy to process and it has better performance with superior stiff ness and anti-interference characteristics than that of the pure spherical CFT-MB. First, the confi guration, magnetic circuits, working principle and mathematical model of the improved CFT-MB are analyzed in detail. The electromagnetic characteristics are then analyzed. In comparison with the analysis results of the pure spherical CFT-MB, the improved CFT-MB has less cost, less force–displacement and force–defl ection stiff ness, and higher force-current stiff ness, which verify its preferable design concept. Related comparative experiments based on the prototype are also conducted. The stiff ness tests results verify the accuracy of the previously presented electromagnetic characteristic analysis results. Performance tests results show that the proposed improved CFTMB is superior to that of the original CFT-MB in resisting to the disturbance or the gyroscopic eff ect, which verifi es the accuracy of the theoretical analysis.

Accurate Parameter Design for Radial AC Hybrid Magnetic Bearing

Wei-Yu Zhang,Huang-Qiu Zhu 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.

For more stable operation of radial AC hybrid magnetic bearing (radial AC HMB), it is particularly important to realize optimizationdesign of parameters for its prototype. The paper focuses on solving the several typical defects of traditional methods and puts forwardspecific countermeasures on improving its disadvantages. Thus, a new parameter design method based on two sets of magnetic fieldsystem (the stator core magnetic field system and the air gap field system) is proposed to calculate the structure and electromagnetismparameters of the radial AC HMB. Using the proposed parameter design method, a finite element model of radial AC HMB basedon the design results are simulated in finite element analysis software. The simulation results are consistent with the expectedparameters calculation results very well, which show accuracy of the parameters and the proposed method. To illustrate the validityof the parameter design approaches further, the verification experiment is conducted. The operating experimental results show thatthe radial AC HMB has high stability, fast start of suspension and fine anti-disturbance. Moreover, system performance comparisonresults show the control system based on the new parameter design method has stronger anti-disturbance characteristics than thatbased on the traditional parameter design method.

Comparison of Hybridization Behavior between Double and Single Strand of Targets and the Application of Asymmetric PCR Targets in cDNA Microarray

Wei, Qing,Liu, Sanzhen,Huang, Jianfeng,Mao, Xueying,Chu, Xiaohui,Wang, Yu,Qiu, Minyan,Mao, Yumin,Xie, Yi,Li, Yao Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.4

Double stranded targets on the cDNA microarray contain representatives of both the coding and noncoding strands, which will introduce hybridization competition with probes. Here, the effect of double and single strands of targets on the signal intensity and the ratios of Cy5/Cy3 within the same slide were compared. The results show that single stranded targets can increase the hybridization efficiency without changing the Cy5/Cy3 ratio. Based on these results, a new strategy was established by generating cDNA targets with asymmetric PCR, instead of conventional PCR, to increase the sensitivity of the cDNA microarray. Furthermore, the feasibility of this approach was validated. The results indicate that the cDNA microarray system based on asymmetric PCR is more sensitive, with no decrease in the reliability and reproducibility as compared with that based on conventional symmetric PCR.

Tool Monitoring System Using Vibration and Current Signals

Zhennan Wei,Zhenyu Qiu,Qian Huang,Yundi Chu 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

The on-line monitoring of tool wear condition plays an important role in reducing production cost and improving production efficiency. Firstly, this paper introduces the wear mechanism of cutting tools, the detection method of tool wear, and the commonly used signal processing technology. Secondly, through the experiments of various cutting parameters, various characteristic information in different grinding processes is obtained, and the correlation analysis is carried out, and the characteristic values related to the grinding process are obtained. Then, the corresponding BP neural network model is established. Finally, according to the characteristics of the CNC machine monitoring system, Cortex_A15 is selected as the core of the monitoring system, and the neural network algorithm is applied to the hardware board which is more economical than the PC to save the production cost.

DC Voltage Balancing and Current Sharing Control of Parallel Multiple Modules Static Var Generator Based on CPS-SPWM

Cai, Wei,Huang, Yanyan,Fangyuan, Zhou,Qiu, Wenjun,Wang, Caixiao,Wu, Qiang,Erlei, Shi,Wen, Tao The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.1

For extending the power and improving the performance of SVG, a topology with several parallel plugging convertor modules is obtained, which has no common DC bus. In respect that the parameter difference among converters, reactive power of total output sharing has to be resolved. In this article, mathematics model with DQ analytic transformation is analyzed. Based on double close-loop decoupling control, and direct current control, a reactive power balance current sharing method is proposed. By using CPS-SPWM, the current harmonic of SVG is reduced, which is indicated by simulation result. Further, in order to apply the method to project application, a 2Mvar platform with a double FPGA-DSP controller broad is carried out. The simulation and practical performance of SVG are given. The validity and feasibility of the method is demonstrated by the results.

Stress variation analysis based on temperature measurements at Zhuhai Opera House

Lu, Wei,Teng, Jun,Qiu, Lihang,Huang, Kai Techno-Press 2018 Structural monitoring and maintenance Vol.5 No.1

The Zhuhai Opera House has an external structure consisting of a type of spatial steel, where the stress of steel elements varies with the ambient temperature. A structural health monitoring system was implemented at Zhuhai Opera House, and the temperatures and stresses of the structures were monitored in real time. The relationship between the stress distribution and temperature variations was analysed by measuring the temperature and stresses of the steel elements. In addition to measurements of the structure stresses and temperatures, further simulation analysis was carried out to provide the detailed relationship between the stress distributions and temperature variations. The limited temperature measurements were used to simulate the structure temperature distribution, and the stress distributions of all steel elements of the structure were analysed by building a finite element model of the Zhuhai Opera House spatial steel structure. This study aims to reveal the stress distributions of steel elements in a real-world project based on temperature variations, and to supply a basic database for the optimal construction time of a spatial steel structure. This will not only provide convenient, rapid and safe early warnings and decision-making for the spatial steel structure construction and operation processes, but also improve the structural safety and construction accuracy of steel space structures.

Security Authentication Method of Speech Perceptual Hashing Based on Fuzzy Commitment Scheme

Zhang Qiu-yu,Ren Zhan-wei,Huang Yi-bo,Yu Shuang,Hu Wen-jin 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.1

Existing speech perceptual hashing authentication algorithms generally encrypt the perceptual hash value to protect the security of the algorithms. But under the principle of Kerckhoffs, the algorithm becomes transparent and fragile. And it can be seen that the secret key may be estimated when the number of times that reuses the secret key reache to a limit through the safety analysis of Shannon unicity distance. To solve these problems, we present a novel security authentication scheme of speech perceptual hashing based on the fuzzy commitment scheme (FCS). Firstly, in sender, the randomly selected BCH code word and the extracted perceptual hash value are sent to the Cmt() function to calculate and the final secure perceptual hash value (h(c),) can be obtained. Secondly, in receiver, the perceptual hash value is calculated again from the received speech information and then the calculated perceptual hash value with the received information  (commitment) are sent to the Decmt() function to calculate to get the h(c′). Finally, the h(c) and h(c′) are matched. The experimental results show that the proposed scheme effectively avoids the probability that an attacker obtains the plaintext/ciphertext pairs without affecting the performance of original algorithm, and at the same time it ensures the security of perceptual hashing algorithm.