Dynamic simulation and control of a triple column process for dimethyl carbonate- methanol separation

Hong-Mei Wei,Qiang Gao,Wei-zhou Jiao,Wei Wei 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

Separation of dimethyl carbonate/methanol azeotropic mixture by using pressure-swing distillation processhas been a hot-point in the study of the synthesis process of dimethyl carbonate by urea methanolysis method. Thisstudy updates the work of the writers (Ind.Eng.Chem.Res,2013,52,11463-11478), which explores the dynamic controlstructure of the three-column separation dimethyl carbonate (DMC)/methanol (MeOH) process from an actual pilotplant. At first, the conventional DMC/MeOH separation process in the pilot test of the DMC synthesis process throughalcoholysis of urea was described in detail. Then an optimized control structure for the entire DMC/MeOH separationunit was obtained by implementing a general heuristic design procedure. An economic analysis was performed to evaluatethe optimized process. Finally, three dynamic control schemes were proposed and evaluated with several large disturbances,an improved control scheme CS3, using the multiplier blocks “QR1/F1” and “RR1” in T1, “QR1/F1” and “R/F”in both T2 and T3, outperformed CS1 and CS2 by maintaining the product specification in each column.

MicroRNA-1285 Regulates 17β-Estradiol-Inhibited Immature Boar Sertoli Cell Proliferation via Adenosine Monophosphate-Activated Protein Kinase Activation

Jiao, Zhang Jiao,Yi, Wang,Rong, Yang Wei,Kee, Jeong Dong,Zhong, Wang Xian The Endocrine Society 2015 Endocrinology Vol.156 No.11

Expression of the Pokemon Proto-oncogene in Nasopharyngeal Carcinoma Cell Lines and Tissues

Jiao, Wei,Liu, Fei,Tang, Feng-Zhu,Lan, Jiao,Xiao, Rui-Ping,Chen, Xing-Zhou,Ye, Hui-Lan,Cai, Yong-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

To study the differentiated expression of the proto-oncogene Pokemon in nasopharyngeal carcinoma (NPC) cell lines and tissues, mRNA and protein expression levels of CNE1, CNE2, CNE3 and C666-1 were detected separately by reverse transcription polymerase chain reaction (RT-PCR), real-time PCR and Western-blotting. The immortalized nasopharyngeal epithelial cell line NP69 was used as a control. The Pokemon protein expression level in biopsy specimens from chronic rhinitis patients and undifferentiated non keratinizing NPC patients was determined by Western-blotting and arranged from high to low: C666-1>CNE1>CNE2> CNE3>NP69. The Pokemon mRNA expression level was also arranged from high to low: CNE1>CNE2>NP69>C666-1>CNE3. Pokemon expression of NP69 and C666-1 obviously varied from mRNA to protein. The Pokemon protein level of NPC biopsy specimens was obviously higher than in chronic rhinitis. The data suggest that high Pokemon protein expression is closely associated with undifferentiated non-keratinizing NPC and may provide useful information for NPC molecular target therapy.

De novo assembly and transcriptome analysis of differentially expressed genes relevant to variegation in hawthorn flowers

Wei Ji,Wei Zhao,Rong‑Chen Liu,Xiao‑Bo Jiao,Kai Han,Zhong‑Yi Yang,Mei‑Ying Gao,Rui Ren,Xiu‑Juan Fan,Ming‑Xia Yang 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.6

Flower color variegation has been observed in many plant species. However, pink flowers on the white-blooming hawthorn trees found by our group earlier have never been reported. To better understand the differentially expressed genes (DEGs) in variegated hawthorn flowers, white and pink flowers at different developmental stages (S1 and S2) underwent transcriptome sequencing separately. Approximately 34.28 Gb of high-quality data were obtained and assembled into 100,013 unigenes with an average length of 706.93 bp. These unigenes were further subjected to functional annotation and biochemical pathway analysis, and DEGs of two types of hawthorn flowers at different developmental stages were studied. Based on the enrichment analysis of DEGs, eight anthocyanin-modified enzyme genes or other enzyme genes that indirectly affect anthocyanin synthesis (5AT, 3GGT , and AI, β-Glu, two Aux/IAAs, two PODs), eight structural genes (UFGT, DFR, CHI, two F3Hs, and three PALs), and three transcription factors (one MYB and two bHLHs) were also identified. We randomly selected 15 genes, and the trends in the expression levels of these genes in the organs of white and pink flowers at different developmental stages were verified by quantitative real-time PCR. Mass sequence data obtained by RNA-seq of variegated hawthorn flowers provided basic sequence information and a unique opportunity to uncover the genetic mechanisms under-lying flower color variegation.

Mechanical, dielectric properties and thermal shock resistance of porous Si2N2O/Si3N4 composite ceramics

Wei Liting,Yu Yinhu,Jiao Jiao 한양대학교 세라믹연구소 2018 Journal of Ceramic Processing Research Vol.19 No.2

Porous Si2N2O/Si3N4 composite ceramics were fabricated by gas pressure sintering of Si3N4 and SiO2 with Sm2O3 as sinteringadditive under N2 atmosphere. Porosity and β-Si3N4 phase of the composites are increased with the increasing α-Si3N4 contentin starting materials. The composite ceramics show high flexural strength (223 ~ 288 MPa at room temperature) and goodthermal shock resistance and the critical thermal shock temperature (ΔTc) could be up to 1100 oC. The dielectric propertiesare mainly influenced by the sample porosity and phase composition. The as-prepared Si2N2O / Si3N4 composite ceramicspossess both low dielectric constant (ε = 4.8-5.2) and loss tangent (tanδ = 0.0014-0.0063), combined with excellent mechanicalperformance and thermal shock resistance, showing Si2N2O/Si3N4 composite ceramics could be promising high-temperaturewave transparent materials.

Clinicopathologic and Prognostic Significance of the Zinc Finger of the Cerebellum Family in Invasive Breast Cancer

Wei Han,Cong Zhang,Xiao-jiao Gao,Hua-bing Wang,Fang Chen,Fang Cao,Yong-wei Hu,Jun Ma,Xing Gu,Hou-zhong Ding 한국유방암학회 2018 Journal of breast cancer Vol.21 No.1

Purpose: Five members of the zinc finger of the cerebellum (ZIC) family—ZIC1, ZIC2, ZIC3, ZIC4, and ZIC5—have been shown to be involved in various carcinomas. Here, we aimed to explore the clinicopathologic and prognostic roles of ZIC family members in invasive breast cancer patients using immunohistochemical analysis, western blotting analysis, and real-time quantitative polymerase chain reaction (RT-qPCR). Methods: A total of 241 female invasive breast cancer patients who underwent radical mastectomy between 2009 and 2011 were enrolled. ZIC proteins in 241 pairs of breast tumors and corresponding normal tissues were investigated using immunohistochemistry and the clinicopathologic roles of proteins were analyzed using Pearson’s chi-square test. Kaplan-Meier curves and Cox regression analysis were also used to analyze the prognostic value of the ZIC proteins. In addition, 12 pairs of fresh-frozen breast tumors and matched normal tissues were used in the western blotting analysis and RT-qPCR. Results: Only ZIC1 expression in normal tissues was obviously higher than that in tumors (p<0.001). On multivariate analysis, ZIC1 expression (in overall survival analysis: hazard ratio [HR], 0.405, 95% confidence interval [CI], 0.233–0.702, p=0.001; in disease-free survival analysis: HR, 0.395, 95% CI, 0.234–0.669, p=0.001) was identified as a prognostic indicator of invasive breast cancer. Conclusion: ZIC1, but not the other proteins, was obviously decreased in breast tumors and associated with clinicopathologic factors. Thus, ZIC1 might be a novel indicator to predict the overall and disease-free survival of invasive breast cancer patients.

韩汉语羡余否定“-잖아”和“不是嘛”的交互主观性类型

魏雪娇,(Wei, Xue-Jiao) 대한중국학회 2021 중국학 Vol.76 No.-

韩汉语都有羡余否定表达方式,但其表现手段各有不同。本文以“-잖아”和“不是嘛”为例,试从交互主观性类型上做以对比。首先,界定了羡余否定的概念及其研究范围,然后以韩中电视剧剧本为依据,从句法位置、情感指向及交互主观性的角度,对比了韩国语“-잖아”和汉语“不是嘛”羡余否定表达的异同。通过语料的对比分析,我们认为韩国语是以对方(第二人)视角为参照的语言,相较汉语的自我视角,具有更强的交互主观性。这一判断也给韩国语更加倾向于交互主观性,汉语倾向主观性和交互主观性并重提供了一种旁证。本文的结论对于把握韩汉语羡余否定的特点具有一定的参考价值。 Korean and Chinese have different ways of expressing redundant negation. This paper takes “-잖아” and “不是嘛” as an example, and tries to make a comparison of the different types of interactive subjectivity between Korean and Chinese redundant negation. Firstly, this paper defines the concept of redundant negation and its research scope. Then, based on Korean and Chinese TV dramas, this paper compares the similarities and differences between Korean “-잖아” and Chinese “不是嘛” from the perspectives of syntactic position, emotional orientation and interactive subjectivity. Through the comparative analysis of the corpus, we believe that Korean is a language with the perspective of the other (second person) as the reference, and has stronger interactive subjectivity compared with the self-perspective of Chinese. This judgment also provides a circumstantial evidence that Korean language is more inclined to interactive subjectivity, while Chinese language is both inclined to interactive subjectivity and reciprocal subjectivity. The conclusion has certain reference value for grasping the characteristics of redundant negation in Korean and Chinese.

Clinical Features of Multiple Primary Malignancies: a Retrospective Analysis of 72 Chinese Patients

Jiao, Feng,Yao, Li-Juan,Zhou, Jin,Hu, Hai,Wang, Li-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

There is a scarcity of reports addressing patients with multiple primary malignancies (MPM), especially for Chinese cses. The aim of this study was to present a detailed analysis of Chinese patients presenting with at least two primary malignancies. Particularly, the clinical characteristics and survival between synchronous and metachronous MPM were compared. Out of 6,545 cases, 72 patients (1.1%) including 39 males (54.2%) and 33 females (45.8%) were diagnosed as MPM, giving a male: female sex ratio of 1.2:1. Of these, there were 16 (22.2%) cases of synchronous MPM (7 males, 9 females), 55(76.4%) metachronous (31 males, 24 females), and 1 "mixed form". For first tumor diagnosis time, synchronous MPM patients generally presented later than the metachronous cases. The top three sites for malignancies with metachronous MPM were colorectum, head and neck, and lung, while for synchronous they were lung, colorectum and breast. Among MPM patients, the median survival time was 15.7 years and the 5-year survival was 56%, and there was statistical difference in MPM categories (P < 0.05). The median survival time was 17.3 years and 3.8 years for metachronous and synchronous MPM patients, respectively. In comparison with synchronous MPM patients, those metachronous had a longer survival. This studies increase understanding of the clinical features of Chinese MPM patients and suggest that those presenting with metachronous cancers have a higher incidence and a better prognosis.

Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds

Wei Dong,Cheng Tian,Z. Galvin Li,David Brand,Yanhong Cao,Xiaoyun Liu,Jiamin Ma,Andy Chai,LindaK.myers,Jian Yan,Karen Hasty,John Stuart,Yan Jiao,Weikuan Gu,Xiaojun Cai 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.4

Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex and limbs accumulated in the past more than two decades from four unique populations of murine arthritis models were analyzed. They are (1) interleukin-1 receptor antagonist (IL-1ra) deficient mice under Balb/c background (Balb/c KO); (2) Mice with collagen II induced arthritis under DBA/1 background; (3) Mice with collagen II induced arthritis under C57BL/6 (B6) background and (4) A F2 generation population created by Balb/c KO X DBA/1 KO. Our data shows that there is a great variation in sexual dimorphism for arthritis incidence and severity of arthritis in mice harboring specific genetic modifications. For a F2 population, the incidence of arthritis was 57.1% in female mice and 75.6% in male mice. There was a difference in severity related to sex in two populations: B6.DR1/ B6.DR4 (P < 0.001) and F2 (P = 0.023) There was no difference Balb/c parental strain or in collagen-induced arthritis (CIA) in DBA/1 mice. Among these populations, the right hindlimbs are significantly higher than the scores for the left hindlimbs in males (P < 0.05). However, when examining disease expression using the collagen induced arthritis model with DBA/1 mice, sex-dimorphism did not reach statistical significance, while left hindlimbs showed a tendency toward greater disease expression over the right. Sexual dimorphism in disease expression in mouse models is strain and genomic background dependent. It sets an alarm that potential variation in sexual dimorphism among different racial and ethnic groups in human populations may exist. It is important to not only include both sexes and but also pay attention to possible variations caused by disease expression and response to treatment in all the studies of arthritis in animal models and human populations.

Microwave Ablation Treatment of Liver Cancer with a 2,450-MHz Cooled-shaft Antenna: Pilot Study on Safety and Efficacy

Jiao, De-Chao,Zhou, Qi,Han, Xin-Wei,Wang, Ya-Feng,Wu, Gang,Ren, Jian-Zhuang,Wang, Yan-Li,Ding, Peng-Xu,Ma, Ji,Fu, Ming-Ti Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

To evaluate efficacy of microwave ablation in a primary clinical study, sixty patients (44 men, 16 women; mean age 53 years) with 96, 1-8 cm (mean $3.20{\pm}0.17$ cm) liver cancers were treated with 2,450-MHz internally cooled-shaft antenna. Complete ablation (CA) and local tumor progression (LTP) rates as well as complications were determined. CA rates in small (< 3.0 cm), intermediate (3.1-5.0 cm) and large (5.1-8.0 cm) liver cancers were 96.4% (54/56), 92.3% (24/26) and 78.6% (11/14), respectively. During a mean follow-up period of $17.17{\pm}6.52$ months, LTP occurred in five (5.21%) treated cases. There was no significant difference in the CA and LTP rates between the HCC and liver metastasis patient subgroups (P<0.05). Microwave ablation provides a reliable, efficient, and safe technique to perform hepatic tumor ablation.