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RISS 인기검색어
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- 저자 : Vijayakumar Karthikeyan A (검색결과 5 건)
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A Review on Peripheral Tinnitus, Causes, and Treatments from the Perspective of Autophagy
Vijayakumar Karthikeyan A,조광원,Maharajan Nagarajan,Jang Chul Ho 한국뇌신경과학회 2022 Experimental Neurobiology Vol.31 No.4
Tinnitus is the perception of phantom noise without any external auditory sources. The degeneration of the function or activity of the peripheral or central auditory nervous systems is one of the causes of tinnitus. This damage has numerous causes, such as loud noise, aging, and ototoxicity. All these sources excite the cells of the auditory pathway, producing reactive oxygen species that leads to the death of sensory neural hair cells. This causes involuntary movement of the tectorial membrane, resulting in the buzzing noise characteristic of tinnitus. Autophagy is an evolutionarily conserved catabolic scavenging activity inside a cell that has evolved as a cell survival mechanism. Numerous studies have demonstrated the effect of autophagy against oxidative stress, which is one of the reasons for cell excitation. This review compiles several studies that highlight the role of autophagy in protecting sensory neural hair cells against oxidative stress-induced damage. This could facilitate the development of strategies to treat tinnitus by activating autophagy.
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Development of a Switched Diode Asymmetric Multilevel Inverter Topology
Karthikeyan, D.,Krishnasamy, Vijayakumar,Sathik, Mohd. Ali Jagabar The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2
This paper presents a new asymmetrical multilevel inverter with a reduced number of power electronic components. The proposed multilevel inverter is analyzed using two different configurations: i) First Configuration (with a switched diode) and ii) Second Configuration (without a switched diode). The presented topologies are compared with recent multilevel inverter topologies in terms of number of switches, gate driver circuits and blocking voltages. The proposed topologies can be cascaded to generate the maximum number of output voltage levels and they are suitable for high voltage applications. Various power quality issues are addressed for both of the configurations. The proposed 11-level inverter configuration is simulated using MATLAB and it is validated with a laboratory based experimental setup.
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Development of a Switched Diode Asymmetric Multilevel Inverter Topology
D. Karthikeyan,Vijayakumar Krishnasamy,Mohd. Ali Jagabar Sathik 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2
This paper presents a new asymmetrical multilevel inverter with a reduced number of power electronic components. The proposed multilevel inverter is analyzed using two different configurations: i) First Configuration (with a switched diode) and ii) Second Configuration (without a switched diode). The presented topologies are compared with recent multilevel inverter topologies in terms of number of switches, gate driver circuits and blocking voltages. The proposed topologies can be cascaded to generate the maximum number of output voltage levels and they are suitable for high voltage applications. Various power quality issues are addressed for both of the configurations. The proposed 11-level inverter configuration is simulated using MATLAB and it is validated with a laboratory based experimental setup.
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Palanisamy R.,Karthikeyan D.,Vidyasagar S.,Kalyanasundaram V.,Selvakumar K.,Vijayakumar K.,Selvabharathi D. 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.4
In this paper, three phase four wire fi ve level Neutral Point Clamped Inverter (NPCI) based Static synchronous Compensator (STATCOM) is implemented for reactive power control and neutral current elimination. Three dimensional Space Vector Pulse Width Modulation (3D-SVPWM) control strategy is developed to control this 5-level NPC inverter. The behaviour of static synchronous compensator is analyzed and reactive power control is done using constant DC voltage. The objective of this compensating method is to provide balanced and sinusoidal source currents under unbalanced and nonlinear load conditions and reactive power control. The 3D-SVPWM technique provides reduced harmonic content in output voltage and current, controlled source current, minimized common mode voltage and improved output voltage. In 3D-SVPWM, switching pulses are generated with non-redundant switching states, which lead to reduce the complexity in switching time calculation and computational time is less. The highlights of the paper includes the neutral current is reduced to 0.25A, source current harmonics is minimized and it provides balanced and sinusoidal source currents with help of STATCOM compensation. The simulation and experimental results demonstrates the sinusoidal and harmonics free source current and minimized neutral current for four wire fi ve level NPCI based STATCOM.
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The Role of Stress Granules in the Neuronal Differentiation of Stem Cells
정신구,온탁범,Chul Ho Jang,Karthikeyan Vijayakumar,조광원 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.10
Cells assemble stress granules (SGs) to protect their RNAs from exposure to harmful chemical reactions induced by environmental stress. These SGs release RNAs, which resume translation once the stress is relieved. During stem cell differentiation, gene expression is altered to allow cells to adopt various functional and morphological features necessary to differentiate. This process induces stress within a cell, and cells that cannot overcome this stress die. Here, we investigated the role of SGs in the progression of stem cell differentiation. SGs aggregated during the neuronal differentiation of human bone marrow-mesenchymal stem cells, and not in cell lines that could not undergo differentiation. SGs were observed between one and three hours post-induction; RNA translation was restrained at the same time. Immediately after disassembly of SGs, the expression of the neuronal marker neurofilament-M (NFM) gradually increased. Assembled SGs that persisted in cells were exposed to salubrinal, which inhibited the dephosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2α), and in eIF2α/S51D mutant cells. When eIF2α/S51A mutant cells differentiated, SGs were not assembled. In all experiments, the disruption of SGs was accompanied by delayed NF-M expression and the number of neuronally differentiated cells was decreased. Decreased differentiation was accompanied by decreased cell viability, indicating the necessity of SGs for preventing cell death during neuronal differentiation. Collectively, these results demonstrate the essential role of SGs during the neuronal differentiation of stem cells.
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