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- 저자 : Vijay Pal Singh (검색결과 4 건)
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Rana, Vijay Kumar,Park, Sung Soo,Parambadath, Surendran,Kim, Mi Ju,Kim, Sun-Hee,Mishra, Satyendra,Singh, Raj Pal,Ha, Chang-Sik Royal Society of Chemistry 2011 MedChemComm Vol.2 No.12
<P>In this communication, we report the facile synthesis of hierarchical mesoporous bio-polymer/silica composite materials with bimodal mesopores using a dual-template of the cationic <I>N</I>,<I>N</I>,<I>N</I>-trimethyl chitosan (TMCs) and the anionic sodium dodecyl sulfate (SDS) <I>via</I> one-step synthetic strategy. Tetraethoxysilane (TEOS) was used as a silica source. The nitrogen adsorption/desorption measurements and transmission electron microscopy analysis showed the hierarchical structure of the mesoporous bio-polymer/silica composites with bimodal mesopores having an average pore size of 5–7 nm with the visible voids between the silica nanoparticles, which allow the mesoporous bio-polymer/silica composites to encapsulate a large number of guest drug molecules, Ibuprofen (IBU) or 5-fluorouracil (5-FU), due to their high surface area and pore volume. In addition, the mesoporous chitosan–silica composites also had a long term biocompatibility for the target release of the drug molecules to the CEM cells, MCF cells, <I>etc.</I> as well as a pH sensitive controlled release behavior of the drug molecules.</P> <P>Graphic Abstract</P><P>A facile, dual-template method was reported to synthesize hierarchical mesoporous bio-polymer/silica composite materials with dual mesopores for controlled drug delivery. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00222d'> </P>
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Reproductive performance of genetically engineered mice housed in different housing systems
Shikha Yadav,Inderjeet Yadav,Kunal Pratap,Pradeep Kumar Tiwari,Vijay Pal Singh 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading undesirable microorganisms. However, the static micro isolation cage housing like SMIC are being replaced with IVC systems in many facilities due to a number of benefits like a higher density housing in limited space, better protection from biohazards and allergens and decreased work load due to decreased frequency of cage changing required in this system. The purpose of this study was to examine the reproductive performance of genetically engineered mice housed in individually ventilated cages (IVC) and Static Micro Isolator Cages (SMIC). When the B6C3-Tg (APPswe, PSEN1dE9) 85Dbo/Mmjax transgenic mice were housed in these two housing systems, the number of litters per dam, number of pups born per dam and number of pups weaned per dam were found to be slightly higher in the IVC as compared to the SMIC but the difference was not significant (P<0.05). In case of Growth Associated Protein 43 (GAP-43) knockout mice, the number of litters born per dam and the number of pups born per dam were marginally higher in the IVC as compared to those housed in SMIC but the difference was not significant (P<0.05). Only the number of pups weaned per dam were found to be significantly higher as compared to those housed in the SMIC system at P<0.05.
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Virmani, Richa,Sajid, Andaleeb,Singhal, Anshika,Gaur, Mohita,Joshi, Jayadev,Bothra, Ankur,Garg, Richa,Misra, Richa,Singh, Vijay Pal,Molle, Virginie,Goel, Ajay K.,Singh, Archana,Kalia, Vipin C.,Lee, Ju American Society for Biochemistry and Molecular Bi 2019 The Journal of biological chemistry Vol.294 No.22
<P><I>Bacillus anthracis</I> is the causative agent of anthrax in humans, bovine, and other animals. <I>B. anthracis</I> pathogenesis requires differentiation of dormant spores into vegetative cells. The spores inherit cellular components as phenotypic memory from the parent cell, and this memory plays a critical role in facilitating the spores' revival. Because metabolism initiates at the beginning of spore germination, here we metabolically reprogrammed <I>B. anthracis</I> cells to understand the role of glycolytic enzymes in this process. We show that increased expression of enolase (Eno) in the sporulating mother cell decreases germination efficiency. Eno is phosphorylated by the conserved Ser/Thr protein kinase PrkC which decreases the catalytic activity of Eno. We found that phosphorylation also regulates Eno expression and localization, thereby controlling the overall spore germination process. Using MS analysis, we identified the sites of phosphorylation in Eno, and substitution(s) of selected phosphorylation sites helped establish the functional correlation between phosphorylation and Eno activity. We propose that PrkC-mediated regulation of Eno may help sporulating <I>B. anthracis</I> cells in adapting to nutrient deprivation. In summary, to the best of our knowledge, our study provides the first evidence that in sporulating <I>B. anthracis</I>, PrkC imprints phenotypic memory that facilitates the germination process.</P>
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Bioletty Mary Lawriniang,Sylvia Badwar,Reetuparna Ghosh,Betylda Jyrwa,Vibha Vansola,Haladhara Naik,Ashok Goswami,Yeshwant Naik,Chandra Shekhar Datrik,Amit Kumar Gupta,Vijay Pal Singh,Sudir Shibaji Pol 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.3
The 115In(n, )116mIn reaction cross section at neutron energies of 1.12, 2.12, 3.12 and 4.12 MeV was determined by using an activation and off-line -ray spectrometric technique. The monoenergetic neutron energies of 1.12 − 4.12 MeV were generated from the 7Li(p,n) reaction by using proton beam with energies of 3 and 4 MeV from the folded tandem ion beam accelerator (FOTIA) at Bhabha Atomic Research Centre (BARC) and with energies of 5 and 6 MeV from the Pelletron facility at Tata Institute of Fundamental Research (TIFR), Mumbai. The 197Au(n, )198Au reaction cross-section was used as the neutron flux monitor. The 115In(n, )116mIn reaction cross-sections at neutron energies of 1.12 − 4.12 MeV were compared with the literature data and were found to be in good agreement with one set of data, but not with others. The 115In(n, )116mIn cross-section was also calculated theoretically by using the computer code TALYS 1.6 and was found to be slightly lower than the experimental data from the present work and the literature.
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